Research

Publications

Below you can find a list of our published research.

6139 results

Cited 10 times since 2010 (0.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 56, Issue 10, 1 1 2010, Pages 754-762 Critical appraisal of the use of cardiac resynchronization therapy beyond current guidelines. Van Bommel RJ, Delgado V, Schalij MJ, Bax JJ

Cardiac resynchronization therapy (CRT) is an effective treatment for patients with drug-refractory, chronic heart failure. Multiple single-center and multicenter studies have shown significant reductions in left ventricular (LV) volumes and an increase in LV systolic function. More importantly, CRT reduces mortality and morbidity during long-term follow-up. Current guidelines consider CRT as a Class I indication for heart failure patients in New York Heart Association (NYHA) functional class II... Abstract

Cited 25 times since 2010 (1.7 per year) source: EuropePMC

Molecular imaging, Volume 9, Issue 4, 1 1 2010, Pages 223-231 Novel intraoperative near-infrared fluorescence camera system for optical image-guided cancer surgery. Mieog JS, Vahrmeijer AL, Hutteman M, van der Vorst JR, Drijfhout van Hooff M, Dijkstra J, Kuppen PJ, Keijzer R, Kaijzel EL, Que I, van de Velde CJ, Löwik CW

Current methods of intraoperative tumor margin detection using palpation and visual inspection frequently result in incomplete resections, which is an important problem in surgical oncology. Therefore, real-time visualization of cancer cells is needed to increase the number of patients with a complete tumor resection. For this purpose, near-infrared fluorescence (NIRF) imaging is a promising technique. Here we describe a novel, handheld, intraoperative NIRF camera system equipped with a 690 nm l... Abstract

Cited 55 times since 2010 (3.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 96, Issue 16, 1 1 2010, Pages 1275-1280 Beneficial effects of catheter ablation on left ventricular and right ventricular function in patients with frequent premature ventricular contractions and preserved ejection fraction. Wijnmaalen AP, Delgado V, Schalij MJ, van Huls van Taxis CF, Holman ER, Bax JJ, Zeppenfeld K

Background: Improvement of left ventricular ejection fraction (LVEF) after radiofrequency catheter ablation (RFCA) of frequent premature ventricular contractions (PVCs) has been reported. However, most patients with frequent PVCs have a normal LVEF. In these patients subtle and early forms of PVC-induced left and right ventricular (RV) impairment may not be detected by standard echocardiographic techniques. Objective: To assess the effect of frequent PVCs on ventricular function in patients with... Abstract

Cited 3 times since 2010 (0.2 per year) source: EuropePMC

Minerva medica, Volume 101, Issue 4, 1 1 2010, Pages 255-270 Young at heart. An update on cardiac regeneration. Smits AM, Ramkisoensing AA, Atsma DE, Goumans MJ

Cardiovascular disease remains one of the most important causes of mortality. Over the past decades important advances have been made in prevention and treatment of acute complications after myocardial infarction (MI). As a result, the number of patients that acutely die from MI has been reduced. Current treatments can not prevent the loss of cardiac contractility caused by cardiomyocyte death, and therefore patients that do survive MI are prone to develop progressive impaired cardiac function,... Abstract

Cited 35 times since 2010 (2.4 per year) source: EuropePMC

Magnetic resonance in medicine, Volume 64, Issue 2, 1 1 2010, Pages 586-594 Automated segmentation of myocardial scar in late enhancement MRI using combined intensity and spatial information. Tao Q, Milles J, Zeppenfeld K, Lamb HJ, Bax JJ, Reiber JH, van der Geest RJ

Accurate assessment of the size and distribution of a myocardial infarction (MI) from late gadolinium enhancement (LGE) MRI is of significant prognostic value for postinfarction patients. In this paper, an automatic MI identification method combining both intensity and spatial information is presented in a clear framework of (i) initialization, (ii) false acceptance removal, and (iii) false rejection removal. The method was validated on LGE MR images of 20 chronic postinfarction patients, using... Abstract

Cited 9 times since 2010 (0.6 per year) source: EuropePMC

European journal of trauma and emergency surgery : official publication of the European Trauma Society, Volume 36, Issue 6, 27 4 2010, Pages 579-585 Appendicular tuberculosis: review of 155 published cases and a report of two cases. Akbulut S, Yagmur Y, Bakir S, Sogutcu N, Yilmaz D, Senol A, Bahadir MV

Purpose: This paper provides an overview of the literature on appendicular tuberculosis (ATB) between 1909 and 2010. Methods: We present two cases of primary ATB and a literature review of studies on ATB published in English and accessed via the Pubmed and Google Scholar databases. Results: One hundred fifty-five published cases of ATB were reviewed, and two patients with primary ATB, treated and followed in our clinic, were reported. The age range of the patients (62 females, 60 males and 33 wi... Abstract

