6173 results
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European heart journal,
Volume 43, Issue 38, 1 1 2022, Pages 3599-3600
The mentorship programme: a new initiative at the European Heart Journal.
Ajmone Marsan N, Cavalcante J, Bucciarelli-Ducci C
Abstract
Cited 3 times since 2022 (1.2 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 9, 30 5 2022, Pages e0274478
Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas.
Bayley JP, Rebel HG, Scheurwater K, Duesman D, Zhang J, Schiavi F, Korpershoek E, Jansen JC, Schepers A, Devilee P
The neuroendocrine tumours paraganglioma and pheochromocytoma (PPGLs) are commonly associated with succinate dehydrogenase (SDH) gene variants, but no human SDH-related PPGL-derived cell line has been developed to date. The aim of this study was to systematically explore practical issues related to the classical 2D-culture of SDH-related human paragangliomas and pheochromocytomas, with the ultimate goal of identifying a viable tumour-derived cell line. PPGL tumour tissue/cells (chromaffin cells)...
Abstract
Cited 204 times since 2022 (79.6 per year)
source: EuropePMC
Nature,
Volume 611, Issue 7934, 30 5 2022, Pages 115-123
Stroke genetics informs drug discovery and risk prediction across ancestries.
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-M
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-r...
Abstract
Cited 8 times since 2022 (3.1 per year)
source: EuropePMC
European journal of endocrinology,
Volume 187, Issue 5, 30 5 2022, Pages S35-S46
Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies.
Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, Kavousi M, Bauer DC, Cappola AR, Yeap BB, Walsh JP, Brown SJ, Ceresini G, Ferrucci L, Gussekloo J, Trompet S, Iacoviello M, Moon JH, Razvi S, Bensenor IM, Azizi F, Amouzegar A, Valdés S, Colomo N, Wareham NJ, Jukema JW, Westendorp RGJ, Kim KW, Rodondi N, Del Giovane C
Objective: Few prospective studies have assessed whether individuals with subclinical thyroid dysfunction are more likely to develop diabetes, with conflicting results. In this study, we conducted a systematic review of the literature and an individual participant data analysis of multiple prospective cohorts to investigate the association between subclinical thyroid dysfunction and incident diabetes. Methods: We performed a systematic review of the literature in Medline, Embase, and the Cochran...
Abstract
Cited 4 times since 2022 (1.6 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 8, Issue 10, 28 4 2022, Pages 1234-1245
Ventricular Arrhythmia Substrate Distribution and Its Relation to Sympathetic Innervation in Nonischemic Cardiomyopathy Patients.
Chen HS, Jungen C, Kimura Y, Dibbets-Schneider P, Piers SR, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K
Background: Nonischemic cardiomyopathy patients referred for catheter ablation of ventricular arrhythmias (VAs) typically have either inferolateral (ILS) or anteroseptal (ASS) VA substrate locations, with poorer outcomes for ASS. Sympathetic denervation is an important determinant of arrhythmogenicity. Its relation to nonischemic fibrosis in general and to the different VA substrates is unknown. Objectives: This study sought to evaluate the association between VA substrates, myocardial fibrosis,...
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 36, Issue 1, 27 4 2022, Pages 128-129
Response to "Why Are Bicuspid Aortic Valve Patients Flying Under the Radar?"
Stassen J, Bax JJ
Abstract
Cited 2 times since 2022 (0.8 per year)
source: EuropePMC
Journal of cardiopulmonary rehabilitation and prevention,
Volume 42, Issue 6, 24 4 2022, Pages E99-E100
Know Your Numbers: Patient and Physician Disparity in Cardiovascular Risk Perception After an Acute Coronary Syndrome.
Ter Hoeve N, Jorstad HT, Sunamura M, Janssen VR, Scholte Op Reimer WJM, Snaterse M
Abstract
Cited 2 times since 2022 (0.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 184, 23 4 2022, Pages 63-71
Impact of Worsening Heart Failure on Long-Term Prognosis in Patients With Heart Failure With Reduced Ejection Fraction.
Chimed S, Stassen J, Galloo X, Meucci MC, van der Bijl P, Knuuti J, Delgado V, Marsan NA, Bax JJ
Worsening heart failure (HF), defined as hospitalization for worsening signs and symptoms of HF or the need for urgent intravenous diuretics, is often considered a surrogate of poor prognosis in clinical trials. However, data on the prognostic implications of worsening HF in patients with HF and reduced ejection fraction is limited. Patients who had a first echocardiographic diagnosis of left ventricular systolic dysfunction, defined as left ventricular ejection fraction (LVEF) ≤45%, were identi...
Abstract
Cited 9 times since 2022 (3.5 per year)
source: EuropePMC
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 62, 23 4 2022, Pages 107478
Structural abnormalities in the non-dilated ascending aortic wall of bicuspid aortic valve patients.
