Research

Publications

Below you can find a list of our published research.

9618 results

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Criminal behaviour and mental health : CBMH, Volume 24, Issue 5, 1 1 2014, Pages 365-367 MAOA, COMT and 5-HTTLPR frequencies in convicted and never convicted Afro-Caribbeans in the Netherlands. Vinkers DJ, Bogaerts S, Van Schaik RH

Abstract

Cited 42 times since 2014 (3.9 per year) source: EuropePMC

Inflammatory bowel diseases, Volume 20, Issue 12, 1 1 2014, Pages 2292-2298 Influence of combination therapy with immune modulators on anti-TNF trough levels and antibodies in patients with IBD. van Schaik T, Maljaars JP, Roopram RK, Verwey MH, Ipenburg N, Hardwick JC, Veenendaal RA, van der Meulen-de Jong AE

Background: It is important to identify factors that can reduce the incidence of immunogenicity against anti-tumor necrosis factor medication in patients with inflammatory bowel disease. The objective of our study was to evaluate the influence of cotreatment with immune modulators (IMs) on trough levels (TLs) and antidrug antibodies. Methods: The records of all patients with inflammatory bowel disease at the Leiden University Medical Center who received either adalimumab or infliximab (IFX) in t... Abstract

Cited 26 times since 2014 (2.4 per year) source: EuropePMC

PloS one, Volume 9, Issue 12, 1 1 2014, Pages e113674 Prevalence of rotavirus genotypes in children younger than 5 years of age before the introduction of a universal rotavirus vaccination program: report of rotavirus surveillance in Turkey. Durmaz R, Kalaycioglu AT, Acar S, Bakkaloglu Z, Karagoz A, Korukluoglu G, Ertek M, Torunoglu MA, Turkish Rotavirus Surveillance Network

Background: Group A rotaviruses are the most common causative agent of acute gastroenteritis among children less than 5 years of age throughout the world. This sentinel surveillance study was aimed to obtain baseline data on the rotavirus G and P genotypes across Turkey before the introduction of a universal rotavirus vaccination program. Methods: Rotavirus antigen-positive samples were collected from 2102 children less than 5 years of age who attended hospitals participating in the Turkish Rota... Abstract

Cited 10 times since 2014 (0.9 per year) source: EuropePMC

Clinical and experimental immunology, Volume 178 Suppl 1, 1 1 2014, Pages 163-168 Immunoglobulins: current understanding and future directions. Jolles S, Jordan SC, Orange JS, van Schaik IN

Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

Pharmacogenomics, Volume 15, Issue 16, 1 1 2014, Pages 1963-1972 POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia. Drogari E, Ragia G, Mollaki V, Elens L, Van Schaik RH, Manolopoulos VG

Background: In children and adolescents with familial hypercholesterolemia (FH) pharmacotherapy with statins is the cornerstone in the current regimen to reduce low-density lipoprotein cholesterol (LDLc) and premature coronary heart disease risk. There is, however, a great interindividual variation in response to therapy, partially attributed to genetic factors. The polymorphic enzyme POR transfers electrons from NADPH to CYP450 enzymes including CYP3A, which metabolize atorvastatin. POR*28 poly... Abstract

Cited 25 times since 2014 (2.3 per year) source: EuropePMC

European heart journal, Volume 35, Issue 48, 1 1 2014, Pages 3417-3425 Non-invasive cardiac imaging evaluation of patients with chronic systolic heart failure: a report from the European Association of Cardiovascular Imaging (EACVI). Gimelli A, Lancellotti P, Badano LP, Lombardi M, Gerber B, Plein S, Neglia D, Edvardsen T, Kitsiou A, Scholte AJ, Schröder S, Cosyns B, Gargiulo P, Zamorano JL, Perrone-Filardi P

Abstract

Cited 21 times since 2014 (2 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 87, Issue 2, 29 5 2014, Pages 201-203 Tumor flare after start of RAF inhibition in KRAS mutated NSCLC: a case report. Mellema WW, Burgers SA, Smit EF

Here we describe a case of striking tumor flare after start of treatment with sorafenib and metformin as part of a phase II clinical trial. Previous reports have described a paradoxal activation of the MAPK pathway after treatment with a weak RAF inhibitor. This mechanism is based on inhibition of a negative feedback loop to upstream effectors of RAF and subsequently increased stimulation of the RAS-RAF-MEK-ERK (MAPK) pathway. We suggest that sorafenib may contribute to tumor progression through... Abstract

Cited 7 times since 2014 (0.7 per year) source: EuropePMC

Vascular, Volume 23, Issue 6, 27 4 2014, Pages 645-647 Persistent endoleak after endovascular aneurysm repair for acute Q-fever-infected aortocaval fistula. Prinsen JH, Boersma D, van Loenhout R, van Schaik PM, Verhoeven BA

