Research

Publications

Below you can find a list of our published research.

6139 results

Cited 7 times since 2012 (0.6 per year) source: EuropePMC

Cytokine, Volume 61, Issue 2, 24 4 2012, Pages 438-444 A comparative study of the immune modulating properties of antifibrinolytics in cardiac surgery. Later AF, Bruggemans EF, Romijn FP, van Pelt J, Klautz RJ

Purpose: Antifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin levels. Additional drug specific immune modulating qualities are often mentioned in the discussion on which antifibrinolytic can best be used. To determine the extent and relevance of these effects, we investigated cytokine and growth factor plasma levels in cardiac surgery patients randomized to receive either tranexamic... Abstract

Cited 21 times since 2012 (1.7 per year) source: EuropePMC

The American journal of cardiology, Volume 111, Issue 3, 20 3 2012, Pages 382-387 Pregnancy outcomes in women with aortic valve substitutes. Heuvelman HJ, Arabkhani B, Cornette JM, Pieper PG, Bogers AJ, Takkenberg JJ, Roos-Hesselink JW

Young women who require aortic valve replacement need information on the potential cardiac and obstetric complications of pregnancy for the different valve substitutes available. We, therefore, assessed the pregnancy outcomes in women who had received an autograft, homograft, or mechanical valve in the aortic position. Women who were pregnant after surviving aortic valve replacement at our institution from 1987 to 2011 were included. Information on cardiac status and pregnancy outcome was obtain... Abstract

Cited 518 times since 2012 (42 per year) source: EuropePMC

mBio, Volume 3, Issue 6, 20 3 2012, Pages e00473-12 Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA

Unlabelled: A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the re... Abstract

Cited 36 times since 2012 (2.9 per year) source: EuropePMC

The American journal of cardiology, Volume 111, Issue 3, 15 3 2012, Pages 312-318 Influence of gender on ischemic times and outcomes after ST-elevation myocardial infarction. Velders MA, Boden H, van Boven AJ, van der Hoeven BL, Heestermans AA, Cannegieter SC, Umans VA, Jukema JW, Hofma SH, Schalij MJ

Previous studies investigating the influence of gender on ST-segment elevation myocardial infarction have reported conflicting results. The aim of this study was to assess the influence of gender on ischemic times and outcomes after ST-segment elevation myocardial infarction in patients treated with primary percutaneous coronary intervention in modern practice. The present multicenter registry included consecutive patients with ST-segment elevation myocardial infarctions treated with primary per... Abstract

Cited 37 times since 2012 (3 per year) source: EuropePMC

European heart journal, Volume 34, Issue 8, 15 3 2012, Pages 586-596 Epicardial substrate mapping for ventricular tachycardia ablation in patients with non-ischaemic cardiomyopathy: a new algorithm to differentiate between scar and viable myocardium developed by simultaneous integration of computed tomography and contrast-enhanced magnetic resonance imaging. Piers SR, van Huls van Taxis CF, Tao Q, van der Geest RJ, Askar SF, Siebelink HM, Schalij MJ, Zeppenfeld K

Aims: During epicardial electroanatomical mapping (EAM), it is difficult to differentiate between fibrosis and fat, as both exhibit attenuated bipolar voltage (BV). The purpose of this study was to assess whether unipolar voltage (UV), BV, and electrogram characteristics (EC) can distinguish fibrosis from viable myocardium and fat during epicardial EAM for ventricular tachycardia (VT) ablation in non-ischaemic cardiomyopathy (NICM). Methods and results: Ten NICM patients (7 males, 56 ± 13 years)... Abstract

Cited 11 times since 2012 (0.9 per year) source: EuropePMC

European journal of heart failure, Volume 15, Issue 4, 9 2 2012, Pages 400-407 Heart failure determines the myocardial inflammatory response to injury. Kortekaas KA, Lindeman JH, Versteegh MI, van Beelen E, Kleemann R, Klautz RJ

Aims: Systemic complications after cardiac surgery are common in heart failure patients. However, the pathophysiological mechanisms, such as a different local inflammatory response of failing hearts, remain in question. This study examines whether failing hearts respond differently to cardioplegic arrest and reperfusion compared with non-failing hearts (controls). Methods and results: The inflammatory response was evaluated in samples collected simultaneously from the radial artery and coronary... Abstract

Cited 33 times since 2012 (2.7 per year) source: EuropePMC

Diabetes care, Volume 36, Issue 2, 8 2 2012, Pages 457-462 Right ventricular involvement in diabetic cardiomyopathy. Widya RL, van der Meer RW, Smit JW, Rijzewijk LJ, Diamant M, Bax JJ, de Roos A, Lamb HJ

