Research

Publications

Below you can find a list of our published research.

9618 results

Cited 222 times since 2014 (20.8 per year) source: EuropePMC

PLoS genetics, Volume 10, Issue 12, 18 3 2014, Pages e1004776 Dissemination of cephalosporin resistance genes between Escherichia coli strains from farm animals and humans by specific plasmid lineages. de Been M, Lanza VF, de Toro M, Scharringa J, Dohmen W, Du Y, Hu J, Lei Y, Li N, Tooming-Klunderud A, Heederik DJ, Fluit AC, Bonten MJ, Willems RJ, de la Cruz F, van Schaik W

Third-generation cephalosporins are a class of β-lactam antibiotics that are often used for the treatment of human infections caused by Gram-negative bacteria, especially Escherichia coli. Worryingly, the incidence of human infections caused by third-generation cephalosporin-resistant E. coli is increasing worldwide. Recent studies have suggested that these E. coli strains, and their antibiotic resistance genes, can spread from food-producing animals, via the food-chain, to humans. However, thes... Abstract

Cited 12 times since 2014 (1.1 per year) source: Scopus

The American journal of cardiology, Volume 115, Issue 5, 18 3 2014, Pages 664-669 Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes. Ewe SH, Muratori M, van der Kley F, Pepi M, Delgado V, Tamborini G, Fusini L, de Weger A, Gripari P, Bartorelli A, Bax JJ, Marsan NA

The prognosis of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the changes in AR grade over time remain unclear. This study evaluated the midterm survival associated with AR after TAVI and examined the evolution of AR over time and its effect on cardiac performance. Successful TAVI was performed in 314 patients (age 81 ± 7 years, 36% men). Serial transthoracic echocardiography and clinical assessment were available in 175 patients who survived >12 months.... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 149, Issue 4, 18 3 2014, Pages 968 Long-term follow-up after the arterial switch operation: Not as perfect as we would have hoped? Hazekamp MG

Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

Veterinary research, Volume 45, 17 3 2014, Pages 129 Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype. Benedictus L, Otten HG, van Schaik G, van Ginkel WG, Heuven HC, Nielen M, Rutten VP, Koets AP

Bovine Neonatal Pancytopenia (BNP), a bleeding syndrome of neonatal calves, is caused by alloantibodies absorbed from the colostrum of particular cows. A commercial BVD vaccine is the likely source of alloantigens eliciting BNP associated alloantibodies. We hypothesized that the rare occurrence of BNP in calves born to vaccinated dams could be associated with genetic differences within dams and calves. We found that the development of BNP within calves was a heritable trait for dams, not for cal... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

Behavior modification, Volume 39, Issue 3, 16 3 2014, Pages 390-412 Cognitive behavior therapy for anxiety in people with dementia: a clinician guideline for a person-centered approach. Charlesworth G, Sadek S, Schepers A, Spector A

This article describes a 10-session cognitive-behavioral therapy (CBT) used in a randomized controlled trial with people with anxiety and mild-to-moderate dementia. The aim of the therapy is to reduce symptoms of anxiety by increasing a sense of safety and self-efficacy. The therapy is characterized by a person-centered approach to CBT, using individual tailoring to accommodate for cognitive deficits and other challenges. Three phases of therapy are described: (a) socialization to model (includi... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Injury, Volume 46, Issue 5, 16 3 2014, Pages 863-869 Impact of combat events on first responders: experiences of the armed conflict in Uruzgan, Afghanistan. Hoencamp R, Idenburg FJ, Vermetten E, Tan E, Plat MC, Hoencamp E, Leenen LP, Hamming JF

Introduction: Care for battle casualties demands special skills from medics, nurses, and tactical commanders. To date, no inventory has been performed evaluating the first responders (medics, nurses and tactical commanders) around battle casualties. Method: This observational cohort study was conducted amongst the first responders (n=195) who were deployed to Southern Afghanistan (2009-2010) in three Marine companies. The survey focused on four main topics: (1) participants general background, (... Abstract

Cited 62 times since 2014 (5.8 per year) source: EuropePMC

Frontiers in immunology, Volume 5, 12 2 2014, Pages 629 Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe. Kerr J, Quinti I, Eibl M, Chapel H, Späth PJ, Sewell WA, Salama A, van Schaik IN, Kuijpers TW, Peter HH

