7494 results
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 12, 1 1 2025, Pages euaf252
Cardiac implantable electronic device upgrades and downgrades: a Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Asia Pacific Heart Rhythm Association (APHRS), Canadian Heart Rhythm Society (CHRS), Heart Rhythm Society (HRS), and the Latin American Heart Rhythm Society (LAHRS).
Keene D, Nielsen JC, Burri H, Chavez-Gutierrez CA, Deharo JC, Drossart I, Ip JE, Israel CW, Johansen JB, Kosztin A, Lau CP, Levy S, Manlucu J, Marcantoni L, Pujol-Lopez M, Rao A, Starck C, Tolosana JM, Van Erven L, Vogler J, Kaza N
Cardiac implantable electronic device upgrade and downgrade procedures are increasingly being performed. Whilst the most appropriate guideline-recommended device may have been followed during a patient's initial procedure, the requirements of patients can change over time. This could be due to worsening of cardiac function due to detrimental effects of pacing itself or the diagnosis, development, or progression of another cardiac comorbidity. Device downgrades are also performed when a pati...
Abstract
Cited 1 times since 2025 (26.1 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 64, Issue SI, 1 1 2025, Pages SI122-SI130
Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis.
Velauthapillai A, Bootsma MFR, Bruni C, Bergmann C, Matucci-Cerinic M, Launay D, Riemekasten G, Garzanova L, Airò P, Rezus E, da Silva JAP, Del Galdo F, Hunzelmann N, Chung LS, Krasowska D, Distler O, van den Ende CHM, Vonk MC, EUSTAR Collaborators
Background: Hypothesizing that early treatment yields improved prognosis, we aimed to investigate how the timing of immunosuppressive treatment relates to interstitial lung disease (ILD) development and the course of pulmonary function in systemic sclerosis (SSc). Methods: A cohort was created using data from the EUSTAR database and Nijmegen Systemic Sclerosis cohort, including adult patients who started their first immunosuppressive treatment (i.e. mycophenolate mofetil, methotrexate, cyclophos...
Abstract
JACC. Cardiovascular interventions,
Volume 18, Issue 23, 1 1 2025, Pages 2833-2845
Anatomical vs Physiological Lesion Characteristics in Prediction of Acute Coronary Syndrome.
Yang S, Chung JW, Park SH, Zhang J, Lee K, Hwang D, Lee KS, Na SH, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Taylor CA, Bax JJ, Shaw LJ, Stone PH, Narula J, Koo BK
Background: Acute coronary syndrome (ACS) arises from a complex interplay among luminal narrowing, plaque morphology, and hemodynamic environment. Objectives: The authors aimed to compare the effectiveness of anatomy- and physiology-based ACS risk assessment. Methods: In this international, multicenter, internal case-control study, 351 ACS patients who underwent coronary computed tomography angiography (CCTA) 1 month to 3 years before the event were analyzed. Lesions were classified as culprit o...
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JAMA network open,
Volume 8, Issue 12, 1 1 2025, Pages e2548538
Economic Evaluation of Comprehensive Genomic Profiling in an Advanced Solid Cancer Population.
van Schaik LF, Maes B, Volders PJ, Froyen G, Aftimos P, de Azambuja E, Blommestein HM, van Harten WH, Retèl VP
Importance: Developments in genomic profiling introduced larger gene panels with decreasing sequencing costs. Although the feasibility of comprehensive genomic profiling (CGP) has been demonstrated, its health economic impact remains uncertain. Objective: To provide insights into the costs related to clinical implementation of CGP-based advice in a large prospective cohort. Design, setting, and participants: In this economic evaluation of a prospective Belgian multicenter observational study (Be...
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European journal of human genetics : EJHG,
29 5 2025
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between TPMT/NUDT15 and thiopurines.
Coenen MJH, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, Swen JJ, Touw DJ, van Westrhenen R, Deneer VHM, van Schaik RHN
The Dutch Pharmacogenetics Working Group (DPWG) describes gene-drug interactions to facilitate pharmacogenetic implementation in clinical practice. The current guideline describes the gene-drug interactions for TPMT, NUDT15 and thiopurines (azathioprine, 6-mercaptopurine and thioguanine). Evidence based recommendations were obtained via a literature review of published studies. This literature review showed that gene variants leading to a decreased activity of TPMT and/or NUDT15 result in higher...
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Nature communications,
Volume 16, Issue 1, 28 4 2025, Pages 10707
Unveiling the global urban virome through wastewater metagenomics.
