9618 results
Cited 28 times since 2014 (2.5 per year)
source: EuropePMC
Transplant international : official journal of the European Society for Organ Transplantation,
Volume 27, Issue 10, 22 4 2014, Pages 994-1004
Do Asian renal transplant patients need another mycophenolate mofetil dose compared with Caucasian or African American patients?
Li P, Shuker N, Hesselink DA, van Schaik RH, Zhang X, van Gelder T
Mycophenolate mofetil (MMF) is used to prevent acute rejection following solid organ transplantation in transplant centers all over the world. Patients from different ethnic backgrounds are treated with this drug, for which therapeutic drug monitoring (TDM) has not become the standard of practice in most centers. Whether or not some ethnic groups require a different MMF dose has been a topic of debate in recent years. In this review, it is shown that Asian patients, compared with Caucasian patie...
Abstract
Cited 9 times since 2014 (0.8 per year)
source: EuropePMC
Cardiovascular and interventional radiology,
Volume 38, Issue 3, 22 4 2014, Pages 600-605
Thromboembolic complications after Zenith® Low Profile Endovascular Graft for infrarenal abdominal aneurysms.
Urlings TA, de Vries AC, de Mol van Otterloo JC, Eefting D, van der Linden E
Purpose: The purpose of this study was to objectify and evaluate risk factors for thromboembolic complications after treatment with a Zenith(®) Low Profile Endovascular Graft (Zenith LP). Results were compared with those in the recent literature on endovascular aortic repair (EVAR) and with the thromboembolic complications in the patient group treated with a Zenith Flex Endovascular Graft in our institute in the period before the use of the Zenith LP. Materials and methods: All consecutive patie...
Abstract
Cited 23 times since 2014 (2.1 per year)
source: EuropePMC
British journal of anaesthesia,
Volume 114, Issue 2, 21 3 2014, Pages 319-326
Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats.
Lirk P, Verhamme C, Boeckh R, Stevens MF, ten Hoope W, Gerner P, Blumenthal S, de Girolami U, van Schaik IN, Hollmann MW, Picardi S
Background: The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. Methods: Experiments were carried out in Zucker diabetic fatty rats aged 10 weeks (early diabetic) or 18 weeks (late diabetic, with or without insulin 3 units per day), and age-match...
Abstract
Cited 31 times since 2014 (2.8 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 41, Issue 6, 20 3 2014, Pages 1512-1520
Characterization and improved quantification of left ventricular inflow using streamline visualization with 4DFlow MRI in healthy controls and patients after atrioventricular septal defect correction.
Calkoen EE, Roest AA, Kroft LJ, van der Geest RJ, Jongbloed MR, van den Boogaard PJ, Blom NA, Hazekamp MG, de Roos A, Westenberg JJ
Purpose: To evaluate trans-left atrioventricular valve (LAVV) blood flow and optimize left ventricular inflow quantification in healthy controls and patients after atrioventricular septal defect (AVSD) correction. Materials and methods: Twenty-five patients after AVSD correction and 25 controls underwent 4DFlow MRI. Using streamline visualization in four- and two-chamber views, inflow direction at early and late filling was defined at the annulus level and at the peak inflow velocity (PIV) level...
Abstract
Cited 59 times since 2014 (5.4 per year)
source: EuropePMC
European heart journal,
Volume 36, Issue 1, 20 3 2014, Pages 39-48
Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin.
Kühnast S, van der Tuin SJ, van der Hoorn JW, van Klinken JB, Simic B, Pieterman E, Havekes LM, Landmesser U, Lüscher TF, Willems van Dijk K, Rensen PC, Jukema JW, Princen HM
Background: The residual risk that remains after statin treatment supports the addition of other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. Epidemiological studies propose HDL-C as a possible candidate. Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from atheroprotective HDL to atherogenic (V)LDL. The CETP inhibitor anacetrapib decreases (V)LDL-C by ∼15-40% and increases HDL-C by ∼40-140% in clinical trials. We evaluated the effec...
Abstract
Cited 144 times since 2014 (13.1 per year)
source: EuropePMC
Journal of lipid research,
Volume 55, Issue 10, 19 3 2014, Pages 2103-2112
Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin.
Kühnast S, van der Hoorn JW, Pieterman EJ, van den Hoek AM, Sasiela WJ, Gusarova V, Peyman A, Schäfer HL, Schwahn U, Jukema JW, Princen HM
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a potential novel strategy for treatment of CVD. Alirocumab is a fully human PCSK9 monoclonal antibody in phase 3 clinical development. We evaluated the antiatherogenic potential of alirocumab in APOE*3Leiden.CETP mice. Mice received a Western-type diet and were treated with alirocumab (3 or 10 mg/kg, weekly subcutaneous dosing) alone and in combination with atorvastatin (3.6 mg/kg/d) for 18 weeks. Alirocumab alone dose-dependen...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 15, Issue 12, 19 3 2014, Pages 1428
Three-dimensional transoesophageal echocardiographic visualization of malignant anomalous left main coronary origin and course causing sudden cardiac death.