We present a case of an endovascular aneurysm repair for a Q-fever-infected acute abdominal aortic aneurysm with aortocaval fistula. Type 2 endoleak persisted after successful endovascular repair. Abstract

Cited 82 times since 2014 (7.6 per year) source: EuropePMC

European journal of heart failure, Volume 17, Issue 1, 27 4 2014, Pages 51-62 Subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relates to outcome in sarcoidosis. Joyce E, Ninaber MK, Katsanos S, Debonnaire P, Kamperidis V, Bax JJ, Taube C, Delgado V, Ajmone Marsan N

Aims: Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis patients. Using LV global longitudinal strain (GLS), an emerging sensitive parameter of LV function, we evaluated the prevalence of subclinical cardiac dysfunction in sarcoidosis and investigated whether LVGLS predicts adverse outcomes in this population. Methods and results: A total of 130 patients with proven sarcoidosis undergoing echocardiography at our referral centre were identi... Abstract

Cited 61 times since 2014 (5.7 per year) source: EuropePMC

British journal of cancer, Volume 112, Issue 3, 27 4 2014, Pages 594-600 Recurrent urinary tract infection and risk of bladder cancer in the Nijmegen bladder cancer study. Vermeulen SH, Hanum N, Grotenhuis AJ, Castaño-Vinyals G, van der Heijden AG, Aben KK, Mysorekar IU, Kiemeney LA

Background: Controversy exists on whether urinary tract infection (UTI) is a risk factor for urinary bladder cancer (UBC). Here, the association is investigated using data from one of the largest bladder cancer case-control studies worldwide. Methods: Information on (i) history and age at onset of regular cystitis ('regular low-UTI') and (ii) number and age at onset of UTI treated with antibiotics ('UTI-ab') from 1809 UBC patients and 4370 controls was analysed. Odds ratios (... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Journal of chromatography. A, Volume 1374, 27 4 2014, Pages 224-230 Impurity profiling of trinitrotoluene using vacuum-outlet gas chromatography-mass spectrometry. Brust H, Willemse S, Zeng T, van Asten A, Koeberg M, van der Heijden A, Bolck A, Schoenmakers P

In this work, a reliable and robust vacuum-outlet gas chromatography-mass spectrometry (GC-MS) method is introduced for the identification and quantification of impurities in trinitrotoluene (TNT). Vacuum-outlet GC-MS allows for short analysis times; the analysis of impurities in TNT was performed in 4min. This study shows that impurity profiling of TNT can be used to investigate relations between TNT samples encountered in forensic casework. A wide variety of TNT samples were analyzed with the... Abstract

Cited 6 times since 2014 (0.6 per year) source: EuropePMC

Frontiers in neuroscience, Volume 8, 25 4 2014, Pages 377 Racing to learn: statistical inference and learning in a single spiking neuron with adaptive kernels. Afshar S, George L, Tapson J, van Schaik A, Hamilton TJ

This paper describes the Synapto-dendritic Kernel Adapting Neuron (SKAN), a simple spiking neuron model that performs statistical inference and unsupervised learning of spatiotemporal spike patterns. SKAN is the first proposed neuron model to investigate the effects of dynamic synapto-dendritic kernels and demonstrate their computational power even at the single neuron scale. The rule-set defining the neuron is simple: there are no complex mathematical operations such as normalization, exponenti... Abstract

Cited 63 times since 2014 (5.9 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 1, 24 4 2014, Pages 102-109 Re-entry using anatomically determined isthmuses: a curable ventricular tachycardia in repaired congenital heart disease. Kapel GF, Reichlin T, Wijnmaalen AP, Piers SR, Holman ER, Tedrow UB, Schalij MJ, Stevenson WG, Zeppenfeld K

Background: Ventricular tachycardia (VT) is an important cause of late morbidity and mortality in repaired congenital heart disease. The substrate often includes anatomic isthmuses that can be transected by radiofrequency catheter ablation similar to isthmus block for atrial flutter. This study evaluates the long-term efficacy of isthmus block for treatment of re-entry VT in adults with repaired congenital heart disease. Methods and results: Thirty-four patients (49±13 years; 74% male) with repa... Abstract

Cited 62 times since 2014 (5.8 per year) source: EuropePMC

Preventive veterinary medicine, Volume 118, Issue 1, 23 4 2014, Pages 80-92 Housing and management factors associated with indicators of dairy cattle welfare. de Vries M, Bokkers EA, van Reenen CG, Engel B, van Schaik G, Dijkstra T, de Boer IJ

Knowledge of potential synergies and trade-offs between housing and management factors for different aspects of animal welfare is essential for farmers who aim to improve the level of welfare in their herds. The aim of this research was to identify and compare housing and management factors associated with prevalence of lameness, prevalence of lesions or swellings, prevalence of dirty hindquarters, and frequency of displacements (social behavior) in dairy herds in free-stall housing. Seven obser... Abstract

