Publications
Below you can find a list of our published research.
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Below you can find a list of our published research.
6241 results
Cited 15 times since 2014 (1.3 per year) source: EuropePMC
Cardiovascular research, Volume 102, Issue 2, 27 4 2014, Pages 224-231 Interaction between myofibroblasts and stem cells in the fibrotic heart: balancing between deterioration and regeneration. Ramkisoensing AA, de Vries AA, Atsma DE, Schalij MJ, Pijnappels DA
Signalling between the various cell types in the heart has been investigated for decades. However, relatively little is known about the interplay between the cardiac fibroblasts and myofibroblasts, which help to maintain myocardial tissue structure and function, and resident cardiac or extracardiac stem cells involved in tissue homeostasis and repair. Much of our knowledge about these interactions is derived from experimental animal models, especially those of myocardial infarction and stem cell... Abstract
Cited 33 times since 2014 (2.9 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 34, Issue 5, 27 4 2014, Pages 1093-1101 Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Huang J, Huffman JE, Yamakuchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Bis JC, Ikram MA, Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group, Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, CARDIoGRAM Consortium, Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Specto
Objective: Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases. We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA. Approach and results: Fourteen cohort studies with tPA measures (N=... Abstract
Cited 47 times since 2014 (4.1 per year) source: EuropePMC
American heart journal, Volume 167, Issue 5, 26 4 2014, Pages 666-673 Prognosis of elderly patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention in 2001 to 2011: A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) registry. Velders MA, James SK, Libungan B, Sarno G, Fröbert O, Carlsson J, Schalij MJ, Albertsson P, Lagerqvist B
Background: Elderly patients constitute a growing part of the population presenting with ST-elevation myocardial infarction (STEMI). The use of primary percutaneous coronary intervention (PCI) in this high-risk population remains poorly investigated. Methods: Using the Swedish Coronary Angiography and Angioplasty Registry (SCAAR), we identified consecutive patients with STEMI 80 years or older undergoing primary PCI during a 10-year period. Temporal trends in care and 1-year prognosis were inves... Abstract
Cited 24 times since 2014 (2.1 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 46, Issue 3, 23 4 2014, Pages 474-9; discussion 479 Reoperation for neoaortic root pathology after the arterial switch operation. Koolbergen DR, Manshanden JS, Yazdanbakhsh AP, Bouma BJ, Blom NA, de Mol BA, Mulder BJ, Hazekamp MG
Objectives: To evaluate incidence and results of surgical intervention for neoaortic root pathology following arterial switch operation (ASO) for transposition of the great arteries (TGA). Methods: Between April 1996 and August 2013, 12 patients underwent reoperation for neoaortic root dilatation (ARD) and/or neoaortic valve regurgitation (AR). Maximal aortic sinus and annulus diameter Z-scores were recorded. Original diagnoses were TGA/IVS (6), TGA/ventricular septal defect (VSD) (4) and Taussi... Abstract
Cited 7 times since 2014 (0.6 per year) source: EuropePMC
TheScientificWorldJournal, Volume 2014, 23 4 2014, Pages 531324 Echocardiographic assessment of embryonic and fetal mouse heart development: a focus on haemodynamics and morphology. Hahurij ND, Calkoen EE, Jongbloed MR, Roest AA, Gittenberger-de Groot AC, Poelmann RE, De Ruiter MC, van Munsteren CJ, Steendijk P, Blom NA
Background: Heart development is a complex process, and abnormal development may result in congenital heart disease (CHD). Currently, studies on animal models mainly focus on cardiac morphology and the availability of hemodynamic data, especially of the right heart half, is limited. Here we aimed to assess the morphological and hemodynamic parameters of normal developing mouse embryos/fetuses by using a high-frequency ultrasound system. Methods: A timed breeding program was initiated with a WT m... Abstract
