Research

Publications

Below you can find a list of our published research.

8223 results

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Circulation research, Volume 115, Issue 4, 1 1 2014, Pages e6-7 Cardiac anisotropy, regeneration, and rhythm. Pijnappels DA, Schalij MJ, Atsma DE, de Vries AA

Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 7-8, 1 1 2014, Pages 336-343 Cardiologist and cardiac surgeon view on decision-making in prosthetic aortic valve selection: does profession matter? Korteland NM, Kluin J, Klautz RJ, Roos-Hesselink JW, Versteegh MI, Bogers AJ, Takkenberg JJ

Aims: Assess and compare among Dutch cardiothoracic surgeons and cardiologists: opinion on (1) patient involvement, (2) conveying risk in aortic valve selection, and (3) aortic valve preferences. Methods and results: A survey among 117 cardiothoracic surgeons and cardiologists was conducted. Group responses were compared using the Mann-Whitney U test. Most respondents agreed that patients should be involved in decision-making, with surgeons leaning more toward patient involvement (always: 83 % v... Abstract

Cited 70 times since 2014 (6.6 per year) source: EuropePMC

Cardiovascular research, Volume 104, Issue 1, 31 5 2014, Pages 194-205 Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes. Bingen BO, Engels MC, Schalij MJ, Jangsangthong W, Neshati Z, Feola I, Ypey DL, Askar SF, Panfilov AV, Pijnappels DA, de Vries AA

Aims: Atrial fibrillation (AF) is the most common cardiac arrhythmia and often involves reentrant electrical activation (e.g. spiral waves). Drug therapy for AF can have serious side effects including proarrhythmia, while electrical shock therapy is associated with discomfort and tissue damage. Hypothetically, forced expression and subsequent activation of light-gated cation channels in cardiomyocytes might deliver a depolarizing force sufficient for defibrillation, thereby circumventing the afo... Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

Pesticide biochemistry and physiology, Volume 114, 27 4 2014, Pages 1-7 Effects of fullerenol nanoparticles on acetamiprid induced cytoxicity and genotoxicity in cultured human lung fibroblasts. Çavaş T, Çinkılıç N, Vatan Ö, Yılmaz D

The aim of this study was to investigate the effects of water soluble fullerene (fullerenol) nanoparticles on the in vitro genotoxicity induced by the insecticide acetamiprid. Healthy human lung cells (IMR-90) were treated with fullerenol C60(OH)n (n: 18-22) alone and in combination with acetamiprid for 24h. The micronucleus test, comet assay and γ-H2AX foci formation assays were used as genotoxicity endpoints. Cytotoxicity was evaluated using the clonogenic assay. The maximum tested concentrati... Abstract

Cited 87 times since 2014 (8.2 per year) source: EuropePMC

European urology, Volume 66, Issue 6, 26 4 2014, Pages 1065-1077 The impact of the extent of lymphadenectomy on oncologic outcomes in patients undergoing radical cystectomy for bladder cancer: a systematic review. Bruins HM, Veskimae E, Hernandez V, Imamura M, Neuberger MM, Dahm P, Stewart F, Lam TB, N'Dow J, van der Heijden AG, Compérat E, Cowan NC, De Santis M, Gakis G, Lebret T, Ribal MJ, Sherif A, Witjes JA

Context: Controversy exists regarding the therapeutic value of lymphadenectomy (LND) in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Objective: To systematically review the relevant literature assessing the impact of LND on oncologic and perioperative outcomes in patients undergoing RC for MIBC. Evidence acquisition: Medline, Medline In-Process, Embase, the Cochrane Central Register of Controlled Trials, and the Latin American and Caribbean Center on Hea... Abstract

