Research

Publications

Below you can find a list of our published research.

6139 results

Cited 47 times since 2011 (3.4 per year) source: EuropePMC

European heart journal, Volume 33, Issue 2, 30 5 2011, Pages 165-175 A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application? Verschuren JJ, Trompet S, Wessels JA, Guchelaar HJ, de Maat MP, Simoons ML, Jukema JW

Pharmacogenetics is the search for heritable genetic polymorphisms that influence responses to drug therapy. The most important application of pharmacogenetics is to guide choosing agents with the greatest potential of efficacy and smallest risk of adverse drug reactions. Many studies focusing on drug-gene interactions have been published in recent years, some of which led to adaptation of FDA recommendations, indicating that we are on the verge of the clinical application of genetic information... Abstract

Cited 44 times since 2011 (3.2 per year) source: EuropePMC

American journal of obstetrics and gynecology, Volume 206, Issue 1, 30 5 2011, Pages 89.e1-5 Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer. Hutteman M, van der Vorst JR, Gaarenstroom KN, Peters AA, Mieog JS, Schaafsma BE, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Objectives: Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study design: Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using (99m)technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 50... Abstract

Brain & development, Volume 34, Issue 4, 23 4 2011, Pages 298-301 Cerebrospinal fluid apolipoprotein E levels in subacute sclerosing panencephalitis. Yüksel D, Ichiyama T, Yilmaz D, Anlar B

Neurofibrillary tangles (NFTs) have been shown in 20% of subacute sclerosing panencephalitis (SSPE) cases. NFTs contain paired helical filaments formed by hyperphosphorylated tau. The intraneuronal tau metabolism and the rate of formation of paired helical filaments can be regulated by interactions between tau and isoforms of Apolipoprotein E (Apo E). Tau binds in vitro to Apo E3, interferes with the hyperphosphorylation of tau and may reduce the formation of NFTs. We investigated cerebrospinal... Abstract

Cited 19 times since 2011 (1.4 per year) source: Scopus

European heart journal, Volume 32, Issue 22, 23 4 2011, Pages 2806-2813 Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation. Ng AC, Yiu KH, Ewe SH, van der Kley F, Bertini M, de Weger A, de Roos A, Leung DY, Schuijf JD, Schalij MJ, Bax JJ, Delgado V

Aims: Evaluate changes in aortic annular dimensions in relation to severe aortic stenosis (AS) and left ventricular (LV) dysfunction. Methods and results: Mean aortic annular diameters and geometries were compared between 90 severe AS patients and 111 controls by multi-detector row computed tomography (MDCT). All severe AS patients were also dichotomized into two groups based on the presence of preserved (≥ 50%) or impaired ( Abstract

Cited 9 times since 2011 (0.7 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 7, 23 4 2011, Pages 968-972 Prognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography. Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, van Velzen JE, Boogers MJ, Roos CJ, de Bie MK, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, de Roos A, Kaufmann PA, Bax JJ, Jukema JW

Chronic kidney disease (CKD) is associated with cardiovascular (CV) events caused by advanced atherosclerosis. Computed tomographic coronary angiography (CTA) can accurately diagnose coronary artery disease (CAD) and predict CV outcomes. The aim of the present study was to evaluate whether moderate CKD provides prognostic information for CV events in patients undergoing CTA. In total 885 patients with suspected CAD underwent CTA and were stratified to moderate CKD (85 patients) or no CKD (770 pa... Abstract

Cited 33 times since 2011 (2.4 per year) source: EuropePMC

Journal of biomechanics, Volume 44, Issue 13, 22 4 2011, Pages 2376-2382 Initial stress in biomechanical models of atherosclerotic plaques. Speelman L, Akyildiz AC, den Adel B, Wentzel JJ, van der Steen AF, Virmani R, van der Weerd L, Jukema JW, Poelmann RE, van Brummelen EH, Gijsen FJ

Rupture of atherosclerotic plaques is the underlying cause for the majority of acute strokes and myocardial infarctions. Rupture of the plaque occurs when the stress in the plaque exceeds the strength of the material locally. Biomechanical stress analyses are commonly based on pressurized geometries, in most cases measured by in-vivo MRI. The geometry is therefore not stress-free. The aim of this study is to identify the effect of neglecting the initial stress state on the plaque stress distribu... Abstract

Cited 22 times since 2011 (1.6 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 22, Issue 12, 21 3 2011, Pages 1346-1350 Primary prevention implantable cardioverter defibrillator recipients: the need for defibrillator back-up after an event-free first battery service-life. Van Welsenes GH, Van Rees JB, Thijssen J, Trines SA, Van Erven L, Schalij MJ, Borleffs CJ

