9618 results
Cited 18 times since 2014 (1.7 per year)
source: EuropePMC
The Journal of biological chemistry,
Volume 289, Issue 51, 27 4 2014, Pages 35421-35430
Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1.
Klop B, van der Pol P, van Bruggen R, Wang Y, de Vries MA, van Santen S, O'Flynn J, van de Geijn GJ, Njo TL, Janssen HW, de Man P, Jukema JW, Rabelink TJ, Rensen PC, van Kooten C, Cabezas MC
Lipoproteins can induce complement activation resulting in opsonization and binding of these complexes to complement receptors. We investigated the binding of opsonized native LDL and acetylated LDL (acLDL) to the complement receptor 1 (CR1). Binding of complement factors C3b, IgM, C1q, mannose-binding lectin (MBL), and properdin to LDL and acLDL were investigated by ELISA. Subsequent binding of opsonized LDL and acLDL to CR1 on CR1-transfected Chinese Hamster Ovarian cells (CHO-CR1) was tested...
Abstract
Cited 10 times since 2014 (0.9 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 31, Issue 2, 24 4 2014, Pages 369-377
Preprocedural magnetic resonance imaging for image-guided catheter ablation of scar-related ventricular tachycardia.
Tao Q, Piers SR, Lamb HJ, Zeppenfeld K, van der Geest RJ
To present and validate a highly automated MRI analysis workflow for image-guided catheter ablation of scar-related ventricular tachycardia (VT) ablation procedures. A cohort of 15 post-infarction patients underwent MRI prior to VT ablation. The MRI study included a black-blood turbo spin echo sequence for visualizing the aortic root and ostium of the left main (LM) coronary artery, and a 3D late gadolinium enhanced sequence for visualizing the LV anatomy and myocardial scar substrate. Semi-auto...
Abstract
Cited 5 times since 2014 (0.5 per year)
source: EuropePMC
Clinica chimica acta; international journal of clinical chemistry,
Volume 439, 23 4 2014, Pages 128-136
Implementation of a companion diagnostic in the clinical laboratory: the BRAF example in melanoma.
Mancini I, Pinzani P, Simi L, Brandslund I, Vermeersch P, Di Resta C, Schwab M, Marc J, van Schaik R, Pazzagli M, European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)–European Society of Pharmacogenomics and Theranostics (ESPT) joint Working Group Personalized Laboratory Medicine (WG-PLM)
A companion diagnostic test provides information that is essential for the safe and effective use of a corresponding therapeutic product as indicated in the drug instructions. The implementation of a companion diagnostic follows the rules of a molecular test for somatic mutations in a routine clinical laboratory environment and needs guidance on practical aspects, including the choice of the proper analytical method and the procedures for internal and external quality controls. Selection of the...
Abstract
Cited 15 times since 2014 (1.4 per year)
source: EuropePMC
Journal of immunology (Baltimore, Md. : 1950),
Volume 193, Issue 10, 22 4 2014, Pages 5338-5344
Discovery of invariant T cells by next-generation sequencing of the human TCR α-chain repertoire.
van Schaik B, Klarenbeek P, Doorenspleet M, van Kampen A, Moody DB, de Vries N, Van Rhijn I
During infection and autoimmune disease, activation and expansion of T cells take place. Consequently, the TCR repertoire contains information about ongoing and past diseases. Analysis and interpretation of the human TCR repertoire are hampered by its size and stochastic variation and by the diversity of Ags and Ag-presenting molecules encoded by the MHC, but are highly desirable and would greatly impact fundamental and clinical immunology. A subset of the TCR repertoire is formed by invariant T...
Abstract
Cited 3 times since 2014 (0.3 per year)
source: EuropePMC
International journal of surgery case reports,
Volume 5, Issue 12, 22 4 2014, Pages 972-974
Cutaneous Ewing's sarcoma secondary to chemotherapy given for testis tumor: Case report.
