Research

Publications

Below you can find a list of our published research.

6143 results

Cited 67 times since 2008 (3.9 per year) source: EuropePMC

European heart journal, Volume 29, Issue 4, 17 3 2008, Pages 557-563 Clinical value, cost-effectiveness, and safety of myocardial perfusion scintigraphy: a position statement. Marcassa C, Bax JJ, Bengel F, Hesse B, Petersen CL, Reyes E, Underwood R, European Council of Nuclear Cardiology (ECNC), European Society of Cardiology Working Group 5 (Nuclear Cardiology and Cardiac CT), European Association of Nuclear Medicine Cardiovascular Committee

Mortality rates due to coronary artery disease (CAD) have declined in recent years as result of improved prevention, diagnosis, and management. Nonetheless, CAD remains the leading cause of death worldwide with most casualties expected to occur in developing nations. Myocardial perfusion scintigraphy (MPS) provides a highly cost-effective tool for the early detection of obstructive CAD in symptomatic individuals and contributes substantially to stratification of patients according to their risk... Abstract

Cited 30 times since 2008 (1.7 per year) source: EuropePMC

Clinical and vaccine immunology : CVI, Volume 15, Issue 3, 16 3 2008, Pages 522-533 Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection. Geluk A, van der Ploeg J, Teles RO, Franken KL, Prins C, Drijfhout JW, Sarno EN, Sampaio EP, Ottenhoff TH

The stable incidence of new leprosy cases suggests that transmission of infection is continuing despite the worldwide implementation of multidrug therapy programs. Highly specific tools are required to accurately diagnose asymptomatic and early stage Mycobacterium leprae infections which are the likely sources of transmission and cannot be identified by using the detection of antibodies against phenolic glycolipid I. One of the hurdles hampering T-cell-based diagnostic tests is that M. leprae an... Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 95, Issue 2, 15 3 2008, Pages 119-124 Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain. van Ramshorst J, Atsma DE, Beeres SL, Mollema SA, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Objective: To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony. Methods: In 14 patients with severe postinfarction heart failure, 93 (14) x 10(6) autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infar... Abstract

Cited 16 times since 2008 (0.9 per year) source: EuropePMC

Archives of gerontology and geriatrics, Volume 48, Issue 1, 4 1 2008, Pages 116-120 Elderly patients undergoing major vascular surgery: risk factors and medication associated with risk reduction. Feringa HH, Bax JJ, Karagiannis SE, Noordzij P, van Domburg R, Klein J, Poldermans D

This study assesses risk factors in elderly vascular surgery patients and to evaluate whether perioperative cardiac medication can reduce postoperative mortality rate. In a cohort study, 1693 consecutive patients > or =65 years undergoing major non-cardiac vascular surgery were preoperatively screened for cardiac risk factors and medication. During follow-up (median: 8.2 years), mortality was noted. Hospital mortality occurred in 8.1% and long-term mortality in 28.5%. In multivariate analysis... Abstract

Cited 43 times since 2008 (2.5 per year) source: EuropePMC

Current pharmaceutical design, Volume 14, Issue 12, 1 1 2008, Pages 1205-1216 Bridging innate immunity and myocardial ischemia/reperfusion injury: the search for therapeutic targets. Arslan F, de Kleijn DP, Timmers L, Doevendans PA, Pasterkamp G

Myocardial infarction necessitates new therapeutic interventions, since it still results in high morbidity and mortality worldwide. Reperfusion therapy itself results in (acceleration of) apoptosis, called myocardial ischemia/reperfusion (I/R) injury. For several decades it is known that the inflammatory response during reperfusion is the major cause of myocardial I/R injury. Therapeutic options are limited by lack of (detailed) understanding of intra- and intercellular mechanisms between inflam... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 1, Issue 1, 1 1 2008, Pages 119-128 Imaging highlights from the European Society of Cardiology, American Society of Nuclear Cardiology, and Heart Failure Society of America. Knuuti J, Poldermans D, Udelson JE, Wackers FJ, Bax JJ

Cardiac imaging has become an integrated part in the diagnostic and prognostic work-up of patients with cardiovascular disease. In this article, highlights of scientific abstracts on cardiac imaging presented at the European Society of Cardiology (ESC), the American Society of Nuclear Cardiology (ASNC), and the Heart Failure Society of America (HFSA) are summarized. Abstract