Grewal N, Girdauskas E, Idhrees M, Velayudhan B, Klautz R, Driessen A, Poelmann RE
Background: A bicuspid aortic valve (BAV) is the most common congenital cardiac malformation. The development of the aortic valve is closely related to the development of the ascending aorta, associated with structural differences in the bicuspid aorta. Here we describe the non-dilated ascending aortic wall in bicuspid aortic valve patients. Methods: BAV (n=41) and tricuspid aortic valve (TAV) (n=18) non-dilated ascending aortic wall samples were studied. We investigated the following features o...
Abstract
Cited 152 times since 2022 (58.8 per year)
source: EuropePMC
Nature medicine,
Volume 28, Issue 11, 22 4 2022, Pages 2309-2320
Metabolomic profiles predict individual multidisease outcomes.
Buergel T, Steinfeldt J, Ruyoga G, Pietzner M, Bizzarri D, Vojinovic D, Upmeier Zu Belzen J, Loock L, Kittner P, Christmann L, Hollmann N, Strangalies H, Braunger JM, Wild B, Chiesa ST, Spranger J, Klostermann F, van den Akker EB, Trompet S, Mooijaart SP, Sattar N, Jukema JW, Lavrijssen B, Kavousi M, Ghanbari M, Ikram MA, Slagboom E, Kivimaki M, Langenberg C, Deanfield J, Eils R, Landmesser U
Risk stratification is critical for the early identification of high-risk individuals and disease prevention. Here we explored the potential of nuclear magnetic resonance (NMR) spectroscopy-derived metabolomic profiles to inform on multidisease risk beyond conventional clinical predictors for the onset of 24 common conditions, including metabolic, vascular, respiratory, musculoskeletal and neurological diseases and cancers. Specifically, we trained a neural network to learn disease-specific meta...
Abstract
Cited 32 times since 2022 (12.4 per year)
source: EuropePMC
Circulation. Cardiovascular interventions,
Volume 15, Issue 9, 20 3 2022, Pages e011958
Atrial Functional Tricuspid Regurgitation: Novel Definition and Impact on Prognosis.
Schlotter F, Dietz MF, Stolz L, Kresoja KP, Besler C, Sannino A, Rommel KP, Unterhuber M, von Roeder M, Delgado V, Thiele H, Hausleiter J, Bax JJ, Lurz P
Background: Atrial functional tricuspid regurgitation (atrial TR) has received growing recognition as a TR entity with a distinct cause owing to its independence from valvular tethering as the predominant mechanism underlying TR. However, characterization of atrial TR varies, and a universal definition is lacking. Methods: In total, 651 patients with significant functional TR were analyzed, including 438 conservatively treated individuals and 213 patients who received transcatheter tricuspid val...
Abstract
Cited 2 times since 2022 (0.8 per year)
source: EuropePMC
BMJ open,
Volume 12, Issue 9, 19 3 2022, Pages e061337
Prevention of vasoplegia with CytoSorb in heart failure patients undergoing cardiac surgery (CytoSorb-HF trial): protocol for a randomised controlled trial.
Papazisi O, Bruggemans EF, Berendsen RR, Hugo JDV, Lindeman JHN, Beeres SLMA, Arbous MS, van den Hout WB, Mertens BJA, Ince C, Klautz RJM, Palmen M
Introduction: Vasoplegia is a common complication after cardiac surgery and is associated with poor prognosis. It is characterised by refractory hypotension despite normal or even increased cardiac output. The pathophysiology is complex and includes the systemic inflammatory response caused by cardiopulmonary bypass (CPB) and surgical trauma. Patients with end-stage heart failure (HF) are at increased risk for developing vasoplegia. The CytoSorb adsorber is a relatively new haemoadsorption devic...
Abstract
Journal of diabetes and its complications,
Volume 36, Issue 12, 15 3 2022, Pages 108309
Extent of subclinical atherosclerosis on coronary computed tomography and impact of statins in patients with diabetes without known coronary artery disease: Results from CONFIRM registry.
Shaikh K, Ahmed A, Gransar H, Lee J, Leipsic J, Nakanishi R, Alla V, Bax JJ, Chow BJW, Berman DS, Maffei E, Lin FY, Ahmad A, DeLago A, Pontone G, Feuchtner G, Marques H, Min JK, Hausleiter J, Hadamitzky M, Kaufmann PA, de Araújo Gonçalves P, Cury RC, Kim YJ, Chang HJ, Rubinshtein R, Villines TC, Lu Y, Shaw LJ, Acenbach S, Al Mallah MH, Andreini D, Cademartiri F, Callister TQ, Budoff MJ
Background: Absence of subclinical atherosclerosis is considered safe to defer statin therapy in general population. However, impact of statins on atherosclerotic cardiovascular disease in patients with diabetes stratified by coronary artery calcium (CAC) scores and extent of non-obstructive CAD on coronary computed tomography angiography (CCTA) has not been evaluated. Methods: CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multi-center Registry) study enroll...