Tanık S, Zengin K, Albayrak S, Eryılmaz R, Yılmaz D, Pirinçci N
Introduction: Testicular cancer has high cure rates, especially after the adjuvant use of chemotherapy. Secondary tumors may develop months and years after the primary tumor. We aimed to report a case of cutaneous Ewing's sarcoma at the site of surgery 3 years after BEP chemotherapy. Presentation of case: 21 year old male underwent radical orchiectomy in 2008. After one year surgical site complaints brought him to same hospital. A limited surgical resection was made. As his complaints conti...
Abstract
Cited 69 times since 2014 (6.4 per year)
source: EuropePMC
Journal of psychosomatic research,
Volume 78, Issue 2, 22 4 2014, Pages 123-129
Depression, anxiety and 6-year risk of cardiovascular disease.
Seldenrijk A, Vogelzangs N, Batelaan NM, Wieman I, van Schaik DJ, Penninx BJ
Objective: Depression and anxiety are considered etiological factors in cardiovascular disease (CVD), though their relative contribution and differentiation by clinical characteristics have not been studied intensively. We examined 6-year associations between depressive and anxiety disorders, clinical characteristics and newly-developed CVD. Methods: DSM-IV diagnoses were established in 2510 CVD-free participants of the Netherlands Study of Depression and Anxiety. Data on subtype, severity, and...
Abstract
Cited 62 times since 2014 (5.7 per year)
source: EuropePMC
Parkinsonism & related disorders,
Volume 21, Issue 1, 22 4 2014, Pages 1-11
Predictors of the psychosocial impact of being a carer of people living with Parkinson's disease: a systematic review.
Greenwell K, Gray WK, van Wersch A, van Schaik P, Walker R
Introduction: Caring for a person with Parkinson's disease (PwP) can have a variety of negative consequences that may challenge their ability to continue their caring role. It is still unknown why some individuals adapt better than others in response to such burdens. This review is the first to synthesize and evaluate the evidence on the predictive factors of psychosocial outcomes in PwP carers. Methods: Studies which identified predictors of psychosocial outcomes for unpaid carers were inc...
Abstract
Cited 24 times since 2014 (2.2 per year)
source: EuropePMC
Journal of virology,
Volume 89, Issue 1, 22 4 2014, Pages 568-580
Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function.
Remmerswaal EB, Klarenbeek PL, Alves NL, Doorenspleet ME, van Schaik BD, Esveldt RE, Idu MM, van Leeuwen EM, van der Bom-Baylon N, van Kampen AH, Koch SD, Pircher H, Bemelman FJ, Ten Brinke A, Baas F, Ten Berge IJ, van Lier RA, de Vries N
Unlabelled: Human cytomegalovirus (hCMV) infection is characterized by a vast expansion of resting effector-type virus-specific T cells in the circulation. In mice, interleukin-7 receptor α (IL-7Rα)-expressing cells contain the precursors for long-lived antigen-experienced CD8(+) T cells, but it is unclear if similar mechanisms operate to maintain these pools in humans. Here, we studied whether IL-7Rα-expressing cells obtained from peripheral blood (PB) or lymph nodes (LNs) sustain the circulati...
Abstract
Cited 17 times since 2014 (1.6 per year)
source: EuropePMC
European journal of cardiovascular nursing,
Volume 15, Issue 1, 20 3 2014, Pages 72-81
Clinical and psychological characteristics predict future healthcare use in adults with congenital heart disease.
Schoormans D, Sprangers MA, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ
Background: To deliver adequate care to patients with congenital heart disease (CHD), it is important to know which patients use what type of care. This knowledge is valuable, as modification of these factors may be used as means to regulate healthcare use. Our objective was to examine the predictive value of psychological characteristics for future healthcare use, independent of clinical characteristics. Methods: In total 845 adult CHD-patients participated in a longitudinal questionnaire study...