Cited 85 times since 2014 (7.5 per year) source: EuropePMC
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 40, Issue 7, 22 4 2014, Pages 850-858 Real-time intraoperative detection of breast cancer using near-infrared fluorescence imaging and Methylene Blue. Tummers QR, Verbeek FP, Schaafsma BE, Boonstra MC, van der Vorst JR, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: Despite recent developments in preoperative breast cancer imaging, intraoperative localization of tumor tissue can be challenging, resulting in tumor-positive resection margins during breast conserving surgery. Based on certain physicochemical similarities between Technetium((99m)Tc)-sestamibi (MIBI), an SPECT radiodiagnostic with a sensitivity of 83-90% to detect breast cancer preoperatively, and the near-infrared (NIR) fluorophore Methylene Blue (MB), we hypothesized that MB might... Abstract
Cited 10 times since 2014 (0.9 per year) source: EuropePMC
PloS one, Volume 9, Issue 2, 21 3 2014, Pages e88984 Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis. Willems S, van der Velden D, Quax PH, de Borst GJ, de Vries JP, Moll FL, Kuiper J, Toes RE, de Jager SC, de Kleijn DP, Hoefer IE, Pasterkamp G, Bot I
Background: Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the endogenous triggers that activate mast cells during the progression and destabilization of atherosclerotic lesions remain unidentified. Mast cells can be activated by immunoglobulins and in the present study, we aimed to... Abstract
Cited 11 times since 2014 (1 per year) source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 47, Issue 5, 20 3 2014, Pages 479-486 Differences in mortality, risk factors, and complications after open and endovascular repair of ruptured abdominal aortic aneurysms. von Meijenfeldt GC, Ultee KH, Eefting D, Hoeks SE, ten Raa S, Rouwet EV, Hendriks JM, Verhagen HJ, Bastos Goncalves FM
Objective/background: Endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysm (rAAA) has faced resistance owing to the marginal evidence of benefit over open surgical repair (OSR). This study aims to determine the impact of treatment modality on early mortality after rAAA, and to assess differences in postoperative complications and long-term survival. Methods: Patients treated between January 2000 and June 2013 were identified. The primary endpoint was early mortality. Second... Abstract
Cited 27 times since 2014 (2.4 per year) source: EuropePMC
Obesity (Silver Spring, Md.), Volume 22, Issue 6, 18 3 2014, Pages 1553-1559 Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation. Hillebrand S, de Mutsert R, Christen T, Maan AC, Jukema JW, Lamb HJ, de Roos A, Rosendaal FR, den Heijer M, Swenne CA, NEO Study Group
Objective: Obesity is associated with sympathetic activation, but the role of different fat depots is unclear. The association between body fat, specifically visceral fat, and electrocardiographic measures of sympathetic activation in a population with structurally normal hearts was investigated. Methods: In this cross-sectional baseline analysis of the Netherlands Epidemiology of Obesity study, body fat percentage was assessed with BIA and abdominal subcutaneous (SAT) and visceral adipose tissu... Abstract
Cited 37 times since 2014 (3.2 per year) source: EuropePMC
European heart journal, Volume 35, Issue 22, 16 3 2014, Pages 1479-1485 Radio-frequency ablation as primary management of well-tolerated sustained monomorphic ventricular tachycardia in patients with structural heart disease and left ventricular ejection fraction over 30%. Maury P, Baratto F, Zeppenfeld K, Klein G, Delacretaz E, Sacher F, Pruvot E, Brigadeau F, Rollin A, Andronache M, Maccabelli G, Gawrysiak M, Brenner R, Forclaz A, Schlaepfer J, Lacroix D, Duparc A, Mondoly P, Bouisset F, Delay M, Hocini M, Derval N, Sadoul N, Magnin-Poull I, Klug D, Haïssaguerre M, Jaïs P, Della Bella P, De Chillou C