Introduction: In primary prevention implantable cardioverter defibrillator (ICD) patients, the relatively low incidence of ventricular arrhythmias (VA) combined with the limited battery service-life potentially results in a large group of patients who have had no benefit of the ICD during first service-life. Data on the occurrence of VA after device replacement remain scarce. The purpose of this study was to give clinicians better insight in the dilemma whether or not to replace an ICD after an... Abstract

Cited 5 times since 2011 (0.4 per year) source: EuropePMC

Atherosclerosis, Volume 218, Issue 2, 20 3 2011, Pages 457-463 ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting. Regieli JJ, Doevendans PA, Grobbee DE, Zwinderman AH, van der Graaf Y, Kastelein JJ, Jukema JW

Objectives: We prospectively investigated the effects of ATP-binding cassette protein-1 (ABCA1) variants on long-term clinical outcome in patients with coronary artery disease (CAD). Background: ABCA1 is implicated in the etiology of atherothrombosis and may offer a target to reduce cardiovascular risk. However, the impact of ABCA1 on recurrent cardiovascular disease in a secondary prevention setting is as of yet unknown. Methods: We studied cause-specific 10-year mortality and quantitative coro... Abstract

Cited 49 times since 2011 (3.6 per year) source: EuropePMC

EMBO molecular medicine, Volume 3, Issue 9, 20 3 2011, Pages 545-558 The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions. Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU

Acute and chronic inflammatory disorders are characterized by detrimental cytokine and chemokine expression. Frequently, the chemotactic activity of cytokines depends on a modified N-terminus of the polypeptide. Among those, the N-terminus of monocyte chemoattractant protein 1 (CCL2 and MCP-1) is modified to a pyroglutamate (pE-) residue protecting against degradation in vivo. Here, we show that the N-terminal pE-formation depends on glutaminyl cyclase activity. The pE-residue increases stabilit... Abstract

Cited 48 times since 2011 (3.5 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 18, Issue 5, 19 3 2011, Pages 893-903 Comprehensive assessment of spotty calcifications on computed tomography angiography: comparison to plaque characteristics on intravascular ultrasound with radiofrequency backscatter analysis. van Velzen JE, de Graaf FR, de Graaf MA, Schuijf JD, Kroft LJ, de Roos A, Reiber JH, Bax JJ, Jukema JW, Boersma E, Schalij MJ, van der Wall EE

Background: The purpose of the study was to systematically compare calcification patterns in plaques on computed tomography angiography (CTA) with plaque characteristics on intravascular ultrasound with radiofrequency backscatter analysis (IVUS-VH). Methods and results: In total, 108 patients underwent CTA and IVUS-VH. On CTA, calcification patterns in plaques were classified as non-calcified, spotty or dense calcifications. Plaques with spotty calcifications were differentiated into small spott... Abstract

Cited 21 times since 2011 (1.5 per year) source: EuropePMC

Cardiovascular diabetology, Volume 10, 19 3 2011, Pages 67 Association of plasma osteoprotegerin and adiponectin with arterial function, cardiac function and metabolism in asymptomatic type 2 diabetic men. Chen WJ, Rijzewijk LJ, van der Meer RW, Heymans MW, van Duinkerken E, Lubberink M, Lammertsma AA, Lamb HJ, de Roos A, Romijn JA, Smit JW, Bax JJ, Bjerre M, Frystyk J, Flyvbjerg A, Diamant M

Background: Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, is linked to cardiovascular disease. Negative associations exist between circulating OPG and cardiac function. The adipocytokine adiponectin (ADPN) is downregulated in type 2 diabetes mellitus (T2DM) and coronary artery disease and shows an inverse correlation with insulin sensitivity and cardiovascular disease risk. We assessed the relationship of plasma OPG and ADPN and arterial function, car... Abstract

Cited 51 times since 2011 (3.7 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 31, Issue 10, 14 2 2011, Pages 2338-2344 Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk. Welsh P, Murray HM, Ford I, Trompet S, de Craen AJ, Jukema JW, Stott DJ, McInnes IB, Packard CJ, Westendorp RG, Sattar N, PROSPER Study Group

Objective: The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD). Methods and results: In the PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) cohort, we related baseline concentrations of circulating IL-10 to risk of CVD events in a nested case (n=819)-control (n=1618) study of 3.2 years of follow-up. Circulating IL-10 showed few strong associations with classical risk factors but was posit... Abstract

Cited 33 times since 2011 (2.4 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 34, Issue 3, 14 2 2011, Pages 526-531 Age-related and regional changes of aortic stiffness in the Marfan syndrome: assessment with velocity-encoded MRI. Westenberg JJ, Scholte AJ, Vaskova Z, van der Geest RJ, Groenink M, Labadie G, van den Boogaard PJ, Radonic T, Hilhorst-Hofstee Y, Mulder BJ, Kroft LJ, Reiber JH, de Roos A

