6136 results
Cited 50 times since 2012 (4.1 per year)
source: EuropePMC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Volume 53, 21 3 2012, Pages 359-363
Radioprotection by two phenolic compounds: chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro.
Cinkilic N, Cetintas SK, Zorlu T, Vatan O, Yilmaz D, Cavas T, Tunc S, Ozkan L, Bilaloglu R
The present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was use...
Abstract
Cited 51 times since 2012 (4.2 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 12, 20 3 2012, Pages e52438
Blood pressure variability and cardiovascular risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
Poortvliet RK, Ford I, Lloyd SM, Sattar N, Mooijaart SP, de Craen AJ, Westendorp RG, Jukema JW, Packard CJ, Gussekloo J, de Ruijter W, Stott DJ
Variability in blood pressure predicts cardiovascular disease in young- and middle-aged subjects, but relevant data for older individuals are sparse. We analysed data from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) study of 5804 participants aged 70-82 years with a history of, or risk factors for cardiovascular disease. Visit-to-visit variability in blood pressure (standard deviation) was determined using a minimum of five measurements over 1 year; an inception cohort...
Abstract
Cited 44 times since 2012 (3.6 per year)
source: EuropePMC
European journal of heart failure,
Volume 15, Issue 5, 18 3 2012, Pages 581-588
Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study.
Nanchen D, Stott DJ, Gussekloo J, Mooijaart SP, Westendorp RG, Jukema JW, Macfarlane PW, Cornuz J, Rodondi N, Buckley BM, Ford I, Sattar N, de Craen AJ, PROSPER Group
Aims: Resting heart rate is a promising modifiable cardiovascular risk marker in older adults, but the mechanisms linking heart rate to cardiovascular disease are not fully understood. We aimed to assess the association between resting heart rate and incident heart failure (HF) and cardiovascular mortality, and to examine whether these associations might be attributable to systemic inflammation and endothelial dysfunction. Methods and results: We studied 4084 older adults aged 70-82 years with k...
Abstract
Cited 97 times since 2012 (7.9 per year)
source: EuropePMC
Circulation,
Volume 127, Issue 3, 17 3 2012, Pages 322-330
Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial.
van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJ
Background: The role of angiotensin II receptor blockers in patients with a systemic right ventricle has not been elucidated. Methods and results: We conducted a multicenter, double-blind, parallel, randomized controlled trial of angiotensin II receptor blocker valsartan 160 mg twice daily compared with placebo in patients with a systemic right ventricle caused by congenitally or surgically corrected transposition of the great arteries. The primary end point was change in right ventricular eject...
Abstract
Cited 7 times since 2012 (0.6 per year)
source: EuropePMC
European journal of radiology,
Volume 82, Issue 4, 14 2 2012, Pages 680-685
High field carotid vessel wall imaging: a study on reproducibility.
Kröner ES, Westenberg JJ, van der Geest RJ, Brouwer NJ, Doornbos J, Kooi ME, van der Wall EE, Lamb HJ, Siebelink HJ
Purpose: Currently, a multi-contrast protocol, including a combination of five MR-sequences is used as reference standard for morphologic imaging and quantitative measurements of the carotid artery vessel wall. The purpose of this study is to investigate the scan-rescan reproducibility together with intra- and inter-observer reproducibility of each of the five MR-sequences. Methods: Twenty healthy volunteers (55% male, mean age=26 years) underwent repeated MR-examinations (3T-Philips-MRI) of the...
Abstract
Cited 4 times since 2012 (0.3 per year)
source: EuropePMC
Case reports in pediatrics,
Volume 2012, 12 2 2012, Pages 314256
Left pulmonary artery thrombosis in a neonate with left lung hypoplasia.
van Schendel MP, Visser DH, Rammeloo LA, Hazekamp MG, Hruda J
Thrombotic events in neonates may origin from fetal life. A 4-day-old newborn infant with a family history of heterozygous type 1 protein C deficiency was diagnosed with left lung hypoplasia and left pulmonary artery thrombosis. Its source was prenatally closed ductus arteriosus. Surgical removal of the thrombus was performed.
Abstract
Cited 25 times since 2012 (2 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 14, Issue 8, 7 1 2012, Pages 774-781
Impact of clinical and echocardiographic response to cardiac resynchronization therapy on long-term survival.
Bertini M, Höke U, van Bommel RJ, Ng AC, Shanks M, Nucifora G, Auger D, Borleffs CJ, van Rijnsoever EP, van Erven L, Schalij MJ, Marsan NA, Bax JJ, Delgado V
Background: Clinical or echocardiographic mid-term responses to cardiac resynchronization therapy (CRT) may have a different influence on a long-term prognosis of heart failure patients treated with CRT. The aim of the evaluation was to establish which definition of response to CRT, clinical or echocardiographic, best predicts long-term prognosis. Methods and results: A total of 679 heart failure patients treated with CRT were included. All the patients underwent a complete history and physical...
