9026 results
Cited 20 times since 2013 (1.6 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 19, Issue 18, 5 1 2013, Pages 5210-5217
A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.
de Graan AJ, Elens L, Smid M, Martens JW, Sparreboom A, Nieuweboer AJ, Friberg LE, Elbouazzaoui S, Wiemer EA, van der Holt B, Verweij J, van Schaik RH, Mathijssen RH
Purpose: Paclitaxel is used in the treatment of solid tumors and displays high interindividual variation in exposure. Low paclitaxel clearance could lead to increased toxicity during treatment. We present a genetic prediction model identifying patients with low paclitaxel clearance, based on the drug-metabolizing enzyme and transporter (DMET)-platform, capable of detecting 1,936 genetic variants in 225 metabolizing enzyme and drug transporter genes. Experimental design: In 270 paclitaxel-treated...
Abstract
Journal of molecular and cellular cardiology,
Volume 63, 2 1 2013, Pages 118-121
Mediators of inflammation after cardiac ischemia: the role of invariant natural killer T (iNKT) cells.
Arslan F
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
Cardiovascular & hematological disorders drug targets,
Volume 13, Issue 2, 1 1 2013, Pages 111-122
Anti-apoptotic serpins as therapeutics in cardiovascular diseases.
Kuiper J, Quax PH, Bot I
Acute cardiovascular syndromes such as myocardial infarction and stroke are a major cause of death in the Western society and are generally caused by rupture of an atherosclerotic plaque. Treatment of atherosclerosis, the main underlying cause of acute cardiovascular syndromes, is still inadequate for most of the patients. Therefore, there is a need for new therapeutic strategies in addition to the existing lipid-lowering drugs such as statins. Lipid accumulation, inflammation and matrix degrada...
Abstract
Cited 51 times since 2013 (4.2 per year)
source: EuropePMC
Lancet (London, England),
Volume 382, Issue 9892, 1 1 2013, Pages 644-657
Future treatment strategies in ST-segment elevation myocardial infarction.
Windecker S, Bax JJ, Myat A, Stone GW, Marber MS
Over the past five decades, management of acute ST-segment elevation myocardial infarction (STEMI) has evolved substantially. Current treatment encompasses a systematic chain of network activation, antithrombotic drugs, and rapid instigation of mechanical reperfusion, although pharmacoinvasive strategies remain relevant. Secondary prevention with drugs and lifestyle modifications completes the contemporary management package. Despite a tangible improvement in outcomes, STEMI remains a frequent c...
Abstract
Cited 14 times since 2013 (1.1 per year)
source: EuropePMC
Pharmacogenomics,
Volume 14, Issue 11, 1 1 2013, Pages 1295-1304
Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.
de Keyser CE, Becker ML, Uitterlinden AG, Hofman A, Lous JJ, Elens L, Visser LE, van Schaik RH, Stricker BH
Aim: Recently, minor alleles of two strongly linked polymorphisms in the PPARA gene, rs4253728 G>A and rs4823613 A>G, were related to decreased CYP3A4 expression and activity. We studied whether they were associated with the cholesterol-lowering effect of simvastatin. Materials & methods: We identified 123 incident users with cholesterol measurements before and after starting statin therapy in a prospective population-based cohort study. Associations between PPARA polymorphisms and cha...
Abstract
Cited 31 times since 2013 (2.5 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 35, Issue 4, 1 1 2013, Pages 459-465
Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus.
Vafadari R, Bouamar R, Hesselink DA, Kraaijeveld R, van Schaik RH, Weimar W, Baan CC, van Gelder T
Introduction: Tacrolimus has a large interindividual pharmacokinetic variability, and quantification of its effect is difficult. It is a substrate of ABCB1, an efflux pump expressed more on CD8 T cells than on CD4 T cells. The ABCB1 3435C>T single-nucleotide polymorphism (SNP) has been associated with interindividual differences in ABCB1 activity and may influence drug efficacy. Here the influence of this SNP on the biological effect of tacrolimus was studied. Methods: Rhodamine (Rh123) efflu...
Abstract
Cited 35 times since 2013 (2.8 per year)
source: EuropePMC
Future microbiology,
Volume 8, Issue 8, 1 1 2013, Pages 993-1010
The cell wall architecture of Enterococcus faecium: from resistance to pathogenesis.
Hendrickx AP, van Schaik W, Willems RJ
The cell wall of Gram-positive bacteria functions as a surface organelle that continuously interacts with its environment through a plethora of cell wall-associated molecules. Enterococcus faecium is a normal inhabitant of the GI tract of mammals, but has recently become an important etiological agent of hospital-acquired infections in debilitated patients. Insights into the assembly and function of enterococcal cell wall components and their interactions with the host during colonization and in...
Abstract
Cited 17 times since 2013 (1.4 per year)
source: EuropePMC
Journal of clinical psychopharmacology,
Volume 33, Issue 4, 1 1 2013, Pages 546-550
Association between genetic variation in the ABCB1 gene and switching, discontinuation, and dosage of antidepressant therapy: results from the Rotterdam Study.
