Research

Publications

Below you can find a list of our published research.

6139 results

Cited 33 times since 2011 (2.5 per year) source: EuropePMC

Cardiovascular research, Volume 93, Issue 3, 22 4 2011, Pages 434-444 Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Askar SF, Bingen BO, Swildens J, Ypey DL, van der Laarse A, Atsma DE, Zeppenfeld K, Schalij MJ, de Vries AA, Pijnappels DA

Aims: Arrhythmogenesis in cardiac fibrosis remains incompletely understood. Therefore, this study aims to investigate how heterocellular coupling between cardiomyocytes (CMCs) and myofibroblasts (MFBs) affects arrhythmogeneity of fibrotic myocardial cultures. Potentially, this may lead to the identification of novel anti-arrhythmic strategies. Methods and results: Co-cultures of neonatal rat CMCs and MFBs in a 1:1 ratio were used as a model of cardiac fibrosis, with purified CMC cultures as cont... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

Nucleic acids research, Volume 40, Issue 8, 20 3 2011, Pages 3443-3455 Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells. Gonçalves MA, van Nierop GP, Holkers M, de Vries AA

The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has been primarily on the former type of DNA lesions mainly due to the paucity of SSB-based recombination models. Here, to investigate the role of nicked DNA molecules as HR-initiating substrates in human s... Abstract

Cited 47 times since 2011 (3.5 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 83, Issue 2, 9 2 2011, Pages S56-61 Primary cilia as biomechanical sensors in regulating endothelial function. Egorova AD, van der Heiden K, Poelmann RE, Hierck BP

Depending on the pattern of blood flow to which they are exposed and their proliferative status, vascular endothelial cells can present a primary cilium into the flow compartment of a blood vessel. The cilium modifies the response of endothelial cells to biomechanical forces. Shear stress, which is the drag force exerted by blood flow, is best studied in this respect. Here we review the structural composition of the endothelial cilia and the current status of knowledge about the relation between... Abstract

Cited 21 times since 2011 (1.6 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 2, 7 1 2011, Pages 456-462 KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipoprotein cholesterol (LDL-C) lowering response to statins, coronary heart disease (CHD) at baseline, or CHD events on trial. We examined SNPs at the KIF6 (rs20455 or 719Arg), LPA (rs3798220), TAS2R50 (rs1376... Abstract

Cited 18 times since 2011 (1.4 per year) source: EuropePMC

PloS one, Volume 6, Issue 12, 6 1 2011, Pages e28638 Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. Schlick SN, Wood CD, Gunnell A, Webb HM, Khasnis S, Schepers A, West MJ

Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV latent gene expression (latency 0, I, II and III). The CDK1 activator, Response Gene to Complement-32 (RGC-32, C13ORF15), is overexpressed in colon, breast and ovarian cancer tissues and we have detected selective high-level RGC-32 protein expression in... Abstract

Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 559-564 Prognostic significance of baseline ST-T-wave abnormalities in diagnostic stress echocardiography. Pedone C, Elhendy A, van Domburg RT, Nelwan SP, Biagini E, Di Pasquale G, Bax JJ, Poldermans D

Objective: The aim of this study was to determine whether resting ST-T wave abnormalities (ST-Ta) provide incremental prognostic information in patients with no history of coronary artery disease undergoing dobutamine stress echocardiography (DSE). Methods: We evaluated 1308 consecutive patients without previous myocardial infarction (MI) or revascularization who underwent DSE. Ischemia was defined as new or worsening wall motion abnormalities. End points during follow-up were all-cause death an... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 533-536 Distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention. Antoni ML, Yiu KH, Atary JZ, Delgado V, Holman ER, van der Wall EE, Schuijf JD, Bax JJ, Schalij MJ

Objectives: Data regarding the distribution of vulnerable lesions in the coronary arteries are scarce. The aim was to evaluate the frequency and distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction. In addition, the location of culprit lesions was related to infarct size. Methods: Consecutive patients (N=1533, mean age 61±12 years) were evaluated. All patients were treated with primary percutaneous coronary intervention and underwent two-dimensional e... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