Kamperidis V, Katsanos S, Bertels RA, Schalij MJ, Delgado V
Abstract
Cited 23 times since 2014 (2.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 16, Issue 10, 19 3 2014, Pages 1104-1111
Super-responders to cardiac resynchronization therapy remain at risk for ventricular arrhythmias and benefit from defibrillator treatment.
van der Heijden AC, Höke U, Thijssen J, Borleffs CJ, van Rees JB, van der Velde ET, Schalij MJ, van Erven L
Aims: Mortality and ventricular arrhythmias are reduced in patients responding to cardiac resynchronization therapy (CRT). This response is accompanied by improvement in LVEF, and some patients even outgrow original eligibility criteria for implantable cardioverter-defibrillator (ICD) implantation. It is however unclear if these patients still benefit from ICD treatment. The current study aimed to evaluate if the incidence of ICD therapy is related to the extent of CRT response. Methods and resu...
Abstract
Cited 21 times since 2014 (1.9 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 98, Issue 5, 19 3 2014, Pages 1680-1686
More than 25 years of experience in managing pulmonary atresia with intact ventricular septum.
Schneider AW, Blom NA, Bruggemans EF, Hazekamp MG
Background: Management of pulmonary atresia with intact ventricular septum (PAIVS) is challenging and depends on the individual patient's morphologic characteristics. We evaluated outcomes of 25 years of experience in morphologically driven management of PAIVS. Methods: Between January 1985 and December 2011, 60 patients were treated for PAIVS. Patients were retrospectively categorized into mild (n=27), moderate (n=18), and severe (n=15) right ventricular (RV) hypoplasia subgroups based on...
Abstract
Cited 22 times since 2014 (2 per year)
source: EuropePMC
International journal of cardiology,
Volume 176, Issue 3, 17 3 2014, Pages 776-781
Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation.
Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ, Mulder BJ
Background: Adult post-coarctectomy patients (CoA) demonstrate increased cardiovascular morbidity and mortality. The carotid intima-media thickness (CIMT), a marker for atherosclerosis, is increased in CoA. The aim was to evaluate the predictive value of CIMT for cardiovascular events. Methods and results: Consecutive CoA patients were prospectively studied during 10.1±0.7 years follow-up. At baseline and follow-up echocardiography, MRI imaging and CIMT imaging were performed, while cardiovascul...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: Scopus
The international journal of cardiovascular imaging,
Volume 31, Issue 1, 17 3 2014, Pages 37-43
Pericardial effusion following transcatheter aortic valve implantation: echocardiography and multi-detector row computed tomography evaluation.
Katsanos S, van Rosendael P, Kamperidis V, van der Kley F, Regeer M, Al-Amri I, Karalis I, Palmen M, de Weger A, Marsan NA, Bax JJ, Delgado V
Although pericardial effusion (PE) early after transcatheter aortic valve implantation (TAVI) has been reported in few registries, late PE at follow-up remains unexplored. Particularly, after transapical TAVI, diagnosis of PE with transthoracic echocardiography (TTE) may be challenging. The present evaluation assessed the incidence of PE early after TAVI and at 1 month follow-up using TTE and multi-detector computed tomography (MDCT). The agreement between TTE and MDCT to diagnose the presence a...
Abstract
Cited 34 times since 2014 (3.1 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 18, Issue 10, 15 3 2014, Pages 2020-2030
Complement factor C5a induces atherosclerotic plaque disruptions.
Wezel A, de Vries MR, Lagraauw HM, Foks AC, Kuiper J, Quax PH, Bot I
Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE(-/-) mice. After 24 days, when advanced plaques had developed, C5a or PBS was applied locally at the lesion site in a pluronic gel. Three days later mice were killed to examine the acute effect of C5a on late stage atherosclerosis. A signi...
Abstract
Cited 141 times since 2014 (12.8 per year)
source: EuropePMC
Circulation,
Volume 130, Issue 15, 14 2 2014, Pages 1225-1235
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J, Gollob MH, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith JD, Psaty BM, Smith NL, Jukema JW, Chasman DI, Albert CM, Ebana Y, Furukawa T, Macfarlane PW, Harris TB, Darbar D, Dörr M, Holst AG, Svendsen JH, Hofman A, Uitterlinden AG, Gudnason V, Isobe M, Malik R, Dichgans M, Rosand J, Van Wagoner DR, METASTROKE Consortium, AFGen Consortium, Benjamin EJ, Milan DJ, Melander O, Heckbert SR, Ford I, Liu Y, Barnard J, Olesen MS, Stricker BH, Tanaka T, Kääb S, Ellinor PT
Background: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. Methods and results: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation. F...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 8, 14 2 2014, Pages e105019
Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques.