Abstract
Cited 51 times since 2012 (4.2 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 19, Issue 3, 6 1 2012, Pages 743-751
A phase II study of sorafenib in patients with platinum-pretreated, advanced (Stage IIIb or IV) non-small cell lung cancer with a KRAS mutation.
Dingemans AM, Mellema WW, Groen HJ, van Wijk A, Burgers SA, Kunst PW, Thunnissen E, Heideman DA, Smit EF
Purpose: Sorafenib inhibits the Ras/Raf pathway, which is overactive in cancer patients with a KRAS mutation. We hypothesized that patients with non-small cell lung cancer (NSCLC) with KRAS mutation will benefit from treatment with sorafenib. Experimental design: In this phase II study, patients with KRAS-mutated, stage IIIb or IV NSCLC that progressed after at least one platinum-containing regimen were treated with sorafenib. Treatment consisted of sorafenib 400 mg twice daily until disease pro...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 14, Issue 5, 5 1 2012, Pages 507
Rapid aortic aneurysm formation in Marfan patient with dissection of the entire aorta.
Scholte AJ, Hilhorst-Hofstee Y, Versteegh MI, Kroft LJ
Abstract
Cited 15 times since 2012 (1.2 per year)
source: EuropePMC
Diabetes care,
Volume 36, Issue 4, 5 1 2012, Pages 985-991
Influence of diabetes on left ventricular systolic and diastolic function and on long-term outcome after cardiac resynchronization therapy.
Höke U, Thijssen J, van Bommel RJ, van Erven L, van der Velde ET, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Objective: The influence of diabetes on cardiac resynchronization therapy (CRT) remains unclear. The aims of the current study were to 1) assess the changes in left ventricular (LV) systolic and diastolic function and 2) evaluate long-term prognosis in CRT recipients with diabetes. Research design and methods: A total of 710 CRT recipients (171 with diabetes) were included from an ongoing registry. Echocardiographic evaluation, including LV systolic and diastolic function assessment, was perform...
Abstract
Cited 24 times since 2012 (2 per year)
source: EuropePMC
Injury,
Volume 44, Issue 4, 3 1 2012, Pages 498-503
Re-displacement of stable distal both-bone forearm fractures in children: a randomised controlled multicentre trial.
Colaris JW, Allema JH, Biter LU, de Vries MR, van de Ven CP, Bloem RM, Kerver AJ, Reijman M, Verhaar JA
Introduction: Displaced metaphyseal both-bone fractures of the distal forearm are generally reduced and stabilised by an above-elbow cast (AEC) with or without additional pinning. The purpose of this study was to find out if re-displacement of a reduced stable metaphyseal both-bone fracture of the distal forearm in a child could be prevented by stabilisation with Kirschner wires. Methods: Consecutive children aged
Abstract
Cited 58 times since 2012 (4.7 per year)
source: EuropePMC
Nature structural & molecular biology,
Volume 20, Issue 1, 2 1 2012, Pages 73-81
Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V
The exoRNase Eri1 inhibits RNA interference and trims the 5.8S rRNA 3' end. It also binds to the stem-loop of histone mRNAs, but the functional importance of this interaction remains elusive. Histone mRNAs are normally degraded at the end of S phase or after pharmacological inhibition of replication. Both processes are impaired in Eri1-deficient mouse cells, which instead accumulate oligouridylated histone mRNAs. Eri1 trims the mature histone mRNAs by two unpaired nucleotides at the 3'...
Abstract
Cited 7 times since 2012 (0.6 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 94, Issue 6, 1 1 2012, Pages 2122-2125
Implantation of a left ventricular assist device in patients with a complex apical anatomy.
Palmen M, Verwey HF, Haeck ML, Holman ER, Schalij MJ, Klautz RJ
Implantation of a left ventricular assist device can be challenging in patients with an altered apical anatomy after cardiac surgery or as the result of the presence of a calcified apical aneurysm. In this paper we present 2 cases with a challenging apical anatomy and introduce a new surgical technique facilitating left ventricular assist device implantation in these patients.
Abstract
Cited 16 times since 2012 (1.3 per year)
source: EuropePMC
Expert review of cardiovascular therapy,
Volume 10, Issue 12, 1 1 2012, Pages 1517-1531
Surgical versus percutaneous treatment of aortic coarctation: new standards in an era of transcatheter repair.
