6173 results
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Scientific reports,
Volume 12, Issue 1, 31 5 2022, Pages 1628
Chemotherapy response prediction with diffuser elapser network.
Koyuncu B, Melek A, Yilmaz D, Tuzer M, Unlu MB
In solid tumors, elevated fluid pressure and inadequate blood perfusion resulting from unbalanced angiogenesis are the prominent reasons for the ineffective drug delivery inside tumors. To normalize the heterogeneous and tortuous tumor vessel structure, antiangiogenic treatment is an effective approach. Additionally, the combined therapy of antiangiogenic agents and chemotherapy drugs has shown promising effects on enhanced drug delivery. However, the need to find the appropriate scheduling and...
Abstract
Cited 7 times since 2022 (2.2 per year)
source: EuropePMC
BMC health services research,
Volume 22, Issue 1, 30 5 2022, Pages 129
Clarifying responsibility: professional digital health in the doctor-patient relationship, recommendations for physicians based on a multi-stakeholder dialogue in the Netherlands.
Silven AV, van Peet PG, Boers SN, Tabak M, de Groot A, Hendriks D, van Os HJA, Bonten TN, Atsma DE, de Graaf TJ, Sombroek MP, Chavannes NH, Villalobos-Quesada M
Background: Implementation of digital health (eHealth) generally involves adapting pre-established and carefully considered processes or routines, and still raises multiple ethical and legal dilemmas. This study aimed to identify challenges regarding responsibility and liability when prescribing digital health in clinical practice. This was part of an overarching project aiming to explore the most pressing ethical and legal obstacles regarding the implementation and adoption of digital health in...
Abstract
Cited 6 times since 2022 (1.9 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 15, Issue 2, 28 4 2022, Pages e009979
Nonsustained Ventricular Tachycardia Is Independently Associated With Sustained Ventricular Arrhythmias in Nonischemic Dilated Cardiomyopathy.
Piers SR, Androulakis AF, Yim KS, van Rein N, Venlet J, Kapel GF, Siebelink HM, Lamb HJ, Cannegieter SC, Man SC, Zeppenfeld K
Background: Spontaneous nonsustained ventricular tachycardia (NSVT) on Holter, VT inducibility during electrophysiology study, and late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) have been associated with sustained ventricular arrhythmias (SVAs) in nonischemic dilated cardiomyopathy (DCM). This study aimed to analyze whether these parameters carry independent prognostic value for spontaneous SVA in DCM. Methods: Between 2011 and 2018, patients with the DCM clinical spectrum...
Abstract
Cited 3 times since 2022 (0.9 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 9, Issue 2, 27 4 2022, Pages 43
Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes.
Yuan Q, Maas RGC, Brouwer ECJ, Pei J, Blok CS, Popovic MA, Paauw NJ, Bovenschen N, Hjortnaes J, Harakalova M, Doevendans PA, Sluijter JPG, van der Velden J, Buikema JW
Contractility of the adult heart relates to the architectural degree of sarcomeres in individual cardiomyocytes (CMs) and appears to be inversely correlated with the ability to regenerate. In this study we utilized multiple imaging techniques to follow the sequence of sarcomere disassembly during mitosis resulting in cellular or nuclear division in a source of proliferating human pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). We observed that both mono- and binuclear hiPSC-CMs give ri...
Abstract
Cited 14 times since 2022 (4.3 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 7, 26 4 2022, Pages 703-711.e3
Noninvasive Left Ventricular Myocardial Work in Patients with Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction.
Meucci MC, Butcher SC, Galloo X, van der Velde ET, Marsan NA, Bax JJ, Delgado V
Background: Left ventricular (LV) global longitudinal strain (GLS) has been proposed as a sensitive marker of myocardial damage in patients with chronic severe aortic regurgitation (AR) and preserved LV ejection fraction (LVEF). However, LV GLS does not take into account the afterload. Noninvasive LV myocardial work is a novel parameter of LV myocardial performance, which integrates measurements of myocardial deformation and noninvasive blood pressure (afterload). The aims of this study were (1)...
Abstract
The American journal of cardiology,
Volume 169, 23 4 2022, Pages 93-99
Long-Term Impact of Preventive Tricuspid Valve Annuloplasty on Right Ventricular Remodeling.
Dietz MF, van Wijngaarden AL, Mack MJ, Braun J, Ajmone Marsan N, Delgado V, Klautz R, Bax JJ
In patients with primary mitral regurgitation (MR), concomitant tricuspid valve (TV) annuloplasty at the time of left-sided valve surgery is indicated in case of a dilated TV annulus ≥40 mm independent of the presence or severity of tricuspid regurgitation (TR). However, the long-term impact on right ventricular (RV) adverse remodeling is less well established and the benefit of preventive TV annuloplasty remains controversial. The aim of the study was to assess differences in long-term RV adver...
