Research

Publications

Below you can find a list of our published research.

8684 results

Cited 7 times since 2022 (2.1 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 63, Issue 2, 10 2 2022, Pages 275-283 Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study. Alberga AJ, Karthaus EG, Wilschut JA, de Bruin JL, Akkersdijk GP, Geelkerken RH, Hamming JF, Wever JJ, Verhagen HJM, Dutch Society of Vascular Surgery, Steering Committee of the Dutch Surgical Aneurysm Audit, and the Dutch Institute for Clinical Auditing

Objective: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. Methods: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outc... Abstract

Non-coding RNA, Volume 8, Issue 1, 10 2 2022, Pages 2 Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease. Zhao Q, Nooren SJL, Zijlstra LE, Westenberg JJM, Kroft LJM, Jukema JW, Berkhout-Byrne NC, Rabelink TJ, van Zonneveld AJ, van Buren M, Mooijaart SP, Bijkerk R

The prevalence of end-stage kidney disease (ESKD) is rapidly increasing and mostly occurring in patients aged 65 years or older. The main cause of death in these patients is cardiovascular disease (CVD). Novel markers of vascular integrity may thus be of clinical value for identifying patients at high risk for CVD. Here we associated the levels of selected circulating angiogenic miRNAs, angiopoietin-2 (Ang-2) and asymmetric dimethylarginine (ADMA) with cardiovascular structure and function (as d... Abstract

Cited 7 times since 2022 (2.1 per year) source: EuropePMC

European radiology, Volume 32, Issue 5, 8 2 2022, Pages 3408-3422 Utilizing (serial) coronary computed tomography angiography (CCTA) to predict plaque progression and major adverse cardiac events (MACE): results, merits and challenges. van Driest FY, Bijns CM, van der Geest RJ, Broersen A, Dijkstra J, Scholte AJHA, Jukema JW

Objectives: To present an overview of studies using serial coronary computed tomography angiography (CCTA) as a tool for finding both quantitative (changes) and qualitative plaque characteristics as well as epicardial adipose tissue (EAT) volume changes as predictors of plaque progression and/or major adverse cardiac events (MACE) and outline the challenges and advantages of using a serial non-invasive imaging approach for assessing cardiovascular prognosis. Methods: A literature search was perf... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Brain and behavior, Volume 12, Issue 2, 7 1 2022, Pages e2407 A neural signature for combined action observation and motor imagery? An fNIRS study into prefrontal activation, automatic imitation, and self-other perceptions. Emerson JR, Scott MW, van Schaik P, Butcher N, Kenny RPW, Eaves DL

Introduction: Research indicates that both observed and imagined actions can be represented in the brain as two parallel sensorimotor representations. One proposal is that higher order cognitive processes would align these two hypothetical action simulations. Methods: We investigated this hypothesis using an automatic imitation paradigm, with functional near-infrared spectroscopy recordings over the prefrontal cortex during different motor simulation states. On each trial, participants (n = 14)... Abstract

Cited 7 times since 2022 (2 per year) source: EuropePMC

PloS one, Volume 17, Issue 1, 7 1 2022, Pages e0261826 Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies. Rostamian S, le Cessie S, Marijt KA, Jukema JW, Mooijaart SP, van Buchem MA, van Hall T, Gussekloo J, Trompet S

Background: Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with the risk of cancer death and all-cause mortality in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) and Leiden 85-plus Study. Additionally, a systematic review and meta-analysis of longitudinal studies... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

Archives of physical medicine and rehabilitation, Volume 103, Issue 8, 6 1 2022, Pages 1582-1591 Reducing the Number of Test Items of the Action Research Arm Test Poststroke: A Decision Tree Analysis✰. Zonjee VJ, Selles RW, Roorda LD, Nijland RH, van der Oest MJW, Bosomworth HJ, van Wijck F, Meskers CGM, van Schaik SM, Van den Berg-Vos RM, Kwakkel G

Objective: The present study aimed to create a shorter version of the Action Research Arm Test (ARAT) without compromising its measurement properties. Design: Secondary analysis of stroke recovery cohorts that used the ARAT to measure upper limb impairment. Setting: Rehabilitation centers. Participants: Patients with stroke from 5 different stroke recovery cohorts (N=1425). Interventions: Not applicable. Main outcome measures: A decision tree version of the ARAT (ARAT-DT) was developed using chi... Abstract

Cited 11 times since 2022 (3.2 per year) source: EuropePMC

Frontiers in microbiology, Volume 12, 6 1 2022, Pages 765492 Temperature-Regulated IncX3 Plasmid Characteristics and the Role of Plasmid-Encoded H-NS in Thermoregulation. Baomo L, Lili S, Moran RA, van Schaik W, Chao Z

Carbapenem-resistant Enterobacteriaceae (CRE) are a critical public health problem worldwide. Globally, IncX3-type plasmids have emerged as the predominant vehicles carrying the metallo-β-lactamase gene bla NDM. Although bla NDM-bearing IncX3 plasmids have been found in various hosts from diverse environments, whether their transfer and persistence properties vary under different conditions and what factors influence any variation is unknown. By observing the effects of different temperatures on... Abstract

