Research

Publications

Below you can find a list of our published research.

8892 results

Cited 16 times since 2018 (2.1 per year) source: EuropePMC

Frontiers in neuroscience, Volume 12, 10 2 2018, Pages 213 An FPGA-Based Massively Parallel Neuromorphic Cortex Simulator. Wang RM, Thakur CS, van Schaik A

This paper presents a massively parallel and scalable neuromorphic cortex simulator designed for simulating large and structurally connected spiking neural networks, such as complex models of various areas of the cortex. The main novelty of this work is the abstraction of a neuromorphic architecture into clusters represented by minicolumns and hypercolumns, analogously to the fundamental structural units observed in neurobiology. Without this approach, simulating large-scale fully connected netw... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

Frontiers in neuroscience, Volume 12, 10 2 2018, Pages 198 A FPGA Implementation of the CAR-FAC Cochlear Model. Xu Y, Thakur CS, Singh RK, Hamilton TJ, Wang RM, van Schaik A

This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC), the inner hair cell (IHC), and the medial olivocochlear efferent system functions. The FAC feeds back to the CAR by moving the poles and zeros of the CAR resonators automatically. We have implemented a 70-section, 44.1 kHz sampling rate C... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Anatolian journal of cardiology, Volume 19, Issue 5, 10 2 2018, Pages 303-310 Increased microvolt T-wave alternans in children and adolescents with Eisenmenger syndrome. Karpuz D, Hallıoğlu O, Yılmaz DÇ

Objective: To determine the values of microvolt T-wave alternans (MTWA) in children and adolescents with Eisenmenger syndrome (ES) and controls. Methods: Thirteen were included in the study. After analyzing the 24-h ECG recordings, MTWA was considered using three leads (V5, V1, and aVF). Right heart catheterization and 6-minute walk test (6-MWD) were applied to the patients and pro-brain natriuretic peptide levels were assessed; echocardiographic parameters were obtained from both the groups and... Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

Journal of cellular biochemistry, Volume 119, Issue 7, 10 2 2018, Pages 6146-6153 Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors. Neshati V, Mollazadeh S, Fazly Bazzaz BS, de Vries AA, Mojarrad M, Naderi-Meshkin H, Neshati Z, Kerachian MA

Ischemic heart disease often results in myocardial infarction and is the leading cause of mortality and morbidity worldwide. Improvement in the function of infarcted myocardium is a main purpose of cardiac regenerative medicine. One possible way to reach this goal is via stem cell therapy. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types but display limited cardiomyogenic differentiation potential. Members of the T-box family of tran... Abstract

Cited 17 times since 2018 (2.3 per year) source: EuropePMC

European radiology, Volume 28, Issue 9, 6 1 2018, Pages 4027-4035 High spatial resolution free-breathing 3D late gadolinium enhancement cardiac magnetic resonance imaging in ischaemic and non-ischaemic cardiomyopathy: quantitative assessment of scar mass and image quality. Bizino MB, Tao Q, Amersfoort J, Siebelink HJ, van den Bogaard PJ, van der Geest RJ, Lamb HJ

Purpose: To compare breath-hold (BH) with navigated free-breathing (FB) 3D late gadolinium enhancement cardiac MRI (LGE-CMR) MATERIALS AND METHODS: Fifty-one patients were retrospectively included (34 ischaemic cardiomyopathy, 14 non-ischaemic cardiomyopathy, three discarded). BH and FB 3D phase sensitive inversion recovery sequences were performed at 3T. FB datasets were reformatted into normal resolution (FB-NR, 1.46x1.46x10mm) and high resolution (FB-HR, isotropic 0.91-mm voxels). Scar mass,... Abstract

Cited 130 times since 2018 (17.2 per year) source: EuropePMC

The Journal of clinical investigation, Volume 128, Issue 5, 3 1 2018, Pages 1837-1851 Mycobacterial growth inhibition is associated with trained innate immunity. Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ, van Crevel R, Netea MG, Ottenhoff TH

The lack of defined correlates of protection hampers development of vaccines against tuberculosis (TB). In vitro mycobacterial outgrowth assays are thought to better capture the complexity of the human host/Mycobacterium tuberculosis (Mtb) interaction. Here, we used a mycobacterial growth inhibition assay (MGIA) based on peripheral blood mononuclear cells to investigate the capacity to control outgrowth of bacille Calmette-Guérin (BCG). Interestingly, strong control of BCG outgrowth was observed... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 12, Issue 3, 3 1 2018, Pages 212-219 Diagnostic accuracy of semi-automatic quantitative metrics as an alternative to expert reading of CT myocardial perfusion in the CORE320 study. Ostovaneh MR, Vavere AL, Mehra VC, Kofoed KF, Matheson MB, Arbab-Zadeh A, Fujisawa Y, Schuijf JD, Rochitte CE, Scholte AJ, Kitagawa K, Dewey M, Cox C, DiCarli MF, George RT, Lima JAC

