Research

Publications

Below you can find a list of our published research.

6173 results

Cited 10 times since 2005 (0.5 per year) source: EuropePMC

The heart surgery forum, Volume 8, Issue 5, 1 1 2005, Pages E389-94; discussion E394-5 The Carpentier-Edwards Classic and Physio mitral annuloplasty rings: a randomized trial. Shahin GM, van der Heijden GJ, Bots ML, Cramer MJ, Jaarsma W, Gadellaa JC, de la Rivière AB, van Swieten HA

Objective: To evaluate clinical and echocardiographic outcomes for the semi-flexible Carpentier-Edwards Physio and the rigid Classic mitral annuloplasty ring. Methods: Ninety-six patients were randomized for either a Classic (n = 53) or a Physio (n = 43) ring from October 1995 through July 1997. Mean follow-up was 5.1 years (range .1-6.6). We included standard patient characteristics at baseline and during follow-up. Analyses were adjusted for age and gender, and for factors that differed across... Abstract

Cited 36 times since 2005 (1.8 per year) source: EuropePMC

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 7, Issue 2, 1 1 2005, Pages 383-389 Disparity between dobutamine stress and physical exercise magnetic resonance imaging in patients with an intra-atrial correction for transposition of the great arteries. Oosterhof T, Tulevski II, Roest AA, Steendijk P, Vliegen HW, van der Wall EE, de Roos A, Tijssen JG, Mulder BJ

Background: In patients with an intra-atrial correction for transposition of the great arteries (TGA) an abnormal response to stress testing is common. However, hemodynamic responses may vary substantially when different stress tests are used. We compared the hemodynamic response to dobutamine stress with the response to physical exercise in patients and controls. Methods: Thirty-nine patients and 25 age/sex-matched control subjects underwent either dobutamine stress (15 microg/kg/min) or submax... Abstract

Cited 34 times since 2005 (1.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 45, Issue 1, 1 1 2005, Pages 93-97 Seven-year follow-up after dobutamine stress echocardiography: impact of gender on prognosis. Biagini E, Elhendy A, Bax JJ, Rizzello V, Schinkel AF, van Domburg RT, Kertai MD, Krenning BJ, Bountioukos M, Rapezzi C, Branzi A, Simoons ML, Poldermans D

Objectives: The aim of this study was to investigate the effects of gender on long-term prognosis of patients undergoing dobutamine stress echocardiography (DSE). Background: Gender differences in the predictors of outcome among patients with known or suspected coronary artery disease undergoing DSE have not been adequately studied. Methods: We studied 2,276 men and 1,105 women with known or suspected coronary artery disease who underwent DSE. Follow-up events were cardiac death and nonfatal myo... Abstract

Cited 21 times since 2005 (1 per year) source: EuropePMC

Progress in cardiovascular diseases, Volume 47, Issue 4, 1 1 2005, Pages 240-257 Predicting perioperative cardiac risk. Kertai MD, Klein J, Bax JJ, Poldermans D

Cardiovascular complications are the major cause of perioperative morbidity and mortality of patients undergoing major vascular surgery. This is related to the frequent presence of an underlying coronary artery disease. This paper reviews the pathology of perioperative cardiac complications and cardiac risk assessment and risk reduction strategies. Guidelines of the American College of Cardiology and American Heart Association for the evaluation of cardiac risk for noncardiac surgery may provide... Abstract

Cited 5 times since 2004 (0.2 per year) source: EuropePMC

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, Volume 6, Issue 4, 20 3 2004, Pages 297-300 Underestimation of severity of mitral regurgitation with varying hemodynamics. Scholte AJ, Holman ER, Haverkamp MC, Poldermans D, van der Wall EE, Dion RA, Bax JJ

Transesophageal echocardiography (TEE) is a valuable technique to assess mitral valve anatomy and the mechanism of mitral regurgitation (MR). We present the case of a 35-year-old woman with severe MR due to restrictive motion of the posterior mitral leaflet, who was referred for mitral annuloplasty. Under physiologic circumstances, a severe (grade 3+) MR was present, whereas in the operating room during general anesthesia, the MR had disappeared almost completely. The downgrading of MR due to ge... Abstract