Cited 19 times since 2014 (1.8 per year) source: EuropePMC

Atherosclerosis, Volume 238, Issue 1, 22 4 2014, Pages 132-139 RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner. Wezel A, van der Velden D, Maassen JM, Lagraauw HM, de Vries MR, Karper JC, Kuiper J, Bot I, Quax PH

Objective: Toll like receptor 4 (TLR4) plays a key role in inflammation and previously it was established that TLR4 deficiency attenuates atherosclerosis. RadioProtective 105 (RP105) is a structural homolog of TLR4 and an important regulator of TLR4 signaling, suggesting that RP105 may also be an important effector in atherosclerosis. We thus aimed to determine the role of RP105 in atherosclerotic lesion development using RP105 deficient mice on an atherosclerotic background. Methods and results... Abstract

Cited 26 times since 2014 (2.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 2, 20 3 2014, Pages 94-100 Non-invasive imaging in atrial fibrillation: focus on prognosis and catheter ablation. Bax JJ, Marsan NA, Delgado V

Imaging identifies patients with high-risk phenotype among the general population with atrial fibrillation, such as the presence of structural and valvular heart disease, which are both related to adverse outcome. Imaging is also potentially important for prediction of success of catheter ablation. Specifically, patients with larger left atrial size, reduced left atrial function and increased left atrial fibrosis content are more likely to experience atrial fibrillation recurrences after ablatio... Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 42, Issue 2, 19 3 2014, Pages 390-399 Automated left ventricle segmentation in late gadolinium-enhanced MRI for objective myocardial scar assessment. Tao Q, Piers SR, Lamb HJ, van der Geest RJ

Purpose: To develop and validate an objective and reproducible left ventricle (LV) segmentation method for late gadolinium enhanced (LGE) magnetic resonance imaging (MRI), which can facilitate accurate myocardial scar assessment. Materials and methods: A cohort of 25 ischemic patients and 25 nonischemic patients were included. A four-step algorithm was proposed: first, the Cine-MRI and LGE-MRI volume were globally registered; second, the registered Cine-MRI contours were fitted to each LGE-MRI s... Abstract

Cited 49 times since 2014 (4.6 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 111, Issue 48, 17 3 2014, Pages 17170-17175 Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry. Konijnenberg A, Yilmaz D, Ingólfsson HI, Dimitrova A, Marrink SJ, Li Z, Vénien-Bryan C, Sobott F, Koçer A

Mechanosensitive ion channels are sensors probing membrane tension in all species; despite their importance and vital role in many cell functions, their gating mechanism remains to be elucidated. Here, we determined the conditions for releasing intact mechanosensitive channel of large conductance (MscL) proteins from their detergents in the gas phase using native ion mobility-mass spectrometry (IM-MS). By using IM-MS, we could detect the native mass of MscL from Escherichia coli, determine vario... Abstract

Cited 32 times since 2014 (3 per year) source: EuropePMC

The Journal of clinical investigation, Volume 124, Issue 12, 17 3 2014, Pages 5159-5174 Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, Kuchinsky A, Hazen SL, Jukema JW, Ganesh SK, Nabel EG, Channon K, Leon MB, Charest A, Quertermous T, Ashley EA

Angioplasty and stenting is the primary treatment for flow-limiting atherosclerosis; however, this strategy is limited by pathological vascular remodeling. Using a systems approach, we identified a role for the network hub gene glutathione peroxidase-1 (GPX1) in pathological remodeling following human blood vessel stenting. Constitutive deletion of Gpx1 in atherosclerotic mice recapitulated this phenotype of increased vascular smooth muscle cell (VSMC) proliferation and plaque formation. In an i... Abstract

Cited 174 times since 2014 (16.2 per year) source: EuropePMC

The Journal of urology, Volume 193, Issue 4, 15 3 2014, Pages 1163-1169 The prostate health index selectively identifies clinically significant prostate cancer. Loeb S, Sanda MG, Broyles DL, Shin SS, Bangma CH, Wei JT, Partin AW, Klee GG, Slawin KM, Marks LS, van Schaik RH, Chan DW, Sokoll LJ, Cruz AB, Mizrahi IA, Catalona WJ

Purpose: The Prostate Health Index (phi) is a new test combining total, free and [-2]proPSA into a single score. It was recently approved by the FDA and is now commercially available in the U.S., Europe and Australia. We investigate whether phi improves specificity for detecting clinically significant prostate cancer and can help reduce prostate cancer over diagnosis. Materials and methods: From a multicenter prospective trial we identified 658 men age 50 years or older with prostate specific an... Abstract