Noordam R, Aarts N, Hofman A, van Schaik RH, Stricker BH, Visser LE
The objective of this study was to investigate whether polymorphisms in the ABCB1 gene were associated with switching, with discontinuation of antidepressants within 45 days after starting therapy, and/or with dose change in a large prospective population-based cohort study. Between April 1, 1991, and December 31, 2007, there were 1257 incident users of antidepressants with known ABCB1 genotypes (1236C>T, 2677G>T/A, 3435C>T) in the population-based Rotterdam Study. Logistic regression m...
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
Spine,
Volume 38, Issue 18, 1 1 2013, Pages 1590-1594
An evaluation of web sites recommended by UK NHS consultants to patients with adolescent idiopathic scoliosis at the first point of diagnosis.
Wellburn S, Bettany-Saltikov J, van Schaik P
Study design: An Internet-based evaluation of Web sites using a validated assessment tool. Objective: To evaluate the quality of information on scoliosis Web sites recommended by UK NHS consultants. Summary of background data: One of the most common sources of inquiry on the Web is for the purposes of health-related information. The number of Web sites in the field of scoliosis has increased, yet the quality of information is reported to continue to be of poor quality. The 2 previous studies in...
Abstract
Cited 8 times since 2013 (0.7 per year)
source: EuropePMC
Kidney international,
Volume 85, Issue 1, 31 5 2013, Pages 94-102
Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling.
San-Cristobal P, Lainez S, Dimke H, de Graaf MJ, Hoenderop JG, Bindels RJ
The voltage-gated potassium channel, Kv1.1, was recently identified as a causative gene in isolated dominant hypomagnesemia. The channel is situated in the distal convoluted tubule, where it participates in maintaining a favorable electrical gradient for driving magnesium ion into the cell through the transient receptor potential melastatin 6 channel. Pull-down experiments coupled to mass spectrometry using the carboxy-terminal domain of Kv1.1 as bait were used in mouse kidney lysates. Ankyrin-3...
Abstract
Cited 93 times since 2013 (7.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 62, Issue 21, 31 5 2013, Pages 1966-1976
Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.
Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EPA, Li M, Leusink M, Trompet S, Verschuren JJW, Hovingh GK, Dehghan A, Nelson CP, Kotti S, Danchin N, Scholz M, Haase CL, Rothenbacher D, Swerdlow DI, Kuchenbaecker KB, Staines-Urias E, Goel A, van 't Hooft F, Gertow K, de Faire U, Panayiotou AG, Tremoli E, Baldassarre D, Veglia F, Holdt LM, Beutner F, Gansevoort RT, Navis GJ, Mateo Leach I, Breitling LP, Brenner H, Thiery J, Dallmeier D, Franco-Cereceda A, Boer JMA, Stephens JW, Hofker MH, Tedgui A, Hofman A, Uitterlinden AG, Adamkova V, Pitha J, Onland-Moret NC, Cramer MJ, Nathoe HM, Spiering W, Klungel OH, Kumari M, Whincup PH, Morrow DA, Braund PS, Hall AS, Olsson AG, Doevendans PA, Trip MD, Tobin MD, Hamsten A, Watkins H, Koenig W, Nicolaides AN, Teupser D, Day INM, Carlquist JF, Gaunt TR, Ford I, Sattar N, Tsimikas S, Schwartz GG, Lawlor DA, Morris RW, Sandhu MS, Poledne R, Maitland-van der
Objectives: This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease. Background: Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal. A recent phase III clinical trial of an sPLA2 inhibitor (varespladib) was stopped prematurely for lack of efficacy. Methods: We conducted a Mendelian randomization meta-anal...
Abstract
Cited 18 times since 2013 (1.5 per year)
source: EuropePMC
Resuscitation,
Volume 84, Issue 11, 30 5 2013, Pages 1530-1535
Association between angiographic culprit lesion and out-of-hospital cardiac arrest in ST-elevation myocardial infarction patients.
Velders MA, van Boven N, Boden H, van der Hoeven BL, Heestermans AA, Jukema JW, de Jonge E, Kuiper MA, van Boven AJ, Hofma SH, Schalij MJ, Umans VA
Background: Factors related to the occurrence of out-of-hospital cardiac arrest (OHCA) in ST-elevation myocardial infarction (STEMI) are still poorly understood. The current study sought to compare STEMI patients presenting with and without OHCA to identify angiographic factors related to OHCA. Methods: This multicenter registry consisted of consecutive STEMI patients, including OHCA patients with return-of-spontaneous circulation. Patients were treated with primary percutaneous coronary interve...
Abstract
Cited 42 times since 2013 (3.4 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 112, Issue 1-2, 30 5 2013, Pages 35-47
Schmallenberg virus epidemic in the Netherlands: spatiotemporal introduction in 2011 and seroprevalence in ruminants.
Veldhuis AM, van Schaik G, Vellema P, Elbers AR, Bouwstra R, van der Heijden HM, Mars MH
This study aimed at estimating the Schmallenberg virus (SBV) seroprevalence in dairy heifers, non-dairy adult cattle, sheep and goats in the Netherlands after cessation of SBV transmission at the end of 2011. Archived serum samples from ruminants submitted to the GD Animal Health Service for monitoring purposes between November 2011 and March 2012 were selected and tested for presence of SBV-specific antibodies using an in-house ELISA. Animal seroprevalences were estimated at 63.4% in dairy heif...
