Research

Publications

Below you can find a list of our published research.

6143 results

Cited 290 times since 2009 (18 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 53, Issue 6, 1 1 2009, Pages 501-510 Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. Timmers L, Henriques JP, de Kleijn DP, Devries JH, Kemperman H, Steendijk P, Verlaan CW, Kerver M, Piek JJ, Doevendans PA, Pasterkamp G, Hoefer IE

Objectives: This study sought to examine whether exenatide is capable of reducing myocardial infarct size. Background: Exenatide is a glucagon-like peptide (GLP)-1 analogue with insulinotropic and insulinomimetic properties. Because insulin and GLP-1 have been described as reducing apoptosis, exenatide might confer cardioprotection after acute myocardial infarction (MI). Methods: Pigs were randomized to exenatide or phosphate-buffered saline (PBS) treatment after 75 min of coronary artery ligati... Abstract

Cited 9 times since 2009 (0.6 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 16, Issue 1, 1 1 2009, Pages 105-113 Effect of stent-graft compliance on endotension after EVAR. Bosman WM, Hinnen JW, Rixen DJ, Hamming JF

Purpose: To investigate whether, and to which extent, the type of graft has influence on the pressure in the aneurysm sac. Methods: The study consisted of a dynamic and a static experiment. In the dynamic experiment, a latex aneurysm was inserted into an in-vitro circulation model, with variable (80-180 mmHg) systemic systolic pressure and a pulse pressure of 40 mmHg. Seven types of devices were used to exclude the aneurysm: a latex reference graft, 3 stentless grafts made of different fabrics,... Abstract

Cited 5 times since 2009 (0.3 per year) source: EuropePMC

European journal of radiology, Volume 74, Issue 1, 29 5 2009, Pages 67-70 Improving the false-negative rate of CT in acute appendicitis-Reassessment of CT images by body imaging radiologists: a blinded prospective study. Poortman P, Lohle PN, Schoemaker CM, Cuesta MA, Oostvogel HJ, de Lange-de Klerk ES, Hamming JF

Purpose: To compare the accuracy of computed tomography (CT) analyzed by individual radiology staff members and body imaging radiologists in a non-academic teaching hospital for the diagnosis of acute appendicitis. Patients and methods: In a prospective study 199 patients with suspected acute appendicitis were examined with unenhanced CT. CT images were pre-operatively analyzed by one of the 12 members of the radiology staff. In a later stage two body imaging radiologist reassessed all CT images... Abstract

Cited 39 times since 2009 (2.4 per year) source: EuropePMC

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, Volume 12, Issue 3, 27 4 2009, Pages 179-186 Colonic diverticulitis: a prospective analysis of diagnostic accuracy and clinical decision-making. Toorenvliet BR, Bakker RF, Breslau PJ, Merkus JW, Hamming JF

Objective: To evaluate the diagnostic accuracy of clinical evaluation and cross-sectional imaging modalities such as ultrasound and computed tomography for patients with suspected colonic diverticulitis and to determine the value of these examinations in clinical decision-making. Method: A prospective analysis was conducted of 802 consecutive patients that presented with abdominal pain at the emergency department. Initial clinical diagnoses and management proposals were compared to the final dia... Abstract

Cited 55 times since 2009 (3.4 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 2, Issue 2, 26 4 2009, Pages 100-106 Prevalence of coronary artery disease assessed by multislice computed tomography coronary angiography in patients with paroxysmal or persistent atrial fibrillation. Nucifora G, Schuijf JD, Tops LF, van Werkhoven JM, Kajander S, Jukema JW, Schreur JH, Heijenbrok MW, Trines SA, Gaemperli O, Turta O, Kaufmann PA, Knuuti J, Schalij MJ, Bax JJ

Background: Although atrial fibrillation (AF) has been linked to underlying coronary artery disease (CAD), data supporting this association have been based on ECG and clinical history for the definition of CAD rather than direct visualization of atherosclerosis. Methods and results: The prevalence of CAD among patients with paroxysmal or persistent AF and without history of CAD was evaluated using multislice computed tomography. Multislice computed tomography was performed in 150 patients with A... Abstract

Cited 38 times since 2009 (2.4 per year) source: EuropePMC

The American journal of cardiology, Volume 103, Issue 6, 24 4 2009, Pages 779-784 Usefulness of peak troponin-T to predict infarct size and long-term outcome in patients with first acute myocardial infarction after primary percutaneous coronary intervention. Hassan AK, Bergheanu SC, Hasan-Ali H, Liem SS, van der Laarse A, Wolterbeek R, Atsma DE, Schalij MJ, Jukema JW