Abstract
Cited 11 times since 2022 (3.4 per year)
source: EuropePMC
ESC heart failure,
Volume 9, Issue 2, 22 4 2022, Pages 912-924
Functional classification of left ventricular remodelling: prognostic relevance in myocardial infarction.
Chimed S, van der Bijl P, Lustosa R, Fortuni F, Montero-Cabezas JM, Ajmone Marsan N, Gersh BJ, Delgado V, Bax JJ
Aims: The current definition of post ST-segment elevation myocardial infarction (STEMI) left ventricular (LV) remodelling is purely structural (LV dilatation) and does not consider LV function (ejection fraction, EF), even though it is known to be a predictor of long-term post-STEMI outcome. This study aimed to reclassify LV remodelling after STEMI by integrating LV dilatation and function (LVEF) and to investigate the prognostic implications. Methods and results: Data from an ongoing registry o...
Abstract
Cited 19 times since 2022 (5.8 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 5, 21 3 2022, Pages 477-485.e3
Left Atrial Reservoir Function and Outcomes in Secondary Mitral Regurgitation.
Stassen J, Namazi F, van der Bijl P, van Wijngaarden SE, Kamperidis V, Marsan NA, Delgado V, Bax JJ
Background: Left atrial (LA) size is a marker of disease severity and is related to worse outcomes in secondary mitral regurgitation (MR). The prognostic value of LA function assessed by LA reservoir strain (LARS), however, remains unknown. The aim of this study was to investigate the prognostic implications of LARS in patients with significant secondary MR. Methods: LARS was evaluated using speckle-tracking echocardiography in patients with more than mild (grade ≥ 2) secondary MR. The populatio...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Life (Basel, Switzerland),
Volume 12, Issue 2, 21 3 2022, Pages 154
Near-Infrared Fluorescence with Indocyanine Green to Assess Bone Perfusion: A Systematic Review.
Michi M, Madu M, Winters HAH, de Bruin DM, van der Vorst JR, Driessen C
Background: Adequate perfusion of a bone flap is essential for successful reconstruction of osseous defects. Unfortunately, complications related to inadequate bone perfusion are common. Near-infrared fluorescence (NIRF) imaging enables intraoperative visualization of perfusion. NIRF has been investigated in reconstructive surgery to aid the surgeon in clinical perioperative assessment of soft tissue perfusion. However, little is known on the beneficial use of NIRF to assess bone perfusion. Ther...
Abstract
Cited 36 times since 2022 (11.1 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 20 3 2022, Pages 827515
Robotic Cardiac Surgery in Europe: Status 2020.
Cerny S, Oosterlinck W, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, Pettinari M, Van Praet F, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Gianoli M, Agnino A, Philipsen T, Jansens JL, Folliguet T, Palmen M, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van den Eynde J, Bonatti J
Background: European surgeons were the first worldwide to use robotic techniques in cardiac surgery and major steps in procedure development were taken in Europe. After a hype in the early 2000s case numbers decreased but due to technological improvements renewed interest can be noted. We assessed the current activities and outcomes in robotically assisted cardiac surgery on the European continent. Methods: Data were collected in an international anonymized registry of 26 European centers with a...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 171, 19 3 2022, Pages 151-158
Prognostic Implications of Right Ventricular Free Wall Strain in Recipients of Cardiac Resynchronization Therapy.
Stassen J, van der Bijl P, Galloo X, Hirasawa K, Prihadi EA, Marsan NA, Bax JJ
Right ventricular (RV) function is an important prognostic marker in cardiac resynchronization therapy (CRT) recipients. Measuring RV systolic function with echocardiography, however, remains challenging due to the complexity of right heart morphology. Evaluation of RV function with RV free wall strain (FWS) may improve risk stratification in recipients of CRT compared with conventional RV function parameters. In 871 recipients of CRT (mean age 65 ± 11 years, 75% were men), RV function was asses...
Abstract
Cited 6 times since 2022 (1.8 per year)
source: EuropePMC
Journal of plastic, reconstructive & aesthetic surgery : JPRAS,
Volume 75, Issue 6, 14 2 2022, Pages 1820-1825
Quantification of near-infrared fluorescence imaging with indocyanine green in free flap breast reconstruction.
Van Den Hoven P, Verduijn PS, Van Capelle L, Tange FP, Michi M, Corion LUM, Sibinga Mulder BG, Mureau MAM, Vahrmeijer AL, Van Der Vorst JR
Background: One of the complications of free flap breast reconstruction is the occurrence of skin and fat necrosis. Intra-operative use of near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG) has the potential to predict these complications. In this study, the quantification of the fluorescence intensity measured in free flap breast reconstruction was performed to gain insight into the perfusion patterns observed with ICG NIR fluorescence imaging. Methods: ICG NIR fluorescence i...