Abstract
Cited 490 times since 2013 (39.9 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 7, 30 5 2013, Pages e65174
The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis.
Singh GM, Danaei G, Farzadfar F, Stevens GA, Woodward M, Wormser D, Kaptoge S, Whitlock G, Qiao Q, Lewington S, Di Angelantonio E, Vander Hoorn S, Lawes CM, Ali MK, Mozaffarian D, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group; Asia-Pacific Cohort Studies Collaboration (APCSC), Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE), Emerging Risk Factor Collaboration (ERFC), Prospective Studies Collaboration (PSC)
Background: The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk of cardiovascular diseases (CVD) have been established in epidemiological studies, but consistent estimates of effect sizes by age and sex are not available. Methods: We reviewed large cohort pooling projects, evaluating effects of baseline or usual exposure to metabolic risks on ischemic heart disease (IHD), hypertensive heart disease (HHD),...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 7, 29 5 2013, Pages e69796
Connectivity between migrating and landlocked populations of a diadromous fish species investigated using otolith microchemistry.
Tulp I, Keller M, Navez J, Winter HV, de Graaf M, Baeyens W
Smelt Osmerus eperlanus has two different life history strategies in The Netherlands. The migrating population inhabits the Wadden Sea and spawns in freshwater areas. After the closure of the Afsluitdijk in 1932, part of the smelt population became landlocked. The fresh water smelt population has been in severe decline since 1990, and has strongly negatively impacted the numbers of piscivorous water birds relying on smelt as their main prey. The lakes that were formed after the dike closure, IJs...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
BMJ case reports,
Volume 2013, 29 5 2013, Pages bcr2013010219
An unusual cause of constipation in a 72-year-old man with a rising creatinine.
Pimenta D, Yilmaz D, Grossman R, Soin B
Abstract
Cited 123 times since 2013 (10 per year)
source: EuropePMC
BMJ (Clinical research ed.),
Volume 347, 29 5 2013, Pages f4600
Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study.
Sabayan B, Wijsman LW, Foster-Dingley JC, Stott DJ, Ford I, Buckley BM, Sattar N, Jukema JW, van Osch MJ, van der Grond J, van Buchem MA, Westendorp RG, de Craen AJ, Mooijaart SP
Objective: To investigate the association between visit-to-visit variability in blood pressure and cognitive function in old age (>70 years). Design: Prospective cohort study. Setting: PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) study, a collaboration between centres in Ireland, Scotland, and the Netherlands. Participants: 5461 participants, mean age 75.3 years, who were at risk of cardiovascular disease. Blood pressure was measured every three months during an average o...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 29, Issue 8, 27 4 2013, Pages 1829-1837
Association of atherosclerosis in the descending thoracic aorta with coronary artery disease on multi detector row computed tomography coronary angiography in patients with suspected coronary artery disease.
Roos CJ, Witkowska AJ, de Graaf MA, Veltman CE, Delgado V, de Grooth GJ, Jukema JW, Bax JJ, Scholte AJ
The association between atherosclerosis in the descending thoracic aorta (DTA) visualized on computed tomography coronary angiography (CTA) and coronary artery disease (CAD) has not been extensively explored. Therefore, a comprehensive analysis of DTA atherosclerosis on CTA was performed and the association of DTA atherosclerosis with CAD was evaluated in patients with suspected CAD. A total of 344 patients (54 ± 12 years, 54% men) with suspected CAD underwent CTA. CTA were classified based on C...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
Renal failure,
Volume 35, Issue 8, 26 4 2013, Pages 1163-1166
Intravascular large B-cell lymphoma presenting with anasarca-type edema and acute renal failure.
Bilgili SG, Yılmaz D, Soyoral YU, Karadag AS, Bayram I
Intravascular lymphoma (IVL) is a rare extra nodal subtype (usually of B-cell origin) presenting with infiltration of large neoplastic lymphocytes into lumina of blood vessels, leading to vascular occlusion. The early diagnosis is very crucial, however it is usually diagnosed postmortem investigation in most of the cases. A 56-year-old female presented with elevated creatinine level, and anasarca-type edema that superimposed with hard, indurated, erythematous plaques extending to inguinal region...
Abstract
Cited 21 times since 2013 (1.7 per year)
source: EuropePMC
BMC palliative care,
Volume 12, Issue 1, 23 4 2013, Pages 26
Improving palliative care outcomes for Aboriginal Australians: service providers' perspectives.
Shahid S, Bessarab D, van Schaik KD, Aoun SM, Thompson SC
Background: Aboriginal Australians have a lower rate of utilisation of palliative care services than the general population. This study aimed to explore care providers' experiences and concerns in providing palliative care for Aboriginal people, and to identify opportunities for overcoming gaps in understanding between them and their Aboriginal patients and families. Methods: In-depth, qualitative interviews with urban, rural and remote palliative care providers were undertaken in inpatient...
Abstract
