9618 results
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 2, 1 1 2015, Pages 130-132
Cardiac arrest during vigorous exercise: coronary plaque rupture or myocardial ischaemia?
van Rosendael AR, de Graaf MA, Scholte AJ
Abstract
Preventive medicine,
Volume 73, 31 5 2015, Pages 117-118
Evolution of prevention: Epidemiological transitions, evolutionary medicine, and clinical practice.
van Schaik K, Rühli F
Abstract
Cited 22 times since 2015 (2.1 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 28, Issue 4, 27 4 2015, Pages 470-477
The relationship between time from myocardial infarction, left ventricular dyssynchrony, and the risk for ventricular arrhythmia: speckle-tracking echocardiographic analysis.
Leong DP, Hoogslag GE, Piers SR, Höke U, Thijssen J, Marsan NA, Schalij MJ, Zeppenfeld K, Bax JJ, Delgado V
Background: Differences in arrhythmogenic substrate may explain the variable efficacy of implantable cardioverter-defibrillators (ICDs) in primary sudden cardiac death prevention over time after myocardial infarction (MI). Speckle-tracking echocardiography allows the assessment left ventricular (LV) dyssynchrony, which may reflect the electromechanical heterogeneity of myocardial tissue. The aim of the present study was to evaluate the relationship among LV dyssynchrony, age of MI, and their ass...
Abstract
Cited 23 times since 2015 (2.2 per year)
source: Scopus
Journal of cardiovascular computed tomography,
Volume 9, Issue 2, 26 4 2015, Pages 129-138
Atherosclerosis burden of the aortic valve and aorta and risk of acute kidney injury after transcatheter aortic valve implantation.
van Rosendael PJ, Kamperidis V, van der Kley F, Katsanos S, Al Amri I, Regeer MV, Schalij MJ, de Weger A, Marsan NA, Bax JJ, Delgado V
Background: Atheroembolic renal disease, due to dislodgement of cholesterol crystals during maneuvering of a large catheter across the aorta and deployment of the transcatheter prosthesis within a calcified aortic valve, may be one of the pathophysiological mechanisms of acute kidney injury (AKI) complicating transcatheter aortic valve implantation (TAVI). Objective: To investigate the association between the atherosclerotic burden and plaque characteristics of the aortic valve and thoracic aort...
Abstract
Cited 268 times since 2015 (25.3 per year)
source: EuropePMC
European heart journal,
Volume 36, Issue 14, 23 4 2015, Pages 847-855
Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutation carriers.
Bhonsale A, Groeneweg JA, James CA, Dooijes D, Tichnell C, Jongbloed JD, Murray B, te Riele AS, van den Berg MP, Bikker H, Atsma DE, de Groot NM, Houweling AC, van der Heijden JF, Russell SD, Doevendans PA, van Veen TA, Tandri H, Wilde AA, Judge DP, van Tintelen JP, Calkins H, Hauer RN
Aims: We sought to determine the influence of genotype on clinical course and arrhythmic outcome among arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)-associated mutation carriers. Methods and results: Pathogenic mutations in desmosomal and non-desmosomal genes were identified in 577 patients (241 families) from USA and Dutch ARVD/C cohorts. Patients with sudden cardiac death (SCD)/ventricular fibrillation (VF) at presentation (n = 36) were younger (median 23 vs. 36 years; P &...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Cell transplantation,
Volume 24, Issue 12, 23 4 2015, Pages 2463-2478
Human Placenta-Derived Multipotent Cells (hPDMCs) Modulate Cardiac Injury: From Bench to Small and Large Animal Myocardial Ischemia Studies.
Liu YH, Peng KY, Chiu YW, Ho YL, Wang YH, Shun CT, Huang SY, Lin YS, de Vries AA, Pijnappels DA, Lee NT, Yen BL, Yen ML
Cardiovascular disease is the leading cause of death globally, and stem cell therapy remains one of the most promising strategies for regeneration or repair of the damaged heart. We report that human placenta-derived multipotent cells (hPDMCs) can modulate cardiac injury in small and large animal models of myocardial ischemia (MI) and elucidate the mechanisms involved. We found that hPDMCs can undergo in vitro cardiomyogenic differentiation when cocultured with mouse neonatal cardiomyocytes. Mor...
Abstract
Cited 106 times since 2015 (10 per year)
source: EuropePMC
Circulation. Cardiovascular genetics,
Volume 8, Issue 2, 22 4 2015, Pages 383-388
Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome.
Franken R, den Hartog AW, Radonic T, Micha D, Maugeri A, van Dijk FS, Meijers-Heijboer HE, Timmermans J, Scholte AJ, van den Berg MP, Groenink M, Mulder BJ, Zwinderman AH, de Waard V, Pals G
Background: It has been shown that losartan reduces aortic dilatation in patients with Marfan syndrome. However, treatment response is highly variable. This study investigates losartan effectiveness in genetically classified subgroups. Methods and results: In this predefined substudy of COMPARE, Marfan patients were randomized to daily receive losartan 100 mg or no losartan. Aortic root dimensions were measured by MRI at baseline and after 3 years. FBN1 mutations were classified based on fibrill...