Objective: To compare magnetic resonance imaging-derived right ventricular (RV) dimensions and function between men with type 2 diabetes and healthy subjects, and to relate these parameters to left ventricular (LV) dimensions and function. Research design and methods: RV and LV volumes and functions were assessed in 78 men with uncomplicated type 2 diabetes and 28 healthy men within the same range of age using magnetic resonance imaging. Steady-state free precession sequences were used to assess... Abstract

Cited 49 times since 2012 (4 per year) source: EuropePMC

Journal of hepato-biliary-pancreatic sciences, Volume 19, Issue 6, 1 1 2012, Pages 626-637 Image-guided hepatopancreatobiliary surgery using near-infrared fluorescent light. Verbeek FP, van der Vorst JR, Schaafsma BE, Hutteman M, Bonsing BA, van Leeuwen FW, Frangioni JV, van de Velde CJ, Swijnenburg RJ, Vahrmeijer AL

Background: Improved imaging methods and surgical techniques have created a new era in hepatopancreatobiliary (HPB) surgery. Despite these developments, visual inspection, palpation, and intraoperative ultrasound remain the most utilized tools during surgery today. This is problematic, though, especially in laparoscopic HPB surgery, where palpation is not possible. Optical imaging using near-infrared (NIR) fluorescence can be used for the real-time assessment of both anatomy (e.g., sensitive det... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

European biophysics journal : EBJ, Volume 42, Issue 4, 23 4 2012, Pages 241-255 Depolarization-induced automaticity in rat ventricular cardiomyocytes is based on the gating properties of L-type calcium and slow Kv channels. Ypey DL, van Meerwijk WP, Umar S, Pijnappels DA, Schalij MJ, van der Laarse A

Depolarization-induced automaticity (DIA) of cardiomyocytes is the property of those cells to generate pacemaker cell-like spontaneous electrical activity when subjected to a depolarizing current. This property provides a candidate mechanism for generation of pathogenic ectopy in cardiac tissue. The purpose of this study was to determine the biophysical mechanism of DIA in terms of the ion conductance properties of the cardiomyocyte membrane. First, we determined, by use of the conventional whol... Abstract

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

Journal of plastic, reconstructive & aesthetic surgery : JPRAS, Volume 66, Issue 1, 23 4 2012, Pages e26-8 Associated anomalies and diagnostic approach in lumbosacral and perineal haemangiomas: case report and review of the literature. de Graaf M, Pasmans SG, van Drooge AM, Nievelstein RA, Gooskens RH, Raphael MF, Breugem CC

Abstract

Cited 30 times since 2012 (2.4 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 5, Issue 6, 22 4 2012, Pages 1059-1063 Prevalence and presentation of externalized conductors and electrical abnormalities in Riata defibrillator leads after fluoroscopic screening: report from the Netherlands Heart Rhythm Association Device Advisory Committee. Theuns DA, Elvan A, de Voogt W, de Cock CC, van Erven L, Meine M

Background: The Riata family of implantable cardioverter-defibrillator (ICD) leads is prone to a specific insulation abrasion characterized by externalization of conductor cables. The objective of this study was to determine the prevalence of externalized conductors and electrical abnormalities in Riata ICD leads by fluoroscopic screening and standard ICD interrogation. Methods and results: All ICD implantation centers were contacted by the Netherlands Heart Rhythm Association Device Advisory Co... Abstract

Cited 17 times since 2012 (1.4 per year) source: EuropePMC

American heart journal, Volume 164, Issue 5, 16 3 2012, Pages 771-778 Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison. Rodrigo SF, van Ramshorst J, Beeres SL, Al Younis I, Dibbets-Schneider P, de Roos A, Fibbe WE, Zwaginga JJ, Schalij MJ, Bax JJ, Atsma DE

Background: We recently demonstrated in a randomized, double-blind, placebo-controlled trial that intramyocardial bone marrow cell (BMC) injection is associated with improvements in myocardial perfusion and anginal symptoms in chronic myocardial ischemia patients. In the present study the results of the crossover phase of this trial, in which patients previously treated with placebo received autologous BMC injections are reported. This allows a unique intra-patient comparison on the effect of BM... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

PloS one, Volume 7, Issue 10, 16 3 2012, Pages e46356 Fractional flow reserve is not associated with inflammatory markers in patients with stable coronary artery disease. Sels JW, Elsenberg EH, Hoefer IE, van Zonneveld AJ, Kuiper J, Jukema JW, Pijls NH, Pasterkamp G

Background: Atherosclerosis is an inflammatory condition and increased blood levels of inflammatory biomarkers have been observed in acute coronary syndromes. In addition, high expression of inflammatory markers is associated with worse prognosis of coronary artery disease. The presence and extent of inducible ischemia in patients with stable angina has previously been shown to have strong prognostic value. We hypothesized that evidence of inducible myocardial ischemia by local lesions, as measu... Abstract

