9618 results
Cited 15 times since 2012 (1.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 20, Issue 3, 1 1 2012, Pages 94-101
Early mitral valve repair versus watchful waiting in patients with severe asymptomatic organic mitral regurgitation; rationale and design of the Dutch AMR trial, a multicenter, randomised trial.
Tietge WJ, de Heer LM, van Hessen MW, Jansen R, Bots ML, van Gilst W, Schalij M, Klautz RJ, Van den Brink RB, Van Herwerden LA, Doevendans PA, Chamuleau SA, Kluin J
Background: Asymptomatic severe mitral valve (MV) regurgitation with preserved left ventricular function is a challenging clinical entity as data on the recommended treatment strategy for these patients are scarce and conflicting. For asymptomatic patients, no randomised trial has been performed for objectivising the best treatment strategy. Methods: The Dutch AMR (Asymptomatic Mitral Regurgitation) trial is a multicenter, prospective, randomised trial comparing early MV repair versus watchful w...
Abstract
Cited 21 times since 2012 (1.6 per year)
source: EuropePMC
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme,
Volume 37, Issue 2, 1 1 2012, Pages 214-224
Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl/6J mice.
Louwe MC, van der Hoorn JW, van den Berg SA, van den Berg SA, Jukema JW, Romijn JA, van Dijk KW, Rensen PC, Smit JW, Steendijk P
Increased availability of fatty acids released from insulin-resistant adipose tissue may lead to excess fatty acid uptake in nonadipose organs, including the heart. Accumulation of toxic fatty acid intermediates may affect cardiac function. Our aim was to identify to which extent high-fat diet feeding leads to alterations in cardiac function and whether this depends on gender and (or) duration of high-fat diet feeding. Male and female C57Bl/6J mice (n = 8 per group) of 12 to 16 weeks old were fe...
Abstract
Cited 5 times since 2012 (0.4 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 14, Issue 6, 29 5 2012, Pages 778-780
Ventricular tachycardia ablation in implantable cardioverter-defibrillator recipients: a need to catch up with current recommendations.
Zeppenfeld K
Abstract
Cited 37 times since 2012 (2.7 per year)
source: EuropePMC
Circulation. Cardiovascular genetics,
Volume 5, Issue 2, 28 4 2012, Pages 202-209
Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study.
Vaarhorst AA, Lu Y, Heijmans BT, Dollé ME, Böhringer S, Putter H, Imholz S, Merry AH, van Greevenbroek MM, Jukema JW, Gorgels AP, van den Brandt PA, Müller M, Schouten LJ, Feskens EJ, Boer JM, Slagboom PE
Background: Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD. Methods and results: Incident cases (n=742), that is, participants who developed CHD during a med...
Abstract
Cited 171 times since 2012 (12.7 per year)
source: EuropePMC
Nature genetics,
Volume 44, Issue 4, 26 4 2012, Pages 445-9, S1
Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome.
Van Houdt JK, Nowakowska BA, Sousa SB, van Schaik BD, Seuntjens E, Avonce N, Sifrim A, Abdul-Rahman OA, van den Boogaard MJ, Bottani A, Castori M, Cormier-Daire V, Deardorff MA, Filges I, Fryer A, Fryns JP, Gana S, Garavelli L, Gillessen-Kaesbach G, Hall BD, Horn D, Huylebroeck D, Klapecki J, Krajewska-Walasek M, Kuechler A, Lines MA, Maas S, Macdermot KD, McKee S, Magee A, de Man SA, Moreau Y, Morice-Picard F, Obersztyn E, Pilch J, Rosser E, Shannon N, Stolte-Dijkstra I, Van Dijck P, Vilain C, Vogels A, Wakeling E, Wieczorek D, Wilson L, Zuffardi O, van Kampen AH, Devriendt K, Hennekam R, Vermeesch JR
Nicolaides-Baraitser syndrome (NBS) is characterized by sparse hair, distinctive facial morphology, distal-limb anomalies and intellectual disability. We sequenced the exomes of ten individuals with NBS and identified heterozygous variants in SMARCA2 in eight of them. Extended molecular screening identified nonsynonymous SMARCA2 mutations in 36 of 44 individuals with NBS; these mutations were confirmed to be de novo when parental samples were available. SMARCA2 encodes the core catalytic unit of...