Worp N, Nieuwenhuijse DF, Izquierdo-Lara RW, Schapendonk CME, Brinch C, Jensen EEB, Munk P, Hendriksen RS, Global Sewage Surveillance Consortium, Aarestrup F, Oude Munnink BB, Koopmans MPG, de Graaf M
Understanding global viral dynamics is critical for public health. Traditional surveillance focuses on individual pathogens and symptomatic cases, which may miss asymptomatic infections or newly emerging viruses, delaying detection and response. Wastewater-based epidemiology has been used to track pathogens through targeted molecular assays, but its reliance on predefined targets limits detection of the full viral spectrum. Here, we analyse longitudinal wastewater samples from 62 cities across s...
Abstract
The American journal of cardiology,
27 4 2025, Pages S0002-9149(25)00691-5
Intravascular Lithotripsy in Diabetic Patients Undergoing Percutaneous Coronary Intervention: Long-Term Outcomes from the BENELUX Registry.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, Sagris M, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Diabetes mellitus (DM) is associated with increased coronary calcification and adverse outcomes after percutaneous coronary intervention (PCI), yet the performance of intravascular lithotripsy (IVL) in this high-risk population remains insufficiently defined. This study, conducted within the all-comers BENELUX-IVL registry, evaluated the safety and efficacy of IVL-assisted PCI in patients with and without DM. The primary endpoint was major adverse cardiovascular events (MACE) at 1 and 2 years, d...
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Communications biology,
Volume 8, Issue 1, 26 4 2025, Pages 1684
Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling.
Muntjewerff EM, Epremidze D, Nezhyva M, Kal S, Rohm TV, Tang K, Singh K, Espes D, Jati S, Bootsma M, Mannaa AM, Ikebuchi H, Nilsson AM, Rajasekaran M, Andrén PE, Jansson ET, Mahata SK, Christoffersson G
Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the roles of these peptides in pancreatic endocrine function, morphology, neurotransmitter dynamics, and systemic glucose homeostasis. CST-KO mice displayed impaired insulin secretion in vivo (but not ex vivo), disru...
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JAMA cardiology,
26 4 2025
Interventions for Tricuspid Regurgitation.
Praz F, Angellotti D, Ajmone Marsan N, Butler J
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BMC primary care,
25 4 2025
Navigating chest pain online: who uses health information and what actions follow?
van Dijkman ED, de Boer YK, de Hollander EL, Numans ME, Siebelink HJ, Bonten TN
Abstract
Polymers,
Volume 17, Issue 23, 24 4 2025, Pages 3115
Snail Shell-Reinforced Waste-Based Polymer Composites for Radiation Shielding and Anti-Reflective Applications.
Pekdemir ME, Pekdemir SS, Yılmaz D, Onay H, Nazem Qader I
The increasing demand for sustainable and multifunctional materials in radiation shielding and optical applications has driven research toward utilizing natural and waste-derived reinforcements in polymer matrices. However, achieving effective attenuation performance across different radiation types using eco-friendly fillers remains a significant challenge. In this study, polyvinyl chloride (PVC)/Polystyrene (PSt) blend composites (1:1 weight ratio) were reinforced with powdered snail shell (SS...
Abstract
Nature human behaviour,
24 4 2025
Culture is critical in driving orangutan diet development past individual potentials.
Howard-Spink E, Tennie C, Mitra Setia T, Perawati D, van Schaik C, Barrett B, Whiten A, Schuppli C
Humans accumulate extensive repertoires of culturally transmitted information, reaching breadths exceeding any individual's innovation capacity (culturally dependent repertoires). It is unclear whether other animals require social learning to acquire adult-like breadths of information in the wild, including by key developmental milestones, or whether animals are capable of constructing their knowledge repertoires primarily through independent exploration. We investigated whether social lear...
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Annals of surgical oncology,
23 4 2025
Correction: Extent and Boundaries of Lymph Node Stations During Minimally Invasive Esophagectomy: A Survey Among Dutch Esophageal Surgeons.
