9607 results
Cited 58 times since 2009 (3.7 per year)
source: EuropePMC
BMC medicine,
Volume 7, 12 2 2009, Pages 70
Oral high dose ascorbic acid treatment for one year in young CMT1A patients: a randomised, double-blind, placebo-controlled phase II trial.
Verhamme C, de Haan RJ, Vermeulen M, Baas F, de Visser M, van Schaik IN
Background: High dose oral ascorbic acid substantially improved myelination and locomotor function in a Charcot-Marie-Tooth type 1A mouse model. A phase II study was warranted to investigate whether high dose ascorbic acid also has such a substantial effect on myelination in Charcot-Marie-Tooth type 1A patients and whether this treatment is safe. Methods: Patients below age 25 years were randomly assigned to receive placebo or ascorbic acid (one gram twice daily) in a double-blind fashion during...
Abstract
Cited 8 times since 2009 (0.5 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 50, Issue 12, 12 2 2009, Pages 1980-1986
Endothelial dysfunction in diabetic patients with abnormal myocardial perfusion in the absence of epicardial obstructive coronary artery disease.
Djaberi R, Roodt Jo, Schuijf JD, Rabelink TJ, de Koning EJ, Pereira AM, Stokkel MP, Smit JW, Bax JJ, Jukema JW
Unlabelled: In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive epicardial coronary artery disease (CAD), thereby presenting a diagnostic problem. We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis. Methods: Prospectively, 130 asymptomatic patients with diabetes mellitus underwent cardiovascular screening by coronary artery calcium (CAC) scoring, multislice...
Abstract
Cited 94 times since 2009 (6 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 95, Issue 1, 11 2 2009, Pages 93-99
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.
Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N
Context: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. Objective: The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach. Methods: In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205)...
Abstract
Cited 31 times since 2009 (2 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 39, Issue 1, 11 2 2009, Pages 70-86
A systematic review of implementation of established recommended secondary prevention measures in patients with PAOD.
Flu HC, Tamsma JT, Lindeman JH, Hamming JF, Lardenoye JH
Objective: Since patients with peripheral arterial occlusive disease (PAOD) are at high-risk for cardiovascular morbidity and mortality, preventive measures aimed to reduce cardiovascular adverse events are advocated in the current guidelines. We conducted a systematic review to assess the implementation of secondary prevention (SP) measures in PAOD patients. Methods: PubMed, Cochrane Library, EMBASE and Web of Science databases were searched to perform a systematic review of the literature from...
Abstract
Cited 15 times since 2009 (1 per year)
source: EuropePMC
Atherosclerosis,
Volume 210, Issue 1, 10 2 2009, Pages 28-34
Lipoprotein-associated phospholipase A(2), inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).
Caslake MJ, Packard CJ, Robertson M, Cooney J, Nelson JJ, Ford I, Gaw A, Jukema JW, Macfarlane PW, Stott DJ, Shepherd J, PROSPER Study Group
Objective: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an inflammatory biomarker that circulates mainly bound to LDL. We evaluated the association of Lp-PLA(2) with vascular events in the elderly where the importance of LDL is diminished as a risk factor for coronary disease. Methods: Mass and activity of Lp-PLA(2) were related to risk over 3.2 years for vascular events (definite or suspected death from CHD, non-fatal MI, fatal or non-fatal stroke) in the 2804 men and 3000 women age...
Abstract
Cited 31 times since 2009 (2 per year)
source: EuropePMC
Transplant infectious disease : an official journal of the Transplantation Society,
Volume 12, Issue 2, 10 2 2009, Pages 98-105
Comparison of the QuantiFERON-TB Gold In-Tube test with the tuberculin skin test for detecting latent tuberculosis infection in hemodialysis patients.
Seyhan EC, Sökücü S, Altin S, Günlüoğlu G, Trablus S, Yilmaz D, Koksalan OK, Issever H
Background and objectives: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis (TB) infection (LTBI). LTBI screening of this population is recommended. The QuantiFERON-TB Gold assay (QFT-G) may be more accurate than the tuberculin skin test (TST) in the detection of LTBI. We prospectively compared the results of QFT-G to TST in HD patients. Methods: We examined 100 patients and performed TST and QFT-G tests. Data obtained from patients and medical records incl...
Abstract
Cited 25 times since 2009 (1.6 per year)
source: EuropePMC
Pediatric nephrology (Berlin, Germany),
Volume 25, Issue 2, 7 1 2009, Pages 289-298
Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study.
Geelhoed JJ, Taal HR, Steegers EA, Arends LR, Lequin M, Moll HA, Hofman A, van der Heijden AJ, Jaddoe VW
Information about growth of kidney structures in early life is limited. In a population-based prospective cohort study, from foetal life onwards, we constructed reference curves for kidney growth from the third trimester of pregnancy until early childhood, using data from 1,158 healthy children. Kidney size, defined as length, width, depth and volume, was measured in the third trimester of pregnancy and at the postnatal ages of 6 months and 24 months. Analyses were based on more than 2,500 kidne...