Abstract
Cited 7 times since 2012 (0.5 per year)
source: EuropePMC
International journal of cardiology,
Volume 167, Issue 3, 25 4 2012, Pages 827-832
Increased risk for ascending aortic dilatation in patients with complex compared to simple aortic coarctation.
Luijendijk P, Franken RJ, Vriend JW, Zwinderman AH, Vliegen HW, Winter MM, Groenink M, Bouma BJ, Mulder BJ
Aims: Aortic coarctation (CoA) occurs as a "simple" isolated disorder, and in a more "complex" form, combined with associated congenital cardiac abnormalities. Long term outcome of all CoA patients may be complicated by dilatation of the thoracic aorta. The aim of this study was to quantify progressive aortic dilatation, and identify determinants for progressive aortic dilatation. Methods and results: Cardiovascular Magnetic Resonance Imaging (CMR) and echocardiographic data...
Abstract
Cited 78 times since 2012 (5.8 per year)
source: EuropePMC
Journal of lipid research,
Volume 53, Issue 5, 24 4 2012, Pages 1000-1011
Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).
Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, Fuller JH, Livingstone S, Charlton-Menys V, Neil A, Poulter N, Sever P, Shields DC, Stanton AV, Chatterjee A, Hyde C, Calle RA, DeMicco DA, Trompet S, Postmus I, Ford I, Jukema JW, Caulfield M, Hitman GA
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the observational phase of ASCOT (n = 651), all of whom were prescribed atorvastatin 10 mg. Following genome-wide imputation, we combined data from the three studies in a meta-analysis. We found associations of LDL-c response to atorvastatin that reach...
Abstract
Cited 5 times since 2012 (0.4 per year)
source: EuropePMC
General and comparative endocrinology,
Volume 177, Issue 1, 24 4 2012, Pages 46-54
Seasonal changes in plasma steroid levels in relation to ovarian steroidogenic ultrastructural features and progesterone receptors in the house gecko, Hemidactylus flaviviridis, in Oman.
Al-Amri IS, Mahmoud IY, Waring CP, Alkindi AY, Khan T, Bakheit C
A comprehensive study of the annual ovarian cycle in the house gecko, Hemidactylus flaviviridis, was conducted in Oman. Circulating estradiol (E(2)), progesterone (P), and testosterone (T) were measured during the active and inactive phases of the cycle. The steroid levels were related to the steroidogenic ultrastructural features such as the abundance of smooth endoplasmic reticulum (SER), the presence of cisternal whorls, and close association of lipid droplets with swollen vesiculated mitocho...
Abstract
Cited 125 times since 2012 (9.3 per year)
source: EuropePMC
PLoS medicine,
Volume 9, Issue 2, 21 3 2012, Pages e1001177
Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.
Clarke R, Bennett DA, Parish S, Verhoef P, Dötsch-Klerk M, Lathrop M, Xu P, Nordestgaard BG, Holm H, Hopewell JC, Saleheen D, Tanaka T, Anand SS, Chambers JC, Kleber ME, Ouwehand WH, Yamada Y, Elbers C, Peters B, Stewart AF, Reilly MM, Thorand B, Yusuf S, Engert JC, Assimes TL, Kooner J, Danesh J, Watkins H, Samani NJ, Collins R, Peto R, MTHFR Studies Collaborative Group
Background: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality. Methods and findings: Nineteen unp...
Abstract
Cited 77 times since 2012 (5.7 per year)
source: EuropePMC
Circulation. Cardiovascular interventions,
Volume 5, Issue 2, 21 3 2012, Pages 279-287
Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs.
Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, O'Neill LA, McGuirk P, Timmers L, Smeets MB, Akeroyd L, Reilly M, Pasterkamp G, de Kleijn DP
Background: Toll-like receptor (TLR)-2 is an important mediator of innate immunity and ischemia/reperfusion-induced cardiac injury. We have previously shown that TLR2 inhibition reduces infarct size and improves cardiac function in mice. However, the therapeutic efficacy of a clinical grade humanized anti-TLR2 antibody, OPN-305, in a large-animal model remained to be addressed. Methods and results: Pigs (n=38) underwent 75 minutes ischemia followed by 24 hours of reperfusion. Saline or OPN-305 (...