Cited 19 times since 2004 (0.9 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 27, Issue 3, 19 3 2004, Pages 462-6; discussion 467 Accurate quantitation of regurgitant volume with MRI in patients selected for mitral valve repair. Westenberg JJ, Doornbos J, Versteegh MI, Bax JJ, van der Geest RJ, de Roos A, Dion RA, Reiber JH

Objective: Echocardiography, the currently preferred diagnostic approach for mitral valve regurgitation, cannot accurately quantify the amount of regurgitation. Flow quantification with MRI is possible, but the conventional method (1-directional velocity-encoding) acquires the flow at a fixed location during the cardiac cycle, which is not necessarily the location of the mitral valve during the whole cycle. In this study, the exact flow through the mitral valve was quantified with a 3-directiona... Abstract

Cited 23 times since 2004 (1.1 per year) source: EuropePMC

Hypertension (Dallas, Tex. : 1979), Volume 45, Issue 2, 13 2 2004, Pages 227-232 Noninvasive evaluation of the coronary arteries with multislice computed tomography in hypertensive patients. Schuijf JD, Bax JJ, Jukema JW, Lamb HJ, Vliegen HW, van der Wall EE, de Roos A

Because patients with hypertension are at increased risk for coronary artery disease, early and noninvasive identification of the disease in patients with hypertension is important. Recently, multislice computed tomography (MSCT) has been demonstrated to allow both noninvasive coronary angiography and assessment of left ventricular function. The purpose of the present study therefore was to demonstrate the feasibility of this approach in patients with hypertension with known or suspected coronar... Abstract

Cited 85 times since 2004 (4.2 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 288, Issue 5, 9 2 2004, Pages H2140-5 Reservoir and conduit function of right atrium: impact on right ventricular filling and cardiac output. Gaynor SL, Maniar HS, Prasad SM, Steendijk P, Moon MR

The purpose of this study was to investigate the relationship between right atrial (RA) reservoir and conduit function and to determine how hemodynamic changes influence this relationship and its impact on cardiac output. In 11 open-chest sheep, RA reservoir and conduit function were quantified as RA inflow with the tricuspid valve closed versus open, respectively. Conduit function was separated into early (before A wave) and late (after A wave) components. The effects of inotropic stimulation,... Abstract

Cited 13 times since 2004 (0.6 per year) source: EuropePMC

American heart journal, Volume 148, Issue 6, 1 1 2004, Pages 1079-1084 Pulsed-wave tissue Doppler quantification of systolic and diastolic function of viable and nonviable myocardium in patients with ischemic cardiomyopathy. Bountioukos M, Schinkel AF, Bax JJ, Biagini E, Rizzello V, Krenning BJ, Vourvouri EC, Roelandt JR, Poldermans D

Background: Detection of myocardial viability is crucial for clinical treatment of patients with ischemic cardiomyopathy. Currently, quantitative information for the evaluation of systolic and diastolic function of viable tissue is limited. Our aim was to compare quantitatively systolic and diastolic function in viable and nonviable dysfunctional myocardium in patients with ischemic cardiomyopathy. Methods: A total of 93 patients (mean age, 62 +/- 10 years) underwent dobutamine stress echocardio... Abstract

Cited 69 times since 2004 (3.4 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 45, Issue 12, 1 1 2004, Pages 1999-2007 Integration of automatically measured transient ischemic dilation ratio into interpretation of adenosine stress myocardial perfusion SPECT for detection of severe and extensive CAD. Abidov A, Bax JJ, Hayes SW, Cohen I, Nishina H, Yoda S, Kang X, Aboul-Enein F, Gerlach J, Friedman JD, Hachamovitch R, Germano G, Berman DS