World journal of surgery, Volume 35, Issue 12, 1 1 2011, Pages 2829-30; author reply 2831 Re: Risk factors for stroke during surgery for carotid body tumors. van der Bogt KE, van Baalen JM, Hamming JF

Abstract

Cited 6 times since 2011 (0.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 12, 1 1 2011, Pages 509-513 Advanced therapy for pulmonary arterial hypertension due to congenital heart disease: a clinical perspective in a new therapeutic era. Schuuring MJ, Boekholdt SM, Windhausen A, Bouma BJ, Groenink M, Keijzers M, De Winter RJ, Koolbergen DR, Blom NA, Mulder BJ

Abstract

Cited 60 times since 2011 (4.5 per year) source: EuropePMC

Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ

Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract

Cited 22 times since 2011 (1.7 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 15, Issue 12, 1 1 2011, Pages 2675-2683 Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. Bax NA, Pijnappels DA, van Oorschot AA, Winter EM, de Vries AA, van Tuyn J, Braun J, Maas S, Schalij MJ, Atsma DE, Goumans MJ, Gittenberger-de Groot AC

The myocardium of the developing heart tube is covered by epicardium. These epicardial cells undergo a process of epithelial-to-mesenchymal transformation (EMT) and develop into epicardium-derived cells (EPDCs). The ingrowing EPDCs differentiate into several celltypes of which the cardiac fibroblasts form the main group. Disturbance of EMT of the epicardium leads to serious hypoplasia of the myocardium, abnormal coronary artery differentiation and Purkinje fibre paucity. Interestingly, the elect... Abstract

Cited 83 times since 2011 (6.2 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 5, Issue 1, 1 1 2011, Pages 51-59 Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T₁ mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Ng AC, Auger D, Delgado V, van Elderen SG, Bertini M, Siebelink HM, van der Geest RJ, Bonetti C, van der Velde ET, de Roos A, Smit JW, Leung DY, Bax JJ, Lamb HJ

Background: Diabetic patients have increased interstitial myocardial fibrosis on histological examination. Magnetic resonance imaging (MRI) T(1) mapping is a previously validated imaging technique that can quantify the burden of global and regional interstitial fibrosis. However, the association between MRI T(1) mapping and subtle left ventricular (LV) dysfunction in diabetic patients is unknown. Methods and results: Fifty diabetic patients with normal LV ejection fraction (EF) and no underlying... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 421-429 Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach: a feasibility study. van der Veen BJ, Al Younis I, Ajmone-Marsan N, Westenberg JJ, Bax JJ, Stokkel MP, de Roos A

Purpose: Left ventricular dyssynchrony may predict response to cardiac resynchronization therapy and may well predict adverse cardiac events. Recently, a geometrical approach for dyssynchrony analysis of myocardial perfusion scintigraphy (MPS) was introduced. In this study the feasibility of this geometrical method to detect dyssynchrony was assessed in a population with a normal MPS and in patients with documented ventricular dyssynchrony. Methods: For the normal population 80 patients (40 men... Abstract

Cited 6 times since 2011 (0.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 416-420 Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy. Paul M, Rahbar K, Gerss J, Kies P, Schober O, Schäfers K, Breithardt G, Schulze-Bahr E, Wichter T, Schäfers M

Purpose: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a nonischaemic cardiomyopathy and leading cause of sudden death in the young. It has been shown that microvascular dysfunction reflected by an impaired myocardial blood flow (MBF) response to stress is present in patients with other forms of nonischaemic cardiomyopathy, e.g. dilated cardiomyopathy, and that the reduced MBF may be related to a poor prognosis. Therefore, we quantified MBF, coronary flow reserve and coronary vascula... Abstract

Cited 2 times since 2011 (0.2 per year) source: EuropePMC

European heart journal, Volume 33, Issue 5, 21 3 2011, Pages 567-569 Prediction of individual response to heart failure therapy. Bax JJ, Delgado V