Cited 59 times since 2014 (5.6 per year) source: EuropePMC

European heart journal, Volume 35, Issue 38, 25 4 2014, Pages 2627-2638 Open issues in transcatheter aortic valve implantation. Part 1: patient selection and treatment strategy for transcatheter aortic valve implantation. Bax JJ, Delgado V, Bapat V, Baumgartner H, Collet JP, Erbel R, Hamm C, Kappetein AP, Leipsic J, Leon MB, MacCarthy P, Piazza N, Pibarot P, Roberts WC, Rodés-Cabau J, Serruys PW, Thomas M, Vahanian A, Webb J, Zamorano JL, Windecker S

An exponential increase in the use of transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis has been witnessed over the recent years. The current article reviews different areas of uncertainty related to patient selection. The use and limitations of risk scores are addressed, followed by an extensive discussion on the value of three-dimensional imaging for prosthesis sizing and the assessment of complex valve anatomy such as degenerated bicuspid valves. The uncer... Abstract

Cited 65 times since 2014 (6.1 per year) source: EuropePMC

European heart journal, Volume 35, Issue 38, 25 4 2014, Pages 2639-2654 Open issues in transcatheter aortic valve implantation. Part 2: procedural issues and outcomes after transcatheter aortic valve implantation. Bax JJ, Delgado V, Bapat V, Baumgartner H, Collet JP, Erbel R, Hamm C, Kappetein AP, Leipsic J, Leon MB, MacCarthy P, Piazza N, Pibarot P, Roberts WC, Rodés-Cabau J, Serruys PW, Thomas M, Vahanian A, Webb J, Zamorano JL, Windecker S

This article provides an overview on procedure-related issues and uncertainties in outcomes after transcatheter aortic valve implantation (TAVI). The different access sites and how to select them in an individual patient are discussed. Also, the occurrence and potential predictors of aortic regurgitation (AR) after TAVI are addressed. The different methods to quantify AR are reviewed, and it appears that accurate and reproducible quantification is suboptimal. Complications such as prosthesis-pat... Abstract

Cited 20 times since 2014 (1.9 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 25, Issue 9, 24 4 2014, Pages 1012-1020 Impact of pacing site on QRS duration and its relationship to hemodynamic response in cardiac resynchronization therapy for congestive heart failure. Derval N, Bordachar P, Lim HS, Sacher F, Ploux S, Laborderie J, Steendijk P, Deplagne A, Ritter P, Garrigue S, Denis A, Hocini M, Haissaguerre M, Clementy J, Jaïs P

Introduction: Recent studies have demonstrated that left ventricular (LV) pacing site is a critical parameter in optimizing cardiac resynchronization therapy (CRT). The present study evaluates the effect of pacing from different LV locations on QRS duration (QRSd) and their relationship to acute hemodynamic response in congestive heart failure patients. Methods and results: Thirty-five patients with nonischemic dilated cardiomyopathy and left bundle branch block referred for CRT device implantat... Abstract

Cited 16 times since 2014 (1.5 per year) source: EuropePMC

BMC cardiovascular disorders, Volume 14, 18 3 2014, Pages 87 Scarcity of atrial fibrillation in a traditional African population: a community-based study. Koopman JJ, van Bodegom D, Westendorp RG, Jukema JW

Background: In western societies, atrial fibrillation is an increasingly common finding among the elderly. Established risk factors of atrial fibrillation include obesity, diabetes, hypertension, and cardiovascular disease. Atrial fibrillation has almost exclusively been studied in western populations where these risk factors are widely present. Therefore, we studied the epidemiology of atrial fibrillation in a traditional African community. Methods: In rural Ghana, among 924 individuals aged 50... Abstract

Clinical and experimental rheumatology, Volume 32, Issue 6 Suppl 86, 17 3 2014, Pages S-60-7 Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures. Ninaber MK, Hamersma WB, Schouffoer AA, Kovacs G, Olschewski H, Holman ER, Ajmone Marsan N, Stolk J

