Research

Publications

Below you can find a list of our published research.

9607 results

Cited 7 times since 2009 (0.4 per year) source: EuropePMC

Disease markers, Volume 26, Issue 2, 1 1 2009, Pages 75-83 Metabolic background determines the importance of NOS3 polymorphisms in restenosis after percutaneous coronary intervention: A study in patients with and without the metabolic syndrome. Pons D, Monraats PS, Zwinderman AH, de Maat MP, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, Jukema JW

Variation in the NOS3 gene has been related to the development of restenosis. The Glu298Asp polymorphism has previously been investigated for its effect on NO levels and the development of restenosis. However, the variability of findings gave rise to the hypothesis that the functional significance of this polymorphism may only become manifest under conditions of endothelial dysfunction. Since patients with the metabolic syndrome are known to have endothelial dysfunction, we aimed to investigate... Abstract

Cited 48 times since 2009 (2.9 per year) source: EuropePMC

PLoS medicine, Volume 6, Issue 1, 1 1 2009, Pages e16 Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis. Ford I, Bezlyak V, Stott DJ, Sattar N, Packard CJ, Perry I, Buckley BM, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J

Background: Reduced glomerular filtration rate (GFR) is associated with increased cardiovascular risk in young and middle aged individuals. Associations with cardiovascular disease and mortality in older people are less clearly established. We aimed to determine the predictive value of the GFR for mortality and morbidity using data from the 5,804 participants randomized in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Methods and findings: Glomerular filtration rate was... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Circulation research, Volume 104, Issue 1, 1 1 2009, Pages e8 Response to the letter by Rose et al. Pijnappels DA, Schalij MJ, Atsma DE

Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Expert review of cardiovascular therapy, Volume 7, Issue 1, 1 1 2009, Pages 49-56 Myocardial perfusion imaging to assess ischemia using multislice computed tomography. van Werkhoven JM, Schuijf JD, Bax JJ

Multislice computed tomography (MSCT) coronary angiography is an accurate noninvasive anatomic imaging technique; but it cannot determine the functional relevance of the lesions it detects. However, MSCT perfusion imaging can detect the presence of myocardial infarction during rest and assess viability using delayed enhancement. With recent developments in MSCT scanner technology, it has become possible to image myocardial perfusion and the capability of MSCT to determine the presence of ischemi... Abstract

Cited 48 times since 2009 (2.9 per year) source: EuropePMC

Current opinion in cardiology, Volume 24, Issue 1, 1 1 2009, Pages 18-28 Critical appraisal of methods to assess mechanical dyssynchrony. Yu CM, Bax JJ, Gorcsan J

Purpose of review: To analyze the strength and weakness of various imaging tools for systolic dyssynchrony assessment in the cardiac resynchronization therapy (CRT) era. Also, controversies and problematic issues of the recent predictors of response to cardiac resynchronization therapy study were addressed. Recent findings: Despite published data from experienced centers that echocardiographic parameters of systolic dyssynchrony assessment with defined cutoff values were able to predict favorabl... Abstract

Cited 4 times since 2009 (0.2 per year) source: EuropePMC

Clinical chemistry and laboratory medicine, Volume 47, Issue 11, 1 1 2009, Pages 1343-1350 Considerations for the development of a reference method for sequencing of haploid DNA--an opinion paper on behalf of the IFCC Committee on Molecular Diagnostics, International Federation of Clinical Chemistry and Laboratory Medicine. Rousseau F, Gancberg D, Schimmel H, Neumaier M, Bureau A, Mamotte C, van Schaik R, Payne D, Pazzagli M, Young I

Following the completion of sequencing of the human genome, there has been a very rapid increase in the development of new molecular diagnostic tests. However, the numerous genetic tests and genetic testing technologies offered do not always satisfy essential quality criteria required to ensure confidence in the results that are produced. This is of particular importance for genetic tests since many patients may be tested for a particular genetic defect only once in their lifetime. Thus, there i... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Tijdschrift voor psychiatrie, Volume 51, Issue 10, 1 1 2009, Pages 727-736 [Treatment for chronic depression: cognitive behavioral analysis system of psychotherapy (CBASP)]. Wiersma JE, van Schaik DJ, Blom MB, Bakker L, van Oppen P, Beekman AT

Background: Chronic depression is a common disorder in secondary care. Treatment results for this group of depressed patients are often disappointing and the existing treatment protocols are insufficiently tailored to chronic MDD. For this reason, an effective psychotherapeutic treatment will constitute a welcome addition to the range of treatments currently available for chronically depressed patients. Aim: To describe 'cognitive behavioral analysis system of psychotherapy' (CBASP), t... Abstract