Abstract
Cited 5 times since 2022 (1.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 183, 14 2 2022, Pages 33-39
Effect of Bi-Atrial Size and Function in Patients With Paroxysmal or Permanent Atrial Fibrillation.
Bax M, Ajmone Marsan N, Delgado V, Bax JJ, van der Bijl P
Atrial fibrillation (AF) remains the most common arrhythmia in clinical practice. The choice between a rate-control and rhythm-control strategy depends on various factors, including the anatomical and functional substrate. This study investigates the anatomical and functional characteristics of both atria in patients with AF and explores the potential therapeutic implications. From an ongoing registry of patients with paroxysmal or permanent AF, those who underwent cardiac computed tomography (C...
Abstract
Cited 3 times since 2022 (1.2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 36, Issue 2, 13 2 2022, Pages 252-254
Left Ventricular Myocardial Work to Differentiate Cardiac Amyloidosis From Hypertrophic Cardiomyopathy.
Stassen J, Tjahjadi C, Adam R, Debonnaire P, Claeys M, Popescu BA, Jurcut R, Delgado V, Bax JJ, Marsan NA
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 182, 6 1 2022, Pages 69-76
Impact of Left Ventricular Global Longitudinal Strain on Outcomes After Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation.
Yoon SH, Makar M, Kar S, Koseki K, Oakley L, Sekhon N, Patel D, Chakravarty T, Nakamura M, Hamilton M, Patel JK, Singh S, Sabah S, Siegel RJ, Bax JJ, Makkar RR
Assessment of left ventricular (LV) systolic function is essential in patient selection for transcatheter edge-to-edge repair (TEER) in secondary mitral regurgitation (MR). Although LV ejection fraction (EF) is mostly used for assessing LV function, it represents the change of LV chamber size, but not myocardial contractility. LV global longitudinal strain (GLS) provides an alternative to assess LV systolic function in patients with secondary MR. This study included 380 patients with secondary M...
Abstract
Cited 4 times since 2022 (1.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 31, Issue 3, 6 1 2022, Pages 89-99
Implantable defibrillator therapy and mortality in patients with non-ischaemic dilated cardiomyopathy : An updated meta-analysis and effect on Dutch clinical practice by the Task Force of the Dutch Society of Cardiology.
Theuns DA, Verstraelen TE, van der Lingen ACJ, Delnoy PP, Allaart CP, van Erven L, Maass AH, Vernooy K, Wilde AAM, Boersma E, Meeder JG
Background: Primary prophylactic implantable cardioverter-defibrillators (ICDs) in patients with non-ischaemic cardiomyopathy (NICMP) remains controversial. This study sought to assess the benefit of ICD therapy with or without cardiac resynchronisation therapy (CRT) in patients with NICMP. In addition, data were compared with real-world clinical data to perform a risk/benefit analysis. Methods: Relevant randomised clinical trials (RCTs) published in meta-analyses since DANISH, and in PubMed, EM...
Abstract
Cited 9 times since 2022 (3.4 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 9, 6 1 2022, Pages e0273182
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.
Pogacar Z, Johnson JL, Krenning L, De Conti G, Jochems F, Lieftink C, Velds A, Wardak L, Groot K, Schepers A, Wang L, Song JY, van de Ven M, van Tellingen O, Medema RH, Beijersbergen RL, Bernards R, Leite de Oliveira R
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional genetic screens in palbociclib-resistant cells. Using this approach, we found that loss of CDK2 results in strong senescence induction in palbociclib-treated cells. Treatment with the CDK2 inhibitor indisulam, which phenocopies genetic CDK2 inactivation, l...
Abstract
Cited 3 times since 2022 (1.1 per year)
source: EuropePMC
Surgery,
Volume 172, Issue 5, 3 1 2022, Pages 1358-1363
The big five: Studying the surgical personality.
Sier VQ, Schmitz RF, Putter H, Schepers A, van der Vorst JR
Background: The challenging nature of performing surgery on a personal and professional level demands specific characteristics. Personality traits play an important role in the nature and behavior of humans, which are studied using the five-factor model. Therefore, we investigated the personality of 3 surgical generations. Methods: Three distinct surgical populations were approached. The Dutch Big Five Inventory-2 was sent out online to 126 surgical residents (response: n = 69) and 104 surgeons...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 10, 1 1 2022, Pages 1336-1344
Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics.
van den Hoogen IJ, van Rosendael AR, Lin FY, Gianni U, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Hyun Choi J, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic J, Maffei E, Pontone G, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Virmani R, Samady H, Stone PH, Narula J, Chang HJ, Min JK, Shaw LJ, Bax JJ
Aims: The magnitude of alterations in which coronary arteries remodel and narrow over time is not well understood. We aimed to examine changes in coronary arterial remodelling and luminal narrowing by three-dimensional (3D) metrics from serial coronary computed tomography angiography (CCTA). Methods and results: From a multicentre registry of patients with suspected coronary artery disease who underwent clinically indicated serial CCTA (median interscan interval = 3.3 years), we quantitatively m...
Abstract
