6221 results
Cited 29 times since 2016 (3.2 per year)
source: EuropePMC
PLoS genetics,
Volume 12, Issue 5, 5 1 2016, Pages e1006034
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.
Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, Sjögren M, Ngwa J, Brandimarto J, Stott DJ, Aguilar D, Rice KM, Sesso HD, Demissie S, Buckley BM, Taylor KD, Ford I, Yao C, Liu C, CHARGE-SCD consortium, EchoGen consortium, QT-IGC consortium, CHARGE-QRS consortium, Sotoodehnia N, van der Harst P, Stricker BH, Kritchevsky SB, Liu Y, Gaziano JM, Hofman A, Moravec CS, Uitterlinden AG, Kellis M, van Meurs JB, Margulies KB, Dehghan A, Levy D, Olde B, Psaty BM, Cupples LA, Jukema JW, Djousse L, Franco OH, Boerwinkle E, Boyer LA, Newton-Cheh C, Butler J, Vasan RS, Cappola TP, Smith NL
Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations. We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% incr...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 49, Issue 5, 1 1 2016, Pages e91-6
Reoperation for right ventricular outflow tract obstruction after arterial switch operation for transposition of the great arteries and aortic arch obstruction.
Bokenkamp R, Aguilar E, van der Palen RL, Sojak V, Bruggemans EF, Hruda J, Kuipers IM, Hazekamp MG
Objectives: Right ventricular outflow tract obstruction (RVOTO) is one of the reasons for late reinterventions after repair of transposition of the great arteries (TGA) with aortic arch obstruction (AAO). The aim of the present study was to identify predictors of reoperation for RVOTO in patients who underwent arterial switch operation (ASO) and arch repair for TGA or Taussig-Bing anomaly with AAO. Methods: Between 1977 and 2015, 45 patients [TGA/intact ventricular septum (IVS) 5, TGA/ventricula...
Abstract
The New England journal of medicine,
Volume 374, Issue 20, 1 1 2016, Pages 1992
Surgery for Severe Ischemic Mitral Regurgitation.
Braun J, Petrus AH, Klautz RJ
Abstract
Journal of clinical and diagnostic research : JCDR,
Volume 10, Issue 5, 1 1 2016, Pages ZL01-2
Antibiotic usage - Ectopic Impacted Lower Third Molar.
Karaca IR, Ulutürk H, Yilmaz D
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
American heart journal,
Volume 178, 30 5 2016, Pages 115-125
Time course, predictors, and prognostic implications of significant mitral regurgitation after ST-segment elevation myocardial infarction.
Abate E, Hoogslag GE, Al Amri I, Debonnaire P, Wolterbeek R, Bax JJ, Delgado V, Marsan NA
Background: Ischemic mitral regurgitation (MR) is a known complication of ST-segment elevation myocardial infarction (STEMI) with important prognostic implications. We evaluated changes over time in ischemic MR after STEMI and the prevalence and predictors of significant (grade ≥2) MR at 12 months. Furthermore, the prognostic additional value of significant MR at 12-month follow-up over acute MR was assessed. Methods: STEMI patients (n = 1,599; 77% male; 60 ± 12 years) treated with primary percu...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Clinical imaging,
Volume 40, Issue 5, 30 5 2016, Pages 907-912
Biplane versus short-axis measures of the left atrium and ventricle in patients with systolic dysfunction assessed by magnetic resonance.
Nanni S, Westenberg JJ, Bax JJ, Siebelink HM, de Roos A, Kroft LJ
Purpose: This study aims to investigate if the time saving biplane method can be an alternative to short-axis measurements for left atrium (LA) and left ventricle (LV) in cardiac magnetic resonance of patients with extensive LV remodeling. Materials and methods: In 45 patients with coronary artery disease and systolic LV dysfunction [ejection fraction (EF)
Abstract
Pacing and clinical electrophysiology : PACE,
Volume 39, Issue 6, 29 5 2016, Pages 565-573
Prognostic Impact of Implementation of QRS Characteristics in the Seattle Heart Failure Model in ICD and CRT-D Recipients.
VAN DER Heijden AC, Levy WC, VAN Erven L, Schalij MJ, Borleffs CJ
Background: The Seattle Heart Failure Model (SHFM) provides accurate estimates of survival in heart failure (HF) patients. The model is, however, not developed for HF patients with cardiac resynchronization therapy (CRT). The aim of this study was to assess the prognostic value of SHFM combined with QRS morphology and CRT-related change in QRS duration in implantable cardioverter defibrillator (ICD) and CRT defibrillator (CRT-D) recipients. Methods: All patients who underwent prophylactic ICD im...