Cited 3 times since 2009 (0.2 per year) source: EuropePMC

Tijdschrift voor psychiatrie, Volume 51, Issue 9, 1 1 2009, Pages 699-703 [Clozapine use and abrupt smoking cessation; a potentially life-threatening combination]. Ruissen A, van Schaik AM, Beijnen JH

A 58-year-old man was in a period of 3 weeks twice admitted to a general hospital with symptoms of clozapine intoxication, i.e. loss of consciousness. We are of the opinion that the patient developed clozapine intoxication because he had been prescribed clozapine (300 mg/day) and at the same time had suddenly stopped smoking. The link is confirmed in the literature. We therefore recommend that clozapine-dosage be adjusted to a patient's smoking behaviour. Abstract

Cited 141 times since 2009 (8.5 per year) source: EuropePMC

The American journal of surgical pathology, Volume 33, Issue 1, 1 1 2009, Pages 50-57 Assessment of interobserver variability and histologic parameters to improve reliability in classification and grading of central cartilaginous tumors. Eefting D, Schrage YM, Geirnaerdt MJ, Le Cessie S, Taminiau AH, Bovée JV, Hogendoorn PC, EuroBoNeT consortium

The distinction between benign and malignant cartilaginous tumors of bone is one of the most difficult subjects in surgical pathology. The grading of chondrosarcoma also seems to vary considerably among pathologists. However, clinical management differs. The purpose of this study was (1) to investigate interobserver variability in histological diagnosis and grading of central cartilaginous tumors and (2) to assess the diagnostic value of defined histologic parameters in differentiating enchondro... Abstract

Cited 75 times since 2009 (4.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 53, Issue 3, 1 1 2009, Pages 254-263 Acute heart failure syndromes in patients with coronary artery disease early assessment and treatment. Flaherty JD, Bax JJ, De Luca L, Rossi JS, Davidson CJ, Filippatos G, Liu PP, Konstam MA, Greenberg B, Mehra MR, Breithardt G, Pang PS, Young JB, Fonarow GC, Bonow RO, Gheorghiade M, Acute Heart Failure Syndromes International Working Group

Acute heart failure syndromes (AHFS) have emerged as a leading public health problem worldwide, accounting for a substantial number of hospitalizations and a high utilization of resources. Although in-hospital mortality rates are relatively low, patients with AHFS have very high early after-discharge mortality and rehospitalization rates. The majority of patients admitted with AHFS have coronary artery disease (CAD), which independently has an adverse impact on prognosis. The initial in-hospital... Abstract

Cited 12 times since 2009 (0.7 per year) source: EuropePMC

Journal of food science, Volume 74, Issue 1, 1 1 2009, Pages S44-52 Effects of electrical stimulation on histochemical muscle fiber staining, quality, and composition of camel and cattle Longissimus thoracis muscles. Kadim IT, Mahgoub O, Al-Marzooqi W, Khalaf SK, Mansour MH, Al-Sinani SS, Al-Amri IS

The effects of electrical stimulation on muscle fiber type, meat quality, and composition of Longissimus thoracis muscles from one-humped camels and Dofari Omani cattle of a comparable age range were investigated. A low-voltage electrical stimulation with 90 V, 14 Hz (pulse of 7.5-millisecond duration every 70 milliseconds) 20 min postmortem was applied. Samples from the left muscle were collected from 20 (2 to 3 y) camels and 24 cattle (1 to 3 y). For chemical composition, muscle samples were d... Abstract

Cited 6 times since 2009 (0.4 per year) source: EuropePMC

Expert review of cardiovascular therapy, Volume 7, Issue 1, 1 1 2009, Pages 65-72 Role of nuclear imaging in cardiac resynchronization therapy. Boogers MM, Chen J, Bax JJ

Cardiac resynchronization therapy (CRT) has become an integrated treatment option for patients with drug-refractory heart failure. Selection of patients for CRT is based on moderate-to-severe heart failure (New York Heart Association functional class III or IV), depressed left ventricular (LV) systolic function of 35% or below and prolonged QRS interval of 120 ms or more. However, 30-40% of selected patients do not exhibit improvement in heart failure symptoms or LV systolic performance. Efforts... Abstract

Cited 1 times since 2009 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 153, 1 1 2009, Pages B376 [The use of imaging in the case of suspected acute appendicitis: opinion of Dutch surgeons]. Poortman P, Oostvogel HJ, de Lange-de Klerk ES, Cuesta MA, Hamming JF