In acute myocardial infarction cardiac troponin-T (cTnT) is the preferred biomarker to detect myocardial necrosis. Our aim was to investigate the prognostic value of peak plasma cTnT in patients with ST-elevation myocardial infarction treated by primary percutaneous coronary intervention (PCI). Patients were eligible if ST-elevation myocardial infarction symptoms started Abstract

Cited 3 times since 2009 (0.2 per year) source: EuropePMC

Journal of child neurology, Volume 24, Issue 5, 23 4 2009, Pages 600-602 Paroxysmal tonic upgaze presenting as a clinical isolated syndrome. Senbil N, Yilmaz D, Yüksel D, Gürer Y

We report a 3.5-year-old boy with sudden onset of episodic upward deviation of the eyes that led to diagnosis of paroxysmal tonic upgaze. Cranial magnetic resonance imaging showed right-hand side dominant bilateral hyperintense lesions in the mesencephalon and the thalamus on T2-weighted images. These lesions suggested a demyelinating pathology. Corticosteroid treatment was started. The episodes of upward eye deviation and the lesions on magnetic resonance imaging completely resolved after 3 day... Abstract

Cited 11 times since 2009 (0.7 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 11, Issue 5, 22 4 2009, Pages 607-611 Requirement for coronary sinus lead interventions and effectiveness of endovascular replacement during long-term follow-up after implantation of a resynchronization device. Borleffs CJ, van Bommel RJ, Molhoek SG, de Leeuw JG, Schalij MJ, van Erven L

Aims: The aim of this study was to assess the requirement for coronary sinus (CS) lead intervention after cardiac resynchronization therapy (CRT) and to evaluate the effectiveness of endovascular replacement. Methods and results: All patients receiving a CRT device with CS lead in the Leiden University Medical Center in the period from 1999 to 2007 were prospectively evaluated and followed. Five hundred and seventy-seven patients were successfully implanted with a CRT device. Nine (1.6%) patient... Abstract

Cited 38 times since 2009 (2.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 29, Issue 5, 22 4 2009, Pages 657-664 Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization. Stone OA, Richer C, Emanueli C, van Weel V, Quax PH, Katare R, Kraenkel N, Campagnolo P, Barcelos LS, Siragusa M, Sala-Newby GB, Baldessari D, Mione M, Vincent MP, Benest AV, Al Haj Zen A, Gonzalez J, Bates DO, Alhenc-Gelas F, Madeddu P

Objective: Human Tissue Kallikrein (hKLK1) overexpression promotes an enduring neovascularization of ischemic tissue, yet the cellular mechanisms of hKLK1-induced arteriogenesis remain unknown. Furthermore, no previous study has compared the angiogenic potency of hKLK1, with its loss of function polymorphic variant, rs5515 (R53H), which possesses reduced kinin-forming activity. Methods and results: Here, we demonstrate that tissue kallikrein knockout mice (KLK1-/-) show impaired muscle neovascul... Abstract

Cited 1 times since 2009 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 25, Issue 3, 22 4 2009, Pages 339-342 CT angiography; no collateral damage. van der Wall EE, Schuijf JD, Jukema JW, Schalij MJ, Bax JJ

Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 16, Issue 3, 22 4 2009, Pages 440-446 Highlights of the 2008 scientific sessions of the American Society of Nuclear Cardiology : Boston, Massachusetts, 10-14 September 2008. Russell RR, Abbott BG, Arrighi JA, Bengel FM, Case JA, Faber TL, Holly TA, Mieres JH, Miller TD, Shaw LJ, Wackers FJ, Bax JJ

Abstract

Cited 147 times since 2009 (9.1 per year) source: EuropePMC

European heart journal, Volume 31, Issue 10, 21 3 2009, Pages 1172-1180 Late stent malapposition risk is higher after drug-eluting stent compared with bare-metal stent implantation and associates with late stent thrombosis. Hassan AK, Bergheanu SC, Stijnen T, van der Hoeven BL, Snoep JD, Plevier JW, Schalij MJ, Wouter Jukema J

Aims: Late stent malapposition (LSM) may be acquired (LASM) or persistent. LSM may play a role in patients who develop late stent thrombosis (ST). Our objective was to compare the risk of LASM in bare metal stents (BMS) with drug-eluting stents (DES) and to investigate the possible association of both acquired and persistent LSM with (very) late ST. Methods and results: We searched PubMed and relevant sources from January 2002 to December 2007. Inclusion criteria were: (a) intra-vascular ultraso... Abstract

Cited 12 times since 2009 (0.7 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 16, Issue 1, 20 3 2009, Pages 10-19 The additive prognostic value of perfusion and functional data assessed by quantitative gated SPECT in women. America YG, Bax JJ, Boersma E, Stokkel M, van der Wall EE

