Research

Publications

Below you can find a list of our published research.

9618 results

Cited 60 times since 2014 (5.4 per year) source: EuropePMC

International journal of cancer, Volume 136, Issue 6, 8 2 2014, Pages 1434-1444 Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation. Groenendijk FH, Mellema WW, van der Burg E, Schut E, Hauptmann M, Horlings HM, Willems SM, van den Heuvel MM, Jonkers J, Smit EF, Bernards R

The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical challenge. Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. We further show in a phase II clinical trial in... Abstract

Cited 253 times since 2014 (22.9 per year) source: EuropePMC

American heart journal, Volume 168, Issue 5, 7 1 2014, Pages 682-689 Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial. Schwartz GG, Bessac L, Berdan LG, Bhatt DL, Bittner V, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Rorick T, Sasiela WJ, Shirodaria C, Szarek M, Tamby JF, Tricoci P, White H, Zeiher A, Steg PG

Background: Following acute coronary syndrome (ACS), the risk for future cardiovascular events is high and is related to levels of low-density lipoprotein cholesterol (LDL-C) even within the setting of intensive statin treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates LDL receptor expression and circulating levels of LDL-C. Antibodies to PCSK9 can produce substantial and sustained reductions of LDL-C. The ODYSSEY Outcomes trial tests the hypothesis that treatment with al... Abstract

Cited 38 times since 2014 (3.4 per year) source: EuropePMC

Psychotherapy and psychosomatics, Volume 83, Issue 5, 6 1 2014, Pages 263-269 The effectiveness of the cognitive behavioral analysis system of psychotherapy for chronic depression: a randomized controlled trial. Wiersma JE, Van Schaik DJ, Hoogendorn AW, Dekker JJ, Van HL, Schoevers RA, Blom MB, Maas K, Smit JH, McCullough JP, Beekman AT, Van Oppen P

Background: It is widely agreed that chronic depression is difficult to treat, knowledge about optimal treatment approaches is emerging. Method: A multisite randomized controlled trial was conducted comparing the cognitive behavioral analysis system of psychotherapy (CBASP), a psychotherapy model developed specifically to treat chronic depression (n = 67) with care as usual (CAU; evidence-based treatments, n = 72) over a period of 52 weeks, with 23 sessions on average, in 3 outpatient clinics in... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

American journal of physical anthropology, Volume 155, Issue 3, 6 1 2014, Pages 430-435 Why do chimpanzee males attack the females of neighboring communities? Pradhan GR, Pandit SA, Van schaik CP

Our closest nonhuman primate relatives, chimpanzees, engage in potentially lethal between-group conflict; this collective aggressive behavior shows parallels with human warfare. In some communities, chimpanzee males also severely attack and even kill females of the neighboring groups. This is surprising given their system of resource defense polygyny, where males are expected to acquire potential mates. We develop a simple mathematical model based on reproductive skew among primate males to solv... Abstract

Cited 876 times since 2014 (79.4 per year) source: EuropePMC

Lancet (London, England), Volume 384, Issue 9959, 6 1 2014, Pages 2027-2035 Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up. Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Zappa M, Nelen V, Kwiatkowski M, Lujan M, Määttänen L, Lilja H, Denis LJ, Recker F, Paez A, Bangma CH, Carlsson S, Puliti D, Villers A, Rebillard X, Hakama M, Stenman UH, Kujala P, Taari K, Aus G, Huber A, van der Kwast TH, van Schaik RH, de Koning HJ, Moss SM, Auvinen A, ERSPC Investigators

Background: The European Randomised study of Screening for Prostate Cancer (ERSPC) has shown significant reductions in prostate cancer mortality after 9 years and 11 years of follow-up, but screening is controversial because of adverse events such as overdiagnosis. We provide updated results of mortality from prostate cancer with follow-up to 2010, with analyses truncated at 9, 11, and 13 years. Methods: ERSPC is a multicentre, randomised trial with a predefined centralised database, analysis pl... Abstract

Revista espanola de cardiologia (English ed.), Volume 67, Issue 10, 4 1 2014, Pages 855-857 Value of intraoperative electrical parameters obtained during implantation of cardiac resynchronization therapy devices for the prediction of reverse remodeling. de Riva-Silva M, López-Gil M, Salgado-Aranda R, Fontenla-Cerezuela A, Salguero-Bodes R, Arribas-Ynsaurriaga F

Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

International journal of cardiology, Volume 176, Issue 3, 3 1 2014, Pages 788-793 RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice. Louwe MC, Karper JC, de Vries MR, Nossent AY, Bastiaansen AJ, van der Hoorn JW, Willems van Dijk K, Rensen PC, Steendijk P, Smit JW, Quax PH

Background: Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signaling, would lead to aggravated cardiac dysfunction after MI. Methods and results: First, whole blood from RP105-/- and wild-type (WT) ma... Abstract

Cited 22 times since 2014 (2 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 86, Issue 1, 2 1 2014, Pages 73-77 Retrospective evaluation of thromboembolic events in patients with non-small cell lung cancer treated with platinum-based chemotherapy. Mellema WW, van der Hoek D, Postmus PE, Smit EF

Objectives: Thromboembolic events (TE) are common in patients with cancer and are potentially life-threatening. In lung cancer, little is known about thrombosis during chemotherapy treatment. The aim of this study was to describe the incidence of TE in patients with non-small cell lung cancer (NSCLC), occurring during treatment with platinum-based chemotherapy. Methods: We retrospectively selected patients with NSCLC treated with platinum-based chemotherapy at the VU University Medical Center Am... Abstract

Cited 35 times since 2014 (3.2 per year) source: EuropePMC

Preventive veterinary medicine, Volume 117, Issue 2, 2 1 2014, Pages 375-387 A multidisciplinary approach to determine factors associated with calf rearing practices and calf mortality in dairy herds. Santman-Berends IM, Buddiger M, Smolenaars AJ, Steuten CD, Roos CA, Van Erp AJ, Van Schaik G

In the Netherlands, an increase in ear-tagged calf mortality (3 days to 1 year of age) in dairy farms was observed. The aim was to determine why calf mortality increased and how to reduce calf mortality in herds with structural high rates. A multi-disciplinary approach was chosen to study this phenomenon. First analysis of census data revealed that the majority of the calves died in the first month of life. In addition, a panel of 236 farmers indicated that the increase in calf mortality might b... Abstract

Circulation. Arrhythmia and electrophysiology, Volume 7, Issue 4, 1 1 2014, Pages 567-569 The ideal end point for ablation in postinfarction ventricular tachycardia: one may not fit all. Zeppenfeld K

Abstract

Cited 19 times since 2014 (1.7 per year) source: EuropePMC

Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume 25, Issue 1, 1 1 2014, Pages 93-99 The role of insulin resistance in the association between body fat and autonomic function. Hillebrand S, Swenne CA, Gast KB, Maan AC, le Cessie S, Jukema JW, Rosendaal FR, den Heijer M, de Mutsert R

Background and aim: Excess body fat is associated with altered autonomic function. We investigated whether this association is mediated by insulin resistance. Methods and results: Cross-sectional analysis of a subgroup of the Netherlands Epidemiology of Obesity study with measurements of autonomic function (heart rate variability calculated as mean interbeat interval, standard deviation of all normal intervals (SDNN), low frequency (LF) power and high frequency (HF) power). We measured BMI(kg/m²... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Der Urologe. Ausg. A, Volume 53, Issue 8, 1 1 2014, Pages 1136-1145 [The demographic development in Germany : challenge and chances for urology]. Schneider AW, Fichtner J

Urology is affected by the demographic development in Germany more than any other medical discipline. Despite a relatively stable total population, by the year 2040 there will be an absolute and relevant increase in urological diseases caused only by the demographic development in the population. This is particularly true for the increase in oncological treatment just in the field of the discipline of urology. Even now the current numbers for tumor development in Germany (RKI 2014) in the urolog... Abstract

Cited 702 times since 2014 (63.5 per year) source: EuropePMC

European heart journal, Volume 35, Issue 35, 1 1 2014, Pages 2383-2431 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, Hert SD, Ford I, Gonzalez-Juanatey JR, Gorenek B, Heyndrickx GR, Hoeft A, Huber K, Iung B, Kjeldsen KP, Longrois D, Lüscher TF, Pierard L, Pocock S, Price S, Roffi M, Sirnes PA, Sousa-Uva M, Voudris V, Funck-Brentano C, Authors/Task Force Members

Abstract

Cited 40 times since 2014 (3.6 per year) source: EuropePMC

Proceedings. Biological sciences, Volume 281, Issue 1788, 1 1 2014, Pages 20140263 Language evolution: syntax before phonology? Collier K, Bickel B, van Schaik CP, Manser MB, Townsend SW