Ketel MHM, van der Aa DC, Henckens SPG, Rosman C, van Berge Henegouwen MI, Klarenbeek BR, Gisbertz SS, DES Collaboration Group
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JACC. Cardiovascular imaging,
22 4 2025, Pages S1936-878X(25)00579-0
Prognostic Value of AI-Based Quantitative Coronary CTA vs Human Reader-Based Visual Assessment: Results From the CONFIRM2 Registry.
van Rosendael A, Nakanishi R, Bax JJ, Pontone G, Mushtaq S, Buechel RR, Gräni C, Feuchtner G, Lacaita PG, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho GW, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves PA, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, van Assen M, De Cecco CN, Kamperidis V, Foldyna B, Brendel JM, Cheng VY, Branch KR, Bittencourt M, Bhatti S, Polsani V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Singh V, Aquino M, Park J, Danad I
Background: The severity and extent of whole heart coronary plaque volume and stenosis can be reliably measured by artificial intelligence-guided quantitative coronary computed tomography angiography (AI-QCT). Limited data are available on the potential incremental prognostic value compared with currently recommended qualitative coronary computed tomography angiography (CTA) reads and the coronary artery calcium score (CACS). Objectives: The aim of this study was to evaluate the prognostic value...
Abstract
Scientific reports,
Volume 15, Issue 1, 19 3 2025, Pages 40760
Explainable and likelihood aware AI framework for MRI-based pixel-level bladder tumour prediction.
Khan M, de Groot AG, Cornel EB, van der Heijden AG, Siepel FJ
Bladder tumours (BTs) pose significant clinical challenges due to their high recurrence rates and risk of progression to invasive malignancies, which emphasises the need for early and accurate detection. Magnetic resonance imaging (MRI), with its superior soft tissue contrast, is a potential modality for BT detection. To analyse the MRI scans, artificial intelligence (AI) models are increasingly being leveraged. However, these models are often limited by a scarcity of annotated datasets, challen...
Abstract
Communications medicine,
Volume 5, Issue 1, 18 3 2025, Pages 472
Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events.
van Eijs MJM, van der Wal MM, Klotškova HB, Dautzenberg NMM, Schuiveling M, Verheijden RJ, van Schaik FDM, Oldenburg B, Nierkens S, UNICIT Consortium, Suijkerbuijk KPM, van Wijk F
Background: High-dose steroids constitute the cornerstone of first-line treatment for immune-related adverse events (irAEs) associated with immune checkpoint inhibitors, but compromise antitumor immunity. A deeper understanding of irAEs and their response to steroids can improve management. Methods: Using a multi-omics approach, we investigated blood- and tissue-based correlates of steroid response, focusing on gastro-intestinal irAEs, in the largest cohort to date. Results: Here we show clear t...
Abstract
Consciousness and cognition,
Volume 137, 17 3 2025, Pages 103964
Disentangling perceptual from non-perceptual expectation biases in short-term memory.
Koopmans JG, Thorat S, Quek GL, Peelen MV
There is debate about how many items can be represented in visual consciousness at once. Evidence against the view that visual consciousness consists of many detailed items has come from a study using the partial-report paradigm. De Gardelle et al. (2009) showed that rotated letters shown in non-cued (i.e., unattended) parts of a briefly presented letter array are sometimes illusorily perceived as upright. Presumably, the expectation that letters are generally seen upright modulated a rotated le...
Abstract
Inflammatory bowel diseases,
17 3 2025, Pages izaf269
Bridging the Gap: From Clinic to Home in IBD Monitoring-Authors' Reply.
Schuurman GS, van Schaik FDM
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 17 3 2025, Pages 1708865
Exploring ethnic differences in the perioperative course of thoracic aortopathy.
Bacour N, Tirpan AU, Grewal S, Klautz RJM, Grewal N
Background: In patients with thoracic aortopathy post-operative recovery can be complicated by a lack of consistent, clear communication and guidance. Despite the growing recognition of these challenges, the specific needs of patients undergoing aortic surgery, especially across different ethnic groups, remain insufficiently explored. This study aims to examine the peri-operative course in thoracic aortopathy in order to identify the specific needs of the patients, particularly across ethnic gro...
Abstract
The Journal of allergy and clinical immunology,
14 2 2025, Pages S0091-6749(25)01126-1
Epidemiology and management of malignancies in patients with inborn errors of immunity-An ESID registry study of 19,959 patients.
Bogaert DJA, Wolfsberger CH, Attarbaschi A, Gathmann J, Warnatz K, Mueller G, Mukhina A, Rusch S, ESID Registry Working Party, Kindle G, van Montfrans JM, Seidel MG
Background: Inborn errors of immunity (IEI), or primary immune disorders (PIDs), predispose individuals to infections, autoimmunity, inflammation, allergy, and malignancy. Malignancies are a major cause of morbidity and mortality in patients with IEI/PIDs, with poorer outcomes compared with the general population. Objective: We sought to determine the frequency and types of malignancies in patients with IEI/PIDs and to assess clinical management approaches across Europe. Methods: Descriptive ana...
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