Abstract
Cited 17 times since 2022 (5.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 6, 12 2 2022, Pages 961-970
Prognostic Impact of Extra-Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation.
van Wijngaarden AL, Mantegazza V, Hiemstra YL, Volpato V, van der Bijl P, Pepi M, Palmen M, Delgado V, Ajmone Marsan N, Tamborini G, Bax JJ
Background: In patients with severe primary mitral regurgitation (MR), the indication for surgery is currently based on the presence of symptoms, left ventricular dilatation and dysfunction, atrial fibrillation, and pulmonary hypertension. Objectives: The aim of this study was to evaluate the prognostic impact of the presence of extra-mitral valve cardiac involvement (including known risk factors but also severe left atrial [LA] dilatation and right ventricular [RV] dysfunction) in a large multi...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 2, 12 2 2022, Pages 221-223
Apical Rocking and Septal Flash: Predictors of Secondary Mitral Regurgitation Improvement After Cardiac Resynchronization Therapy.
Bax JJ, van der Bijl P
Abstract
Cited 4 times since 2022 (1.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 5, 12 2 2022, Pages 745-746
Etiology and Outcomes of Isolated Tricuspid Regurgitation.
Bax JJ, van der Bijl P
Abstract
Cited 3 times since 2022 (0.9 per year)
source: EuropePMC
Cardiovascular revascularization medicine : including molecular interventions,
Volume 40, 11 2 2022, Pages 189-194
Bailout Intravascular Lithotripsy for the Treatment of Acutely Underexpanded Stents in Heavily Calcified Coronary Lesions: A Case Series.
Mousa MAA, Bingen BO, Amri IA, Digiacomo S, Karalis I, Jukema JW, Montero-Cabezas JM
Stent underexpansion is a common problem in heavily calcified coronary lesions treated with percutaneous coronary intervention, and has been associated with in-stent restenosis, stent thrombosis and, subsequently, poor clinical outcomes. Adequate preparation of heavily calcified coronary lesions (e.g. using non-compliant balloons, cutting/scoring balloons, rotational/orbital atherectomy or intravascular lithotripsy) prior to stent implantation is essential in preventing stent underexpansion. How...
Abstract
Cited 6 times since 2022 (1.8 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 63, Issue 2, 10 2 2022, Pages 275-283
Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study.
Alberga AJ, Karthaus EG, Wilschut JA, de Bruin JL, Akkersdijk GP, Geelkerken RH, Hamming JF, Wever JJ, Verhagen HJM, Dutch Society of Vascular Surgery, Steering Committee of the Dutch Surgical Aneurysm Audit, and the Dutch Institute for Clinical Auditing
Objective: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. Methods: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outc...
Abstract
Non-coding RNA,
Volume 8, Issue 1, 10 2 2022, Pages 2
Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease.
Zhao Q, Nooren SJL, Zijlstra LE, Westenberg JJM, Kroft LJM, Jukema JW, Berkhout-Byrne NC, Rabelink TJ, van Zonneveld AJ, van Buren M, Mooijaart SP, Bijkerk R
The prevalence of end-stage kidney disease (ESKD) is rapidly increasing and mostly occurring in patients aged 65 years or older. The main cause of death in these patients is cardiovascular disease (CVD). Novel markers of vascular integrity may thus be of clinical value for identifying patients at high risk for CVD. Here we associated the levels of selected circulating angiogenic miRNAs, angiopoietin-2 (Ang-2) and asymmetric dimethylarginine (ADMA) with cardiovascular structure and function (as d...
Abstract
Cited 7 times since 2022 (2.1 per year)
source: EuropePMC
European radiology,
Volume 32, Issue 5, 8 2 2022, Pages 3408-3422
Utilizing (serial) coronary computed tomography angiography (CCTA) to predict plaque progression and major adverse cardiac events (MACE): results, merits and challenges.
van Driest FY, Bijns CM, van der Geest RJ, Broersen A, Dijkstra J, Scholte AJHA, Jukema JW
Objectives: To present an overview of studies using serial coronary computed tomography angiography (CCTA) as a tool for finding both quantitative (changes) and qualitative plaque characteristics as well as epicardial adipose tissue (EAT) volume changes as predictors of plaque progression and/or major adverse cardiac events (MACE) and outline the challenges and advantages of using a serial non-invasive imaging approach for assessing cardiovascular prognosis. Methods: A literature search was perf...
Abstract
Cited 7 times since 2022 (2.1 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 1, 7 1 2022, Pages e0261826
Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies.
Rostamian S, le Cessie S, Marijt KA, Jukema JW, Mooijaart SP, van Buchem MA, van Hall T, Gussekloo J, Trompet S
Background: Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with the risk of cancer death and all-cause mortality in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) and Leiden 85-plus Study. Additionally, a systematic review and meta-analysis of longitudinal studies...
Abstract