Aims: To determine the diagnostic accuracy of semi-automatic quantitative metrics compared to expert reading for interpretation of computed tomography perfusion (CTP) imaging. Methods: The CORE320 multicenter diagnostic accuracy clinical study enrolled patients between 45 and 85 years of age who were clinically referred for invasive coronary angiography (ICA). Computed tomography angiography (CTA), CTP, single photon emission computed tomography (SPECT), and ICA images were interpreted manually... Abstract

Cited 20 times since 2018 (2.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 106, Issue 2, 3 1 2018, Pages 412-420 National Comparison of Hospital Performances in Lung Cancer Surgery: The Role of Case Mix Adjustment. Beck N, Hoeijmakers F, van der Willik EM, Heineman DJ, Braun J, Tollenaar RAEM, Schreurs WH, Wouters MWJM

Background: When comparing hospitals on outcome indicators, proper adjustment for case mix (a combination of patient and disease characteristics) is indispensable. This study examines the need for case mix adjustment in evaluating hospital outcomes for non-small cell lung cancer surgery. Methods: Data from the Dutch Lung Cancer Audit for Surgery were used to validate factors associated with postoperative 30-day mortality and complicated course with multivariable logistic regression models. Betwe... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 71, Issue 15, 1 1 2018, Pages 1661-1662 Machine Learning for Electrocardiographic Diagnosis of Left Ventricular Early Diastolic Dysfunction. Bax JJ, van der Bijl P, Delgado V

Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 11, Issue 4, 1 1 2018, Pages e007117 Cardiac Rotational Mechanics As a Predictor of Myocardial Recovery in Heart Failure Patients Undergoing Chronic Mechanical Circulatory Support: A Pilot Study. Bonios MJ, Koliopoulou A, Wever-Pinzon O, Taleb I, Stehlik J, Xu W, Wever-Pinzon J, Catino A, Kfoury AG, Horne BD, Nativi-Nicolau J, Adamopoulos SN, Fang JC, Selzman CH, Bax JJ, Drakos SG

Background: Impaired qualitative and quantitative left ventricular (LV) rotational mechanics predict cardiac remodeling progression and prognosis after myocardial infarction. We investigated whether cardiac rotational mechanics can predict cardiac recovery in chronic advanced cardiomyopathy patients. Methods and results: Sixty-three patients with advanced and chronic dilated cardiomyopathy undergoing implantation of LV assist device (LVAD) were prospectively investigated using speckle tracking e... Abstract

Cited 25 times since 2018 (3.3 per year) source: EuropePMC

International journal of epidemiology, Volume 47, Issue 2, 1 1 2018, Pages 396-396j Cohort Profile: The Hoorn Studies. Rutters F, Nijpels G, Elders P, Stehouwer CDA, van der Heijden AA, Groeneveld L, 't Hart LM, Dekker JM, Beulens JWJ

Abstract

Cited 115 times since 2018 (15.2 per year) source: EuropePMC

European heart journal, Volume 39, Issue 14, 1 1 2018, Pages 1131-1143 2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia. Landmesser U, Chapman MJ, Stock JK, Amarenco P, Belch JJF, Borén J, Farnier M, Ference BA, Gielen S, Graham I, Grobbee DE, Hovingh GK, Lüscher TF, Piepoli MF, Ray KK, Ray KK, Stroes ES, Wiklund O, Windecker S, Zamorano JL, Pinto F, Tokgözoglu L, Bax JJ, Catapano AL

Abstract

Cited 49 times since 2018 (6.5 per year) source: EuropePMC

Clinical pharmacokinetics, Volume 57, Issue 4, 1 1 2018, Pages 475-489 A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation. Andrews LM, Hesselink DA, van Gelder T, Koch BCP, Cornelissen EAM, Brüggemann RJM, van Schaik RHN, de Wildt SN, Cransberg K, de Winter BCM