Journal of the American College of Cardiology, Volume 51, Issue 4, 1 1 2008, Pages 490-512 Highlights of the year in JACC 2007. DeMaria AN, Bax JJ, Ben-Yehuda O, Clopton P, Feld GK, Ginsburg GS, Greenberg BH, Knoke JD, Lew WY, Lima JA, Maisel AS, Narayan SM, Narula J, Sahn DJ, Tsimikas S

Abstract

Cited 23 times since 2008 (1.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 3, 1 1 2008, Pages 79-87 Guidelines for heart transplantation. de Jonge N, Kirkels JH, Klöpping C, Lahpor JR, Caliskan K, Maat AP, Brügemann J, Erasmus ME, Klautz RJ, Verwey HF, Oomen A, Peels CH, Golüke AE, Nicastia D, Koole MA, Balk AH

Based on the changes in the field of heart transplantation and the treatment and prognosis of patients with heart failure, these updated guidelines were composed by a committee under the supervision of both the Netherlands Society of Cardiology and the Netherlands Association for Cardiothoracic surgery (NVVC and NVT).THE INDICATION FOR HEART TRANSPLANTATION IS DEFINED AS: 'End-stage heart disease not remediable by more conservative measures'.CONTRAINDICATIONS ARE: irreversible pulmonar... Abstract

Cited 17 times since 2008 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 2, 1 1 2008, Pages 144-148 Comparison of multislice computed tomography to gated single-photon emission computed tomography for imaging of healed myocardial infarcts. Henneman MM, Schuijf JD, Dibbets-Schneider P, Stokkel MP, van der Geest RJ, van der Wall EE, Bax JJ

The aim of the study was to evaluate the performance of multislice computed tomography (MSCT) for the detection and semiquantitative analysis of healed myocardial infarct in comparison to single-photon emission computed tomography (SPECT). Recently, MSCT was shown to allow detection of myocardial infarct by the presence of hypoenhanced areas. However, direct comparisons to other imaging modalities for infarct imaging were scarce. In 69 patients with healed myocardial infarct (>3 months), the... Abstract

Cited 169 times since 2008 (9.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 51, Issue 1, 1 1 2008, Pages 37-45 Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. Afilalo J, Duque G, Steele R, Jukema JW, de Craen AJ, Eisenberg MJ

Objectives: This study was designed to determine whether statins reduce all-cause mortality in elderly patients with coronary heart disease. Background: Statins continue to be underutilized in elderly patients because evidence has not consistently shown that they reduce mortality. Methods: We searched 5 electronic databases, the Internet, and conference proceedings to identify relevant trials. In addition, we obtained unpublished data for the elderly patient subgroups from 4 trials and for the s... Abstract

Cited 19 times since 2008 (1.1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 1, Issue 1, 1 1 2008, Pages 94-106 Noncoronary applications of cardiac multidetector row computed tomography. Tops LF, Krishnàn SC, Schuijf JD, Schalij MJ, Bax JJ

Multidetector row computed tomography (MDCT) has a high diagnostic accuracy to evaluate coronary artery stenoses. Additionally, the 4-dimensional aspect of cardiac MDCT allows a comprehensive evaluation of cardiac structure and function. Left ventricular volumes and systolic function can be accurately assessed with MDCT, and imaging of myocardial infarction is a promising application of cardiac MDCT. In addition, MDCT may provide anatomical visualization of heart valves. Also, evaluation of anat... Abstract

Cited 6 times since 2008 (0.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 1, 1 1 2008, Pages 30-32 Epigenetic histone acetylation modifiers in vascular remodelling - new targets for therapy in cardiovascular disease. Pons D, Jukema JW

Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Multimedia manual of cardiothoracic surgery : MMCTS, Volume 2008, Issue 915, 1 1 2008, Pages mmcts.2006.002329 Surgery for supravalvular aortic stenosis - the three-patch technique. Arnáiz E, Koolbergen D, Adsuar A, Hazekamp MG

The objective of this paper is to describe the three-patch technique for repair of supravalvular aortic stenosis (SVAS). Supravalvular aortic stenosis is a rare malformation as a result of an abnormal thickening of the aortic wall. SVAS may present in two forms: a localized form (affecting only the aortic sinotubular junction) and a diffuse form, where the aortic arch and its side branches are also affected. Since 1960, multiple surgical techniques have been described with the aim of relieving t... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Mayo Clinic proceedings, Volume 83, Issue 1, 1 1 2008, Pages 10-12 Can coronary calcification define the warranty period of a normal myocardial perfusion study? Bax JJ, Schuijf JD