Objective: To gauge the opinion of Dutch surgeons concerning the use of ultrasound and CT in the case of a suspected acute appendicitis. Design: Written survey. Method: All 1020 members of the Association of the Surgeons of the Netherlands received a questionnaire with 8 statements concerning the diagnosis of acute appendicitis. The statements could be answered with 'agree', 'disagree', or 'no opinion'. Results: The questionnaire was returned by 439 members (43%). A... Abstract

Cited 1 times since 2009 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 53, Issue 4, 1 1 2009, Pages 373-398 Highlights of the Year in JACC 2008. DeMaria AN, Ben-Yehuda O, Bax JJ, Feld GK, Greenberg BH, Lew WY, Lima JA, Maisel AS, Narayan SM, Sahn DJ, Tsimikas S

Abstract

Cited 42 times since 2009 (2.5 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 238, Issue 1, 1 1 2009, Pages 183-193 Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Mahtab EA, Vicente-Steijn R, Hahurij ND, Jongbloed MR, Wisse LJ, DeRuiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC

We investigated the role of podoplanin in development of the sinus venosus myocardium comprising the sinoatrial node, dorsal atrial wall, and primary atrial septum as well as the myocardium of the cardinal and pulmonary veins. We analyzed podoplanin wild-type and knockout mouse embryos between embryonic day 9.5-15.5 using immunohistochemical marker podoplanin; sinoatrial-node marker HCN4; myocardial markers MLC-2a, Nkx2.5, as well as Cx43; coelomic marker WT-1; and epithelial-to-mesenchymal tran... Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 37, Issue 4, 31 5 2009, Pages 486-491 Implementation of endovenous laser ablation for varicose veins in a large community hospital: the first 400 procedures. van den Bremer J, Joosten PP, Hamming JF, Moll FL

Unlabelled: Endovenous laser ablation (ELA) has become a standard treatment of the incompetent great saphenous vein (GSV). Our prospective audit examines the implementation of this new method in a large community hospital with special attention to obstacles, technical results, pain scores, failures and our learning curve. Methods: Three hundred and twenty-three patients (403 limbs) with incompetence of the GSV underwent ELA. Patients were assessed by clinical examination and venous duplex ultras... Abstract

Cited 24 times since 2008 (1.4 per year) source: EuropePMC

International journal of cardiology, Volume 134, Issue 3, 30 5 2009, Pages 302-312 Pulmonary vein and atrial wall pathology in human total anomalous pulmonary venous connection. Douglas YL, Jongbloed MR, den Hartog WC, Bartelings MM, Bogers AJ, Ebels T, DeRuiter MC, Gittenberger-de Groot AC

Background: Normally, the inside of the left atrial (LA) body and pulmonary veins (PVs) is lined by vessel wall tissue covered by myocardium. In total anomalous pulmonary venous connection (TAPVC), no connection of the PVs with the LA body exists. These veins have an increased incidence of PV stenosis. We describe the consequences of the absent connection for the histopathology of the wall of the LA body and the PVs, and hypothesize on a mechanism predisposing to PV stenosis. Methods and results... Abstract

Cited 38 times since 2008 (2.3 per year) source: EuropePMC

The American journal of cardiology, Volume 103, Issue 5, 26 4 2008, Pages 690-694 Comparison of time course of response to cardiac resynchronization therapy in patients with ischemic versus nonischemic cardiomyopathy. Marsan NA, Bleeker GB, van Bommel RJ, Ypenburg C, Delgado V, Borleffs CJ, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

The time course of the effects of cardiac resynchronization therapy (CRT) on left ventricular (LV) systolic function and reverse remodeling is still unknown and was the subject of this study. In particular, whether the acute benefit of CRT translates in late response was explored. Furthermore, the time course of response was compared between ischemic and nonischemic patients. A total of 222 consecutive patients with heart failure (135 ischemic) scheduled for CRT were included. Standard echocardi... Abstract

Cited 30 times since 2008 (1.8 per year) source: EuropePMC

Biochimica et biophysica acta, Volume 1791, Issue 3, 25 4 2008, Pages 191-197 PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice. de Haan W, de Vries-van der Weij J, Mol IM, Hoekstra M, Romijn JA, Jukema JW, Havekes LM, Princen HM, Rensen PC

Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR agonism on HDL metabolism in ApoE3-Leiden (E3L) and E3L.CETP mice, well-established models for human-like lipoprotein metabolism. Female mice were fed a diet with increasing amounts of the potent PXR agonist 5-pregnen-3beta-ol-20-one-16alpha-carbonitri... Abstract

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 37, Issue 3, 25 4 2008, Pages 371 Comment on "Clinical endpoints in peripheral endovascular revascularisation trials: a case for standardised definitions Eur J Vasc Endovasc Surg 2008;36:409-9". Breek JC, De Vries J, Hamming JF

Abstract