6173 results
Allergy,
Volume 80, Issue 4, 14 2 2024, Pages 1060-1073
Tralokinumab Treatment in Adult Atopic Dermatitis Patients: 28-Week Evaluation of Clinical Effectiveness, Safety, Serum Proteins and Total IgE Levels.
Dekkers C, Zuithoff N, Bakker D, Knol E, Wevers A, Touwslager W, Christoffers W, Prosje P, van Lynden-van Nes A, van Lümig P, Kamsteeg M, Oosting AJ, Schuttelaar MLA, Haeck I, de Graaf M, van Wijk F, de Bruin-Weller M
Introduction and objectives: Tralokinumab-a biological that specifically targets interleukin-13-is one of the newer advanced systemic treatments for patients with moderate-to-severe atopic dermatitis (AD). Although safety and efficacy have been shown in phase-III clinical trials, daily practice data are needed. Therefore, the aim of this study was to evaluate 28-week safety and effectiveness, serum proteins and total IgE levels in adult AD patients treated with tralokinumab in daily practice. Ma...
Abstract
Heart (British Cardiac Society),
Volume 111, Issue 1, 13 2 2024, Pages 35-42
Clinical and echocardiographic parameters associated with outcomes in patients with moderate secondary mitral regurgitation.
Sarrazyn C, Fortuni F, Laenens D, Chua AP, Lopez Santi MP, Myagmardorj R, Nabeta T, Meucci MC, Singh GK, Velders BJJ, Galloo X, Bax JJ, Ajmone Marsan N
Background: Significant secondary mitral regurgitation (SMR) is known to be associated with worse prognosis. However, data focusing specifically on moderate SMR and associated risk factors are lacking. In the present study, clinical and echocardiographic parameters associated with outcomes were evaluated in a large cohort of patients with moderate SMR. Methods: Patients with moderate SMR were retrospectively included and stratified by New York Heart Association (NYHA) class and specific aetiolog...
Abstract
The Pediatric infectious disease journal,
10 2 2024
Petechial and Purpuric Rashes During a Parvovirus B19 Outbreak: Are Skin Symptoms Differentiated?
Kus S, Elvan-Tuz A, Aslan-Saritas U, Yilmaz D
Human parvovirus B19 typically causes erythema infectiosum, but unusual exanthems and hemorrhagic manifestations, such as purpuric-petechial rashes, have also been reported. PVB19-associated purpuric-petechial eruption (PAPPE) should be recognized as a distinct clinical feature of primary parvovirus B19 infection and considered in the differential diagnosis of patients with febrile purpura. This report aims to highlight several scenarios of B19V-associated petechial and purpuric rashes, which ma...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 33, Issue 1, 10 2 2024, Pages 2-4
Career perspectives of early-career cardiologists in the Netherlands.
Kalkman DN, Baggen VJM, Beusekamp JC, Kleinnibbelink G, Meijers WC, Peeters FECM, van der Wall SJ, Yilmaz D, Minneboo M, Bosch L
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 38, Issue 3, 9 2 2024, Pages 236-238
Are New Thresholds Required for the Assessment of Right Ventricular Function in Patients With and Without Tricuspid Regurgitation?
Galloo X, Ajmone Marsan N
Abstract
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
7 1 2024, Pages 15266028241301278
Ultrasound-Guided vs Non-Ultrasound-Guided Angio-Seal Vascular Hemosasis After Endovascular Treatment for Peripheral Artery Disease: An Observational Study.
Groenewegen FA, Charehbili A, Panfilov IA, Engels C, De Jong WJ, Burgmans M, Van der Bogt KEA, Eefting D, Van der Steenhoven TJ, Van der Linden E, Urlings T
Clinical impact: Ultrasound visualization of vascular closure devices during endovascular access closure leads to a significant decrease in overall and major post interventional access site complications. This non-invasive and often readily available imaging technique could therefore lead to an important decrease in morbidity and subsequent overall health care costs when added to the standard intervention protocol. With the increasing use of endovascular techniques to treat peripheral artery dis...
Abstract
Cited 1 times since 2024 (2.7 per year)
source: EuropePMC
European journal of clinical investigation,
Volume 55, Issue 3, 5 1 2024, Pages e14368
Risk of cardiovascular disease in elderly subjects with obesity and liver fibrosis and the potential benefit of statin treatment.
Theel WB, de Jong VD, Castro Cabezas M, Grobbee DE, Jukema JW, Trompet S
Background: Liver fibrosis progression is influenced by older age and cardiometabolic risk factors such as obesity and is associated with an increased risk of cardiovascular events. While statins may protect against cardiovascular complications, their effects in elderly individuals with obesity and liver fibrosis are unclear. Method: The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) database was used to evaluate the effect of pravastatin on major adverse cardiovascular events...