Abstract

Cited 57 times since 2008 (3.3 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 15, Issue 1, 1 1 2008, Pages 127-136 Assessment of left ventricular mechanical dyssynchrony by phase analysis of ECG-gated SPECT myocardial perfusion imaging. Chen J, Henneman MM, Trimble MA, Bax JJ, Borges-Neto S, Iskandrian AE, Nichols KJ, Garcia EV

Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. However, at least 30% of patients selected for CRT by use of traditional criteria (New York Heart Association class III or IV, depressed left ventricular [LV] ejection fraction, and prolonged QRS duration) do not respond to CRT. Recent studies with tissue Doppler imaging have shown that the presence of LV dyssynchrony is an important predictor of response to CRT. Phase analysis has been developed to... Abstract

Cited 40 times since 2008 (2.3 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 1, 1 1 2008, Pages 122-126 Influence of renal function on the usefulness of N-terminal pro-B-type natriuretic peptide as a prognostic cardiac risk marker in patients undergoing noncardiac vascular surgery. Goei D, Schouten O, Boersma E, Welten GM, Dunkelgrun M, Lindemans J, van Gestel YR, Hoeks SE, Bax JJ, Poldermans D

N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is related to stress-induced myocardial ischemia and/or volume overload, both common in patients with renal dysfunction. This might compromise the prognostic usefulness of NT-pro-BNP in patients with renal impairment before vascular surgery. We assessed the prognostic value of NT-pro-BNP in the entire strata of renal function. In 356 patients (median age 69 years, 77% men), cardiac history, glomerular filtration rate (GFR, ml/min/1.73 m(2)),... Abstract

Cited 35 times since 2007 (2 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 1, 27 4 2007, Pages 161-167 High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants. van Acker BA, Botma GJ, Zwinderman AH, Kuivenhoven JA, Dallinga-Thie GM, Sijbrands EJ, Boer JM, Seidell JC, Jukema JW, Kastelein JJ, Jansen H, Verhoeven AJ, REGRESS Study Group

Cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are two HDL modifying proteins that have both pro- and anti-atherogenic properties. We hypothesized that CETP and HL synergistically affect HDL cholesterol and atherosclerotic risk. To test our hypothesis, we analysed the genotype frequencies of CETP Taq1B (rs708272) and LIPC-514C/T (rs1800588) polymorphisms in male coronary artery disease patients (CAD; n=792) and non-symptomatic controls (n=539). Cases and controls had similar a... Abstract

Cited 33 times since 2007 (1.9 per year) source: EuropePMC

Tuberculosis (Edinburgh, Scotland), Volume 88, Issue 3, 26 4 2007, Pages 249-261 Double-blind randomized Phase I study comparing rdESAT-6 to tuberculin as skin test reagent in the diagnosis of tuberculosis infection. Arend SM, Franken WP, Aggerbeck H, Prins C, van Dissel JT, Thierry-Carstensen B, Tingskov PN, Weldingh K, Andersen P

Limited specificity of the tuberculin skin test incited the development of in vitro assays based on Mycobacterium tuberculosis-specific antigens such as ESAT-6 that are lacking in Bacillus Calmette Guérin (BCG). In animal studies, intradermal ESAT-6 was safe and induced specific skin test responses. The aim of the study was to assess the safety of intradermal recombinant dimer ESAT-6 (rdESAT-6) compared with tuberculin and to determine the human dose. The study design was a double-blind Phase I... Abstract

Cited 79 times since 2007 (4.6 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 19, Issue 4, 20 3 2007, Pages 392-399 Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Ghio S, van de Veire NR, Holman ER, van der Wall EE, Tavazzi L, Schalij MJ, Bax JJ

Objective: To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT). Methods: Sixty consecutive heart failure patients scheduled for CRT were included. RT3DE was performed before and within 48 hours after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard deviation of the time taken to reach the minimum systolic volume for... Abstract

Cited 43 times since 2007 (2.5 per year) source: EuropePMC

Biochemical and biophysical research communications, Volume 366, Issue 4, 18 3 2007, Pages 910-916 Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity. Pols TW, Ottenhoff R, Vos M, Levels JH, Quax PH, Meijers JC, Pannekoek H, Groen AK, de Vries CJ

NR4A nuclear receptors are induced in the liver upon fasting and regulate hepatic gluconeogenesis. Here, we studied the role of nuclear receptor Nur77 (NR4A1) in hepatic lipid metabolism. We generated mice expressing hepatic Nur77 using adenoviral vectors, and demonstrate that these mice exhibit a modulation of the plasma lipid profile and a reduction in hepatic triglyceride. Expression analysis of >25 key genes involved in lipid metabolism revealed that Nur77 inhibits SREBP1c expression. Thi... Abstract