6228 results
Cited 246 times since 2014 (22.6 per year)
source: EuropePMC
American heart journal,
Volume 168, Issue 5, 7 1 2014, Pages 682-689
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial.
Schwartz GG, Bessac L, Berdan LG, Bhatt DL, Bittner V, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Rorick T, Sasiela WJ, Shirodaria C, Szarek M, Tamby JF, Tricoci P, White H, Zeiher A, Steg PG
Background: Following acute coronary syndrome (ACS), the risk for future cardiovascular events is high and is related to levels of low-density lipoprotein cholesterol (LDL-C) even within the setting of intensive statin treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates LDL receptor expression and circulating levels of LDL-C. Antibodies to PCSK9 can produce substantial and sustained reductions of LDL-C. The ODYSSEY Outcomes trial tests the hypothesis that treatment with al...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 10, 4 1 2014, Pages 855-857
Value of intraoperative electrical parameters obtained during implantation of cardiac resynchronization therapy devices for the prediction of reverse remodeling.
de Riva-Silva M, López-Gil M, Salgado-Aranda R, Fontenla-Cerezuela A, Salguero-Bodes R, Arribas-Ynsaurriaga F
Abstract
Cited 15 times since 2014 (1.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 176, Issue 3, 3 1 2014, Pages 788-793
RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice.
Louwe MC, Karper JC, de Vries MR, Nossent AY, Bastiaansen AJ, van der Hoorn JW, Willems van Dijk K, Rensen PC, Steendijk P, Smit JW, Quax PH
Background: Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signaling, would lead to aggravated cardiac dysfunction after MI. Methods and results: First, whole blood from RP105-/- and wild-type (WT) ma...
Abstract
Cited 22 times since 2014 (2 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 86, Issue 1, 2 1 2014, Pages 73-77
Retrospective evaluation of thromboembolic events in patients with non-small cell lung cancer treated with platinum-based chemotherapy.
Mellema WW, van der Hoek D, Postmus PE, Smit EF
Objectives: Thromboembolic events (TE) are common in patients with cancer and are potentially life-threatening. In lung cancer, little is known about thrombosis during chemotherapy treatment. The aim of this study was to describe the incidence of TE in patients with non-small cell lung cancer (NSCLC), occurring during treatment with platinum-based chemotherapy. Methods: We retrospectively selected patients with NSCLC treated with platinum-based chemotherapy at the VU University Medical Center Am...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 7, Issue 4, 1 1 2014, Pages 567-569
The ideal end point for ablation in postinfarction ventricular tachycardia: one may not fit all.
Zeppenfeld K
Abstract
Cited 19 times since 2014 (1.7 per year)
source: EuropePMC
Nutrition, metabolism, and cardiovascular diseases : NMCD,
Volume 25, Issue 1, 1 1 2014, Pages 93-99
The role of insulin resistance in the association between body fat and autonomic function.
Hillebrand S, Swenne CA, Gast KB, Maan AC, le Cessie S, Jukema JW, Rosendaal FR, den Heijer M, de Mutsert R
Background and aim: Excess body fat is associated with altered autonomic function. We investigated whether this association is mediated by insulin resistance. Methods and results: Cross-sectional analysis of a subgroup of the Netherlands Epidemiology of Obesity study with measurements of autonomic function (heart rate variability calculated as mean interbeat interval, standard deviation of all normal intervals (SDNN), low frequency (LF) power and high frequency (HF) power). We measured BMI(kg/m²...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Der Urologe. Ausg. A,
Volume 53, Issue 8, 1 1 2014, Pages 1136-1145
[The demographic development in Germany : challenge and chances for urology].
Schneider AW, Fichtner J
Urology is affected by the demographic development in Germany more than any other medical discipline. Despite a relatively stable total population, by the year 2040 there will be an absolute and relevant increase in urological diseases caused only by the demographic development in the population. This is particularly true for the increase in oncological treatment just in the field of the discipline of urology. Even now the current numbers for tumor development in Germany (RKI 2014) in the urolog...
Abstract
Cited 117 times since 2014 (10.7 per year)
source: EuropePMC
Circulation research,
Volume 115, Issue 8, 1 1 2014, Pages 696-708
Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia.
Welten SM, Bastiaansen AJ, de Jong RC, de Vries MR, Peters EA, Boonstra MC, Sheikh SP, La Monica N, Kandimalla ER, Quax PH, Nossent AY
Rationale: Effective neovascularization is crucial for recovery after cardiovascular events. Objective: Because microRNAs regulate expression of up to several hundred target genes, we set out to identify microRNAs that target genes in all pathways of the multifactorial neovascularization process. Using www.targetscan.org, we performed a reverse target prediction analysis on a set of 197 genes involved in neovascularization. We found enrichment of binding sites for 27 microRNAs in a single microR...