Background: Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform body-weight based starting dose is used. It can take weeks to reach the target tacrolimus pre-dose concentration. Objectives: The objectives of this study were to determine the pharmacokinetics of tacrolimus immediately after kidney transplantation and to find relevant parameters for dose individualization using a population pharmacokinetic analy... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Annals of translational medicine, Volume 6, Issue 7, 1 1 2018, Pages 115 No association between systemic complement activation and intensive care unit-acquired weakness. Witteveen E, Wieske L, de Beer FM, Juffermans NP, Verhamme C, Schultz MJ, van Schaik IN, Horn J, BASIC study group

Background: The main risk factors for intensive care unit-acquired weakness (ICU-AW) are sepsis, the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction. These risk factors are associated with systemic complement activation. We hypothesized that critically ill patients who develop ICU-AW have increased systemic complement activation compared to critically ill patients who do not develop ICU-AW. Methods: Complement activation products C3b/c, C4b/c and C5a were measured i... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 566-572 Outcome reporting for surgical treatment of degenerative mitral valve disease: a systematic review and critical appraisal. Tomšic A, Arabkhani B, Schoones JW, van Brakel TJ, Takkenberg JJM, Palmen M, Klautz RJM

Objectives: Standardized outcome reporting is of critical importance for performance monitoring, improvement of existing techniques and introduction of novel technologies. Whether outcome reporting for surgical treatment of degenerative mitral valve disease complies with the guidelines has not been assessed to date. Methods: A systematic review of PubMed, EMBASE, Web of Science and the Cochrane Library was conducted for articles published between 1 January 2009 and 7 March 2016. Inclusion criter... Abstract

Cited 41 times since 2018 (5.4 per year) source: EuropePMC

Endocrine reviews, Volume 39, Issue 2, 1 1 2018, Pages 154-191 Diagnostic Utility of Molecular and Imaging Biomarkers in Cytological Indeterminate Thyroid Nodules. de Koster EJ, de Geus-Oei LF, Dekkers OM, van Engen-van Grunsven I, Hamming J, Corssmit EPM, Morreau H, Schepers A, Smit J, Oyen WJG, Vriens D

Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As ~25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a preoperative clinical setting, includi... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

Journal of hypertension, Volume 36, Issue 4, 1 1 2018, Pages 773-778 Association of diastolic blood pressure with cardiovascular events in older people varies upon cardiovascular history. Wijsman LW, Muller M, de Craen AJM, Jukema JW, Westendorp RGJ, Mooijaart SP

Background: In older age, a low DBP has been associated with increased risk of cardiovascular events, especially in frail older people. We tested the hypothesis that low DBP is associated with a high risk of cardiovascular events in people with a previous history of cardiovascular disease, as a proxy of vascular impairment. Methods: We included 5804 participants (mean age 75 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) who as part of the trial were intensivel... Abstract

Cited 12 times since 2018 (1.6 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 610-616 Early and late results of surgical treatment for isolated active native mitral valve infective endocarditis. Tomšic A, Versteegh MIM, Ajmone Marsan N, van Brakel TJ, Klautz RJM, Palmen M

Objectives: Native mitral valve infective endocarditis (IE) is a complicated disease with high mortality and morbidity rates. Mitral valve repair (MVRep) is feasible when limited valve destruction is present. However, recurrent valve dysfunction and reintervention are common. Methods: Between January 2000 and March 2016, 83 patients underwent surgery for isolated active native mitral valve IE. We applied an early surgery, MVRep-oriented approach with progressive utilization of patch techniques t... Abstract

Cited 9 times since 2018 (1.2 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 559-565 Mitral valve repair in Barlow's disease with bileaflet prolapse: the effect of annular stabilization on functional mitral valve leaflet prolapse. Tomšic A, Hiemstra YL, Bissessar DD, van Brakel TJ, Versteegh MIM, Ajmone Marsan N, Klautz RJM, Palmen M

Objectives: Barlow's disease is the most severe form of degenerative mitral valve disease, commonly characterized by bileaflet prolapse. Abnormal mitral annular dynamics is typically present and results in functional prolapse of the mitral leaflets that may be addressed with annular stabilization alone. Methods: Between January 2001 and December 2015, 128 patients with Barlow's disease and bileaflet prolapse underwent valve repair. This included anterior mitral valve leaflet (AMVL) rep... Abstract

Cited 41 times since 2018 (5.4 per year) source: EuropePMC

European heart journal, Volume 39, Issue 15, 1 1 2018, Pages 1308-1313 Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve. Kong WKF, Regeer MV, Poh KK, Yip JW, van Rosendael PJ, Yeo TC, Tay E, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may... Abstract