Unlabelled: The aim of our study was to derive and to validate the normal threshold for an automatically measured left ventricular transient ischemic dilation (TID) ratio in patients referred for adenosine stress myocardial perfusion SPECT (MPS) and to assess the value of integrating TID in detecting severe and extensive coronary artery disease (CAD). Methods: Normal limits for the TID ratio were derived using dual-isotope MPS data from 38 patients with a low ( or =90% stenosis) in the proximal... Abstract

Cited 52 times since 2004 (2.5 per year) source: EuropePMC

American heart journal, Volume 148, Issue 6, 1 1 2004, Pages 1047-1052 Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery: rationale and design of the DECREASE-IV study. Schouten O, Poldermans D, Visser L, Kertai MD, Klein J, van Urk H, Simoons ML, van de Ven LL, Vermeulen M, Bax JJ, Lameris TW, Boersma E

Abstract

Cited 37 times since 2004 (1.8 per year) source: EuropePMC

Diabetes care, Volume 27, Issue 12, 1 1 2004, Pages 2905-2910 Noninvasive angiography and assessment of left ventricular function using multislice computed tomography in patients with type 2 diabetes. Schuijf JD, Bax JJ, Jukema JW, Lamb HJ, Vliegen HW, Salm LP, de Roos A, van der Wall EE

Objective: Early identification of coronary artery disease (CAD) in patients with diabetes is important because these patients are at increased risk for CAD and have worse outcome than nondiabetic patients after CAD is diagnosed. Recently, noninvasive coronary angiography and assessment of left ventricular function has been demonstrated with multislice computed tomography (MSCT). The purpose of the present study was to validate this approach in patients with type 2 diabetes. Research design and... Abstract

Cited 144 times since 2004 (7.1 per year) source: EuropePMC

The American journal of cardiology, Volume 94, Issue 12, 1 1 2004, Pages 1506-1509 Comparison of response to cardiac resynchronization therapy in patients with sinus rhythm versus chronic atrial fibrillation. Molhoek SG, Bax JJ, Bleeker GB, Boersma E, van Erven L, Steendijk P, van der Wall EE, Schalij MJ

Cardiac resynchronization therapy (CRT) is a new therapeutic option for patients who have drug-refractory end-stage heart failure. Much information has been obtained from patients who have sinus rhythm, but the use of CRT in patients who have chronic atrial fibrillation (AF) has not been studied extensively. Accordingly, we evaluated the clinical response and long-term survival rate of CRT in patients who had heart failure and chronic AF, and the results were compared with those in patients who... Abstract

Cited 16 times since 2004 (0.8 per year) source: EuropePMC

Biochemical pharmacology, Volume 68, Issue 11, 1 1 2004, Pages 2273-2281 A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy. de Graaf M, Nevalainen TJ, Scheeren HW, Pinedo HM, Haisma HJ, Boven E

The glucuronide prodrug of doxorubicin, DOX-GA3, can be selectively activated in tumors by extracellular human beta-glucuronidase, resulting in a better therapeutic index than doxorubicin. DOX-GA3, however, is rapidly excreted by the kidney. We hypothesized that slow release of DOX-GA3 from its methylester, DOX-mGA3, by esterase activity in blood would result in improved circulation half-life (t(1/2)) of DOX-GA3. DOX-mGA3 was synthesized more efficiently with an overall yield of 60% as compared... Abstract

Cited 34 times since 2004 (1.7 per year) source: EuropePMC

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 34, Issue 12, 1 1 2004, Pages 1827-1833 Serum surfactant protein D is elevated in allergic patients. Koopmans JG, van der Zee JS, Krop EJ, Lopuhaä CE, Jansen HM, Batenburg JJ

Background: There is evidence that surfactant protein (SP)-D is important in the innate, as well as in the adaptive pulmonary immune response. Serum concentrations of SP-D have been proposed as parameter of the integrity of the blood-airspace barrier in interstitial lung diseases. We hypothesized that serum SP-D concentrations are affected in allergic patients and correlate with changes in allergic airway inflammation. Objective: To determine levels of serum SP-D in allergic patients compared wi... Abstract