Cited 33 times since 2012 (2.7 per year) source: EuropePMC

Cardiovascular research, Volume 97, Issue 2, 14 2 2012, Pages 311-320 Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. de Vries MR, Wezel A, Schepers A, van Santbrink PJ, Woodruff TM, Niessen HW, Hamming JF, Kuiper J, Bot I, Quax PH

Aims: Failure of vein graft conduits due to vein graft thickening, accelerated atherosclerosis, and subsequent plaque rupture is applicable to 50% of all vein grafts within 10 years. New potential therapeutic targets to treat vein graft disease may be found in components of the innate immune system, such as mast cells and complement factors, which are known to be involved in atherosclerosis and plaque destabilization. Interestingly, mast cells can be activated by complement factor C5a and, there... Abstract

Cited 51 times since 2012 (4.1 per year) source: EuropePMC

Heart rhythm, Volume 10, Issue 2, 13 2 2012, Pages 158-164 Electrophysiological characteristics of ventricular tachyarrhythmias in cardiac sarcoidosis versus arrhythmogenic right ventricular cardiomyopathy. Dechering DG, Kochhäuser S, Wasmer K, Zellerhoff S, Pott C, Köbe J, Spieker T, Piers SR, Bittner A, Mönnig G, Breithardt G, Wichter T, Zeppenfeld K, Eckardt L

Background: Recent evidence suggests that cardiac sarcoidosis (CS) and arrhythmogenic right ventricular cardiomyopathy (ARVC) can manifest very similarly. Objective: To investigate whether there are significant demographic and electrophysiological differences between patients with CS and ARVC. Methods: We prospectively compared patients with proven CS or ARVC who underwent radiofrequency catheter ablation of ventricular tachycardias by using 3-dimensional electroanatomical mapping. Furthermore,... Abstract

Cited 32 times since 2012 (2.6 per year) source: EuropePMC

PloS one, Volume 7, Issue 10, 11 2 2012, Pages e46855 Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study. Koopman JJ, van Bodegom D, Jukema JW, Westendorp RG

Background: To test the inflammatory origin of cardiovascular disease, as opposed to its origin in western lifestyle. Population-based assessment of the prevalences of cardiovascular risk factors and cardiovascular disease in an inflammation-prone African population, including electrocardiography and ankle-arm index measurement. Comparison with known prevalences in American and European societies. Methodology/principal findings: Traditional population in rural Ghana, characterised by adverse env... Abstract

Cited 34 times since 2012 (2.7 per year) source: EuropePMC

PloS one, Volume 7, Issue 10, 11 2 2012, Pages e47134 Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression. de Vries MR, Niessen HW, Löwik CW, Hamming JF, Jukema JW, Quax PH

The current study describes the incidence and phenotype of plaque rupture complications in murine vein grafts. Since matrix metalloproteinases (MMPs) are highly involved in atherosclerotic plaque vulnerability and plaque rupture, we hypothesized that this model can be validated by overexpression of the MMP inhibitor TIMP-1. First we studied 47 vein grafts in hypercholesterolemic ApoE3*Leiden mice for the incidence of plaque complications. In 79% of these grafts, extensive lesions with plaque rup... Abstract

Cited 11 times since 2012 (0.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 60, Issue 19, 10 2 2012, Pages 1991-1992 Does pregnancy influence the durability of human aortic valve substitutes? Arabkhani B, Heuvelman HJ, Bogers AJ, Mokhles MM, Roos-Hesselink JW, Takkenberg JJ

Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Cardiology in the young, Volume 23, Issue 4, 2 1 2012, Pages 540-545 Peri-operative care in adults with congenital heart disease: room for improvement in after care. Schoormans D, Smets EM, Zwart R, Sprangers MA, Veelenturg TH, de Mol BA, Hazekamp MG, Koolbergen DR, Sojak V, Bouma BJ, Groenink M, Boekholdt MS, Backx AP, Mulder BJ

Background: Patient satisfaction with care has received little attention within the field of congenital heart disease. Our objective was to examine patient satisfaction with the care received when undergoing open-heart surgery in order to identify the best and worst aspects of peri-operative care. Moreover, we examined whether having contact with a specialised nurse in addition to usual care is associated with higher patient satisfaction levels. Methods: Patient satisfaction was measured by the... Abstract

Expert review of cardiovascular therapy, Volume 10, Issue 10, 1 1 2012, Pages 1197-1199 Primary prevention implantable cardioverter-defibrillator treatment: how to identify patients most likely to benefit? Thijssen J, van Rees JB, Schalij MJ, Borleffs CJ

Abstract