Abstract
Cited 10 times since 2015 (0.9 per year)
source: EuropePMC
Physics in medicine and biology,
Volume 60, Issue 4, 22 4 2015, Pages 1477-1496
Influence of vascular normalization on interstitial flow and delivery of liposomes in tumors.
Ozturk D, Yonucu S, Yilmaz D, Unlu MB
Elevated interstitial fluid pressure is one of the barriers of drug delivery in solid tumors. Recent studies have shown that normalization of tumor vasculature by anti-angiogenic factors may improve the delivery of conventional cytotoxic drugs, possibly by increasing blood flow, decreasing interstitial fluid pressure, and enhancing the convective transvascular transport of drug molecules. Delivery of large therapeutic agents such as nanoparticles and liposomes might also benefit from normalizati...
Abstract
Cited 33 times since 2015 (3.1 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 20, Issue 4, 22 4 2015, Pages 520-530
Mortality after cardiac surgery in patients with liver cirrhosis classified by the Child-Pugh score.
Jacob KA, Hjortnaes J, Kranenburg G, de Heer F, Kluin J
Liver cirrhosis is a known risk factor for postoperative mortality in patients undergoing cardiac surgery. Clinical assessment of liver cirrhosis using the widely accepted Child-Pugh (CP) score is thus vital for evaluation of surgical options and perioperative care. However, detailed mortality rates as a consequence of liver cirrhosis are unclear. This review aimed to stratify the risk of short-term (
Abstract
Cited 61 times since 2015 (5.8 per year)
source: EuropePMC
Journal of virology,
Volume 89, Issue 7, 21 3 2015, Pages 3763-3775
Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses.
Koel BF, Mögling R, Chutinimitkul S, Fraaij PL, Burke DF, van der Vliet S, de Wit E, Bestebroer TM, Rimmelzwaan GF, Osterhaus AD, Smith DJ, Fouchier RA, de Graaf M
Unlabelled: The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from neutralizing antibodies, affect viral fitness, and change receptor preference. In this study, we constructed mutants with substitutions in the hemagglutinin of A/Netherlands/602/0...
Abstract
Cited 59 times since 2015 (5.6 per year)
source: EuropePMC
Circulation research,
Volume 116, Issue 5, 21 3 2015, Pages 836-845
Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling.
Qi XY, Huang H, Ordog B, Luo X, Naud P, Sun Y, Wu CT, Dawson K, Tadevosyan A, Chen Y, Harada M, Dobrev D, Nattel S
Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. Fibroblasts display robust ion currents, but their functional importance is poorly understood. Objective: To characterize atrial fibroblast inward-rectifier K(+) current (IK1) remodeling in CHF and its effects on fibroblast properties. Methods and results: Freshly isolated left atrial fibroblasts were obtained from co...
Abstract
Cited 16 times since 2015 (1.5 per year)
source: EuropePMC
European journal of radiology,
Volume 84, Issue 5, 20 3 2015, Pages 856-861
Volumetric CT-images improve testing of radiological image interpretation skills.
Ravesloot CJ, van der Schaaf MF, van Schaik JP, ten Cate OT, van der Gijp A, Mol CP, Vincken KL
Rationale and objectives: Current radiology practice increasingly involves interpretation of volumetric data sets. In contrast, most radiology tests still contain only 2D images. We introduced a new testing tool that allows for stack viewing of volumetric images in our undergraduate radiology program. We hypothesized that tests with volumetric CT-images enhance test quality, in comparison with traditional completely 2D image-based tests, because they might better reflect required skills for clin...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Renal failure,
Volume 37, Issue 3, 19 3 2015, Pages 387-391
Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies.
Yılmaz D, Yenigün A, Sönmez F, Kurt Ömürlü İ
Background: The etiology of minimal-change disease is not fully known, it is believed to be mediated by the immune system. Minimal-change disease also reported as having association with atopy. In this study, atopy history, the levels of serum IgE, and skin prick test in children with steroid-sensitive nephrotic syndrome were investigated. Methods: A group of 30 children (mean age 7.7 ± 2.2 years, 56.6% male) diagnosed with steroid-sensitive nephrotic syndrome were included in the study. Serum i...
Abstract
Cited 584 times since 2015 (55.2 per year)
source: EuropePMC
Nature communications,
Volume 6, 19 3 2015, Pages 5890
Biological interpretation of genome-wide association studies using predicted gene functions.
Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L
The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant...
Abstract
Cited 22 times since 2015 (2.1 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 48, Issue 6, 18 3 2015, Pages 833-40; discussion 840-1
Comprehensive rhythm evaluation in a large contemporary Fontan population.
