6196 results
Cited 5 times since 2011 (0.4 per year)
source: EuropePMC
Transfusion medicine (Oxford, England),
Volume 21, Issue 4, 24 4 2011, Pages 236-246
The effect of RBC transfusions on cytokine gene expression after cardiac surgery in patients developing post-operative multiple organ failure.
Sitniakowsky LS, Later AF, van de Watering LM, Bogaerts M, Brand A, Klautz RJ, Smit NP, van Hilten JA
Aim: To determine the effect of red blood cell (RBC) transfusions during cardiac surgery on cytokine gene expression (GE) in relation to multiple organ failure (MOF) development after systemic inflammatory response syndrome (SIRS). Background: RBC transfusion in cardiac surgery patients is dose-dependently associated with post-operative MOF, possibly acting as a second hit after cardiopulmonary bypass. Methods: For this observational study, 29 patients divided into four groups of cardiac surgery...
Abstract
Cited 50 times since 2011 (3.6 per year)
source: EuropePMC
Basic research in cardiology,
Volume 106, Issue 5, 24 4 2011, Pages 829-847
In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1.
Bax NA, van Oorschot AA, Maas S, Braun J, van Tuyn J, de Vries AA, Groot AC, Goumans MJ
Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibroblasts, which contribute to cardiac repair. To understand what drives epicardial EMT, we used an in vitro model for human adult epicardial cells. These cells have an epithelium-like...
Abstract
Cited 12 times since 2011 (0.9 per year)
source: EuropePMC
Emergency medicine journal : EMJ,
Volume 29, Issue 4, 21 3 2011, Pages 301-305
The utility of EEG in the emergency department.
Yigit O, Eray O, Mihci E, Yilmaz D, Arslan S, Eray B
Background and aim: Seizure-related visits are common in the emergency department (ED) but the clinical situations for ordering emergency electroencephalography (EEG) are unclear. The aim of this study is to identify which clinical conditions meet with the pathological EEG and whether patient management is changed by abnormal results. Methods: A retrospective chart review study of all patients visiting the ED with a seizure or symptoms mimicking a seizure was performed. Patients who recorded an...
Abstract
Cited 2 times since 2011 (0.1 per year)
source: EuropePMC
Applied nursing research : ANR,
Volume 25, Issue 3, 20 3 2011, Pages 158-163
Examining barriers to emergency contraception use.
Kisa S, Zeyneloğlu S, Yilmaz D, Verim E
Using a cross-sectional survey research design, this study examined barriers to emergency contraception (EC) use among a sample of 318 Turkish women. Only 34% of the respondents reported being aware of EC methods, and about 20% had actually used EC. More than 90% of the participant women considered use of EC methods as a sin. The results of the study showed that the major barriers to EC use are lack of awareness and common misconceptions about EC methods. This study highlights the need of educat...
Abstract
Cited 13 times since 2011 (0.9 per year)
source: EuropePMC
Neuromodulation : journal of the International Neuromodulation Society,
Volume 14, Issue 3, 19 3 2011, Pages 258-65; discussion 265
Subcutaneous electrical nerve stimulation: a feasible and new method for the treatment of patients with refractory angina.
Buiten MS, DeJongste MJ, Beese U, Kliphuis C, Durenkamp A, Staal MJ
Introduction: Patients suffering from chronic angina pectoris, insufficiently controllable with medication and revascularization, are an increasing medical and psychosocial problem. Although spinal cord stimulation (SCS) is proven to employ, safe, long-term anti-angina, and anti-ischemic effects for these patients, the use of SCS in this group remains limited. The reason for this restricted use is largely unknown. However, among other reasons, it may be related to the difficulties in positioni...
Abstract
Cited 47 times since 2011 (3.3 per year)
source: EuropePMC
Circulation,
Volume 123, Issue 17, 18 3 2011, Pages 1864-1872
Genetic predictors of fibrin D-dimer levels in healthy adults.
Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, Lopez LM, Shin SY, Baumert J, Vitart V, Bis JC, Wild SH, Rumley A, Yang Q, Uitterlinden AG, Stott DJ, Davies G, Carter AM, Thorand B, Polašek O, McKnight B, Campbell H, Rudnicka AR, Chen MH, Buckley BM, Harris SE, Peters A, Pulanic D, Lumley T, de Craen AJ, Liewald DC, Gieger C, Campbell S, Ford I, Gow AJ, Luciano M, Porteous DJ, Guo X, Sattar N, Tenesa A, Cushman M, Slagboom PE, Visscher PM, Spector TD, Illig T, Rudan I, Bovill EG, Wright AF, McArdle WL, Tofler G, Hofman A, Westendorp RG, Starr JM, Grant PJ, Karakas M, Hastie ND, Psaty BM, Wilson JF, Lowe GD, O'Donnell CJ, Witteman JC, Jukema JW, Deary IJ, Soranzo N, Koenig W, Hayward C
Background: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. Methods and results: A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21 052 European-ancestry adults. Plasma levels of D-dimer were measur...
Abstract
Cited 8 times since 2011 (0.6 per year)
source: EuropePMC
Contemporary clinical trials,
Volume 32, Issue 4, 17 3 2011, Pages 586-591
Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity?
