Research

Publications

Below you can find a list of our published research.

9618 results

Cited 17 times since 2015 (1.6 per year) source: EuropePMC

Molecular ecology, Volume 24, Issue 10, 21 3 2015, Pages 2324-2335 Host and parasite life history interplay to yield divergent population genetic structures in two ectoparasites living on the same bat species. van Schaik J, Dekeukeleire D, Kerth G

Host-parasite interactions are ubiquitous in nature. However, how parasite population genetic structure is shaped by the interaction between host and parasite life history remains understudied. Studies comparing multiple parasites infecting a single host can be used to investigate how different parasite life history traits interplay with host behaviour and life history. In this study, we used 10 newly developed microsatellite loci to investigate the genetic structure of a parasitic bat fly (Basi... Abstract

Cited 41 times since 2015 (4 per year) source: EuropePMC

PloS one, Volume 10, Issue 4, 17 3 2015, Pages e0124347 Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages. Yıldırım C, Vogel DY, Hollander MR, Baggen JM, Fontijn RD, Nieuwenhuis S, Haverkamp A, de Vries MR, Quax PH, Garcia-Vallejo JJ, van der Laan AM, Dijkstra CD, van der Pouw Kraan TC, van Royen N, Horrevoets AJ

Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of galectin-2 on arteriogenesis was confirmed in vivo, but the mechanism is largely unknown. In this study we aimed to explore the effects of galectin-2 on monocyte/macrophage phenotype in vitro and vivo, and to identify the receptor by which galectin-... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Canadian journal of physiology and pharmacology, Volume 93, Issue 7, 17 3 2015, Pages 569-575 Identification and functional characterisation of a novel KCNJ2 mutation, Val302del, causing Andersen-Tawil syndrome. Ördög B, Hategan L, Kovács M, Seprényi G, Kohajda Z, Nagy I, Hegedűs Z, Környei L, Jost N, Katona M, Szekeres M, Forster T, Papp JG, Varró A, Sepp R

Loss-of-function mutations of the KCNJ2 gene encoding for the inward rectifier potassium channel subunit Kir2.1 cause Andersen-Tawil Syndrome (ATS), a rare genetic disorder characterised by periodic paralysis, ventricular arrhythmias, and dysmorphic features. Clinical manifestations of the disease appear to vary greatly with the nature of mutation, therefore, functional characterisation of ATS-causing mutations is of clinical importance. In this study, we describe the identification and function... Abstract

Cited 57 times since 2015 (5.5 per year) source: EuropePMC

BMC sports science, medicine & rehabilitation, Volume 7, 17 3 2015, Pages 8 The effects of exergaming on balance, gait, technology acceptance and flow experience in people with multiple sclerosis: a randomized controlled trial. Robinson J, Dixon J, Macsween A, van Schaik P, Martin D

Background: Exergaming is a promising new alternative to traditional modes of therapeutic exercise which may be preferable and more effective for people with Multiple Sclerosis (MS). Impaired balance is reported as one of the most disabling aspects of MS. The purposes of this study were to examine the effects of exergaming on: (1) postural sway, (2) gait, (3) technology acceptance and (4) flow experience in people with MS. Secondary outcomes were disability: 12-item Multiple Sclerosis Walking Sc... Abstract

Cited 94 times since 2015 (9.1 per year) source: EuropePMC

Genome research, Volume 25, Issue 6, 16 3 2015, Pages 792-801 Characteristics of de novo structural changes in the human genome. Kloosterman WP, Francioli LC, Hormozdiari F, Marschall T, Hehir-Kwa JY, Abdellaoui A, Lameijer EW, Moed MH, Koval V, Renkens I, van Roosmalen MJ, Arp P, Karssen LC, Coe BP, Handsaker RE, Suchiman ED, Cuppen E, Thung DT, McVey M, Wendl MC, Genome of Netherlands Consortium, Uitterlinden A, van Duijn CM, Swertz MA, Wijmenga C, van Ommen GB, Slagboom PE, Boomsma DI, Schönhuth A, Eichler EE, de Bakker PI, Ye K, Guryev V