Luijendijk P, Bouma BJ, Groenink M, Boekholdt M, Hazekamp MG, Blom NA, Koolbergen DR, de Winter RJ, Mulder BJ
Aortic coarctation is a common congenital cardiovascular defect, which can be diagnosed over a wide range of ages and with varying degrees of severity. Surgery has proven to be an effective treatment for the management of native aortic coarctation, and remains the treatment of choice in neonates. Balloon angioplasty with or without stenting has evolved rapidly over the past decade. Balloon angioplasty is the treatment of choice in children with re-coarctation, and currently available immediate r...
Abstract
Cited 3 times since 2012 (0.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 20, Issue 12, 1 1 2012, Pages 509-512
Two cases of aorto-right atrial tunnel: clinical presentation, imaging and percutaneous closure.
de Winter RJ, Blom NA, Straver B, Bouma BJ, Backx AP, Clur SA, Kuipers IM, Hoekstra F, Boekholdt SM, Groenink M, Koolbergen DR, Hazekamp MG, Mulder BJ
Communication between the aortic sinus and a cardiac chamber is a rare anomaly that can be diagnosed in children and young adults. We describe two cases with a tunnel between the aortic sinus and right atrium, discuss diagnostic modalities, and review the literature on this anomaly.
Abstract
Cited 3 times since 2012 (0.2 per year)
source: EuropePMC
Stem cells (Dayton, Ohio),
Volume 30, Issue 12, 1 1 2012, Pages 2830-2834
Brief report: Misinterpretation of coculture differentiation experiments by unintended labeling of cardiomyocytes through secondary transduction: delusions and solutions.
Ramkisoensing AA, De Vries AA, Schalij MJ, Atsma DE, Pijnappels DA
Cardiomyogenic differentiation of stem cells can be accomplished by coculture with cardiomyocytes (CMCs). To facilitate their identification, stem cells are often labeled through viral transduction with a fluorescent protein. A second marker to distinguish stem cell-derived CMCs from native CMCs is rarely used. This study aimed to investigate the occurrence of secondary transduction of unlabeled neonatal rat (nr) CMCs after coculture with human cells that had been transduced 0, 7, or 14 days ear...
Abstract
Cited 69 times since 2012 (5.6 per year)
source: EuropePMC
Radiation oncology (London, England),
Volume 7, 24 4 2012, Pages 198
Management of radiation oncology patients with a pacemaker or ICD: a new comprehensive practical guideline in The Netherlands. Dutch Society of Radiotherapy and Oncology (NVRO).
Hurkmans CW, Knegjens JL, Oei BS, Maas AJ, Uiterwaal GJ, van der Borden AJ, Ploegmakers MM, van Erven L, Dutch Society of Radiotherapy and Oncology (NVRO)
Current clinical guidelines for the management of radiotherapy patients having either a pacemaker or implantable cardioverter defibrillator (both CIEDs: Cardiac Implantable Electronic Devices) do not cover modern radiotherapy techniques and do not take the patient's perspective into account. Available data on the frequency and cause of CIED failure during radiation therapy are limited and do not converge. The Dutch Society of Radiotherapy and Oncology (NVRO) initiated a multidisciplinary ta...
Abstract
Cited 7 times since 2012 (0.6 per year)
source: EuropePMC
Cytokine,
Volume 61, Issue 2, 24 4 2012, Pages 438-444
A comparative study of the immune modulating properties of antifibrinolytics in cardiac surgery.
Later AF, Bruggemans EF, Romijn FP, van Pelt J, Klautz RJ
Purpose: Antifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin levels. Additional drug specific immune modulating qualities are often mentioned in the discussion on which antifibrinolytic can best be used. To determine the extent and relevance of these effects, we investigated cytokine and growth factor plasma levels in cardiac surgery patients randomized to receive either tranexamic...
Abstract
Cited 21 times since 2012 (1.7 per year)
source: EuropePMC
The American journal of cardiology,
Volume 111, Issue 3, 20 3 2012, Pages 382-387
Pregnancy outcomes in women with aortic valve substitutes.
Heuvelman HJ, Arabkhani B, Cornette JM, Pieper PG, Bogers AJ, Takkenberg JJ, Roos-Hesselink JW
Young women who require aortic valve replacement need information on the potential cardiac and obstetric complications of pregnancy for the different valve substitutes available. We, therefore, assessed the pregnancy outcomes in women who had received an autograft, homograft, or mechanical valve in the aortic position. Women who were pregnant after surviving aortic valve replacement at our institution from 1987 to 2011 were included. Information on cardiac status and pregnancy outcome was obtain...
Abstract
Cited 518 times since 2012 (42.1 per year)
source: EuropePMC
mBio,
Volume 3, Issue 6, 20 3 2012, Pages e00473-12
Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans.
van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA
Unlabelled: A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the re...
Abstract
