Research

Publications

Below you can find a list of our published research.

6255 results

Journal of thoracic disease, Volume 17, Issue 4, 25 4 2025, Pages 2194-2205 Early versus late chest tube removal after surgery for primary spontaneous pneumothorax-a systematic review and meta-analysis. van Steenwijk QCA, Spaans LN, Braun J, Dijkgraaf MGW, van den Broek FJC

Background: The optimal timing of postoperative chest tube removal remains disputable. Traditionally, chest tubes are left in place for several days for adequate pleurodesis and recurrence prevention after surgery for primary spontaneous pneumothorax (PSP). Currently, early tube removal, defined as immediate removal upon cessation of air leakage, is increasingly practiced. This study aimed to evaluate the safety of early chest tube removal in terms of recurrence in these patients. Methods: MEDLI... Abstract

Cardiology and therapy, Volume 14, Issue 2, 23 4 2025, Pages 219-230 Defibrillation Threshold Testing After ICD Implantation in Patients with Chronic Kidney Disease. Timal RJ, Osman L, Rotmans JI, Bootsma M, Mertens B, Schalij MJ, Rabelink TJ, Jukema JW

Introduction: Routine defibrillation threshold (DFT) testing at the time of implantable cardioverter-defibrillator (ICD) implantation is no longer recommended because testing did not improve shock efficacy or reduce arrhythmic death. However, patients with severe chronic kidney disease (CKD) were not included in these trials and might benefit from DFT testing. International guidelines shed no light on the subject of the effect of kidney function on DFT testing in patients with CKD. Methods: In t... Abstract

Cited 1 times since 2025 (4 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 18, Issue 7, 23 4 2025, Pages 784-795 Prognostic Time Frame of Plaque and Hemodynamic Characteristics and Integrative Risk Prediction for Acute Coronary Syndrome. Yang S, Jung JW, Park SH, Zhang J, Lee K, Hwang D, Lee KS, Na SH, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Taylor CA, Bax JJ, Shaw LJ, Stone PH, Narula J, Koo BK

Background: The relevant time frame for predicting future acute coronary syndrome (ACS) based on coronary lesion characteristics remains uncertain. Objectives: The aim of this study was to investigate the association of lesion characteristics with test-to-event time and their prognostic impact on ACS. Methods: The EMERALD II (Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II) study analyzed 351 patients who unde... Abstract

Journal of cardiothoracic and vascular anesthesia, Volume 39, Issue 8, 22 4 2025, Pages 2040-2048 Effect of Bicuspid or Tricuspid Aortic Valve on Preoperative Coagulation in Patients Scheduled for Thoracic Aortic Surgery. van Haeren MMT, Bozic C, Eberl S, Hollmann MW, Breel JS, Grewal N, Driessen AHG, Vlaar APJ, Müller MCA, Hermanns H

Objectives: This study aimed to analyze the impact of aortic valve morphology on preoperative coagulation status in patients undergoing elective thoracic aortic surgery. Preoperative ROTEM and conventional coagulation tests of patients with a bicuspid aortic valve (BAV) were compared to those with a tricuspid aortic valve (TAV). Design: An exploratory prospective observational study. Setting: Conducted in a single center. Participants: The study included 169 patients (63 BAV and 106 TAV). Interv... Abstract

The international journal of cardiovascular imaging, Volume 41, Issue 6, 22 4 2025, Pages 1131-1140 Plaque burden improves the detection of ischemic CAD over stenosis from coronary computed tomography angiography. Kero T, Bär S, Saraste A, Klén R, Bax JJ, Knuuti J, Maaniitty T

In symptomatic patients undergoing coronary CTA for suspected coronary artery disease (CAD), we assessed if quantification of plaque burden, in addition to luminal narrowing and clinical risk factors, offers incremental value for the identification of ischemic CAD on a per patient level. We evaluated 2145 patients who underwent coronary CTA for suspected CAD with sequential selective downstream 15O-water positron emission tomography (PET) myocardial perfusion imaging. Coronary CTA scans were ana... Abstract

Frontiers in pediatrics, Volume 13, 22 4 2025, Pages 1511086 Current methods in the diagnosis of invasive meningococcal disease. Ciftci E, Ocal D, Somer A, Tezer H, Yilmaz D, Bozkurt S, Dursun OU, Merter Ş, Dinleyici EC

Invasive meningococcal disease (IMD) remains a significant health concern due to its global distribution, potential for epidemic spread, unpredictable nature, rapid progression, and high mortality rates or permanent sequelae. The global elimination of meningococcal illness via immunization is a primary objective of the World Health Organization's strategy to defeat meningitis by 2030. Timely recognition of meningococcal infection and immediate, precise, and specific identification of Neisse... Abstract