Small insertions and deletions (indels) and large structural variations (SVs) are major contributors to human genetic diversity and disease. However, mutation rates and characteristics of de novo indels and SVs in the general population have remained largely unexplored. We report 332 validated de novo structural changes identified in whole genomes of 250 families, including complex indels, retrotransposon insertions, and interchromosomal events. These data indicate a mutation rate of 2.94 indels... Abstract

Cited 24 times since 2015 (2.3 per year) source: EuropePMC

European heart journal, Volume 36, Issue 31, 16 3 2015, Pages 2079-2086 Secundum atrial septal defect is associated with reduced survival in adult men. Kuijpers JM, van der Bom T, van Riel AC, Meijboom FJ, van Dijk AP, Pieper PG, Vliegen HW, Waskowsky WM, Oomen T, Zomer AC, Wagenaar LJ, Heesen WF, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ

Aims: The identification of sex differences in the prognosis of adults with a secundum atrial septal defect (ASD2) could help tailor their clinical management, as it has in other cardiovascular diseases. We investigated whether disparity between the sexes exists in long-term outcome of adult ASD2 patients. Methods and results: Patients with ASD2 classified as the primary defect were selected from the Dutch national registry of adult congenital heart disease. Survival stratified by sex was compar... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Journal of electrocardiology, Volume 48, Issue 4, 15 3 2015, Pages 490-497 Intra-individual ECG changes over 25 years: How long can elective ECGs be used as reference for acute ischemia detection? De Jongh MC, Ter Haar CC, Man S, Treskes RW, Maan AC, Schalij MJ, Swenne CA

Background: The guidelines advocate, in patients with chest pain, comparison of the acute ECG with a previously made, non-ischemic ECG that serves as a reference, to corroborate the working diagnosis of acute coronary syndrome (ACS). Our approach of this serial comparison is to compute the differences between the ST vectors at the J point and 60 ms thereafter (∆ST(J+0), ∆ST(J+60)) and between the ventricular gradient (VG) vectors (∆VG). In the current study, we investigate if reference ECGs rema... Abstract

Cited 99 times since 2015 (9.6 per year) source: EuropePMC

Molecular psychiatry, Volume 21, Issue 2, 14 2 2015, Pages 189-197 GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ, Schmidt CO, Mather KA, Chouraki V, Sun Q, Resnick SM, Rose LM, Oldmeadow C, Stewart M, Smith BH, Gudnason V, Yang Q, Mirza SS, Jukema JW, deJager PL, Harris TB, Liewald DC, Amin N, Coker LH, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai N, Becker JT, Jonsdottir MK, Au R, Fehrmann R, Herms S, Nalls M, Zhao W, Turner ST, Yaffe K, Lohman K, van Swieten JC, Kardia S, Knopman DS, Meeks WM, Heiss G, Holliday EG, Schofield PW, Tanaka T, Stott DJ, Wang J, Ridker P, Gow AJ, Pattie A, Starr JM, Hocking LJ, Armstrong NJ, McLachlan S, Shulman JM, Pilling LC, Eiriksdottir G, Scott RJ, Kochan NA, Palotie A, Hsieh YC, Eriksson JG, Penman A, Gottesman RF, Oostra BA, Yu L, DeStefano AL, Beiser A, Garcia M, Rotter JI, Nöthen MM, Hofman A, Slagboom PE, Westendorp R, Buckley

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time... Abstract

Cited 15 times since 2015 (1.4 per year) source: EuropePMC

The pharmacogenomics journal, Volume 16, Issue 1, 14 2 2015, Pages 54-59 Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study. Crona DJ, Ramirez J, Qiao W, de Graan AJ, Ratain MJ, van Schaik RH, Mathijssen RH, Rosner GL, Innocenti F