Cited 20 times since 2022 (5.9 per year) source: EuropePMC

Nature biomedical engineering, Volume 6, Issue 4, 6 1 2022, Pages 389-402 Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation. Harlaar N, Dekker SO, Zhang J, Snabel RR, Veldkamp MW, Verkerk AO, Fabres CC, Schwach V, Lerink LJS, Rivaud MR, Mulder AA, Corver WE, Goumans MJTH, Dobrev D, Klautz RJM, Schalij MJ, Veenstra GJC, Passier R, van Brakel TJ, Pijnappels DA, de Vries AAF

The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional atrial myocytes can be generated and expanded one-quadrillion-fold via a conditional cell-immortalization method relying on lentiviral vectors and the doxycycline-controlled expression of a recombinant viral oncogene in human foetal atrial myocytes, and that the immortalized cells can be used to generat... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

Surgical endoscopy, Volume 36, Issue 8, 6 1 2022, Pages 6214-6222 Does livestreaming surgical education have the future? Development and participant evaluation of a national COVID-19 livestreaming initiative. Feenstra TM, van Felius LP, Vriens MR, Stassen LPS, van Acker GJD, van Dijkum EJMN, Schijven MP, Bonjer HJ, NVvH Livestream Collaborative Group

Backgrounds: COVID-19 related reduction of surgical procedures jeopardizes learning on the job of surgical residents. Many educators resorted to digital resources in the search for alternatives. However, these resources are often limited to the extent they offer resident-surgeon interaction like a joint surgical performance does. Here we present a roadmap of livestreaming surgical procedures, and evaluate how surgical livestreams on human cadavers address the unmet educational needs of surgical... Abstract

Cited 28 times since 2022 (8.2 per year) source: EuropePMC

European journal of cancer (Oxford, England : 1990), Volume 162, 5 1 2022, Pages 148-157 UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients. Hulshof EC, de With M, de Man FM, Creemers GJ, Deiman BALM, Swen JJ, Houterman S, Koolen SLW, Bins S, Thijs AMJ, Laven MMJ, Hövels AM, Luelmo SAC, Houtsma D, Shulman K, McLeod HL, van Schaik RHN, Guchelaar HJ, Mathijssen RHJ, Gelderblom H, Deenen MJ

Aim: To determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan. Patients and methods: In this prospective, multicentre, non-randomised study, patients intended for treatment with irinotecan were pre-therapeutically genotyped for UGT1A1∗28 and UGT1A1∗93. Homozygous variant carriers (UGT1A1 poor metabolisers; PMs) received an initial 30% dose reduction. The primary endpoint was incidence of febrile neutropenia in the first two cycles of treatme... Abstract

Cited 8 times since 2022 (2.3 per year) source: EuropePMC

Frontiers in immunology, Volume 12, 3 1 2022, Pages 802877 Spatial and Temporal Heterogeneity of Tumor-Infiltrating Lymphocytes in Advanced Urothelial Cancer. van Wilpe S, Gorris MAJ, van der Woude LL, Sultan S, Koornstra RHT, van der Heijden AG, Gerritsen WR, Simons M, de Vries IJM, Mehra N

Checkpoint inhibitors targeting PD-(L)1 induce objective responses in 20% of patients with metastatic urothelial cancer (UC). CD8+ T cell infiltration has been proposed as a putative biomarker for response to checkpoint inhibitors. Nevertheless, data on spatial and temporal heterogeneity of tumor-infiltrating lymphocytes in advanced UC are lacking. The major aims of this study were to explore spatial heterogeneity for lymphocyte infiltration and to investigate how the immune landscape changes du... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 2, 3 1 2022, Pages 76-83 No substantial excess all-cause mortality among cardiac implantable electronic device patients during the first COVID‑19 lockdown in the Leiden area. Feijen M, Egorova AD, van der Velde ET, Schalij MJ, Beeres SLMA

In the Netherlands, the coronavirus disease 2019 (COVID‑19) pandemic has resulted in excess mortality nationwide. Chronic heart disease patients are at risk for a complicated COVID‑19 course. The current study investigates all-cause mortality among cardiac implantable electronic device (CIED) patients during the first peak of the pandemic and compares the data to the statistics for the corresponding period in the two previous years. Data of adult CIED patients undergoing follow-up at the Leiden... Abstract

Cited 12 times since 2022 (3.5 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 107, Issue 2, 1 1 2022, Pages 512-524 The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy. Brinks J, van Dijk EHC, Kiełbasa SM, Mei H, van der Veen I, Peters HAB, Sips HCM, Notenboom RGE, Quax PHA, Boon CJF, Meijer OC

Context: Central serous chorioretinopathy (CSC) is a severe ocular disease characterized by fluid accumulation under the retina and abnormalities in the underlying vascular layer, the choroid. CSC has a striking prevalence in males of 80% to 90% of total patients. Corticosteroids are the most pronounced extrinsic risk factor for CSC. Choroidal endothelial cells (CECs) are important for the vascular integrity of the choroid, but the effects of corticosteroid effects in these cells are unknown. Ob... Abstract