The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody deficiencies, an aging population, and new indications. This review aims to examine the various dosing regimens and research developments in the established and in some of the relevant off-label indications in Europe. The background to the current regulatory settings in Europe is provided as a backdrop for the latest developments in primary and secondary immunodeficiencies and in immunomodulatory indicati... Abstract

Cited 71 times since 2014 (6.6 per year) source: EuropePMC

PLoS pathogens, Volume 10, Issue 12, 11 2 2014, Pages e1004569 Apoplastic venom allergen-like proteins of cyst nematodes modulate the activation of basal plant innate immunity by cell surface receptors. Lozano-Torres JL, Wilbers RH, Warmerdam S, Finkers-Tomczak A, Diaz-Granados A, van Schaik CC, Helder J, Bakker J, Goverse A, Schots A, Smant G

Despite causing considerable damage to host tissue during the onset of parasitism, nematodes establish remarkably persistent infections in both animals and plants. It is thought that an elaborate repertoire of effector proteins in nematode secretions suppresses damage-triggered immune responses of the host. However, the nature and mode of action of most immunomodulatory compounds in nematode secretions are not well understood. Here, we show that venom allergen-like proteins of plant-parasitic ne... Abstract

Cited 36 times since 2014 (3.4 per year) source: EuropePMC

BMC nephrology, Volume 15, 11 2 2014, Pages 197 Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients. Buiten MS, de Bie MK, Bouma-de Krijger A, van Dam B, Dekker FW, Jukema JW, Rabelink TJ, Rotmans JI

Background: Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum Klotho (sKlotho) and the presence of CVD in dialysis patients. Methods: Plasma levels o... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

World journal of urology, Volume 33, Issue 10, 10 2 2014, Pages 1411-1417 Urinary cytokines in patients treated with intravesical mitomycin-C with and without hyperthermia. Arends TJ, Falke J, Lammers RJ, Somford DM, Hendriks JC, de Weijert MC, Arentsen HC, van der Heijden AG, Oosterwijk E, Alfred Witjes J

Objectives: To explore whether urinary cytokine and chemokine (CK) levels differed between cold mitomycin-C (cold-MMC)-treated patients and chemohyperthermia (C-HT)-treated patients, to shed light on the possible molecular mechanisms that might explain the superior outcome of C-HT. Furthermore, CK-differences were explored between C-HT responders and C-HT non-responders. Methods: Twelve NMIBC patients were included. Nine received six-weekly C-HT, and three received four-weekly cold-MMC instillat... Abstract

Cited 13 times since 2014 (1.2 per year) source: EuropePMC

The International journal of social psychiatry, Volume 61, Issue 6, 8 2 2014, Pages 530-538 The influence of acculturation on mental health and specialized mental healthcare for non-western migrants. Nap A, van Loon A, Peen J, van Schaik DJ, Beekman AT, Dekker JJ

Background: The level of acculturation of migrants varies and is associated with variations in mental health. However, this association is complex and may differ among migrant groups. Aim: The aim of this study is to explore the association between acculturation, mental health and treatment effect. Methods: In a longitudinal cohort study of patients treated in specialized mental health facilities, different dimensions of acculturation (skills, social integration, traditions, norms/values and fee... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

Forensic science international, Volume 248, 8 2 2014, Pages 101-112 Isotopic and elemental profiling of ammonium nitrate in forensic explosives investigations. Brust H, Koeberg M, van der Heijden A, Wiarda W, Mügler I, Schrader M, Vivo-Truyols G, Schoenmakers P, van Asten A

Ammonium nitrate (AN) is frequently encountered in explosives in forensic casework. It is widely available as fertilizer and easy to implement in explosive devices, for example by mixing it with a fuel. Forensic profiling methods to determine whether material found on a crime scene and material retrieved from a suspect arise from the same source are becoming increasingly important. In this work, we have explored the possibility of using isotopic and elemental profiling to discriminate between di... Abstract

Cited 29 times since 2014 (2.7 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 79, 5 1 2014, Pages 244-253 Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction. Borgdorff MA, Koop AM, Bloks VW, Dickinson MG, Steendijk P, Sillje HH, van Wiechen MP, Berger RM, Bartelds B

Background: Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are unknown. We used an experimental approach based upon clinical signs of RVF to delineate functional and biological processes associated with RVF. Methods and results: Wistar rats were subjected to a pulmonary artery banding (PAB n=12) or sham surgery (CON, n=7). After 52±5days, 5/12 PAB rats developed clinical symptoms of RVF... Abstract

