9618 results
Cited 11 times since 2012 (0.8 per year)
source: Scopus
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 41, Issue 5, 9 2 2012, Pages e117-25
No prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery.
Kortekaas KA, van der Pol P, Lindeman JH, Baan CC, van Kooten C, Klautz RJ
Objectives: Complement activation is considered an important mediator of myocardial ischaemia/reperfusion (I/R) injury. Although complement inhibitors are highly effective in animals, clinical trials fail to show a substantial benefit in humans. This raises questions on the role of complement activation in human myocardial I/R injury. Methods: Soluble C5b-9, i.e. terminal complement complex, and C5a were assessed in patients with non-ischaemic (n = 10) and ischaemic heart failure (n = 10), and p...
Abstract
Cited 17 times since 2012 (1.3 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 144, Issue 6, 8 2 2012, Pages 1315-1322
Disturbed myocardial connexin 43 and N-cadherin expressions in hypoplastic left heart syndrome and borderline left ventricle.
Mahtab EA, Gittenberger-de Groot AC, Vicente-Steijn R, Lie-Venema H, Rijlaarsdam ME, Hazekamp MG, Bartelings MM
Objectives: Borderline left ventricle is the left ventricular morphology at the favorable end of the hypoplastic left heart syndrome. In contrast to the severe end, it is suitable for biventricular repair. Wondering whether it is possible to identify cases suitable for biventricular repair from a developmental viewpoint, we investigated the myocardial histology of borderline and severely hypoplastic left ventricles. Methods: Postmortem specimens of neonatal, unoperated human hearts with severe h...
Abstract
Cited 29 times since 2012 (2.2 per year)
source: EuropePMC
Journal of proteome research,
Volume 11, Issue 4, 8 2 2012, Pages 2331-2346
Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteome.
Li X, Arslan F, Ren Y, Adav SS, Poh KK, Sorokin V, Lee CN, de Kleijn D, Lim SK, Sze SK
Despite decades of intensive research, there is still no effective treatment for ischemia/reperfusion (I/R) injury, an important corollary in the treatment of ischemic disease. I/R injury is initiated when the altered biochemistry of cells after ischemia is no longer compatible with oxygenated microenvironment (or reperfusion). To better understand the molecular basis of this alteration and subsequent incompatibility, we assessed the temporal and quantitative alterations in the cardiac proteome...
Abstract
Cited 11 times since 2012 (0.8 per year)
source: EuropePMC
Bone,
Volume 50, Issue 6, 8 2 2012, Pages 1260-1265
5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients.
van Dijk SC, de Herder WW, Kwekkeboom DJ, Zillikens MC, Feelders RA, van Schaik RH, van Driel M, van Leeuwen JP
In patients with a carcinoid syndrome and neuroendocrine tumors of the digestive tract (carcinoids), elevated circulating serotonin (5-hydroxytryptamine, 5-HT) levels can be demonstrated. It can be hypothesized that bone metabolism will be affected in these patients, since serotonin receptors are expressed on bone cells and serotonin effects on bone have been demonstrated. However, to date, no data are available on bone metabolism parameters in patients with neuroendocrine tumors of the digestiv...
Abstract
Cited 8 times since 2012 (0.6 per year)
source: EuropePMC
Nurse education today,
Volume 33, Issue 2, 8 2 2012, Pages 110-115
Turkish nursing students' knowledge and perceptions regarding virginity.
Zeyneloğlu S, Kısa S, Yılmaz D
The aim of this study was to describe the level of knowledge and perceptions of the Turkish nursing students regarding virginity, the virginity examination and the hymen repair. A convenience sample was used for the study purpose. An investigator designed questionnaire was administered to a total sample of 781 undergraduate nursing students originating from two universities in Mersin and Gaziantep, Turkey, respectively. The results showed that the participating nursing students agreed that a man...
Abstract
Cited 28 times since 2012 (2.1 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 3, 7 1 2012, Pages e32494
Impartial third-party interventions in captive chimpanzees: a reflection of community concern.
von Rohr CR, Koski SE, Burkart JM, Caws C, Fraser ON, Ziltener A, van Schaik CP
Because conflicts among social group members are inevitable, their management is crucial for group stability. The rarest and most interesting form of conflict management is policing, i.e., impartial interventions by bystanders, which is of considerable interest due to its potentially moral nature. Here, we provide descriptive and quantitative data on policing in captive chimpanzees. First, we report on a high rate of policing in one captive group characterized by recently introduced females and...
Abstract
Cited 33 times since 2012 (2.5 per year)
source: Scopus
European journal of preventive cardiology,
Volume 20, Issue 3, 6 1 2012, Pages 431-441
Beyond resolutions? A randomized controlled trial of a self-regulation lifestyle programme for post-cardiac rehabilitation patients.
Janssen V, De Gucht V, van Exel H, Maes S
Background: As lifestyle adherence and risk factor management following completion of cardiac rehabilitation (CR) have been shown to be problematic, we developed a brief self-regulation lifestyle programme for post-CR patients. Design: Randomized-controlled trial. Methods: Following completion of CR 210 patients were randomized to receive either a lifestyle maintenance programme (n = 112) or standard care (n = 98). The programme was based on self-regulation principles and consisted of a motivati...