Objectives: During cardiopulmonary exercise testing (CPET) compromised pulmonary vasculature in patients with systemic sclerosis (SSc) may lead to increases in pulmonary arterial pressures (PAP) and decreased oxygen uptake. We hypothesised that this may lead into a disproportional heart rate (HR) increase with a corresponding V'O₂/HR breakpoint and relates to systolic PAP at rest. Methods: In a prospective design we evaluated V'O₂/HR slopes for breakpoints. To understand its physiologi... Abstract

Cited 78 times since 2014 (7.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 100, Issue 17, 17 3 2014, Pages 1373-1381 Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease. Balci A, Sollie-Szarynska KM, van der Bijl AG, Ruys TP, Mulder BJ, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG, ZAHARA-II investigators

Objectives: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregnancy in women with CHD. Methods: In this prospective study, we determined the outcomes of 213 pregnancies in 203 women with CHD. The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPR... Abstract

Cited 51 times since 2014 (4.8 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 7, Issue 8, 16 3 2014, Pages 774-784 CMR-based identification of critical isthmus sites of ischemic and nonischemic ventricular tachycardia. Piers SR, Tao Q, de Riva Silva M, Siebelink HM, Schalij MJ, van der Geest RJ, Zeppenfeld K

Objectives: This study evaluates whether contrast-enhanced (CE) cardiac magnetic resonance (CMR) can be used to identify critical isthmus sites for ventricular tachycardia (VT) in ischemic and nonischemic heart disease. Background: Fibrosis interspersed with viable myocytes may cause re-entrant VT. CE-CMR has the ability to accurately delineate fibrosis. Methods: Patients who underwent VT ablation with CE-CMR integration were included. After the procedure, critical isthmus sites (defined as site... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

PloS one, Volume 9, Issue 7, 16 3 2014, Pages e102433 Development of a lentivirus vector-based assay for non-destructive monitoring of cell fusion activity. Neshati Z, Liu J, Zhou G, Schalij MJ, de Vries AA

Cell-to-cell fusion can be quantified by endowing acceptor and donor cells with latent reporter genes/proteins and activators of these genes/proteins, respectively. One way to accomplish this goal is by using a bipartite lentivirus vector (LV)-based cell fusion assay system in which the cellular fusion partners are transduced with a flippase-activatable Photinus pyralis luciferase (PpLuc) expression unit (acceptor cells) or with a recombinant gene encoding FLPeNLS+, a nuclear-targeted and molecu... Abstract

Cited 335 times since 2014 (31.5 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 349, 10 2 2014, Pages g4164 Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, Cavadino A, Drogan D, Padmanabhan S, Li S, Yesupriya A, Leusink M, Sundstrom J, Hubacek JA, Pikhart H, Swerdlow DI, Panayiotou AG, Borinskaya SA, Finan C, Shah S, Kuchenbaecker KB, Shah T, Engmann J, Folkersen L, Eriksson P, Ricceri F, Melander O, Sacerdote C, Gamble DM, Rayaprolu S, Ross OA, McLachlan S, Vikhireva O, Sluijs I, Scott RA, Adamkova V, Flicker L, Bockxmeer FM, Power C, Marques-Vidal P, Meade T, Marmot MG, Ferro JM, Paulos-Pinheiro S, Humphries SE, Talmud PJ, Mateo Leach I, Verweij N, Linneberg A, Skaaby T, Doevendans PA, Cramer MJ, van der Harst P, Klungel OH, Dowling NF, Dominiczak AF, Kumari M, Nicolaides AN, Weikert C, Boeing H, Ebrahim S, Gaunt TR, Price JF, Lannfelt L, Peasey A, Kubinova R, Pajak A, Malyutina S, Voevoda MI, Tamosiunas A, Maitland-van der Zee AH, Norman PE, Hankey GJ, Bergmann MM, Hofman A, Franco OH, Cooper J, Palmen J, Spiering W, de Jong PA, Kuh D, Hardy R, Uitterlind

Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures: Odd... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Annals of neurology, Volume 76, Issue 2, 9 2 2014, Pages 213-222 N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk. Wijsman LW, Sabayan B, van Vliet P, Trompet S, de Ruijter W, Poortvliet RK, van Peet PG, Gussekloo J, Jukema JW, Stott DJ, Sattar N, Ford I, Westendorp RG, de Craen AJ, Mooijaart SP

Objective: Elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with cognitive impairment, which might be explained by cardiovascular diseases or risk factors. The aim of this study was to investigate the association of NT-proBNP with cognitive function and decline in older adults at high risk of cardiovascular disease. Methods: We studied 5,205 men and women (mean age = 75 years) who were recruited into the PROspective Study of Pravastatin in the Elderly at Ris... Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

Neuro-oncology, Volume 17, Issue 1, 3 1 2014, Pages 145-150 A prospective open-label study of sirolimus for the treatment of anti-Hu associated paraneoplastic neurological syndromes. de Jongste AH, van Gelder T, Bromberg JE, de Graaf MT, Gratama JW, Schreurs MW, Hooijkaas H, Sillevis Smitt PA

Background: Several lines of evidence suggest a T cell-mediated immune response in paraneoplastic neurological syndromes with anti-Hu antibodies (Hu-PNS). In order to investigate whether suppression of T cell-mediated immune responses in Hu-PNS patients improved their neurological outcome, we performed a prospective open-label, single-arm study on sirolimus. Methods: Seventeen progressive Hu-PNS patients were treated with sirolimus with an intended treatment duration of 8 weeks. Primary outcome... Abstract

Cited 7 times since 2014 (0.7 per year) source: EuropePMC

International journal of cardiology, Volume 175, Issue 3, 2 1 2014, Pages 539-544 Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. Rodrigo SF, van Ramshorst J, Mann I, Leong DP, Cannegieter SC, Al Younis I, Dibbets-Schneider P, de Roos A, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Beeres SL, Atsma DE

Background: We previously showed that intramyocardial bone marrow cell (BMC) injection in patients with refractory angina and chronic myocardial ischemia improves myocardial perfusion, cardiac function and disease-related complaints. Treatment effect varied between patients, but the predictors of response remain to be identified. Therefore, the aim of the present study was to assess whether patient characteristics, procedural data and baseline measurements influence the response to intramyocardi... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

The Turkish journal of pediatrics, Volume 56, Issue 4, 1 1 2014, Pages 458-461 Development of end-stage renal disease at a young age in two cases with Joubert syndrome. Sönmez F, Güzünler-Şen M, Yılmaz D, Cömertpay G, Heise M, Çırak S, Uyanık G

Joubert syndrome (JS) is an autosomal recessive genetic disorder. To date, mutations in 20 genes of the genetically heterogeneous JS and JS-related disorders (JSRD) have been reported. Renal involvement occurs in 2-20% of JS cases. Identified renal abnormalities are cystic dysplasia and nephronophthisis. Here we report the clinical course and management of renal failure in early childhood. We present two cases diagnosed with JS that developed end-stage renal disease at young ages. In the genetic... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 10, Issue 3, 1 1 2014, Pages 364-371 Geometry of left atrial appendage assessed with multidetector-row computed tomography: implications for transcatheter closure devices. van Rosendael PJ, Katsanos S, van den Brink OW, Scholte AJ, Trines SA, Bax JJ, Schalij MJ, Marsan NA, Delgado V

Aims: To assess the left atrial appendage (LAA) geometry with multidetector-row computed tomography (MDCT) and its implications for selection of closure devices. Methods and results: One hundred and ninety-seven patients who underwent MDCT prior to catheter ablation for atrial fibrillation were evaluated. Feasibility for Watchman and Amplatzer Cardiac Plug (ACP) devices was assessed based on the maximal cross-sectional diameter and perimeter of the ostium and at 10 mm depth and on the LAA diamet... Abstract

Michigan medicine, Volume 113, Issue 4, 1 1 2014, Pages 12-13 Voice of medicine heard in state budget process. Schepers AR

Abstract