Schuuring MJ, Vis JC, Bouma BJ, van Dijk AP, van Melle JP, Pieper PG, Vliegen HW, Sieswerda GT, Mulder BJ
Background: The Fontan circulation is a palliative procedure performed in patients with complex congenital heart disease (CHD), making transpulmonary blood flow dependent on the systemic venous pressure. In a Fontan circulation a low pulmonary vascular resistance (PVR) is crucial, as is epitomized by the observation that a high PVR is a strong predictor of mortality. Long-term follow-up has shown that PVR may rise many years after the Fontan procedure has been performed, possibly due to micro-em...
Abstract
Cited 468 times since 2011 (33.3 per year)
source: EuropePMC
Journal of surgical oncology,
Volume 104, Issue 3, 14 2 2011, Pages 323-332
The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery.
Schaafsma BE, Mieog JS, Hutteman M, van der Vorst JR, Kuppen PJ, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the founda...
Abstract
ISRN cardiology,
Volume 2011, 11 2 2011, Pages 638764
Increased B-type natriuretic Peptide concentration is associated with reduced coronary vasoreactivity in patients with dilated cardiomyopathy but not in healthy young subjects.
Sundell J, Engblom E, Koistinen J, Ylitalo A, Laine H, Kalliokoski R, Airaksinen KE, Bax JJ, Knuuti J
Background/Aims. Natriuretic peptides are associated with the cardiovascular disease risk under a range of different circumstances. However, less is known about whether this association is found also in young healthy subjects. Methods. 9 patients with dilated cardiomyopathy and 26 healthy young subjects were studied. The myocardial blood flow measurements were performed basally and during adenosine infusion using PET. Results. S-proBNP concentrations were significantly higher (2153 ± 1964 versus...
Abstract
Cited 49 times since 2011 (3.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 107, Issue 12, 8 2 2011, Pages 1725-1729
Positive remodeling on coronary computed tomography as a marker for plaque vulnerability on virtual histology intravascular ultrasound.
Kröner ES, van Velzen JE, Boogers MJ, Siebelink HM, Schalij MJ, Kroft LJ, de Roos A, van der Wall EE, Jukema JW, Reiber JH, Schuijf JD, Bax JJ
Coronary computed tomographic angiography allows direct evaluation of the vessel wall and thus positive remodeling, which is a marker of vulnerability. The purpose of this study was to assess the association between positive remodeling on computed tomography angiogram (CTA) and vulnerable plaque characteristics on virtual histologic intravascular ultrasound (VH IVUS) images. Forty-five patients (78% men, 58 ± 11 years old) underwent computed tomographic angiography followed by VH IVUS. On CTA, t...
Abstract
Cited 18 times since 2011 (1.3 per year)
source: EuropePMC
Cellular and molecular life sciences : CMLS,
Volume 68, Issue 22, 2 1 2011, Pages 3741-3756
Different roles of the human Orc6 protein in the replication initiation process.
Thomae AW, Baltin J, Pich D, Deutsch MJ, Ravasz M, Zeller K, Gossen M, Hammerschmidt W, Schepers A
In eukaryotes, binding of the six-subunit origin recognition complex (ORC) to DNA provides an interactive platform for the sequential assembly of pre-replicative complexes. This process licenses replication origins competent for the subsequent initiation step. Here, we analyze the contribution of human Orc6, the smallest subunit of ORC, to DNA binding and pre-replicative complex formation. We show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6. Biochemical a...
Abstract
Cited 13 times since 2011 (0.9 per year)
source: EuropePMC
Ocular immunology and inflammation,
Volume 19, Issue 2, 1 1 2011, Pages 135-138
Ocular findings in subacute sclerosing panencephalitis.
Yuksel D, Sonmez PA, Yilmaz D, Senbil N, Gurer Y
Purpose: The aim of this study was to evaluate the ocular manifestations of subacute sclerosing panencephalitis (SSPE) and to investigate possible risk factors in a relatively large series of patients. Methods: In this prospective study, patients who were diagnosed with SSPE and had undergone ophthalmic examination were included. Results: Of the 59 patients with SSPE, 25 (42.4%) had ocular findings. Ocular involvement was bilateral in 22 (88%) patients. The most characteristic fundus findings in...
Abstract
Cited 148 times since 2011 (10.5 per year)
source: EuropePMC
Molecular imaging and biology,
Volume 13, Issue 2, 1 1 2011, Pages 199-207
Optical image-guided surgery--where do we stand?
Keereweer S, Kerrebijn JD, van Driel PB, Xie B, Kaijzel EL, Snoeks TJ, Que I, Hutteman M, van der Vorst JR, Mieog JS, Vahrmeijer AL, van de Velde CJ, Baatenburg de Jong RJ, Löwik CW
In cancer surgery, intra-operative assessment of the tumor-free margin, which is critical for the prognosis of the patient, relies on the visual appearance and palpation of the tumor. Optical imaging techniques provide real-time visualization of the tumor, warranting intra-operative image-guided surgery. Within this field, imaging in the near-infrared light spectrum offers two essential advantages: increased tissue penetration of light and an increased signal-to-background-ratio of contrast agen...