Abstract
Cited 22 times since 2009 (1.4 per year)
source: EuropePMC
Veterinary microbiology,
Volume 142, Issue 3-4, 6 1 2009, Pages 268-275
The increase in seroprevalence of bluetongue virus (BTV) serotype 8 infections and associated risk factors in Dutch dairy herds, in 2007.
Santman-Berends IM, Bartels CJ, van Schaik G, Stegeman JA, Vellema P
Bluetongue virus serotype 8 (BTV-8) emerged in the Netherlands in August 2006 for the first time. In the winter of 2006/2007, during the transmission free period, the government decided to establish a sentinel network to monitor the re-emergence of BTV-8 in 2007. Between June and December 2007, a sentinel network of 275 dairy herds with 8901 seronegative cows at start, was in place for BTV-8 testing in milk samples. Besides estimates of the monthly BTV-8 within-herd prevalence per region (south,...
Abstract
Cited 43 times since 2009 (2.7 per year)
source: EuropePMC
American journal of epidemiology,
Volume 170, Issue 11, 4 1 2009, Pages 1415-1421
Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study.
Trompet S, Jukema JW, Katan MB, Blauw GJ, Sattar N, Buckley B, Caslake M, Ford I, Shepherd J, Westendorp RG, de Craen AJ
Observational studies have shown an association between low plasma cholesterol levels and increased risk of cancer, whereas most randomized clinical trials involving cholesterol-lowering medications have not shown this association. Between 1997 and 2002, the authors assessed the association between plasma cholesterol levels and cancer risk, free from confounding and reverse causality, in a Mendelian randomization study using apolipoprotein E (ApoE) genotype. ApoE genotype, plasma cholesterol lev...
Abstract
Cited 28 times since 2009 (1.8 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 10, Issue 3, 3 1 2009, Pages 219-225
The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients.
Schenk PW, van Vliet M, Mathot RA, van Gelder T, Vulto AG, van Fessem MA, Verploegh-Van Rij S, Lindemans J, Bruijn JA, van Schaik RH
CYP2C19 converts the tricyclic antidepressant imipramine to its active metabolite desipramine, which is subsequently inactivated by CYP2D6. The novel CYP2C19*17 allele causes ultrarapid metabolism of CYP2C19 substrates. We genotyped 178 depressed patients on imipramine for CYP2C19*17, and measured steady-state imipramine and desipramine plasma concentrations. Mean dose-corrected imipramine plasma concentration was significantly dependent on CYP2C19 genotype (Kruskal-Wallis test, P=0.01), with ci...
Abstract
Cited 34 times since 2009 (2.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 2, Issue 11, 1 1 2009, Pages 1271-1281
Integrated assessment of diastolic and systolic ventricular function using diagnostic cardiac magnetic resonance catheterization: validation in pigs and application in a clinical pilot study.
Schmitt B, Steendijk P, Lunze K, Ovroutski S, Falkenberg J, Rahmanzadeh P, Maarouf N, Ewert P, Berger F, Kuehne T
Objectives: This study sought to develop and validate a method for the integrated analysis of systolic and diastolic ventricular function. Background: An integrated approach to assess ventricular pump function, myocontractility (end-systolic pressure-volume relationship [ESPVR]), and diastolic compliance (end-diastolic pressure-volume relation [EDPVR]) is of high clinical value. Cardiac magnetic resonance (CMR) is well established for measuring global pump function, and catheterization-combined...
Abstract
Cited 71 times since 2009 (4.5 per year)
source: EuropePMC
Diabetes care,
Volume 32, Issue 11, 1 1 2009, Pages 2094-2098
Prediction of coronary heart disease risk in a general, pre-diabetic, and diabetic population during 10 years of follow-up: accuracy of the Framingham, SCORE, and UKPDS risk functions: The Hoorn Study.
van der Heijden AA, Ortegon MM, Niessen LW, Nijpels G, Dekker JM
Objective: To test the validity of the Framingham, Systematic Coronary Risk Evaluation (SCORE), and UK Prospective Diabetes Study (UKPDS) risk function in the prediction of risk of coronary heart disease (CHD) in populations with normal glucose tolerance (NGT), intermediate hyperglycemia, and type 2 diabetes. Research design and methods: Calibration and discrimination of the three prediction models were tested using prospective data for 1,482 Caucasian men and women, 50-75 years of age, who part...
Abstract
Cited 7 times since 2009 (0.4 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 11 Suppl 5, 1 1 2009, Pages v32-9
The role of non-invasive imaging in patient selection.
Van de Veire NR, Delgado V, Schuijf JD, van der Wall EE, Schalij MJ, Bax JJ
Cardiac resynchronization therapy (CRT) is an established therapy for patients with advanced heart failure, depressed left ventricular (LV) function and wide QRS complex. A substantial amount of patients do not respond to CRT. Recent studies suggest that assessment of mechanical dyssynchrony may allow identification of potential CRT responders. In addition, presence of scar tissue and venous anatomy may play a role in the selection of candidates. This article summarizes the role of non-invasive...