Abstract
Cited 23 times since 2014 (2.1 per year)
source: EuropePMC
Magnetic resonance in medicine,
Volume 72, Issue 2, 1 1 2014, Pages 409-417
Quantitative T2 mapping of the mouse heart by segmented MLEV phase-cycled T2 preparation.
Coolen BF, Simonis FF, Geelen T, Moonen RP, Arslan F, Paulis LE, Nicolay K, Strijkers GJ
Purpose: A high-quality, reproducible, multi-slice T2-mapping protocol for the mouse heart is presented. Methods: A T2-prepared sequence with composite 90° and 180° radiofrequency pulses in a segmented MLEV phase cycling scheme was developed. The T2-mapping protocol was optimized using simulations and evaluated with phantoms. Results: Repeatability for determination of myocardial T2 values was assessed in vivo in n = 5 healthy mice on 2 different days. The average baseline T2 of the left ventric...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: Scopus
Perfusion,
Volume 30, Issue 4, 1 1 2014, Pages 295-301
Sevoflurane-enriched blood cardioplegia: the intramyocardial delivery of a volatile anesthetic.
van der Baan A, Kortekaas KA, van Es E, Meier S, Klautz RJ, Engbers FH
Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with a sevoflurane vaporizer was integrated into the blood cardioplegia system of an adult bypass system. In addition, a gas ble...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Circulation research,
Volume 115, Issue 4, 1 1 2014, Pages e6-7
Cardiac anisotropy, regeneration, and rhythm.
Pijnappels DA, Schalij MJ, Atsma DE, de Vries AA
Abstract
Cited 11 times since 2014 (1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 7-8, 1 1 2014, Pages 336-343
Cardiologist and cardiac surgeon view on decision-making in prosthetic aortic valve selection: does profession matter?
Korteland NM, Kluin J, Klautz RJ, Roos-Hesselink JW, Versteegh MI, Bogers AJ, Takkenberg JJ
Aims: Assess and compare among Dutch cardiothoracic surgeons and cardiologists: opinion on (1) patient involvement, (2) conveying risk in aortic valve selection, and (3) aortic valve preferences. Methods and results: A survey among 117 cardiothoracic surgeons and cardiologists was conducted. Group responses were compared using the Mann-Whitney U test. Most respondents agreed that patients should be involved in decision-making, with surgeons leaning more toward patient involvement (always: 83 % v...
Abstract
Cited 76 times since 2014 (7 per year)
source: EuropePMC
Cardiovascular research,
Volume 104, Issue 1, 31 5 2014, Pages 194-205
Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes.
Bingen BO, Engels MC, Schalij MJ, Jangsangthong W, Neshati Z, Feola I, Ypey DL, Askar SF, Panfilov AV, Pijnappels DA, de Vries AA
Aims: Atrial fibrillation (AF) is the most common cardiac arrhythmia and often involves reentrant electrical activation (e.g. spiral waves). Drug therapy for AF can have serious side effects including proarrhythmia, while electrical shock therapy is associated with discomfort and tissue damage. Hypothetically, forced expression and subsequent activation of light-gated cation channels in cardiomyocytes might deliver a depolarizing force sufficient for defibrillation, thereby circumventing the afo...
Abstract
Cited 64 times since 2014 (5.9 per year)
source: EuropePMC
European heart journal,
Volume 35, Issue 38, 25 4 2014, Pages 2627-2638
Open issues in transcatheter aortic valve implantation. Part 1: patient selection and treatment strategy for transcatheter aortic valve implantation.
Bax JJ, Delgado V, Bapat V, Baumgartner H, Collet JP, Erbel R, Hamm C, Kappetein AP, Leipsic J, Leon MB, MacCarthy P, Piazza N, Pibarot P, Roberts WC, Rodés-Cabau J, Serruys PW, Thomas M, Vahanian A, Webb J, Zamorano JL, Windecker S
An exponential increase in the use of transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis has been witnessed over the recent years. The current article reviews different areas of uncertainty related to patient selection. The use and limitations of risk scores are addressed, followed by an extensive discussion on the value of three-dimensional imaging for prosthesis sizing and the assessment of complex valve anatomy such as degenerated bicuspid valves. The uncer...
Abstract
Cited 67 times since 2014 (6.1 per year)
source: EuropePMC
European heart journal,
Volume 35, Issue 38, 25 4 2014, Pages 2639-2654
Open issues in transcatheter aortic valve implantation. Part 2: procedural issues and outcomes after transcatheter aortic valve implantation.