Rheumatology advances in practice, Volume 9, Issue 2, 18 3 2025, Pages rkae155 Improving efficiency of a rheumatology outpatient clinic through classification of newly referred patients. Dijkstra S, de Man YA, Braaksma A, de Graaf M, Bernelot Moens HJ, Boucherie RJ

Objectives: Diagnosing a rheumatological disease in patients newly referred by their general practitioner requires assessment by a rheumatologist and often diagnostic tests. Ideally, these tests are performed prior to the patient's first consultation with the rheumatologist, aiming for quick diagnosis and fewer visits. We retrospectively studied whether a pre-first visit digital patient questionnaire can lead to fewer consultations and faster diagnosis. Methods: We applied machine learning-... Abstract

Heart rhythm, 17 3 2025, Pages S1547-5271(25)02342-2 Visualization of acute atrial injury after ablation by contrast-enhanced T1-weighted short inversion time cardiac magnetic resonance imaging. van Pouderoijen N, Hopman LHGA, Escartin T, Sheagren C, van Rosendael PJ, Allaart CP, Hofman MBM, Wright GA, Götte MJW

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Cancers, Volume 17, Issue 8, 17 3 2025, Pages 1352 Molecular-Targeted Fluorescence Lymph Node Imaging Could Play a Clinical Role in the Surgical Setting: A Systematic Review. Zweedijk BE, Dalmeijer SWR, van Manen L, Galema HA, Lauwerends LJ, Abbasi H, Kremer B, Verhoef C, Robinson DJ, Koppes SA, Vahrmeijer AL, van der Vorst JR, Hilling DE, Keereweer S

The lymphatic system plays a crucial role in the spread of solid tumors and is often the first site of metastasis, as cancer cells typically invade nearby lymph nodes (LN) before potentially spreading to other LNs through the lymphatic system and distant organs through the bloodstream [...]. Abstract

European urology focus, 16 3 2025, Pages S2405-4569(25)00074-4 External Urinary Devices for Stress Urinary Incontinence: Does One Size Fit All? Cobussen-Boekhorst H, van Benthum-van Ooijen N, Janssen V, Schuurmans C

Both males and females can be effected by stress urinary incontinence (SUI), with symptoms ranging from mild to severe. External urinary devices (EUDs) can help in managing incontinence in daily life and thus improve quality of life. EUDs include absorbent products, female external catheters, male external catheters/sheaths, and penile compression devices/clamps. To address the needs of individual patient, a shared decision-making process is essential, with the involvement of health care profess... Abstract

Digestive diseases and sciences, 16 3 2025 Obesity Is Associated with Inferior Clinical Treatment Outcomes in Inflammatory Bowel Disease: A Nationwide Dutch Registry Study. Oomkens D, Mujagic Z, de Vries A, van der Meulen-de Jong A, Straatmijer T, Löwenberg M, van der Marel S, West R, Bodelier A, van Schaik F, Visschedijk M, Duijvestein M, Initiative on Crohn and Colitis (ICC)

Purpose: To examine the impact of obesity on treatment outcomes in inflammatory bowel disease (IBD). Methods: Patients aged ≥ 16 years, with IBD, a documented baseline body mass index (BMI), and starting thiopurines and allopurinol, intravenous (iv) vedolizumab, subcutaneous (sc) vedolizumab, ustekinumab, ozanimod, filgotinib, or tofacitinib were selected from the Dutch Initiative on Crohn and Colitis (ICC) registry. Underweight patients (BMI Abstract

Cardiovascular drugs and therapy, 14 2 2025 Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY). S Ramos K, Nassiri S, Wijdeveld LFJ, van der Palen RL, Kuipers MF, Hills MT, Slijkerman P, van Raalte DH, Handoko ML, de Groot NMS, Grewal N, Klautz RJM, Eringa EC, Brundel BJJM

Purpose: Interestingly, 30-50% of patients undergoing elective cardiothoracic surgery develop postoperative AF (PoAF). Unfortunately, preventive PoAF therapy is still suboptimal. In our previous studies, we showed that oral Geranylgeranylacetone (GGA) administration increased cardioprotective heat shock protein (HSP) protecting against AF onset and progression in clinically relevant animal model studies. Methods: The GENIALITY study is a phase II single-center, double-blind, placebo-controlled r... Abstract

International journal of cardiology, Volume 432, 11 2 2025, Pages 133269 Early aortic valve replacement versus conservative management in asymptomatic severe aortic stenosis: Meta-analysis of time-to-event data of randomized controlled trials. Jacquemyn X, Sá MP, Marín-Cuartas M, Bax JJ, Borger MA, Clavel MA, Pibarot P, Généreux P, Sultan I

Background: Current guidelines recommend aortic valve replacement (AVR) for symptomatic patients with severe aortic stenosis (AS), but the optimal timing for intervention in asymptomatic patients is still debated. Recent randomized controlled trials (RCTs) have offered new insights, prompting a reevaluation of the potential benefits of early AVR. Methods: A systematic review and pooled meta-analysis of Kaplan-Meier-derived reconstructed time-to-event data of RCTs published by November 2024 was c... Abstract