The overall goal of this study was to provide evidence for the clinical validity of nine genetic variants in five genes previously associated with irinotecan neutropenia and pharmacokinetics. Variants associated with absolute neutrophil count (ANC) nadir and/or irinotecan pharmacokinetics in a discovery cohort of cancer patients were genotyped in an independent replication cohort of 108 cancer patients. Patients received single-agent irinotecan every 3 weeks. For ANC nadir, we replicated UGT1A1*... Abstract

Cited 53 times since 2015 (5.1 per year) source: EuropePMC

BMC genomics, Volume 16, 10 2 2015, Pages 282 Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis. Mikalsen T, Pedersen T, Willems R, Coque TM, Werner G, Sadowy E, van Schaik W, Jensen LB, Sundsfjord A, Hegstad K

Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGEs). Here, we investigate this mobilome in successful hospital associated genetic lineages, E. faecium sequence type (ST)17 (n=10) and ST78 (n=10), E. faecalis ST6 (n=10) and ST40 (n=10) by DNA microarray analyses. Results: The hybridiza... Abstract

Cited 9 times since 2015 (0.9 per year) source: EuropePMC

Nutrition journal, Volume 14, 10 2 2015, Pages 35 Dietary intake of patients with moderate to severe COPD in relation to fat-free mass index: a cross-sectional study. Yılmaz D, Çapan N, Canbakan S, Besler HT

Background: Fat-free mass (FFM) depletion has been shown to be a better predictor of mortality than BMI in chronic obstructive pulmonary disease (COPD) patients. The specific aim of the current study was to assess the nutritional status of stable COPD patients in relation to fat free mass index profiles. Methods: We investigated 65 male moderate-to-severe stable COPD patients. A self-reported questionnaire was applied about general characteristics and smoking history. Nutritional intake was asse... Abstract

Cited 119 times since 2015 (11.5 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 100, Issue 6, 9 2 2015, Pages 2181-2191 Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. Chaker L, Baumgartner C, den Elzen WP, Ikram MA, Blum MR, Collet TH, Bakker SJ, Dehghan A, Drechsler C, Luben RN, Hofman A, Portegies ML, Medici M, Iervasi G, Stott DJ, Ford I, Bremner A, Wanner C, Ferrucci L, Newman AB, Dullaart RP, Sgarbi JA, Ceresini G, Maciel RM, Westendorp RG, Jukema JW, Imaizumi M, Franklyn JA, Bauer DC, Walsh JP, Razvi S, Khaw KT, Cappola AR, Völzke H, Franco OH, Gussekloo J, Rodondi N, Peeters RP, Thyroid Studies Collaboration

Objective: The objective was to determine the risk of stroke associated with subclinical hypothyroidism. Data sources and study selection: Published prospective cohort studies were identified through a systematic search through November 2013 without restrictions in several databases. Unpublished studies were identified through the Thyroid Studies Collaboration. We collected individual participant data on thyroid function and stroke outcome. Euthyroidism was defined as TSH levels of 0.45-4.49 mIU... Abstract

Cited 21 times since 2015 (2 per year) source: EuropePMC

Open heart, Volume 2, Issue 1, 8 2 2015, Pages e000237 Prosthetic aortic valve selection: current patient experience, preferences and knowledge. Korteland NM, Bras FJ, van Hout FM, Kluin J, Klautz RJ, Bogers AJ, Takkenberg JJ

Objective: Current clinical practice guidelines advocate shared decision-making (SDM) in prosthetic valve selection. This study assesses among adult patients accepted for aortic valve replacement (AVR): (1) experience with current clinical decision-making regarding prosthetic valve selection, (2) preferences for SDM and risk presentation and (3) prosthetic valve knowledge and numeracy. Methods: In a prospective multicentre cohort study, AVR patients were surveyed preoperatively and 3 months post... Abstract