Abstract
Stem cell reports,
Volume 20, Issue 1, 5 1 2024, Pages 102371
Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling.
Yuan Q, Verbueken D, Dinani R, Kim R, Schoger E, Morsink CD, Simkooei SA, Kemna LJM, Hjortnaes J, Kuster DWD, Boon RA, Zelarayan LC, van der Velden J, Buikema JW
Embryonic signaling pathways exert stage-specific effects during cardiac development, yet the precise signals for proliferation or maturation remain elusive. To uncover the cues for proliferation, we performed a combinatory cell-cycle screen for insulin and glycogen synthase kinase-3 (GSK3) inhibition in spontaneously beating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Our analysis for proliferation, and subsequential downstream sarcomere development, gene expression...
Abstract
JTCVS open,
Volume 23, 4 1 2024, Pages 69-80
Total aortic arch replacement versus proximal aortic repair for acute type a aortic dissection: A single-center 30-year experience.
de Oliveira Marreiros DJ, Arabkhani B, Verhoef JL, Keekstra N, van der Vorst JR, van Schaik J, Braun J, Klautz RJM, Groenwold RHH, Hjortnaes J
Objective: Optimal surgical management of the aortic arch for acute type A aortic dissection remains contentious. We assessed clinical outcomes after total arch replacement and proximal aortic repair (ascending aortic ± hemiarch replacement) for acute type A aortic dissection. Methods: All patients surgically treated for acute type A aortic dissection at our institution between 1992 and 2021 were included. Study end points included all-cause mortality, distal aortic reintervention, stroke, and m...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 1, 1 1 2024, Pages 173-174
Mural thickening of the coronary arteries in a COVID-19 patient.
Groen RA, de Graaf MA, Stöger JL, van der Woude D, Antoni ML
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 26, Issue 12, 1 1 2024, Pages euae283
Ventricular septal defect characteristics influence presence of septal anatomical isthmuses in patients with repaired tetralogy of Fallot.
Wallet J, Kimura Y, Blom NA, Hazekamp MG, Bartelings MM, Jongbloed MRM, Zeppenfeld K
Aims: In repaired tetralogy of Fallot (rTOF), the septal anatomical isthmuses (AI), AI 3, between the ventricular septal defect (VSD) and pulmonary annulus, and AI 4, between the VSD and tricuspid annulus, are important ventricular tachycardia (VT) substrates when slow conducting. Our aim was to assess the influence of VSD characteristics, specifically the presence of muscular or fibrous tissue at its border, on the presence or absence of septal AIs, potentially related to VT. Methods and result...
Abstract
Cited 1 times since 2024 (2.6 per year)
source: EuropePMC
Current protocols,
Volume 4, Issue 12, 1 1 2024, Pages e70068
Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices.
Lodrini AM, Groeneveld EJ, Palmen M, Hjortnaes J, Smits AM, Goumans MJ
Living myocardial slices (LMS) are ultrathin sections of adult myocardium that can be maintained in culture. These slices provide a unique platform for studying interactions between cardiomyocytes (CMs), other cardiac cell types, and the extracellular matrix while maintaining the cytoarchitecture and electrical phenotype of CMs over extended periods. Despite their advantages over other cardiac models, LMS have limitations, particularly their reliance on slice quality. The primary factor influenc...
Abstract
Cited 1 times since 2024 (2.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 1, 1 1 2024, Pages euae300
Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user.
De Coster T, Nobacht A, Oostendorp T, de Vries AAF, Coronel R, Pijnappels DA
In 2024, we celebrate the 100th anniversary of Willem Einthoven receiving the Nobel Prize for his discovery of the mechanism of the electrocardiogram (ECG). Building on Einthoven's legacy, electrocardiography allows the monitoring of cardiac bioelectricity through solutions to the so-called forward and inverse problems. These solutions link local cardiac electrical signals with the morphology of the ECG, offering a reversible connection between the heart's electrical activity and its r...
Abstract
Interdisciplinary cardiovascular and thoracic surgery,
Volume 40, Issue 1, 1 1 2024, Pages ivae227
Examining the learning curves in robotic cardiac surgery wet lab simulation training.
Atroshchenko GV, Navarra E, Valdis M, Sandoval E, Hashemi N, Cerny S, Pereda D, Palmen M, Bjerrum F, Bruun NH, Tolsgaard MG
Background: Simulation-based training has gained distinction in cardiothoracic surgery as robotic-assisted cardiac procedures evolve. Despite the increasing use of wet lab simulators, the effectiveness of these training methods and skill acquisition rates remain poorly understood. Objectives: This study aimed to compare learning curves and assess the robotic cardiac surgical skill acquisition rate for cardiac and noncardiac surgeons who had no robotic experience in a wet lab simulation setting....