Phonology and syntax represent two layers of sound combination central to language's expressive power. Comparative animal studies represent one approach to understand the origins of these combinatorial layers. Traditionally, phonology, where meaningless sounds form words, has been considered a simpler combination than syntax, and thus should be more common in animals. A linguistically informed review of animal call sequences demonstrates that phonology in animal vocal systems is rare, where... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

Pharmacogenomics, Volume 15, Issue 11, 1 1 2014, Pages 1471-1477 No association between CYP3A4*22 and statin effectiveness in reducing the risk for myocardial infarction. Leusink M, de Keyser CE, Onland-Moret NC, Hofman A, Visser LE, Stricker BH, de Bakker PI, de Boer A, van Schaik RH, Maitland-van der Zee AH

Aim: Genetic variation has been shown to influence statin response in terms of lowering LDL cholesterol. The recently discovered CYP3A4*22 allele (defined as rs35599367) has been shown to affect statin-induced LDL cholesterol lowering. Our objective was to investigate whether this polymorphism modifies the risk reduction for myocardial infarction (MI) by statins. Patients & methods: We analyzed the interaction between the *22 minor allele and statin use in the independent Utrecht Cardiovascu... Abstract

Cited 120 times since 2014 (10.9 per year) source: EuropePMC

Circulation research, Volume 115, Issue 8, 1 1 2014, Pages 696-708 Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia. Welten SM, Bastiaansen AJ, de Jong RC, de Vries MR, Peters EA, Boonstra MC, Sheikh SP, La Monica N, Kandimalla ER, Quax PH, Nossent AY

Rationale: Effective neovascularization is crucial for recovery after cardiovascular events. Objective: Because microRNAs regulate expression of up to several hundred target genes, we set out to identify microRNAs that target genes in all pathways of the multifactorial neovascularization process. Using www.targetscan.org, we performed a reverse target prediction analysis on a set of 197 genes involved in neovascularization. We found enrichment of binding sites for 27 microRNAs in a single microR... Abstract

Cited 24 times since 2014 (2.2 per year) source: EuropePMC

Magnetic resonance in medicine, Volume 72, Issue 2, 1 1 2014, Pages 409-417 Quantitative T2 mapping of the mouse heart by segmented MLEV phase-cycled T2 preparation. Coolen BF, Simonis FF, Geelen T, Moonen RP, Arslan F, Paulis LE, Nicolay K, Strijkers GJ

Purpose: A high-quality, reproducible, multi-slice T2-mapping protocol for the mouse heart is presented. Methods: A T2-prepared sequence with composite 90° and 180° radiofrequency pulses in a segmented MLEV phase cycling scheme was developed. The T2-mapping protocol was optimized using simulations and evaluated with phantoms. Results: Repeatability for determination of myocardial T2 values was assessed in vivo in n = 5 healthy mice on 2 different days. The average baseline T2 of the left ventric... Abstract

Cited 4 times since 2014 (0.4 per year) source: Scopus

Perfusion, Volume 30, Issue 4, 1 1 2014, Pages 295-301 Sevoflurane-enriched blood cardioplegia: the intramyocardial delivery of a volatile anesthetic. van der Baan A, Kortekaas KA, van Es E, Meier S, Klautz RJ, Engbers FH

Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with a sevoflurane vaporizer was integrated into the blood cardioplegia system of an adult bypass system. In addition, a gas ble... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Circulation research, Volume 115, Issue 4, 1 1 2014, Pages e6-7 Cardiac anisotropy, regeneration, and rhythm. Pijnappels DA, Schalij MJ, Atsma DE, de Vries AA

Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 7-8, 1 1 2014, Pages 336-343 Cardiologist and cardiac surgeon view on decision-making in prosthetic aortic valve selection: does profession matter? Korteland NM, Kluin J, Klautz RJ, Roos-Hesselink JW, Versteegh MI, Bogers AJ, Takkenberg JJ

Aims: Assess and compare among Dutch cardiothoracic surgeons and cardiologists: opinion on (1) patient involvement, (2) conveying risk in aortic valve selection, and (3) aortic valve preferences. Methods and results: A survey among 117 cardiothoracic surgeons and cardiologists was conducted. Group responses were compared using the Mann-Whitney U test. Most respondents agreed that patients should be involved in decision-making, with surgeons leaning more toward patient involvement (always: 83 % v... Abstract