Cited 48 times since 2014 (4.5 per year) source: Scopus

PloS one, Volume 9, Issue 12, 4 1 2014, Pages e111952 ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm. Kortekaas KE, Meijer CA, Hinnen JW, Dalman RL, Xu B, Hamming JF, Lindeman JH

Background: Independent of their blood pressure lowering effect, ACE inhibitors are thought to reduce vascular inflammation. The clinical relevance of this effect is unclear with the current knowledge. Abdominal aortic aneurysms (AAA) are characterized by a broad, non-specific inflammatory response, and thus provide a clinical platform to evaluate the anti-inflammatory potential of ACE inhibitors. Methods and results: Eleven patients scheduled for open AAA repair received ramipril (5 mg/day) dur... Abstract

Cited 42 times since 2014 (3.9 per year) source: EuropePMC

PLoS genetics, Volume 10, Issue 12, 4 1 2014, Pages e1004799 Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, Männistö S, Marques-Vidal P, Kaakinen M, Cavadino A, Postmus I, Husemoen LL, Skaaby T, Ahluwalia TS, Treur JL, Willemsen G, Dale C, Wannamethee SG, Lahti J, Palotie A, Räikkönen K, Kisialiou A, McConnachie A, Padmanabhan S, Wong A, Dalgård C, Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood J, Fergusson DM, Kennedy MA, Frayling T, Nohr EA, Christiansen L, Ohm Kyvik K, Kuh D, Watt G, Eriksson J, Whincup PH, Vink JM, Boomsma DI, Davey Smith G, Lawlor D, Linneberg A, Ford I, Jukema JW, Power C, Hyppönen E, Jarvelin MR, Preisig M, Borodulin K, Kaprio J, Kivimaki M, Smith BH, Smith BH, Hayward C, Romundstad PR, Sørensen TI, Munafò MR, Sattar N

We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00 × 10(-10)), but also unexpectedly found t... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

International journal of cardiology, Volume 183, 3 1 2014, Pages 249-257 Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling. Calkoen EE, Vicente-Steijn R, Hahurij ND, van Munsteren CJ, Roest AA, DeRuiter MC, Steendijk P, Schalij MJ, Gittenberger-de Groot AC, Blom NA, Jongbloed MR

Background: Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim of the study is to assess the effect of VEGF over-expression on SAN development and function. Methods: Heart rate was measured in Vegf(120/120) and wildtype (WT) embryos during high frequency ul... Abstract

Cited 44 times since 2014 (4.1 per year) source: EuropePMC

BMJ open diabetes research & care, Volume 2, Issue 1, 3 1 2014, Pages e000034 Inflammation increases plasma angiopoietin-like protein 4 in patients with the metabolic syndrome and type 2 diabetes. Tjeerdema N, Georgiadi A, Jonker JT, van Glabbeek M, Alizadeh Dehnavi R, Tamsma JT, Smit JW, Kersten S, Rensen PC

Background: Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase and associates with dyslipidemia. The expression of ANGPTL4 is regulated by free fatty acids (FFA) that activate lipid-sensing peroxisome proliferator-activated receptors (PPARs), but FFA can also activate pattern recognition receptors including Toll-like receptor 4 (TLR4) in macrophages. Objective: To assess whether systemic low-grade inflammation is a determinant for plasma ANGPTL4 levels in patients with the metabol... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 6, 1 1 2014, Pages 1245-1251 Multimodality imaging: bird's eye view from The European Society of Cardiology Congress 2014 Barcelona, August 30-September 3, 2014. Bax JJ, Delgado V, Achenbach S, Sechtem U, Knuuti J

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Cited 127 times since 2014 (11.8 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 111, Issue 50, 1 1 2014, Pages E5383-92 Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M

Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of sudden death due to ventricular tachycardia, and congenital bilateral deafness. In contrast to the autosomal dominant forms of long QT syndrome, JLNS is a recessive trait, resulting from homozygous (or compound heterozygous) mutations in KCNQ1 or KCNE1. These genes encode the α and β subunits, respectively, of the ion c... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Clinical and experimental immunology, Volume 178 Suppl 1, 1 1 2014, Pages 1-2 7th International Immunoglobulin Conference: Foreword. Jolles S, Jordan SC, Orange JS, van Schaik IN

Abstract