Abstract
Cited 9 times since 2014 (0.8 per year)
source: EuropePMC
Journal of cardiac surgery,
Volume 30, Issue 1, 17 3 2014, Pages 13-19
Aortic valve repair versus replacement for aortic regurgitation: effects on left ventricular remodeling.
Regeer MV, Versteegh MI, Klautz RJ, Stijnen T, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V
Background: Left ventricular (LV) reverse remodeling after aortic valve replacement (AVR) for aortic regurgitation (AR) is associated with superior prognosis. The outcomes of valve-sparing aortic root replacement techniques on LV performance have not been compared with LV reverse remodeling in AVR. The present evaluation compared the extent of long-term LV reverse remodeling in patients with aortic root pathology and/or AR who underwent aortic valve repair (AVr) with patients who underwent AVR....
Abstract
Cited 45 times since 2014 (4.1 per year)
source: EuropePMC
Surgical endoscopy,
Volume 29, Issue 8, 16 3 2014, Pages 2235-2243
Increasing efficiency of surgical training: effects of spacing practice on skill acquisition and retention in laparoscopy training.
Spruit EN, Band GP, Hamming JF
Objectives: The goal of this study was to investigate the effects of spaced versus massed practice on skill acquisition and retention in the context of laparoscopic motor skill training. Background: Reaching proficiency in performing laparoscopic surgery involves extensive training to acquire the required motor skills. Conventionally, training of such skills occurs during a full day training event utilizing surgical simulators that train specific motor skills pertinent to laparoscopic surgery. A...
Abstract
Cited 50 times since 2014 (4.6 per year)
source: EuropePMC
Annals of medicine,
Volume 46, Issue 8, 13 2 2014, Pages 640-652
Morphogenesis and molecular considerations on congenital cardiac septal defects.
Gittenberger-de Groot AC, Calkoen EE, Poelmann RE, Bartelings MM, Jongbloed MR
The primary unseptated heart tube undergoes extensive remodeling including septation at the atrial, atrioventricular, ventricular, and ventriculo-arterial level. Alignment and fusion of the septal components is required to ensure full septation of the heart. Deficiencies lead to septal defects at various levels. Addition of myocardium and mesenchymal tissues from the second heart field (SHF) to the primary heart tube, as well as a population of neural crest cells, provides the necessary cellular...
Abstract
Cited 44 times since 2014 (4 per year)
source: EuropePMC
Acta diabetologica,
Volume 52, Issue 2, 8 2 2014, Pages 267-275
Distinct HbA1c trajectories in a type 2 diabetes cohort.
Walraven I, Mast MR, Hoekstra T, Jansen AP, van der Heijden AA, Rauh SP, Rutters F, van 't Riet E, Elders PJ, Moll AC, Polak BC, Dekker JM, Nijpels G
Aims: The aim of this study was to identify subgroups of type 2 diabetes mellitus patients with distinct hemoglobin A1c (HbA1c) trajectories. Subgroup characteristics were determined and the prevalence of microvascular complications over time was investigated. Study design and setting: Data from a cohort of 5,423 type 2 diabetes patients from a managed primary care system were used [mean follow-up 5.7 years (range 2-9 years)]. Latent class growth modeling was used to identify subgroups of patien...
Abstract
Cited 8 times since 2014 (0.7 per year)
source: EuropePMC
American journal of hypertension,
Volume 28, Issue 4, 8 2 2014, Pages 469-479
Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease.
Poortvliet RK, Lloyd SM, Ford I, Sattar N, de Craen AJ, Wijsman LW, Mooijaart SP, Westendorp RG, Jukema JW, de Ruijter W, Gussekloo J, Stott DJ
Background: Visit-to-visit variability in blood pressure is an independent predictor of cardiovascular disease. This study investigates biological correlates of intra-individual variability in blood pressure in older persons. Methods: Nested observational study within the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) among 3,794 male and female participants (range 70-82 years) with a history of, or risk factors for cardiovascular disease. Individual visit-to-visit variability...