European journal of preventive cardiology, 9 2 2025, Pages zwaf193 Lifestyle behaviour change of patients following cardiac rehabilitation: the BENEFIT intervention study with one-year follow-up. Breeman LD, Janssen VR, Kraaijenhagen RA, Al-Dhahir I, IJzerman RVH, Wolstencroft K, Kraaij W, Bonten TN, Atsma DE, Chavannes NH, van Gemert-Pijnen L, Kemps HMC, Scholte Op Reimer W, Evers AWM

Background: The majority of people with cardiovascular disease (CVD) do not maintain a healthy lifestyle. To help patients implement behaviour change at home, the BENEFIT programme was developed as an addition to cardiac rehabilitation (CR) care. Methods: Using a cluster non-randomised controlled trial design involving 7 CR centres, we examined whether intervention group patients (n=587) showed increased improvements in health behaviour change compared to control group patients (n=298) who (only... Abstract

Circulation, Volume 151, Issue 14, 7 1 2025, Pages 1047-1050 Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES. Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators

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Cited 1 times since 2025 (3.4 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 12, Issue 4, 7 1 2025, Pages 140 Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms. Bacour N, Theijsse RT, Grewal S, Klautz RJM, Grewal N

(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of early detection and intervention. Despite established clinical risk factors for the early detection of TAAs, the influence of racial disparities on TAAs remains underexplored. This study aims to provide a comprehensive summary of existing... Abstract

Cited 1 times since 2025 (3.3 per year) source: EuropePMC

Journal of the European Academy of Dermatology and Venereology : JEADV, 3 1 2025 Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results. van der Gang LF, Atash K, Zuithoff NPA, Haeck I, Boesjes CM, Bacoş-Cosma OI, Loman L, Kamsteeg M, Stadhouders-Keet S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynksi A, Berntsen-Zandbergen L, Christoffers WA, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, de Graaf M, Schuttelaar MA, de Bruin-Weller MS

Background: Limited data exist on the comparative risk of infections during biologic and Janus kinase inhibitor (JAKi) treatment for atopic dermatitis (AD) in daily practice. Objective: To assess the differential infection risk of biologic and JAKi treatment in patients with moderate-to-severe AD in a real-world setting. Methods: This prospective, multicentre study evaluated treatment-emergent infections in patients (age ≥ 12 years) using biologics or JAKi from the BioDay registry from October 2... Abstract

International journal of cardiology. Congenital heart disease, Volume 20, 3 1 2025, Pages 100580 A 2:1 atrioventricular block in an adult patient with a Fontan circulation: from transesophageal pacing to echocardiographic guidance of epicardial pacemaker lead placement. Smit JM, Regeer MV, Wijnmaalen AP, Jongbloed MRM, Hazekamp MG, Egorova AD

Background: The diagnosis and management of atrioventricular (AV)-conduction disorders in patients with a Fontan circulation can be challenging. Little is known about the effects of various pacing strategies in single-ventricle patients. Here we report 1) the feasibility of transesophageal electrophysiological study (EPS) to assess AV-conduction in a patient with limited venous access and 2) the potential of echocardiography to guide epicardial systemic right ventricular (sRV) lead positioning a... Abstract

Atherosclerosis, Volume 404, 3 1 2025, Pages 119184 Sex related coronary plaque progression patterns among patients with family history as the sole cardiovascular risk factor: A PARADIGM sub-study. Conte E, Lee SE, Chang HJ, Hadamitzky M, Kim YJ, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Di Lenarda F, Guarnieri G, Leipsic JA, Shin S, Choi JH, Mouaz AM, Chinnaiyan K, Pedro AG, Sung JM, Virmani R, Samady H, Lin FY, Stone PH, Narula J, Shaw L, Bax JJ, Andreini D

Background and aims: How sex may influence the prevalence and progression of coronary atherosclerosis in patients with positive family history for CAD is still unclear. Aim of the present study was to explore the role of family history of CAD in coronary atherosclerosis expression and progression in male and female subjects. Methods: A total of 2252 patients who underwent clinically indicated serial CCTAs at an interscan interval of more than 2 years were enrolled in the PARADIGM Study. For the... Abstract

Cited 2 times since 2025 (6.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 85, Issue 14, 1 1 2025, Pages 1471-1484 Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis. Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E, CAPRICE Co-Investigators

Background: The extent to which high-sensitivity cardiac troponin can predict cardiovascular disease (CVD) is uncertain. Objectives: We aimed to quantify the potential advantage of adding information on cardiac troponins to conventional risk factors in the prevention of CVD. Methods: We meta-analyzed individual-participant data from 15 cohorts, comprising 62,150 participants without prior CVD. We calculated HRs, measures of risk discrimination, and reclassification after adding cardiac troponin... Abstract