Background: The aim of this study was to assess the prognostic value of technetium-99m tetrofosmin gated SPECT imaging in women using quantitative gated single photon emission computed tomography (SPECT) imaging. Methods: We followed 453 consecutive female patients. Average follow-up was 1.33 years (max. 2.55). Hard endpoints were cardiac death, acute myocardial infarction, or documented ventricular fibrillation. Event-free survival curves were obtained. Optimal cutoff values for left ventricula... Abstract

Cited 1 times since 2009 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 25, Issue 3, 15 3 2009, Pages 315-318 CT angiography; useful in non-selected outpatients? van der Wall EE, Schuijf JD, Schalij MJ, Jukema JW, Bax JJ

Abstract

Cited 104 times since 2009 (6.4 per year) source: EuropePMC

European heart journal, Volume 30, Issue 3, 15 3 2009, Pages 266-277 Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease. Pons D, de Vries FR, van den Elsen PJ, Heijmans BT, Quax PH, Jukema JW

Significant progress has been made in the clinical management of a variety of cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current treatment modalities for atherosclerosis and restenosis is not fully sufficient in a large proportion of patients. One of the major contributing factors is the clinical and biological heterogeneity of these still life-threatening diseases, which involve processes that we do not fully understand at the moment. Over the past decades, it has be... Abstract

Cited 3 times since 2009 (0.2 per year) source: EuropePMC

Nuklearmedizin. Nuclear medicine, Volume 48, Issue 2, 14 2 2009, Pages 71-78 [Position paper nuclear cardiology: update 2008]. Schäfers M, Bengel F, Büll U, Burchert W, Kies P, Kluge R, Krause BJ, Lindner O, Nienaber C, Nowak B, Schäfer W, Schober O, Schwaiger M, Silber S, Vom Dahl J, Zimmermann R

Nuclear cardiology is well established in clinical diagnostic algorithms for many years. This is an update 2008 of the first common position paper of the German Association of Nuclear Medicine and the German Association of Cardiology, Heart and Circulation Research published in 2001 aiming at an overview of state-of-the-art scintigraphic methods. Abstract

The Annals of thoracic surgery, Volume 87, Issue 1, 1 1 2009, Pages 155-156 Invited commentary. Braun J

Abstract

Cited 22 times since 2009 (1.4 per year) source: EuropePMC

Pediatric research, Volume 65, Issue 1, 1 1 2009, Pages 27-32 Pulmonary vein, dorsal atrial wall and atrial septum abnormalities in podoplanin knockout mice with disturbed posterior heart field contribution. Douglas YL, Mahtab EA, Jongbloed MR, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Deruiter MC, Gittenberger-de Groot AC

The developing sinus venosus myocardium, derived from the posterior heart field, contributes to the atrial septum, the posterior atrial wall, the sino-atrial node, and myocardium lining the pulmonary and cardinal veins, all expressing podoplanin, a coelomic and myocardial marker. We compared development and differentiation of the myocardium and vascular wall of the pulmonary veins (PV), left atrial dorsal wall, and atrial septum in wild type with podoplanin knockout mouse embryos (E10.5-E18.5) b... Abstract

Cited 7 times since 2009 (0.4 per year) source: EuropePMC

Disease markers, Volume 26, Issue 2, 1 1 2009, Pages 75-83 Metabolic background determines the importance of NOS3 polymorphisms in restenosis after percutaneous coronary intervention: A study in patients with and without the metabolic syndrome. Pons D, Monraats PS, Zwinderman AH, de Maat MP, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, Jukema JW

Variation in the NOS3 gene has been related to the development of restenosis. The Glu298Asp polymorphism has previously been investigated for its effect on NO levels and the development of restenosis. However, the variability of findings gave rise to the hypothesis that the functional significance of this polymorphism may only become manifest under conditions of endothelial dysfunction. Since patients with the metabolic syndrome are known to have endothelial dysfunction, we aimed to investigate... Abstract

Cited 43 times since 2009 (2.7 per year) source: EuropePMC

PLoS medicine, Volume 6, Issue 1, 1 1 2009, Pages e16 Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis. Ford I, Bezlyak V, Stott DJ, Sattar N, Packard CJ, Perry I, Buckley BM, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J

Background: Reduced glomerular filtration rate (GFR) is associated with increased cardiovascular risk in young and middle aged individuals. Associations with cardiovascular disease and mortality in older people are less clearly established. We aimed to determine the predictive value of the GFR for mortality and morbidity using data from the 5,804 participants randomized in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Methods and findings: Glomerular filtration rate was... Abstract