Bossers SS, Duppen N, Kapusta L, Maan AC, Duim AR, Bogers AJ, Hazekamp MG, van Iperen G, Helbing WA, Blom NA
Objectives: Rhythm disturbances are an important cause of morbidity in Fontan patients. Currently, the total cavopulmonary connection is performed by using the intra-atrial lateral tunnel (ILT) ('baffle ILT' or 'prosthetic ILT'), or the extracardiac conduit (ECC). The aim of the study was to evaluate rhythm abnormalities and compare the surgical techniques in a contemporary cohort. Methods: In a cross-sectional multicentre study, 115 patients (age 12.5 ± 3.1 years) underwent...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Cardiorenal medicine,
Volume 5, Issue 1, 16 3 2015, Pages 69-78
Neuronal nitric oxide synthase-dependent amelioration of diastolic dysfunction in rats with chronic renocardiac syndrome.
Bongartz LG, Soni S, Cramer MJ, Steendijk P, Gaillard CA, Verhaar MC, Doevendans PA, van Veen TA, Joles JA, Braam B
We have recently described the chronic renocardiac syndrome (CRCS) in rats with renal failure, cardiac dysfunction and low nitric oxide (NO) availability by combining subtotal nephrectomy and transient low-dose NO synthase (NOS) inhibition. Cardiac gene expression of the neuronal isoform of NOS (nNOS) was induced. Hence, we studied the role of nNOS, in vivo cardiac function and β-adrenergic response in our CRCS model by micromanometer/conductance catheter. Left ventricular (LV) hemodynamics were...
Abstract
Cited 25 times since 2015 (2.4 per year)
source: EuropePMC
Journal of the American Academy of Dermatology,
Volume 72, Issue 3, 13 2 2015, Pages 465-472
Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas?: A cohort study.
Raphael MF, Breugem CC, Vlasveld FA, de Graaf M, Slieker MG, Pasmans SG, Breur JM
Background: Although consensus guidelines for pretreatment evaluation and monitoring of propranolol therapy in patients with infantile hemangiomas (IH) have been formulated, little is known about the cardiovascular side effects. Objectives: We sought to analyze cardiovascular evaluations in patients with IH at baseline and during treatment with an oral beta-blocker. Methods: Data from 109 patients with IH were retrospectively analyzed. Patient and family history, pretreatment electrocardiogram (...
Abstract
Cited 24 times since 2015 (2.3 per year)
source: EuropePMC
Molecular ecology,
Volume 24, Issue 2, 9 2 2015, Pages 310-327
Reconstructing the demographic history of orang-utans using Approximate Bayesian Computation.
Nater A, Greminger MP, Arora N, van Schaik CP, Goossens B, Singleton I, Verschoor EJ, Warren KS, Krützen M
Investigating how different evolutionary forces have shaped patterns of DNA variation within and among species requires detailed knowledge of their demographic history. Orang-utans, whose distribution is currently restricted to the South-East Asian islands of Borneo (Pongo pygmaeus) and Sumatra (Pongo abelii), have likely experienced a complex demographic history, influenced by recurrent changes in climate and sea levels, volcanic activities and anthropogenic pressures. Using the most extensive...
Abstract
Cited 12 times since 2015 (1.1 per year)
source: EuropePMC
Acta physiologica (Oxford, England),
Volume 213, Issue 3, 9 2 2015, Pages 653-663
Mild hypothermia induces incomplete left ventricular relaxation despite spontaneous bradycardia in pigs.
Schwarzl M, Alogna A, Zirngast B, Steendijk P, Verderber J, Zweiker D, Huber S, Maechler H, Pieske BM, Post H
Aim: Mild hypothermia (MH) decreases left ventricular (LV) end-diastolic capacitance. We sought to clarify whether this results from incomplete relaxation. Methods: Ten anaesthetized pigs were cooled from normothermia (NT, 38 °C) to MH (33 °C). LV end-diastolic pressure (LVPed), volume (LVVed) and pressure-volume relationships (EDPVRs) were determined during stepwise right atrial pacing. LV capacitance (i.e. LVVed at LVPed of 10 mmHg, LV VPed10) was derived from the EDPVR. Pacing-induced changes...
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 20, Issue 4, 6 1 2015, Pages 499-503
Hybrid branch pulmonary artery stent placement in adults with congenital heart disease.
Lynch W, Boekholdt SM, Hazekamp MG, de Winter RJ, Koolbergen DR
Objectives: Valuable treatment modalities for branch pulmonary artery (BPA) stenoses are surgical patch angioplasty, percutaneous BPA stenting and hybrid stent placement. The purpose of this study was to report our institutional experience with hybrid stent placement to relieve BPA stenoses. Methods: Between August 2007 and May 2014, 7 adults (5 females) with congenital heart disease (CHD) had elective intraoperative BPA stent placement. All 7 patients had undergone previous surgery [6 tetralogy...
Abstract