Abstract
Cited 1 times since 2011 (0.1 per year)
source: EuropePMC
Cardiology in the young,
Volume 21, Issue 2, 1 1 2011
Assessment of proximal right coronary artery and cardiac dimensions with low-dose volumetric computed tomographic angiography in a child.
Roest AA, Hazekamp MG, Kroft LJ
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 18, Issue 2, 1 1 2011, Pages 368-370
Subvalvular hypertrophic calcification of the mitral annulus: [(18)F]FDG-PET-CT, MRI, and echocardiography findings.
Persigehl T, Maintz D, Kies P, Heindel W, Schober O, Tiemann K, Rahbar K
Abstract
Cited 5 times since 2011 (0.4 per year)
source: EuropePMC
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
Volume 18, Issue 2, 1 1 2011, Pages 205-213
Treatment of types II-IV endoleaks by injecting biocompatible elastomer (PDMS) in the aneurysm sac: an in vitro study.
Bosman WM, Hinnen JW, van der Steenhoven TJ, de Vries AC, Brom HL, Jacobs MJ, Hamming JF
Purpose: To investigate if an elastomer [polydimethylsiloxane (PDMS)] can be used to effectively treat endoleaks after endovascular aneurysm repair. Methods: A latex aneurysm (36-mm inner diameter sac, 15-mm inner diameter neck) was attached to an in vitro circulation model. The aneurysm was excluded from the circulation by placing an unstented polyester graft. Endoleak types II-IV were created using different setups. While the circulation setup running, the aneurysm was filled with contrast med...
Abstract
Cited 7 times since 2011 (0.5 per year)
source: EuropePMC
Radiology,
Volume 260, Issue 1, 1 1 2011, Pages 88-97
Corrected tetralogy of Fallot: comparison of tissue doppler imaging and velocity-encoded MR for assessment of performance and temporal activation of right ventricle.
van der Hulst AE, Roest AA, Delgado V, Kroft LJ, Holman ER, Blom NA, Bax JJ, de Roos A, Westenberg JJ
Purpose: To compare velocity-encoded (VE) magnetic resonance (MR) imaging with tissue Doppler imaging to assess right ventricular (RV) peak systolic velocities and timing of velocities in patients with corrected tetralogy of Fallot and healthy subjects. Materials and methods: Local institutional review board approval was obtained; patients or their parents gave informed consent. Thirty-three patients (20 male, 13 female; median age, 12 years; interquartile range [IQR], 11-15 years; age range, 8-...
Abstract
Cited 2 times since 2011 (0.1 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 59, Issue 2, 1 1 2011, Pages 149-169
Ventricular tachycardia ablation: indications and techniques.
Wijnmaalen AP, Zeppenfeld K
Over the last decades indications have broadened and techniques have been developed resulting in an increasing use of catheter ablation for different types of ventricular tachycardia (VT). Due to the high ablation success for non scar-related ventricular arrhythmia (VA) catheter ablation has become a first line therapy for symptomatic idiopathic VA or VA presumed to cause ventricular dysfunction. For the ablation of scar-related VTs individual patient factors and operator experience play an impo...
Abstract
Cited 51 times since 2011 (3.6 per year)
source: EuropePMC
European heart journal,
Volume 32, Issue 9, 1 1 2011, Pages 1161-1170
Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy.
Christiaans I, Birnie E, Bonsel GJ, Mannens MM, Michels M, Majoor-Krakauer D, Dooijes D, van Tintelen JP, van den Berg MP, Volders PG, Arens YH, van den Wijngaard A, Atsma DE, Helderman-van den Enden AT, Houweling AC, de Boer K, van der Smagt JJ, Hauer RN, Marcelis CL, Timmermans J, van Langen IM, Wilde AA
Aims: We investigated the presence of a clinical diagnosis of hypertrophic cardiomyopathy (HCM), risk factors for sudden cardiac death (SCD), and cardiac events during follow-up in predictively tested-not known to have a clinical diagnosis of HCM before the DNA test-carriers of a sarcomeric gene mutation and associations with age and gender to determine the best cardiological screening strategy. Methods and results: One hundred and thirty-six (30%) of 446 mutation carriers were diagnosed with HC...
Abstract
Cited 36 times since 2011 (2.6 per year)
source: EuropePMC
PloS one,
Volume 6, Issue 3, 31 5 2011, Pages e14783
Modelling the costs and effects of selective and universal hospital admission screening for methicillin-resistant Staphylococcus aureus.
Hubben G, Bootsma M, Luteijn M, Glynn D, Bishai D, Bonten M, Postma M
Background: Screening at hospital admission for carriage of methicillin-resistant Staphylococcus aureus (MRSA) has been proposed as a strategy to reduce nosocomial infections. The objective of this study was to determine the long-term costs and health benefits of selective and universal screening for MRSA at hospital admission, using both PCR-based and chromogenic media-based tests in various settings. Methodology/principal findings: A simulation model of MRSA transmission was used to determine...
Abstract