Cited 56 times since 2004 (2.7 per year) source: EuropePMC

Radiology, Volume 233, Issue 3, 1 1 2004, Pages 824-829 Right ventricular function after pulmonary valve replacement in patients with tetralogy of Fallot. van Straten A, Vliegen HW, Hazekamp MG, Bax JJ, Schoof PH, Ottenkamp J, van der Wall EE, de Roos A

Purpose: To assess the time course of right ventricular (RV) function improvement after pulmonary valve replacement (PVR) in patients 25.2 years +/- 7.0 after repair of tetralogy of Fallot. Materials and methods: The medical ethics committee approved this study, and informed consent was obtained. Cardiac magnetic resonance (MR) imaging was performed before, 7 months after, and 19 months after PVR in 25 consecutive patients with tetralogy of Fallot with a 1.5-T MR imager. RV function was assessed... Abstract

Cited 24 times since 2004 (1.2 per year) source: EuropePMC

Inorganic chemistry, Volume 43, Issue 26, 1 1 2004, Pages 8461-8469 Rare-earth quinolinates: infrared-emitting molecular materials with a rich structural chemistry. Van Deun R, Fias P, Nockemann P, Schepers A, Parac-Vogt TN, Van Hecke K, Van Meervelt L, Binnemans K

Near-infrared-emitting rare-earth chelates based on 8-hydroxyquinoline have appeared frequently in recent literature, because they are promising candidates for active components in near-infrared-luminescent optical devices, such as optical amplifiers, organic light-emitting diodes, .... Unfortunately, the absence of a full structural investigation of these rare-earth quinolinates is hampering the further development of rare-earth quinolinate based materials, because the luminescence output canno... Abstract

Cited 8 times since 2004 (0.4 per year) source: EuropePMC

Gene, Volume 343, Issue 1, 1 1 2004, Pages 91-97 Efficient somatic gene targeting in the lymphoid human cell line DG75. Feederle R, Delecluse HJ, Rouault JP, Schepers A, Hammerschmidt W

Among the different approaches used to define the function of a protein of interest, alteration and/or deletion of its encoding gene is the most direct strategy. Homologous recombination between the chromosomal gene locus and an appropriately designed targeting vector results in an alteration or knockout of the gene of interest. Homologous recombination is easily performed in yeast or in murine embryonic stem cells, but is cumbersome in more differentiated and diploid somatic cell lines. Here we... Abstract

Cited 28 times since 2004 (1.4 per year) source: EuropePMC

European journal of radiology, Volume 52, Issue 3, 1 1 2004, Pages 240-245 The value of MR angiography techniques in the detection of head and neck paragangliomas. van den Berg R, Schepers A, de Bruïne FT, Liauw L, Mertens BJ, van der Mey AG, van Buchem MA

Objective: The objective of this study was to compare three-dimensional phase-contrast angiography (3D PCA), 2D time-of-flight (2D TOF), and 3D TOF magnetic resonance (MR) angiography and a proton density weighted technique in terms of their ability to detect head and neck paragangliomas. Materials and methods: 14 patients with 29 paragangliomas were examined at 1.5 T. Three MR angiography sequences (3D PCA, 2D TOF, and multi-slab 3D TOF) and a proton density (PD) weighted sequence were reviewed... Abstract

Cited 60 times since 2004 (2.9 per year) source: EuropePMC

Diabetes care, Volume 27, Issue 12, 1 1 2004, Pages 2887-2892 Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease. Beishuizen ED, van de Ree MA, Jukema JW, Tamsma JT, van der Vijver JC, Meinders AE, Putter H, Huisman MV

Objective: Cardiovascular disease (CVD) is the most important cause of mortality in patients with type 2 diabetes. We aimed to determine the effect of statin therapy versus placebo on the progression of carotid intima-media thickness (IMT) in type 2 diabetic patients without manifest CVD. Research design and methods: A randomized, placebo-controlled, double-blind clinical trial was performed in 250 patients with type 2 diabetes. Patients were given either 0.4 mg cerivastatin or placebo daily. In... Abstract