Purpose: To study age-related change in aortic stiffness in patients with Marfan syndrome (MFS) versus healthy volunteers using velocity-encoded (VE) MRI. Materials and methods: Twenty-five MFS patients (age range, 18-63 years; mean age 36 ± 14 years, 13 men) and 25 age-/gender-matched healthy volunteers were examined with VE-MRI. Aortic stiffness was expressed by pulse wave velocity (PWV), assessed in the proximal and distal part of the aorta and in the total aorta. PWV was compared between pat... Abstract

Cited 22 times since 2011 (1.6 per year) source: EuropePMC

European radiology, Volume 21, Issue 11, 7 1 2011, Pages 2285-2296 Diagnostic performance of 320-slice multidetector computed tomography coronary angiography in patients after coronary artery bypass grafting. de Graaf FR, van Velzen JE, Witkowska AJ, Schuijf JD, van der Bijl N, Kroft LJ, de Roos A, Reiber JH, Bax JJ, de Grooth GJ, Jukema JW, van der Wall EE

Objectives: To evaluate the diagnostic performance of 320-slice computed tomography coronary angiography (CTA) in the evaluation of patients with prior coronary artery bypass grafting (CABG). Invasive coronary angiography (ICA) served as the standard of reference, using a quantitative approach. Methods: CTA studies were performed using CT equipment with 320 detector-rows, each 0.5 mm wide, and a gantry rotation time of 0.35 s. All grafts, recipient and nongrafted vessels were deemed interpretabl... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

Heart failure reviews, Volume 16, Issue 4, 1 1 2011, Pages 411-423 The role of nuclear imaging in the failing heart: myocardial blood flow, sympathetic innervation, and future applications. Boogers MJ, Fukushima K, Bengel FM, Bax JJ

Heart failure represents a common disease affecting approximately 5 million patients in the United States. Several conditions play an important role in the development and progression of heart failure, including abnormalities in myocardial blood flow and sympathetic innervation. Nuclear imaging represents the only imaging modality with sufficient sensitivity to assess myocardial blood flow and sympathetic innervation of the failing heart. Although nuclear imaging with single-photon emission comp... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 453-459 Predictive power of T-wave alternans and of ventricular gradient hysteresis for the occurrence of ventricular arrhythmias in primary prevention cardioverter-defibrillator patients. Man S, De Winter PV, Maan AC, Thijssen J, Borleffs CJ, van Meerwijk WP, Bootsma M, van Erven L, van der Wall EE, Schalij MJ, Burattini L, Burattini R, Swenne CA

Background and purpose: Left ventricular ejection fraction lacks specificity to predict sudden cardiac death in heart failure. T-wave alternans (TWA; beat-to-beat T-wave instability, often measured during exercise) is deemed a promising noninvasive predictor of major cardiac arrhythmic event. Recently, it was demonstrated that TWA during recovery from exercise has additional predictive value. Another mechanism that potentially contributes to arrhythmogeneity is exercise-recovery hysteresis in ac... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, Volume 19, Issue 7, 1 1 2011, Pages 678-679 Successful electroconvulsive therapy in a 95-year-old man with a cardiac pacemaker--a case report. Gosselink MJ, Schenkeveld KW, Trines SA, van Vliet IM

Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Pediatric research, Volume 70, Issue 1, 1 1 2011, Pages 37-43 Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias. Hahurij ND, Kolditz DP, Bökenkamp R, Markwald RR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Blom NA

Atrioventricular reentry tachycardia (AVRT) requiring an accessory atrioventricular pathway (AP) is the most common type of arrhythmia in the perinatal period. The etiology of these arrhythmias is not fully understood as well as their capability to dissipate spontaneously in the first year of life. Temporary presence of APs during annulus fibrosus development might cause this specific type of arrhythmias. To study the presence of APs, electrophysiological recordings of ventricular activation pat... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 410-415 Influence of the vectorcardiogram synthesis matrix on the power of the electrocardiogram-derived spatial QRS-T angle to predict arrhythmias in patients with ischemic heart disease and systolic left ventricular dysfunction. Man S, Algra AM, Schreurs CA, Borleffs CJ, Scherptong RW, van Erven L, van der Wall EE, Cannegieter SC, Schalij MJ, Swenne CA

Background and purpose: Several studies have demonstrated that the spatial mean QRS-T angle (SA) predicts cardiac events and mortality. Spatial mean QRS-T angle is a vectorcardiographic variable. Because in clinical practice, 12-lead standard electrocardiograms (ECGs) are recorded rather than vectorcardiograms (VCGs) according to Frank, VCGs are commonly obtained by synthesizing them from 12-lead ECGs, by using a VCG synthesis matrix. Hence, the thus computed SA is an estimate of the real SA mea... Abstract

The Annals of thoracic surgery, Volume 92, Issue 1, 1 1 2011, Pages 166 Invited commentary. Hazekamp MG

Abstract