Cited 38 times since 2010 (2.6 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 5, 23 4 2010, Pages 723-729 Relation of left ventricular twist and global strain with right ventricular dysfunction in patients after operative "correction" of tetralogy of fallot. van der Hulst AE, Delgado V, Holman ER, Kroft LJ, de Roos A, Hazekamp MG, Blom NA, Bax JJ, Roest AA

In patients with corrected tetralogy of Fallot (cToF), left ventricular (LV) dysfunction is closely related to right ventricular (RV) dysfunction, indicating adverse ventricular-ventricular interactions. However, the mechanism that links RV dysfunction to LV dysfunction remains unclear. In this prospective study, 32 patients with cToF and 19 controls were enrolled. With cardiac magnetic resonance imaging, biventricular ejection fractions were assessed. Using 2-dimensional speckle tracking, globa... Abstract

Cited 8 times since 2010 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 5, 23 4 2010, Pages 682-687 Effect of cardiac resynchronization therapy on subendo- and subepicardial left ventricular twist mechanics and relation to favorable outcome. Bertini M, Delgado V, Nucifora G, Marsan NA, Ng AC, Shanks M, Van Bommel RJ, Borleffs CJ, Ewe SH, Boriani G, Biffi M, Schalij MJ, Bax JJ

The analysis of left ventricular (LV) mechanics provides novel insights into the effects of cardiac resynchronization therapy (CRT) on LV performance. Currently, advances in speckle-tracking echocardiographic analysis have permitted the characterization of subendocardial and subepicardial LV twist. The aim of this study was to investigate the role of the acute changes in subendocardial and subepicardial LV twist for the prediction of midterm beneficial effects of CRT. A total of 84 patients with... Abstract

Cited 4 times since 2010 (0.3 per year) source: EuropePMC

The Journal of oral implantology, Volume 37 Spec No, 21 3 2010, Pages 183-191 Prosthetic rehabilitation of edentulous ridges following alveolar distraction osteogenesis: clinical report of three cases. Ergun G, Nagas IC, Yilmaz D, Ozturk M

Patients with complete edentulism who have insufficient bone for endosseous dental implant treatment present a challenge for dental practitioners. Distraction osteogenesis of the edentulous alveolar ridges is a process for augmentation of atrophic alveolar bone before dental implant placement. This clinical report describes the use of distraction osteogenesis and rehabilitation of patients with a fixed or removable implant-supported prosthesis to treat mandibular defects. Two female patients wit... Abstract

Cited 14 times since 2010 (1 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 3, Issue 6, 21 3 2010, Pages 718-726 Predictive value of multislice computed tomography variables of atherosclerosis for ischemia on stress-rest single-photon emission computed tomography. van Velzen JE, Schuijf JD, van Werkhoven JM, Herzog BA, Pazhenkottil AP, Boersma E, de Graaf FR, Scholte AJ, Kroft LJ, de Roos A, Stokkel MP, Jukema JW, Kaufmann PA, van der Wall EE, Bax JJ

Background: previous studies have shown that the presence of stenosis alone on multislice computed tomography (MSCT) has a limited positive predictive value for the presence of ischemia on myocardial perfusion imaging (MPI). The purpose of this study was to assess which variables of atherosclerosis on MSCT angiography are related to ischemia on MPI. Methods and results: both MSCT and MPI were performed in 514 patients. On MSCT, the calcium score, degree of stenosis (≥ 50% and ≥ 70% stenosis), an... Abstract

Cited 66 times since 2010 (4.5 per year) source: EuropePMC

Circulation, Volume 122, Issue 5, 19 3 2010, Pages 470-477 Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility. Vergeer M, Boekholdt SM, Sandhu MS, Ricketts SL, Wareham NJ, Brown MJ, de Faire U, Leander K, Gigante B, Kavousi M, Hofman A, Uitterlinden AG, van Duijn CM, Witteman JC, Jukema JW, Schadt EE, van der Schoot E, Kastelein JJ, Khaw KT, Dullaart RP, van Tol A, Trip MD, Dallinga-Thie GM

Background: In contrast to clear associations between variants in genes participating in low-density lipoprotein metabolism and cardiovascular disease risk, such associations for high-density lipoprotein (HDL)-related genes are not well supported by recent large studies. We aimed to determine whether genetic variants at the locus encoding phospholipid transfer protein (PLTP), a protein involved in HDL remodeling, underlie altered PLTP activity, HDL particle concentration and size, and cardiovasc... Abstract

Cited 3 times since 2010 (0.2 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 11, 16 3 2010, Pages 1581-1588 Right ventricular stimulation threshold at ICD implant predicts device therapy in primary prevention patients with ischaemic heart disease. Atary JZ, Borleffs CJ, van der Bom JG, Trines SA, Bootsma M, Zeppenfeld K, van Erven L, Schalij MJ