Abstract
Cited 35 times since 2014 (3.2 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 15, Issue 2, 7 1 2014, Pages 144-152
The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients.
de Jonge H, Elens L, de Loor H, van Schaik RH, Kuypers DR
Tacrolimus, a dual substrate of CYP3A4 and CYP3A5 has a narrow therapeutic index and is characterized by high between-subject variability in oral bioavailability. This study investigated the effects of the recently described CYP3A4*22 intron 6 C>T single nucleotide polymorphism on in vivo CYP3A4 activity as measured by midazolam (MDZ) clearance and tacrolimus pharmacokinetics in two cohorts of renal allograft recipients, taking into account the CYP3A5*1/*3 genotype and other determinants of d...
Abstract
Cited 138 times since 2014 (12.7 per year)
source: EuropePMC
American journal of epidemiology,
Volume 180, Issue 9, 7 1 2014, Pages 865-875
Serial intervals of respiratory infectious diseases: a systematic review and analysis.
Vink MA, Bootsma MC, Wallinga J
The serial interval of an infectious disease represents the duration between symptom onset of a primary case and symptom onset of its secondary cases. A good evidence base for such values is essential, because they allow investigators to identify epidemiologic links between cases and serve as an important parameter in epidemic transmission models used to design infection control strategies. We reviewed the literature for available data sets containing serial intervals and for reported values of...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
International journal of cardiology,
Volume 177, Issue 2, 5 1 2014, Pages e70-1
Computed tomography coronary angiography should be performed in all patients with Marfan Syndrome prior to aortic root replacement.
Winter MM, Koolbergen DR, Groenink M, Franken R, Mulder BJ, Bouma BJ
Abstract
Cited 1289 times since 2014 (118.5 per year)
source: EuropePMC
Nature genetics,
Volume 46, Issue 11, 5 1 2014, Pages 1173-1186
Defining the role of common variation in the genomic and biological architecture of adult human height.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AA, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Mateo Leach I, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspers
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for gen...
Abstract
Cited 8 times since 2014 (0.7 per year)
source: EuropePMC
World journal of surgery,
Volume 38, Issue 10, 1 1 2014, Pages 2551-2557
Impact of explosive devices in modern armed conflicts: in-depth analysis of Dutch battle casualties in southern Afghanistan.
Hoencamp R, Huizinga EP, van Dongen TT, Idenburg FJ, Ramasamy A, Leenen LP, Hamming JF
Background: The patterns and mechanisms of injuries of all Dutch battle casualties (BCs) were analyzed to improve the care for injured service members. We performed an in-depth analysis of all Dutch BCs during the participation of The Netherlands as lead nation in the International Security Assistance Force mission in southern Afghanistan. Methods: Participants were selected from the trauma registry at the Dutch Role 2 Medical Treatment Facility if they met the criteria for Dutch BC between Augu...
Abstract
Cited 17 times since 2014 (1.6 per year)
source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,
Volume 9, Issue 10, 1 1 2014, Pages 1547-1553
Phase II multicenter clinical trial of pulmonary metastasectomy and isolated lung perfusion with melphalan in patients with resectable lung metastases.
den Hengst WA, Hendriks JM, Balduyck B, Rodrigus I, Vermorken JB, Lardon F, Versteegh MI, Braun J, Gelderblom H, Schramel FM, Van Boven WJ, Van Putte BP, Birim Ö, Maat AP, Van Schil PE
Introduction: The 5-year overall survival rate of patients undergoing complete surgical resection of pulmonary metastases (PM) from colorectal cancer (CRC) and sarcoma remains low (20-50%). Local recurrence rate is high (48-66%). Isolated lung perfusion (ILuP) allows the delivery of high-dose locoregional chemotherapy with minimal systemic leakage to improve local control. Methods: From 2006 to 2011, 50 patients, 28 male, median age 57 years (15-76), with PM from CRC (n = 30) or sarcoma (n = 20)...
Abstract