Abstract
Cited 98 times since 2016 (10.7 per year)
source: EuropePMC
Diabetes,
Volume 65, Issue 8, 26 4 2016, Pages 2448-2460
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RA, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, Ruth KS, Padmanabhan S, Jukema JW, Palmer CC, Hattersley A, Freathy RM, Langenberg C, Wareham NJ, Wood AR, Murray A, Weedon MN, Sattar N, Pearson E, Scott RA, Frayling TM
Recent genetic studies have identified some alleles that are associated with higher BMI but lower risk of type 2 diabetes, hypertension, and heart disease. These "favorable adiposity" alleles are collectively associated with lower insulin levels and higher subcutaneous-to-visceral adipose tissue ratio and may protect from disease through higher adipose storage capacity. We aimed to use data from 164,609 individuals from the UK Biobank and five other studies to replicate associations be...
Abstract
Journal of cardiovascular electrophysiology,
Volume 27, Issue 5, 26 4 2016, Pages 600-601
QRS Remodeling to Predict Left Ventricular Reverse Remodeling After Cardiac Resynchronization Therapy.
VAN DER Bijl P, Delgado V, Bax JJ
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 6, 20 3 2016, Pages 400-409
Tailored circulatory intervention in adults with pulmonary hypertension due to congenital heart disease.
Couperus LE, Henkens IR, Jongbloed MRM, Hazekamp MG, Schalij MJ, Vliegen HW
Background: Adults with pulmonary hypertension associated with congenital heart disease (PH-CHD) often have residual shunts. Invasive interventions aim to optimise pulmonary flow and prevent right ventricular failure. However, eligibility for procedures strongly depends on the adaptation potential of the pulmonary vasculature and right ventricle to resultant circulatory changes. Current guidelines are not sufficiently applicable to individual patients, who exhibit great diversity and complexity...
Abstract
Cited 14 times since 2016 (1.5 per year)
source: Scopus
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Volume 42, Issue 8, 19 3 2016, Pages 1183-1190
Delaying surgery after neoadjuvant chemoradiotherapy does not significantly influence postoperative morbidity or oncological outcome in patients with oesophageal adenocarcinoma.
Kathiravetpillai N, Koëter M, van der Sangen MJ, Creemers GJ, Luyer MD, Rutten HJ, Nieuwenhuijzen GA
Background: Patients with resectable oesophageal cancer are treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgery within 3-8 weeks. In practice, surgery is often delayed for various reasons. The aim of this study was to evaluate whether delaying surgery beyond 8 weeks has an effect on postoperative morbidity, long-term survival, and pathologic response in patients treated for oesophageal ADC. Methods: Patients who underwent nCRT followed by surgery, for cT1-3, N0-3, M0 ADC betwee...
Abstract
Cited 15 times since 2016 (1.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 102, Issue 14, 13 2 2016, Pages 1127-1133
Surgical options after Fontan failure.
van Melle JP, Wolff D, Hörer J, Belli E, Meyns B, Padalino M, Lindberg H, Jacobs JP, Mattila IP, Berggren H, Berger RM, Prêtre R, Hazekamp MG, Helvind M, Nosál M, Tlaskal T, Rubay J, Lazarov S, Kadner A, Hraska V, Fragata J, Pozzi M, Sarris G, Michielon G, di Carlo D, Ebels T
Objective: The objective of this European multicenter study was to report surgical outcomes of Fontan takedown, Fontan conversion and heart transplantation (HTX) for failing Fontan patients in terms of all-cause mortality and (re-)HTX. Methods: A retrospective international study was conducted by the European Congenital Heart Surgeons Association among 22 member centres. Outcome of surgery to address failing Fontan was collected in 225 patients among which were patients with Fontan takedown (n=3...
Abstract
Cited 17 times since 2016 (1.9 per year)
source: EuropePMC
Scientific reports,
Volume 6, 13 2 2016, Pages 24334
Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium.
Majumder R, Engels MC, de Vries AA, Panfilov AV, Pijnappels DA
Fibrosis and altered gap junctional coupling are key features of ventricular remodelling and are associated with abnormal electrical impulse generation and propagation. Such abnormalities predispose to reentrant electrical activity in the heart. In the absence of tissue heterogeneity, high-frequency impulse generation can also induce dynamic electrical instabilities leading to reentrant arrhythmias. However, because of the complexity and stochastic nature of such arrhythmias, the combined effect...
Abstract
Cited 53 times since 2016 (5.8 per year)
source: EuropePMC
European journal of heart failure,
Volume 18, Issue 5, 12 2 2016, Pages 482-489
Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency.
Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Le Floch C, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F
Composite endpoints are commonly used as the primary measure of efficacy in heart failure clinical trials to assess the overall treatment effect and to increase the efficiency of trials. Clinical trials still must enrol large numbers of patients to accrue a sufficient number of outcome events and have adequate power to draw conclusions about the efficacy and safety of new treatments for heart failure. Additionally, the societal and health system perspectives on heart failure have raised interest...
Abstract
Cited 14 times since 2016 (1.5 per year)
source: EuropePMC
Scientific reports,
Volume 6, 7 1 2016, Pages 24248
Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
Wezel A, de Vries MR, Maassen JM, Kip P, Peters EA, Karper JC, Kuiper J, Bot I, Quax PHA
Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, reduces vein graft disease. Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area compared to controls. In a hypercholesterolemic setting (LDLr(-/-)/RP105(-/-) versus LDLr(-/-) mice),...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Applied neuropsychology. Child,
Volume 6, Issue 2, 6 1 2016, Pages 145-157
Neuropsychological presentation and adaptive skills in high-functioning adolescents with visual impairment: A preliminary investigation.
Greenaway R, Pring L, Schepers A, Isaacs DP, Dale NJ
Studies in infants and young children with congenital visual impairment (VI) have indicated early developmental vulnerabilities, conversely research with older children and adults have highlighted areas of cognitive strength. A minimal amount is known, however, about the possible combination of strengths and weaknesses in adolescence, and this present study therefore aims to explore the neuropsychological presentation and adaptive behavior profile in high-functioning adolescents with congenital...
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 4, 6 1 2016, Pages e0152938
Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?
den Haan MC, van Zuylen VL, Pluijmert NJ, Schutte CI, Fibbe WE, Schalij MJ, Roelofs H, Atsma DE
Background: Human mesenchymal stromal cells (MSCs) have been reported to preserve cardiac function in myocardial infarction (MI) models. Previously, we found a beneficial effect of intramyocardial injection of unstimulated human MSCs (uMSCs) on cardiac function after permanent coronary artery ligation. In the present study we aimed to extend this research by investigating the effect of intramyocardial injection of human MSCs pre-stimulated with the pro-inflammatory cytokine interferon-gamma (iMS...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
Renal failure,
Volume 38, Issue 5, 6 1 2016, Pages 781-786
Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
Okuturlar Y, Akalin N, Kaptanogullari OH, Guner NT, Yilmaz D, Gedikbasi A, Soyluk O, Mert M, Serin SO, Kocoglu H, Hursitoglu M, Kumbasar A
Objective: Altered paraoxonase (PON) and arylesterase (ARE) activities have been shown in anemic chronic kidney disease (CKD) patients and in iron deficiency anemia (IDA) patients. Whether accompanying anemia alone is responsible for this diminished PON and ARE activities in CKD patients or an additive factor for this is not well studied. Therefore, we tried to clarify this issue here. Methods: A total of 82 subjects that consisted of 19 patients with IDA (group 1), 23 anemic CKD patients (group...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Neurourology and urodynamics,
Volume 36, Issue 3, 6 1 2016, Pages 597-603
Effects of silodosin, a selective alpha-1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction.
Bastaskın T, Kaya E, Ozakca I, Yilmaz D, Bayatlı N, Akdemir AO, Gur S
Aim: We investigated the effects of silodosin (selective α1A -adrenoceptor antagonist) on erectile dysfunction (ED) in a rat model of bladder outlet obstruction. Methods: Adult male Sprague-Dawley rats (n = 32) were divided into four groups: (i) sham-operated control; (ii) silodosin-treated (sham) control (0.1 mg/kg/day); (iii) partial bladder outlet obstruction (PBOO); and (iv) silodosin-treated with PBOO. PBOO was induced by ligation of the urethra for 6 weeks. In vivo, erectile responses were...
Abstract
Cited 18 times since 2016 (2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 102, Issue 16, 5 1 2016, Pages 1302-1308
Cardiac adaption during pregnancy in women with congenital heart disease and healthy women.
Kampman MA, Valente MA, van Melle JP, Balci A, Roos-Hesselink JW, Mulder BJ, van Dijk AP, Oudijk MA, Jongbloed MR, van Veldhuisen DJ, Pieper PG, ZAHARA II investigators
Objective: Pregnancy in women with congenital heart disease (CHD) is associated with deterioration in cardiac function. However, longitudinal data are scarce. This study describes serial changes in cardiac dimensions and function during pregnancy in women with CHD and compares these with healthy pregnant women (controls). Methods: Eight tertiary centres prospectively enrolled 125 pregnant women with CHD (pregnancy duration 0.1). Left ventricular ejection fraction (LVEF)
Abstract