Aims: Myocardial excitability is known (amongst other reasons) to be related to the degree of ischaemia, contractile dysfunction and heart failure. It was hypothesized that the right ventricular (RV) stimulation threshold has prognostic value with respect to the occurrence of ventricular arrhythmias (VAs) and patient survival in recipients of an implantable cardioverter defibrillator (ICD). Methods and results: Ischaemic heart disease patients receiving an ICD at Leiden University Medical Center... Abstract

Cited 38 times since 2010 (2.6 per year) source: EuropePMC

Radiology, Volume 256, Issue 3, 15 3 2010, Pages 724-734 Tetralogy of fallot: 3D velocity-encoded MR imaging for evaluation of right ventricular valve flow and diastolic function in patients after correction. van der Hulst AE, Westenberg JJ, Kroft LJ, Bax JJ, Blom NA, de Roos A, Roest AA

Purpose: To evaluate three-dimensional (3D) velocity-encoded (VE) magnetic resonance (MR) imaging, as compared with two-dimensional (2D) VE MR imaging, for assessment of pulmonary valve (PV) and tricuspid valve (TV) flow, with planimetry as the reference standard, and to evaluate diastolic function in patients with a corrected tetralogy of Fallot (TOF). Materials and methods: Local institutional review board approval was obtained, and patients or their parents gave informed consent. Twenty-five... Abstract

Cited 39 times since 2010 (2.7 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 3, Issue 5, 14 2 2010, Pages 623-631 Pulmonary vascular resistance, collateral flow, and ventricular function in patients with a Fontan circulation at rest and during dobutamine stress. Schmitt B, Steendijk P, Ovroutski S, Lunze K, Rahmanzadeh P, Maarouf N, Ewert P, Berger F, Kuehne T

Background: The role, interplay, and relative importance of the multifactorial hemodynamic and myocardial mechanisms causing dysfunction of the Fontan circulation remain incompletely understood. Methods and results: Using an MRI catheterization technique, we performed a differential analysis of pulmonary vascular resistance and aortopulmonary collateral blood flow in conjunction with global ventricular pump function, myocontractility (end-systolic pressure-volume relation), and diastolic complia... Abstract

Cited 104 times since 2010 (7.1 per year) source: EuropePMC

Nature genetics, Volume 42, Issue 8, 11 2 2010, Pages 688-691 Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Bezzina CR, Pazoki R, Bardai A, Marsman RF, de Jong JSSG, Blom MT, Scicluna BP, Jukema JW, Bindraban NR, Lichtner P, Pfeufer A, Bishopric NH, Roden DM, Meitinger T, Chugh SS, Myerburg RJ, Jouven X, Kääb S, Dekker LRC, Tan HL, Tanck MWT, Wilde AAM

Sudden cardiac death from ventricular fibrillation during acute myocardial infarction is a leading cause of total and cardiovascular mortality. To our knowledge, we here report the first genome-wide association study for this trait, conducted in a set of 972 individuals with a first acute myocardial infarction, 515 of whom had ventricular fibrillation and 457 of whom did not, from the Arrhythmia Genetics in The Netherlands (AGNES) study. The most significant association to ventricular fibrillati... Abstract

Cited 2 times since 2010 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 27, Issue 7, 11 2 2010, Pages 1011-1014 IVUS detects more coronary calcifications than MSCT; matter of both resolution and cross-sectional assessment? van der Wall EE, de Graaf FR, van Velzen JE, Jukema JW, Bax JJ, Schuijf JD

Abstract

The international journal of cardiovascular imaging, Volume 27, Issue 1, 8 2 2010, Pages 59-63 Evidence of scar tissue: contra-indication to cardiac resynchronization therapy? van der Wall EE, Schalij MJ, Verwey HF, Bax JJ

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European heart journal, Volume 31, Issue 19, 8 2 2010, Pages 2323-2325 Changes in functional mitral regurgitation after cardiac resynchronization therapy. Marsan NA, Bax JJ

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Cited 523 times since 2010 (35.5 per year) source: EuropePMC

Nature genetics, Volume 42, Issue 8, 4 1 2010, Pages 665-667 Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tönnissen ER, van der Heijden A, Scheele TN, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH

In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS. Abstract

Cited 123 times since 2010 (8.4 per year) source: EuropePMC

European heart journal, Volume 31, Issue 16, 2 1 2010, Pages 1975-1984 Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E

Aims: Westernized countries face a growing burden of cardiovascular calcification and osteoporosis. Despite its vast clinical significance, the precise nature of this reciprocal relationship remains obscure. We hypothesize that cardiovascular calcification progresses with inflammation and inversely correlates with bone tissue mineral density (TMD). Methods and results: Arterial, valvular, and bone metabolism were visualized using near-infrared fluorescence (NIRF) molecular imaging agents, target... Abstract