Cited 16 times since 2022 (4.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 2, 1 1 2022, Pages e62-e84 Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging. Marwick TH, Gimelli A, Plein S, Bax JJ, Charron P, Delgado V, Donal E, Lancellotti P, Levelt E, Maurovich-Horvat P, Neubauer S, Pontone G, Saraste A, Cosyns B, Edvardsen T, Popescu BA, Galderisi M, Derumeaux G, Reviewers: This document was reviewed by members of the 2020–2022 EACVI Scientific Documents Committee, Bäck M, Bertrand PB, Dweck M, Keenan N, Magne J, Neglia D, Stankovic I

Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem wil... Abstract

Tijdschrift voor psychiatrie, Volume 64, Issue 9, 1 1 2022, Pages 574-579 [Guided discontinuation of antidepressants: approach and first results of a Dutch multidisciplinary outpatient clinic]. Dozeman E, van der Lande HJ, Bet PM, Fransen K, Jager I, Jonker J, Philippo E, Reisman-Dolman J, van Schaik DJF, Scholten W, van de Velde I, Verheijen V, van der Wart M, van Zon M, Batelaan N, Vinkers CH

Background: Discontinuation of antidepressant medication can be difficult due to withdrawal symptoms and relapse risk. Scientific evidence on the questions of who, when, and how to stop antidepressants is limited. In Amsterdam a multidisciplinary outpatient clinic was started to provide advice and guidance. Aim: To substantiate the design of the clinic. Central questions relate to knowing which patients are referred, the background of their request, and their experiences with the outpatient clin... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Methods in molecular biology (Clifton, N.J.), Volume 2478, 1 1 2022, Pages 701-723 Quantifying the Interaction Strength Between Biopolymers. Lorenz C, Schepers AV, Köster S

The cytoskeleton consists of three types of biopolymers-actin filaments, microtubules, and intermediate filaments-and the interplay between these components is essential for many cellular functions such as cell migration, mitosis, and the mechanical response to external cues. In the cell, the interactions between the filaments are mediated by a myriad of cross-linkers and motor proteins; however, direct forces, mediated by electrostatics or hydrophobicity, may also play an important role. Here,... Abstract

Cited 84 times since 2022 (24.5 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 119, Issue 1, 1 1 2022, Pages e2110877119 Coxiella burnetii inhibits host immunity by a protein phosphatase adapted from glycolysis. Zhang Y, Fu J, Liu S, Wang L, Qiu J, van Schaik EJ, Samuel JE, Song L, Luo ZQ

Coxiella burnetii is a bacterial pathogen that replicates within host cells by establishing a membrane-bound niche called the Coxiella-containing vacuole. Biogenesis of this compartment requires effectors of its Dot/Icm type IV secretion system. A large cohort of such effectors has been identified, but the function of most of them remain elusive. Here, by a cell-based functional screening, we identified the effector Cbu0513 (designated as CinF) as an inhibitor of NF-κB signaling. CinF is highly... Abstract

Tijdschrift voor psychiatrie, Volume 64, Issue 2, 1 1 2022, Pages 108-111 [Plea for a work policy aiming autonomy and recovery in child and adolescent psychiatry]. van Schaik HJ, Pelzer ACM

When a child or adolescent is admitted to a High & Intensive Care (HIC) unit for adolescents, this implies that they find themselves in a severe psychiatric crisis. The work policy aiming autonomy and recovery is a vision that has been implemented in the treatment method at the HIC unit for adolescents. This policy focuses on the recovery of young people, in which learning to understand their own story and learning taking responsibility, are essential components. Sharing these experience... Abstract

Cited 11 times since 2022 (3.2 per year) source: EuropePMC

Gut microbes, Volume 14, Issue 1, 1 1 2022, Pages 2060676 Enterobacteriaceae and Bacteroidaceae provide resistance to travel-associated intestinal colonization by multi-drug resistant Escherichia coli. Davies M, Galazzo G, van Hattem JM, Arcilla MS, Melles DC, de Jong MD, Schultsz C, Wolffs P, McNally A, Schaik WV, Penders J

Previous studies have shown high acquisition risks of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) among international travelers visiting antimicrobial resistance (AMR) hotspots. Although antibiotic use and travelers' diarrhea have shown to influence the ESBL-E acquisition risk, it remains largely unknown whether successful colonization of ESBL-E during travel is associated with the composition, functional capacity and resilience of the traveler's microbiome.... Abstract

Cited 12 times since 2022 (3.5 per year) source: EuropePMC

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume 23, Issue 1, 1 1 2022, Pages 54-59 Establishing Entrustable Professional Activities in Pediatric Cardiac Critical Care. Werho DK, DeWitt AG, Owens ST, McBride ME, van Schaik S, Roth SJ

Objectives: Define a set of entrustable professional activities for pediatric cardiac critical care that are recognized as the core activities of the subspecialty by a diverse group of pediatric cardiac critical care physicians and that can be broadly and consistently applied irrespective of training pathway. Design: Mixed methods study with sequential integration of qualitative and quantitative data. Setting: Structured telephone interviews of pediatric cardiac critical care medical directors a... Abstract