Abstract
Cited 35 times since 2012 (2.6 per year)
source: EuropePMC
European heart journal,
Volume 33, Issue 11, 4 1 2012, Pages 1367-1377
Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography.
Veltman CE, de Graaf FR, Schuijf JD, van Werkhoven JM, Jukema JW, Kaufmann PA, Pazhenkottil AP, Kroft LJ, Boersma E, Bax JJ, Schalij MJ, van der Wall EE
Aims: Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). Methods and results: The study population consisted of 1425 patients (869 men, 57 ± 12 years) referred for CTA. To evaluate the impact of vessel domina...
Abstract
Cited 45 times since 2012 (3.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 167, Issue 3, 3 1 2012, Pages 833-839
Abnormal right atrial and right ventricular diastolic function relate to impaired clinical condition in patients operated for tetralogy of Fallot.
Luijnenburg SE, Peters RE, van der Geest RJ, Moelker A, Roos-Hesselink JW, de Rijke YB, Mulder BJ, Vliegen HW, Helbing WA
Background: Atrial enlargement may reflect ventricular diastolic dysfunction. Although patients with tetralogy of Fallot (TOF) have been studied extensively, little is known about atrial size and function. We assessed bi-atrial size and function in patients after TOF repair, and related them to biventricular systolic and diastolic function, and clinical parameters. Methods: 51 Patients (21 ± 8 years) and 30 healthy controls (31 ± 7 years) were included and underwent magnetic resonance imaging to...
Abstract
Cited 13 times since 2012 (1 per year)
source: EuropePMC
Current opinion in cardiology,
Volume 27, Issue 2, 1 1 2012, Pages 111-117
Mitral valve surgery in low ejection fraction, severe ischemic mitral regurgitation patients: should we repair them all?
Braun J, Klautz RJ
Purpose of review: The optimal surgical treatment of chronic ischemic mitral regurgitation still is the subject of much debate in the surgical and cardiological communities. Although combined restrictive mitral annuloplasty and revascularization has demonstrated good results with regard to improvement of clinical status, low rates of recurrent mitral regurgitation and sustained left ventricular reverse remodeling, a survival benefit still has not been demonstrated. In addition, not all patients...
Abstract
Cited 30 times since 2012 (2.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 14, Issue 3, 1 1 2012, Pages 423-425
Practices of cardiac implantable electronic device follow-up: results of the European Heart Rhythm Association survey.
Marinskis G, van Erven L, Bongiorni MG, Lip GY, Pison L, Blomström-Lundqvist C, Scientific Initiative Committee, European Heart Rhythm Association
This survey analyses some details of follow-up of patients with cardiac implantable electronic devices (CIEDs) in 40 centres-the members of the European Heart Rhythm Association (EHRA) research network. Results of this survey show that practices of CIED follow-up are not homogeneous between EHRA research network centres, and recommended clinical evaluation of the patients regarding possible device up-grade is not always performed. Remote device monitoring appears to be an evolving practice, most...
Abstract
Cited 17 times since 2012 (1.3 per year)
source: EuropePMC
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
Volume 29, Issue 1-2, 1 1 2012, Pages 163-170
Interaction of diesel exhaust particles with human, rat and mouse erythrocytes in vitro.
Nemmar A, Zia S, Subramaniyan D, Al-Amri I, Al Kindi MA, Ali BH
Inhaled ultrafine (nano) particles can translocate into the bloodstream and interact with circulatory cells causing systemic and cardiovascular events. To gain more insight into this potential mechanism, we studied the interaction of diesel exhaust particles (DEP) with human, rat and mouse erythrocytes in vitro. Incubation of erythrocytes with DEP (1, 10 or 100 μg/ml) for 30 min caused the highest hemolytic effect (up to 38%) in rats, compared to small but significant hemolysis in mice (up to 2....
Abstract
Cited 11 times since 2012 (0.8 per year)
source: EuropePMC
Current pharmaceutical biotechnology,
Volume 13, Issue 4, 1 1 2012, Pages 498-503
Translational optical imaging in diagnosis and treatment of cancer.
Keereweer S, Hutteman M, Kerrebijn JD, van de Velde CJ, Vahrmeijer AL, Löwik CW
In cancer imaging, many different modalities are used that each have their specific features, leading to the combined use of different techniques for the detection, staging and treatment evaluation of cancer. Optical imaging using near-infrared fluorescence light is a new imaging modality that has recently emerged in the field of cancer imaging. After extensive preclinical research, the first steps of translation to the clinical practice are currently being made. In this article, we discuss the...
Abstract
Postgraduate medical journal,
Volume 88, Issue 1037, 1 1 2012, Pages 176-184
Republished article: Pharmacogenetics of antiplatelet therapy: ready for clinical application?
Verschuren JJ, Jukema JW
Abstract
Cited 42 times since 2012 (3.1 per year)
source: EuropePMC
Evolutionary anthropology,
Volume 21, Issue 2, 1 1 2012, Pages 58-68
The role of terrestriality in promoting primate technology.