Abstract
Cited 13 times since 2012 (1 per year)
source: EuropePMC
Journal of inherited metabolic disease,
Volume 35, Issue 6, 21 3 2012, Pages 1093-1099
The cognitive profile of type 1 Gaucher disease patients.
Biegstraaten M, Wesnes KA, Luzy C, Petakov M, Mrsic M, Niederau C, Giraldo P, Hughes D, Mehta A, Mengel KE, Hollak CE, Maródi L, van Schaik IN
Background: The absence of neurological symptoms and signs is traditionally considered mandatory for a diagnosis of type 1 Gaucher disease (GD1), but in recent years many reports have emerged on neurological manifestations in GD1 patients. Nevertheless, it has been unclear whether cognitive deficits are part of the disease as well. Methods: Cognitive function was assessed in a large cohort of GD1 patients with the use of the CDR system, a set of computerised cognitive tests. Testing was performe...
Abstract
Cited 68 times since 2012 (5 per year)
source: EuropePMC
Science signaling,
Volume 5, Issue 212, 21 3 2012, Pages pt2
TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia.
Ten Dijke P, Egorova AD, Goumans MJ, Poelmann RE, Hierck BP
Endothelial-to-mesenchymal transition (EndoMT) is an instrumental step in the development of valves in the embryonic heart. This process is driven by activation of transforming growth factor-β (TGF-β) signaling and is characterized by the loss of endothelial and gain of mesenchymal phenotype, and by delamination of cells from the surface into the underlying endocardial cushion matrix. The endothelial cells (ECs) overlying the cushions are typically exposed to high blood flow and concomitant shea...
Abstract
Cited 17 times since 2012 (1.3 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 35, Issue 6, 21 3 2012, Pages 652-658
Update on small-diameter implantable cardioverter-defibrillator leads performance.
van Rees JB, van Welsenes GH, Borleffs CJ, Thijssen J, van der Velde ET, van der Wall EE, van Erven L, Schalij MJ
Background: The performance of small diameter implantable cardioverter defibrillator (ICD) leads is questionable. However, data on performance during long-term follow-up are scarce. The aim of this study is to provide an update for the lead failure and cardiac perforation rate of Medtronic's Sprint Fidelis ICD lead (Medtronic Inc., Minneapolis, MN, USA) and St. Jude Medical's Riata ICD lead (St. Jude Medical Inc., St. Paul, MN, USA). Methods: Since 1996, all ICD system implantations at...
Abstract
Cited 58 times since 2012 (4.3 per year)
source: EuropePMC
International psychogeriatrics,
Volume 24, Issue 7, 20 3 2012, Pages 1153-1162
Sense of competence in dementia care staff (SCIDS) scale: development, reliability, and validity.
Schepers AK, Orrell M, Shanahan N, Spector A
Background: Sense of competence in dementia care staff (SCIDS) may be associated with more positive attitudes to dementia among care staff and better outcomes for those being cared for. There is a need for a reliable and valid measure of sense of competence specific to dementia care staff. This study describes the development and evaluation of a measure to assess "sense of competence" in dementia care staff and reports on its psychometric properties. Methods: The systematic measure dev...
Abstract
Cited 12 times since 2012 (0.9 per year)
source: EuropePMC
Heart and vessels,
Volume 28, Issue 2, 18 3 2012, Pages 166-172
The maximum necrotic core area is most often located proximally to the site of most severe narrowing: a virtual histology intravascular ultrasound study.
de Graaf MA, van Velzen JE, de Graaf FR, Schuijf JD, Dijkstra J, Bax JJ, Reiber JH, Schalij MJ, van der Wall EE, Jukema JW
Previous angiographic studies have shown that almost two-thirds of vulnerable plaques are located in non-obstructive lesions. Possibly, the maximum necrotic core (Max NC) area is not always identical to the site of most severe stenosis. Therefore, the purpose of this study was to evaluate the potential difference in location between the maximum necrotic core area and the site of most severe narrowing as assessed by virtual histology intravascular ultrasound (VH IVUS). Overall, 77 patients (139 v...