Abstract
Cited 1 times since 2024 (2.6 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 66, Issue 1, 29 5 2024, Pages 3-16
Hemodynamic considerations in arteriovenous vascular access modalities for hemodialysis.
White NA, Xiao Z, De Winter EP, Li M, De Vries MR, Van Der Bogt KE, Rotmans JI
Arteriovenous fistulas and arteriovenous grafts are the most commonly used vascular access for hemodialysis in patients with end-stage chronic kidney disease. However, both methods face significant challenges due to the hemodynamic disturbances induced by the arteriovenous anastomosis. This causes changes in vascular structure and blood flow velocity near the anastomosis site after the fistula/graft surgery, and introduces abnormal wall shear stress and cyclic stretch. This leads to endothelial...
Abstract
Cited 1 times since 2024 (2.6 per year)
source: EuropePMC
Talanta,
Volume 285, 29 5 2024, Pages 127293
Flexible 3D nanofiber-based SERS biosensor for detection of miRNA-223-3p in early Laryngeal Cancer diagnosis.
Martino S, Yilmaz D, Tammaro C, Misso G, Esposito A, Falco M, Cossu AM, Lombardi A, Amler E, Divin R, Giannetti A, Scrima M, Dardano P, De Stefano L, Rea I, De Luca AC, Caraglia M
MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nucleotides) that regulate gene expression and are associated with various diseases, including Laryngeal Cancer (LCa), which has a high mortality rate due to late diagnosis. Traditional methods for miRNA detection present several drawbacks (time-consuming steps, high cost and high false positive rate). Early-stage diagnosis and selective detection of miRNAs remain challenging. This study proposes a 3D flexible biosensor that combines nanofibers...
Abstract
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
Volume 44, Issue 2, 29 5 2024, Pages 333-342
Overview of Pediatric Respiratory Syncytial Virus (RSV) infections: has risk perception for RSV changed in children with comorbid conditions?
Yilmaz D, Tasar S, Tuz AE, Eroz NA, Oncel EK, Aksay AK, Yilmaz N
Objective: Respiratory syncytial virus (RSV) is the primary etiology of lower respiratory tract infection in children. The fluctuating incidence of RSV, particularly in light of the COVID-19 pandemic, has shifted the spotlight onto preventive strategies. Our study aims to investigate both the risk factors and clinical symptoms of RSV. Materials and methods: From February 2015 to February 2023, samples were analyzed during all seasons to identify viral respiratory infections. RSV was identified i...
Abstract
Cited 1 times since 2024 (2.5 per year)
source: EuropePMC
Scientific reports,
Volume 14, Issue 1, 26 4 2024, Pages 29256
Severe and post-COVID-19 are associated with high expression of vimentin and reduced expression of N-cadherin.
Yilmaz E, Yilmaz D, Cacan E
SARS-CoV-2 penetrates human cells via its spike protein, which mainly interacts with ACE2 receptors, triggering viral replication and an exacerbated immune response characterized by a cytokine storm. Vimentin III, an intermediate filament protein predominantly found in mesenchymal cells, has garnered considerable attention in recent research due to its multifaceted biological roles and significance in the endothelial-mesenchymal transition (EndMT) during various fibrotic processes. However, the...
Abstract
Cited 1 times since 2024 (2.5 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 105, Issue 2, 24 4 2024, Pages 385-393
Intravascular Lithotripsy in Acute Coronary Syndromes: Procedural and One-Year Clinical Outcomes From the BENELUX-IVL Registry.
Oliveri F, van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Despite the excellent success and safety of intravascular lithotripsy (IVL) in heavily calcified lesions, evidence in acute coronary syndromes (ACS) remains limited. Aims: This study aimed to evaluate the procedural and clinical outcomes of IVL in heavily calcified ACS. Methods: Patients who underwent IVL between 2019 and 2024 from the ongoing prospective BENELUX registry were eligible for inclusion. Patients were therefore classified in ACS and chronic coronary syndrome (CCS) groups...
Abstract
Annals of vascular surgery,
Volume 111, 23 4 2024, Pages 203-211
A Diagnostic Comparison Study between Maximal Systolic Acceleration and Acceleration Time to Detect Peripheral Arterial Disease.
Willems SA, van Bennekom OO, Schepers A, van Schaik J, van der Vorst JR, Hamming JF, Brouwers JJWM
Background: Detecting peripheral arterial disease (PAD) can be particularly challenging in patients with diabetes mellitus (DM) or chronic kidney disease (CKD) due to medial arterial calcification (MAC). Current bedside tests, such as the ankle-brachial index, are less accurate in these patient groups. The primary aim of this study is to evaluate the diagnostic accuracy of point-of-care duplex ultrasound parameters maximal systolic acceleration (ACCmax) and acceleration time (AT) to detect PAD,...
Abstract