Cited 37 times since 2015 (3.6 per year) source: EuropePMC

International journal of epidemiology, Volume 44, Issue 2, 7 1 2015, Pages 604-612 LDL cholesterol still a problem in old age? A Mendelian randomization study. Postmus I, Deelen J, Sedaghat S, Trompet S, de Craen AJ, Heijmans BT, Franco OH, Hofman A, Dehghan A, Slagboom PE, Westendorp RG, Jukema JW

Background: Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality. However, in old age plasma low-density lipoprotein cholesterol (LDL-C) may not reflect the lifetime level due to reverse causality, and hence the risk may be underestimated. In the current study, we used an LDL genetic risk score (GRS) to overcome this problem. Methods: A weighted GRS was created using 51 single nucleotide polymorphisms associated with LDL-C levels.... Abstract

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 2, 7 1 2015, Pages 538-44; discussion 544-5 A single-centre 37-year experience with reoperation after primary repair of atrioventricular septal defect. Sojak V, Kooij M, Yazdanbakhsh A, Koolbergen DR, Bruggemans EF, Hazekamp MG

Objectives: To evaluate our experience with patients reoperated after primary repair of atrioventricular septal defect (AVSD) and identify predictors of poor outcome. Methods: Between 1976 and 2014, 69 patients were reoperated after primary repair of partial (n = 28), intermediate (n = 15) or complete (n = 26) AVSD. Results: Median age at first reoperation was 62.4 (range, 1.6-845) months, median interval to first reoperation was 22.3 (range, 0.2-598) months. Main indications for first reoperati... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 42, Issue 5, 7 1 2015, Pages 1297-1304 High-temporal velocity-encoded MRI for the assessment of left ventricular inflow propagation velocity: Comparison with color M-mode echocardiography. Calkoen EE, Marsan NA, Bax JJ, van den Boogaard PJ, Roest AA, de Roos A, Westenberg JJ

Purpose: To develop an alternative method for Vp-assessment using high-temporal velocity-encoded magnetic resonance imaging (VE-MRI). Left ventricular (LV) inflow propagation velocity (Vp) is considered a useful parameter in the complex assessment of LV diastolic function and is measured by Color M-mode echocardiography. Materials and methods: A total of 43 patients diagnosed with ischemic heart failure (61 ± 11 years) and 22 healthy volunteers (29 ± 13 years) underwent Color M-mode echocardiogr... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Critical care medicine, Volume 43, Issue 4, 1 1 2015, Pages 919-920 I'm okay, you're not okay: moral distress in health care as an issue of affective perspective taking and in-group/out-group tensions. van Schaik S

Abstract

Cited 34 times since 2015 (3.3 per year) source: Scopus

JACC. Cardiovascular interventions, Volume 8, Issue 5, 1 1 2015, Pages 670-677 Surgical sutureless and transcatheter aortic valves: hemodynamic performance and clinical outcomes in propensity score-matched high-risk populations with severe aortic stenosis. Kamperidis V, van Rosendael PJ, de Weger A, Katsanos S, Regeer M, van der Kley F, Mertens B, Sianos G, Ajmone Marsan N, Bax JJ, Delgado V

Objectives: In propensity score-matched patients with severe aortic stenosis treated with surgical aortic valve replacement (AVR) with the 3f Enable sutureless prosthesis (Medtronic, Minneapolis, Minnesota) or transcatheter aortic valve replacement (TAVR), the hemodynamic performance of both valves and mid-term survival of patients were evaluated. Background: Data on hemodynamic performance of surgical sutureless bioprostheses in high operative risk patients with aortic stenosis are scarce. Meth... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 10, Issue 12, 1 1 2015, Pages 1488-1492 How should I treat recurrent concomitant para-ring and valvular mitral regurgitation after surgical mitral valve repair in a high-risk patient? van Rosendael P, van der Kley F, Martina B, Palmen M, Delgado V, Schillinger W, von Bardeleben RS, Yeo KK, Ho KW, Jack Tan WC

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European heart journal, Volume 36, Issue 14, 1 1 2015, Pages 832-833 The first European Congress on e-Cardiology & e-Health. Bruining N, van der Velde ET, Saner H

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