Meulman EJ, Sanz CM, Visalberghi E, van Schaik CP
"Complex technology" has often been considered a hallmark of human evolution. However, recent findings show that wild monkeys are also capable of habitual tool use. Here we suggest that terrestriality may have been of crucial importance for the innovation, acquisition, and maintenance of "complex" technological skills in primates. Here we define complex technological skills as tool-use variants that include at least two tool elements (for example, hammer and anvil), flexibili...
Abstract
Cited 11 times since 2012 (0.8 per year)
source: EuropePMC
Histology and histopathology,
Volume 27, Issue 3, 1 1 2012, Pages 387-396
Visualizing TGF-β and BMP signaling in human atherosclerosis: a histological evaluation based on Smad activation.
van Dijk RA, Engels CC, Schaapherder AF, Mulder-Stapel A, Ten Dijke P, Hamming JF, Lindeman JH
Background: The TGF-β superfamily members transforming growth factor-β (TGF-β/Activin) and bone morphogenetic proteins (BMP) have been implicated in the pathogenesis of atherosclerosis. However, their role in human disease remains controversial. In this study we used Smad phosphorylation as a read out for TGF-β and BMP signaling during the initiation, progression and (de)stabilization of human atherosclerotic disease. Material and methods: A systematic analysis was performed in 114 peri-renal ao...
Abstract
Cited 7 times since 2012 (0.5 per year)
source: EuropePMC
Pharmacogenomics,
Volume 13, Issue 4, 1 1 2012, Pages 387-392
Institutional Profile: Golden Helix Institute of Biomedical Research: interdisciplinary research and educational activities in pharmacogenomics and personalized medicine.
Mitropoulos K, Innocenti F, van Schaik RH, Lezhava A, Tzimas G, Kollia P, Macek M, Fortina P, Patrinos GP
The Golden Helix Institute of Biomedical Research is an international nonprofit scientific organization with interdisciplinary research and educational activities in the field of genome medicine in Europe, Asia and Latin America. These activities are supervised by an international scientific advisory council, consisting of world leaders in the field of genomics and translational medicine. Research activities include the regional coordination of the Pharmacogenomics for Every Nation Initiative in...
Abstract
Cited 82 times since 2012 (6.1 per year)
source: EuropePMC
Journal of acquired immune deficiency syndromes (1999),
Volume 59, Issue 3, 1 1 2012, Pages e28-34
An incentivized HIV counseling and testing program targeting hard-to-reach unemployed men in Cape Town, South Africa.
Nglazi MD, van Schaik N, Kranzer K, Lawn SD, Wood R, Bekker LG
Background: In Southern Africa, men access HIV counseling and testing (HCT) services less than women. Innovative strategies are needed to increase uptake of testing among men. This study assessed the effectiveness of incentivized mobile HCT in reaching unemployed men in Cape Town, South Africa. Methods: A retrospective analysis of HCT data collected between August 2008 and August 2010 from adult men accessing clinic-based stationary and non-incentivized and incentivized mobile services. Data fro...
Abstract
Cited 769 times since 2012 (57.1 per year)
source: EuropePMC
The New England journal of medicine,
Volume 366, Issue 11, 1 1 2012, Pages 981-990
Prostate-cancer mortality at 11 years of follow-up.
Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Páez A, Määttänen L, Bangma CH, Aus G, Carlsson S, Villers A, Rebillard X, van der Kwast T, Kujala PM, Blijenberg BG, Stenman UH, Huber A, Taari K, Hakama M, Moss SM, de Koning HJ, Auvinen A, ERSPC Investigators
Background: Several trials evaluating the effect of prostate-specific antigen (PSA) testing on prostate-cancer mortality have shown conflicting results. We updated prostate-cancer mortality in the European Randomized Study of Screening for Prostate Cancer with 2 additional years of follow-up. Methods: The study involved 182,160 men between the ages of 50 and 74 years at entry, with a predefined core age group of 162,388 men 55 to 69 years of age. The trial was conducted in eight European countri...
Abstract
Cited 4 times since 2012 (0.3 per year)
source: EuropePMC
Investigative radiology,
Volume 47, Issue 3, 1 1 2012, Pages 189-196
Tissue-velocity magnetic resonance imaging and tissue Doppler imaging to assess regional myocardial diastolic velocities at the right ventricle in corrected pediatric Tetralogy of Fallot patients.
van der Hulst AE, Westenberg JJ, Delgado V, Kroft LJ, Holman ER, Blom NA, Bax JJ, de Roos A, Roest AA
Objectives: In patients with corrected Tetralogy of Fallot (cToF), pulmonary regurgitation and subsequent increased right ventricular (RV) end-diastolic volume are diastolic parameters related to adverse outcome. In addition, abnormalities of the RV outflow tract (RVOT) independently promote RV dilatation in cToF patients. Tissue Doppler imaging (TDI) and tissue-velocity magnetic resonance imaging (TV-MRI) enable quantitative assessment of regional diastolic performance by measuring myocardial v...
Abstract