Aims: Patients with well-tolerated sustained monomorphic ventricular tachycardia (SMVT) and left ventricular ejection fraction (LVEF) over 30% may benefit from a primary strategy of VT ablation without immediate need for a 'back-up' implantable cardioverter-defibrillator (ICD). Methods and results: One hundred and sixty-six patients with structural heart disease (SHD), LVEF over 30%, and well-tolerated SMVT (no syncope) underwent primary radiofrequency ablation without ICD implantation... Abstract
Cited 41 times since 2014 (3.6 per year) source: EuropePMC
Injury, Volume 45, Issue 7, 15 3 2014, Pages 1028-1034 Systematic review of the prevalence and characteristics of battle casualties from NATO coalition forces in Iraq and Afghanistan. Hoencamp R, Vermetten E, Tan EC, Putter H, Leenen LP, Hamming JF
Background: The North Atlantic Treaty Organization (NATO) coalition forces remain heavily committed on combat operations overseas. Understanding the prevalence and characteristics of battlefield injury of coalition partners is vital to combat casualty care performance improvement. The aim of this systematic review was to evaluate the prevalence and characteristics of battle casualties from NATO coalition partners in Iraq and Afghanistan. The primary outcome was mechanism of injury and the second... Abstract
Cited 36 times since 2014 (3.2 per year) source: EuropePMC
Annals of surgical oncology, Volume 21 Suppl 4, 11 2 2014, Pages S528-37 Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe. Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL
Background: Irradical tumor resections and iatrogenic ureteral injury remain a significant problem during lower abdominal surgery. The aim of the current study was to intraoperatively identify both colorectal tumors and ureters in subcutaneous and orthotopic animal models using cRGD-ZW800-1 and near-infrared (NIR) fluorescence. Methods: The zwitterionic fluorophore ZW800-1 was conjugated to the tumor specific peptide cRGD (targeting integrins) and to the a-specific peptide cRAD. One nmol cRGD-ZW... Abstract
Cited 7 times since 2014 (0.6 per year) source: EuropePMC
Journal of the American Academy of Dermatology, Volume 70, Issue 5, 10 2 2014, Pages 893-898 E-learning enables parents to assess an infantile hemangioma. de Graaf M, Knol MJ, Totté JE, van Os-Medendorp H, Breugem CC, Pasmans SG
Background: Infantile hemangiomas (IH) at risk for complications need to be recognized early. Objective: We sought to determine if parents are able to assess, after e-learning, whether their child has an IH, is at risk for complications, and needs to be seen (urgently) by a specialist. Methods: This was a prospective study of 158 parents participating in an IH e-learning module. Parents were asked to assess their child's skin abnormality. A dermatologist answered the same questions (by e-co... Abstract
Cited 11 times since 2014 (1 per year) source: EuropePMC
PloS one, Volume 9, Issue 2, 10 2 2014, Pages e86665 Temporal trends of system of care for STEMI: insights from the Jakarta Cardiovascular Care Unit Network System. Dharma S, Siswanto BB, Firdaus I, Dakota I, Andriantoro H, Wardeh AJ, van der Laarse A, Jukema JW
Aim: Guideline implementation programs are of paramount importance in optimizing acute ST-elevation myocardial infarction (STEMI) care. Assessment of performance indicators from a local STEMI network will provide knowledge of how to improve the system of care. Methods and results: Between 2008-2011, 1505 STEMI patients were enrolled. We compared the performance indicators before (n = 869) and after implementation (n = 636) of a local STEMI network. In 2011 (after introduction of STEMI networking... Abstract
Cited 40 times since 2014 (3.5 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 30, Issue 3, 6 1 2014, Pages 549-558 Global longitudinal strain and left atrial volume index improve prediction of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy patients. Debonnaire P, Thijssen J, Leong DP, Joyce E, Katsanos S, Hoogslag GE, Schalij MJ, Atsma DE, Bax JJ, Delgado V, Marsan NA