Abstract

Cited 64 times since 2011 (4.8 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 12, 21 3 2011, Pages 262 Outcome in hip fracture patients related to anemia at admission and allogeneic blood transfusion: an analysis of 1262 surgically treated patients. Vochteloo AJ, Borger van der Burg BL, Mertens B, Niggebrugge AH, de Vries MR, Tuinebreijer WE, Bloem RM, Nelissen RG, Pilot P

Background: Anemia is more often seen in older patients. As the mean age of hip fracture patients is rising, anemia is common in this population. Allogeneic blood transfusion (ABT) and anemia have been pointed out as possible risk factors for poorer outcome in hip fracture patients. Methods: In the timeframe 2005-2010, 1262 admissions for surgical treatment of a hip fracture in patients aged 65 years and older were recorded. Registration was prospective from 2008 on. Anemic and non-anemic patien... Abstract

Cited 29 times since 2011 (2.2 per year) source: EuropePMC

In vitro cellular & developmental biology. Animal, Volume 48, Issue 1, 20 3 2011, Pages 21-29 Endothelial colony-forming cells show a mature transcriptional response to shear stress. Egorova AD, DeRuiter MC, de Boer HC, van de Pas S, Gittenberger-de Groot AC, van Zonneveld AJ, Poelmann RE, Hierck BP

Endothelial progenitor cells (EPC) play a central role in endothelial maintenance and repair. Endothelial colony-forming cells (ECFC) form a subpopulation of EPC. ECFC are readily attainable, can be easily isolated, possess a high proliferation potential, and are therefore a promising source of endothelial cells (EC) for future cardiovascular therapeutic applications. The extent to which these cells respond to shear stress as adult vascular EC remains to be elucidated. Here, we study the transcr... Abstract

Cited 46 times since 2011 (3.4 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 5, Issue 1, 17 3 2011, Pages 101-110 Implantable cardioverter defibrillator therapy in adults with congenital heart disease: who is at risk of shocks? Koyak Z, de Groot JR, Van Gelder IC, Bouma BJ, van Dessel PF, Budts W, van Erven L, van Dijk AP, Wilde AA, Pieper PG, Sieswerda GT, Mulder BJ

Background: The value of implantable cardioverter defibrillators (ICDs) in adults with congenital heart disease (CHD) is unknown. We investigated the long-term outcome after ICD implantation and developed a simple risk stratification score for ICD therapy. Methods and results: A total of 136 adults with CHD and ICD (mean age±SD, 41±13 years; 67% male) were identified from 10 tertiary referral centers in the Netherlands and Belgium. The indication for ICD implantation was primary prevention in 50... Abstract

Cited 48 times since 2011 (3.6 per year) source: EuropePMC

International journal of epidemiology, Volume 41, Issue 1, 17 3 2011, Pages 106-115 Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. Talens RP, Jukema JW, Trompet S, Kremer D, Westendorp RG, Lumey LH, Sattar N, Putter H, Slagboom PE, Heijmans BT, PROSPER Group

Background: Human epidemiological studies suggest that small size at birth and food deprivation during gestation confer an excess risk of coronary heart diseases (CHD) in adulthood, frequently in a sex-specific manner. Prior epigenetic studies indicate that such prenatal conditions are marked by persistent and sometimes sex-specific changes in DNA methylation. Here, we have investigated the association between DNA methylation and myocardial infarction (MI) at six loci sensitive to prenatal nutri... Abstract

Cited 31 times since 2011 (2.3 per year) source: Scopus

Interactive cardiovascular and thoracic surgery, Volume 14, Issue 1, 16 3 2011, Pages 17-21 Vacuum-assisted closure of post-sternotomy mediastinitis as compared to open packing. Vos RJ, Yilmaz A, Sonker U, Kelder JC, Kloppenburg GT

Post-sternotomy mediastinitis is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. The aim of this study is to describe clinical outcomes of VAC as compared to open packing and to predict risk factors for mortality. We performed a retrospective analysis of 113 patients with mediastinitis undergoing... Abstract