Rutten B, Tersteeg C, Vrijenhoek JE, van Holten TC, Elsenberg EH, Mak-Nienhuis EM, de Borst GJ, Jukema JW, Pijls NH, Waltenberger J, van Zonneveld AJ, Moll FL, McClellan E, Stubbs A, Pasterkamp G, Hoefer I, de Groot PG, Roest M
Objective: Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (PMCs) and macrophages in human atherosclerotic carotid plaques. Methods: Platelet reactivity was determined by measuring platelet P-selectin expression after platelet stimulation with increasing concentrations of adenosine diphosphate...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
European journal of psychotraumatology,
Volume 5, 14 2 2014
Do soldiers seek more mental health care after deployment? Analysis of mental health consultations in the Netherlands Armed Forces following deployment to Afghanistan.
Taal EL, Vermetten E, van Schaik DA, Leenstra T
Background: Military deployment to combat zones puts military personnel to a number of physical and mental challenges that may adversely affect mental health. Until now, few studies have been performed in Europe on mental health utilization after military deployment. Objective: We compared the incidence of mental health consultations with the Military Mental Health Service (MMHS) of military deployed to Afghanistan to that of non-deployed military personnel. Method: We assessed utilization of th...
Abstract
Cited 25 times since 2014 (2.3 per year)
source: EuropePMC
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Volume 104, Issue 10, 13 2 2014, Pages 680-687
Monitoring of non-communicable diseases such as hypertension in South Africa: challenges for the post-2015 global development agenda.
Day C, Groenewald P, Laubscher R, Chaudhry S, Van Schaik N, Bradshaw D
Background: Examining the non-communicable disease (NCD) profile for South Africa (SA) is crucial when developing health interventions that aim to reduce the burden of NCDs. Objective: To review NCD indicators in national data sources in order to describe the burden of NCDs in SA, using hypertension as an example. Methods: Age, gender, district of death and underlying cause of death data were obtained for 2008 and 2009 mortality unit records from Statistics SA and adjusted using STATA 11. Data f...
Abstract
Cited 10 times since 2014 (0.9 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 8, 12 2 2014, Pages e105052
Estimation of the use of antibiotics in the small ruminant industry in The Netherlands in 2011 and 2012.
Santman-Berends I, Luttikholt S, Van den Brom R, Van Schaik G, Gonggrijp M, Hage H, Vellema P
The aim of this study was to estimate the quantity of antibiotics and classes of antibiotics used in the small ruminant industry in the Netherlands in 2011 and 2012. Twelve large veterinary practices, located throughout the Netherlands were selected for this study. All small ruminant farms associated with these practices that had complete records on the quantity of antibiotics prescribed were included. The veterinary practices provided data on all antibiotics prescribed, and the estimated animal...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 6, 12 2 2014, Pages 1072-1074
The potential role of gated myocardial perfusion SPECT imaging in patient selection for cardiac resynchronization therapy.
Marsan NA, Bax JJ
Abstract
Cited 35 times since 2014 (3.2 per year)
source: EuropePMC
Journal of surgical oncology,
Volume 110, Issue 7, 11 2 2014, Pages 845-850
Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging.
Schaafsma BE, Verbeek FP, Elzevier HW, Tummers QR, van der Vorst JR, Frangioni JV, van de Velde CJ, Pelger RC, Vahrmeijer AL
Background and objectives: Unlike other cancers, the Sentinel Lymph Node (SLN) procedure in bladder cancer requires special attention to the injection technique. The aim of this study was to assess feasibility and to optimize tracer injection technique for SLN mapping in bladder cancer patients using NIR fluorescence imaging. Methods: Twenty patients with invasive bladder cancer scheduled for radical cystectomy were prospectively enrolled. Indocyanine green (ICG) bound to human serum albumin (co...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Volume 73, 10 2 2014, Pages 105-112
Evaluation of in vitro cytotoxicity and genotoxicity of copper-zinc alloy nanoparticles in human lung epithelial cells.
Kumbıçak U, Cavaş T, Cinkılıç N, Kumbıçak Z, Vatan O, Yılmaz D
In the present study, in vitro cytotoxic and genotoxic effect of copper-zinc alloy nanoparticles (Cu-Zn ANPs) on human lung epithelial cells (BEAS-2B) were investigated. XTT test and clonogenic assay were used to determine cytotoxic effects. Cell death mode and intracellular reactive oxygen species formations were analyzed using M30, M65 and ROS Elisa assays. Genotoxic effects were evaluated using micronucleus, comet and γ-H2AX foci assays. Cu-Zn ANPs were characterized by transmission electron...
Abstract