Abstract
Cited 34 times since 2012 (2.5 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 2, 17 3 2012, Pages e30319
Hospital and community ampicillin-resistant Enterococcus faecium are evolutionarily closely linked but have diversified through niche adaptation.
de Regt MJ, van Schaik W, van Luit-Asbroek M, Dekker HA, van Duijkeren E, Koning CJ, Bonten MJ, Willems RJ
Background: Ampicillin-resistant Enterococcus faecium (ARE) has emerged as a nosocomial pathogen. Here, we quantified ARE carriage in different community sources and determined genetic relatedness with hospital ARE. Methods and results: ARE was recovered from rectal swabs of 24 of 79 (30%) dogs, 11 of 85 (13%) cats and 0 of 42 horses and from 3 of 40 (8%) faecal samples of non-hospitalized humans receiving amoxicillin. Multi-locus Sequence Typing revealed 21 sequence types (STs), including 5 STs...
Abstract
Cited 148 times since 2012 (11 per year)
source: EuropePMC
European heart journal,
Volume 33, Issue 7, 16 3 2012, Pages 857-865
Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial.
Lüscher TF, Taddei S, Kaski JC, Jukema JW, Kallend D, Münzel T, Kastelein JJ, Deanfield JE, dal-VESSEL Investigators
Aims: High-density lipoprotein cholesterol (HDL-C) is inversely associated with cardiovascular (CV) events and thus an attractive therapeutic target. However, in spite of marked elevations in HDL-C, the first cholesterol transport protein (CETP) inhibitor torcetrapib raised blood pressure (BP), impaired endothelial function, and increased CV mortality and morbidity. Dalcetrapib is a novel molecule acting on CETP with a different chemical structure to torcetrapib. As HDL stimulates nitric oxide (...
Abstract
Cited 22 times since 2012 (1.6 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 9, Issue 6, 14 2 2012, Pages 333-346
Multimodality imaging in interventional cardiology.
van der Hoeven BL, Schalij MJ, Delgado V
'Multimodality' imaging--the side-by-side interpretation of data obtained from various noninvasive imaging techniques, such as echocardiography, radionuclide techniques, multidetector CT (MDCT), and MRI--allows anatomical, morphological, and functional data to be combined, increases diagnostic accuracy, and improves the efficacy of cardiovascular interventions and clinical outcomes. During the past decade, advances in software and hardware have allowed co-registration of various imagin...
Abstract
Cited 28 times since 2012 (2.1 per year)
source: EuropePMC
Alimentary pharmacology & therapeutics,
Volume 35, Issue 7, 13 2 2012, Pages 810-818
A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and CYP2C19 polymorphism.
Hunfeld NG, Touw DJ, Mathot RA, van Schaik RH, Kuipers EJ
Background: Esomeprazole and rabeprazole are metabolised in the liver by means of the CYP2C19 enzyme, which has several functional genetic polymorphisms. Among Caucasians, 70% of the population has a fast metaboliser phenotype, 25-30% an intermediate and 2-5% a slow metaboliser phenotype. It is unknown whether different PPIs are affected to the same extent by these phenotypic differences. Aim: To compare the acid-inhibitory effects of esomeprazole 40 mg and rabeprazole 20 mg in relation to CYP2C...
Abstract
Cited 22 times since 2012 (1.6 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 42, Issue 3, 13 2 2012, Pages 520-523
Arterial switch in the first hours of life: no need for Rashkind septostomy?
Nevvazhay T, Chernogrivov A, Biryukov E, Biktasheva L, Karchevskaya K, Sulejmanov S, Kalinicheva J, Artemiev N
Objectives: We describe our experience of arterial switch operation (ASO) in the first hours of life in children with D-transposition of the great arteries (TGA) intact ventricular septum and restrictive patent foramen ovale (PFO) with severe metabolic disorders. The Rashkind procedure is the usual strategy to stabilize critically ill patient before surgery. We assume that primary ASO is also the safe option. Methods: Between 2008 and 2010, 44 neonates underwent ASO. Of these, eight with simple...
Abstract