Abstract
Cited 29 times since 2009 (1.8 per year)
source: EuropePMC
Blood,
Volume 114, Issue 20, 1 1 2009, Pages 4603-4; author reply 4604-5
Elevated fibrinogen gamma' ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical outcome.
Cheung EY, Vos HL, Kruip MJ, den Hertog HM, Jukema JW, de Maat MP
Abstract
Cited 26 times since 2009 (1.7 per year)
source: EuropePMC
Pharmacogenomics,
Volume 10, Issue 11, 1 1 2009, Pages 1743-1751
Common genetic variation in the ABCB1 gene is associated with the cholesterol-lowering effect of simvastatin in males.
Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH
Aims: The cholesterol-lowering drug simvastatin is a substrate for P-glycoprotein (P-gp). P-gp, encoded by ABCB1, is an efflux transporter and genetic variation in ABCB1 is associated with drug levels and response. We examined the Rotterdam Study, which is a population-based cohort study of people aged 55 years and older, to see whether the C1236T, G2677T/A and C3435T polymorphisms and haplotypes in the ABCB1 gene are associated with the total cholesterol and low-density lipoprotein cholesterol-...
Abstract
Cited 28 times since 2009 (1.8 per year)
source: EuropePMC
Journal of experimental psychology. Learning, memory, and cognition,
Volume 35, Issue 6, 1 1 2009, Pages 1487-1505
Exaggerated risk: prospect theory and probability weighting in risky choice.
Kusev P, van Schaik P, Ayton P, Dent J, Chater N
In 5 experiments, we studied precautionary decisions in which participants decided whether or not to buy insurance with specified cost against an undesirable event with specified probability and cost. We compared the risks taken for precautionary decisions with those taken for equivalent monetary gambles. Fitting these data to Tversky and Kahneman's (1992) prospect theory, we found that the weighting function required to model precautionary decisions differed from that required for monetary...
Abstract
Cited 60 times since 2009 (3.8 per year)
source: EuropePMC
Neurology,
Volume 73, Issue 18, 1 1 2009, Pages 1457-1461
Somatosensory evoked potentials during mild hypothermia after cardiopulmonary resuscitation.
Bouwes A, Binnekade JM, Zandstra DF, Koelman JH, van Schaik IN, Hijdra A, Horn J
Objective: In patients who remain in a coma after cardiopulmonary resuscitation (CPR), the bilateral absence of cortical N20 responses of median nerve somatosensory evoked potentials (SSEP) 24 hours after admission invariably correlates with a poor neurologic outcome. Nowadays, CPR patients are treated with mild hypothermia, with simultaneously administered sedative drugs, hampering clinical neurologic assessment. We investigated whether SSEP performed during hypothermia can reliably predict a p...
Abstract
Cited 118 times since 2009 (7.5 per year)
source: EuropePMC
Future microbiology,
Volume 4, Issue 9, 1 1 2009, Pages 1125-1135
Transition of Enterococcus faecium from commensal organism to nosocomial pathogen.
Willems RJ, van Schaik W
The Gram-positive species Enterococcus faecium has long been thought of as a harmless commensal of the mammalian GI tract. In the last two decades, however, E. faecium has become an important cause of nosocomial bacteremias. These infections are often difficult to treat owing to the resistance of E. faecium to a large number of antibiotics. In this article, we review the recent transition of E. faecium from commensal to nosocomial pathogen. We focus on population biology-based studies, which sug...
Abstract
Cited 26 times since 2009 (1.7 per year)
source: EuropePMC
American heart journal,
Volume 158, Issue 5, 1 1 2009, Pages 860-866
Low- and high-density lipoprotein cholesterol goal attainment in dyslipidemic women: The Lipid Treatment Assessment Project (L-TAP) 2.
Santos RD, Waters DD, Tarasenko L, Messig M, Jukema JW, Ferrières J, Verdejo J, Chiang CW, L-TAP 2 Investigators
Background: Differences between women and men have been documented for both diagnostic testing and treatment in cardiology. This analysis evaluates whether low-density lipoprotein cholesterol (LDL-C) success rates according to current guidelines and high-density lipoprotein cholesterol (HDL-C) levels differ by gender in the L-TAP 2 population. Methods: Patients aged > or =20 years with dyslipidemia on stable lipid-lowering therapy were assessed in 9 countries between September 2006 and April...
Abstract
Cited 23 times since 2009 (1.5 per year)
source: EuropePMC
American heart journal,
Volume 158, Issue 5, 1 1 2009, Pages 769-776
Cardiac resynchronization therapy in patients with ischemic versus non-ischemic heart failure: Differential effect of optimizing interventricular pacing interval.
Marsan NA, Bleeker GB, Van Bommel RJ, Borleffs C, Bertini M, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Whether sequential biventricular pacing provides substantial benefits over conventional simultaneous stimulation remains unclear, particularly regarding the differences between ischemic and non-ischemic patients. The purpose of this study was to evaluate the acute effect of interventricular pacing interval (V-V) optimization on left ventricular (LV) systolic performance and dyssynchrony in ischemic versus non-ischemic patients. Methods: Sixty-nine consecutive patients underwent cardi...
Abstract