Accurate predictors of appropriate implantable cardioverter defibrillator (ICD) therapy in hypertrophic cardiomyopathy (HCM) patients are lacking. Both left atrial volume index (LAVI) and global longitudinal strain (GLS) have been proposed as prognostic markers in HCM patients. The specific value of LAVI and GLS to predict appropriate ICD therapy in high-risk HCM patients was studied. LAVI and 2-dimensional speckle tracking-derived GLS were assessed in 92 HCM patients undergoing ICD implantation... Abstract
Cited 2 times since 2014 (0.2 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 15, Issue 7, 4 1 2014, Pages 832 CoreValve stent frame misdeployment and increased transvalvular gradient. Kamperidis V, van der Kley F, Katsanos S, Delgado V
Cited 113 times since 2014 (9.9 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 16, Issue 5, 4 1 2014, Pages 681-688 Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the wireless stimulation endocardially for CRT (WiSE-CRT) study. Auricchio A, Delnoy PP, Butter C, Brachmann J, Van Erven L, Spitzer S, Moccetti T, Seifert M, Markou T, Laszo K, Regoli F, Collaborative Study Group
Aims: Left ventricular (LV) endocardial pacing may address the limitations in the selection of an LV pacing site and provide improvements in cardiac resynchronization therapy (CRT) effectiveness. We report on the feasibility, the safety, and the short-term outcome of a leadless ultrasound-based technology for LV endocardial resynchronization in heart failure (HF) patients enroled into the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study. Methods and results: Seventeen HF patients were... Abstract
Cited 14 times since 2014 (1.2 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 30, Issue 4, 4 1 2014, Pages 713-720 Impact of right ventricular dyssynchrony on left ventricular performance in patients with pulmonary hypertension. Haeck ML, Höke U, Marsan NA, Holman ER, Wolterbeek R, Bax JJ, Schalij MJ, Vliegen HW, Delgado V
Pulmonary hypertension has been associated with right ventricular (RV) dyssynchrony which may induce left ventricular (LV) dysfunction and dyssynchrony through ventricular interdependence. The present study evaluated the influence of RV dyssynchrony on LV performance in patients with pulmonary hypertension. One hundred and seven patients with pulmonary hypertension (age 63 ± 14 years, systolic pulmonary arterial pressure 60 ± 19 mmHg) and LV ejection fraction (EF) >35% were evaluated. Ventric... Abstract
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 2, 1 1 2014, Pages 77-79 ST-segment elevation associated with allergic reaction to echocardiographic contrast agent administration. van Ginkel A, Sorgdrager B, de Graaf MA, Karalis I, Ajmone Marsan N
We report a case of an allergic reaction after the administration of an echocardiographic contrast agent which resulted in ST-segment elevation. Hypersensitivity and allergic reactions are known causes of acute cardiovascular events. However, only limited reports are available which suggest the exact mechanism of the occurrence of angina or myocardial infarction during severe allergic reactions. In our case, through invasive imaging (coronary angiography and IVUS) we have shown for the first tim... Abstract
Cited 16 times since 2014 (1.4 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 2, 1 1 2014, Pages 64-69 Antithrombotic therapy in patients undergoing TAVI: an overview of Dutch hospitals. Nijenhuis VJ, Stella PR, Baan J, Brueren BR, de Jaegere PP, den Heijer P, Hofma SH, Kievit P, Slagboom T, van den Heuvel AF, van der Kley F, van Garsse L, van Houwelingen KG, Van't Hof AW, Ten Berg JM
Purpose: To assess current antithrombotic treatment strategies in the Netherlands in patients undergoing transcatheter aortic valve implantation (TAVI). Methods: For every Dutch hospital performing TAVI (n = 14) an interventional cardiologist experienced in performing TAVI was interviewed concerning heparin, aspirin, thienopyridine and oral anticoagulation treatment in patients undergoing TAVI. Results: The response rate was 100 %. In every centre, a protocol for antithrombotic treatment after T... Abstract