Bax JJ, Delgado V, Bapat V, Baumgartner H, Collet JP, Erbel R, Hamm C, Kappetein AP, Leipsic J, Leon MB, MacCarthy P, Piazza N, Pibarot P, Roberts WC, Rodés-Cabau J, Serruys PW, Thomas M, Vahanian A, Webb J, Zamorano JL, Windecker S
This article provides an overview on procedure-related issues and uncertainties in outcomes after transcatheter aortic valve implantation (TAVI). The different access sites and how to select them in an individual patient are discussed. Also, the occurrence and potential predictors of aortic regurgitation (AR) after TAVI are addressed. The different methods to quantify AR are reviewed, and it appears that accurate and reproducible quantification is suboptimal. Complications such as prosthesis-pat...
Abstract
Cited 22 times since 2014 (2 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 25, Issue 9, 24 4 2014, Pages 1012-1020
Impact of pacing site on QRS duration and its relationship to hemodynamic response in cardiac resynchronization therapy for congestive heart failure.
Derval N, Bordachar P, Lim HS, Sacher F, Ploux S, Laborderie J, Steendijk P, Deplagne A, Ritter P, Garrigue S, Denis A, Hocini M, Haissaguerre M, Clementy J, Jaïs P
Introduction: Recent studies have demonstrated that left ventricular (LV) pacing site is a critical parameter in optimizing cardiac resynchronization therapy (CRT). The present study evaluates the effect of pacing from different LV locations on QRS duration (QRSd) and their relationship to acute hemodynamic response in congestive heart failure patients. Methods and results: Thirty-five patients with nonischemic dilated cardiomyopathy and left bundle branch block referred for CRT device implantat...
Abstract
Cited 19 times since 2014 (1.7 per year)
source: EuropePMC
BMC cardiovascular disorders,
Volume 14, 18 3 2014, Pages 87
Scarcity of atrial fibrillation in a traditional African population: a community-based study.
Koopman JJ, van Bodegom D, Westendorp RG, Jukema JW
Background: In western societies, atrial fibrillation is an increasingly common finding among the elderly. Established risk factors of atrial fibrillation include obesity, diabetes, hypertension, and cardiovascular disease. Atrial fibrillation has almost exclusively been studied in western populations where these risk factors are widely present. Therefore, we studied the epidemiology of atrial fibrillation in a traditional African community. Methods: In rural Ghana, among 924 individuals aged 50...
Abstract
Clinical and experimental rheumatology,
Volume 32, Issue 6 Suppl 86, 17 3 2014, Pages S-60-7
Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures.
Ninaber MK, Hamersma WB, Schouffoer AA, Kovacs G, Olschewski H, Holman ER, Ajmone Marsan N, Stolk J
Objectives: During cardiopulmonary exercise testing (CPET) compromised pulmonary vasculature in patients with systemic sclerosis (SSc) may lead to increases in pulmonary arterial pressures (PAP) and decreased oxygen uptake. We hypothesised that this may lead into a disproportional heart rate (HR) increase with a corresponding V'O₂/HR breakpoint and relates to systolic PAP at rest. Methods: In a prospective design we evaluated V'O₂/HR slopes for breakpoints. To understand its physiologi...
Abstract
Cited 96 times since 2014 (8.8 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 100, Issue 17, 17 3 2014, Pages 1373-1381
Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease.
Balci A, Sollie-Szarynska KM, van der Bijl AG, Ruys TP, Mulder BJ, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG, ZAHARA-II investigators
Objectives: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregnancy in women with CHD. Methods: In this prospective study, we determined the outcomes of 213 pregnancies in 203 women with CHD. The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPR...
Abstract
Cited 61 times since 2014 (5.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 7, Issue 8, 16 3 2014, Pages 774-784
CMR-based identification of critical isthmus sites of ischemic and nonischemic ventricular tachycardia.
Piers SR, Tao Q, de Riva Silva M, Siebelink HM, Schalij MJ, van der Geest RJ, Zeppenfeld K
Objectives: This study evaluates whether contrast-enhanced (CE) cardiac magnetic resonance (CMR) can be used to identify critical isthmus sites for ventricular tachycardia (VT) in ischemic and nonischemic heart disease. Background: Fibrosis interspersed with viable myocytes may cause re-entrant VT. CE-CMR has the ability to accurately delineate fibrosis. Methods: Patients who underwent VT ablation with CE-CMR integration were included. After the procedure, critical isthmus sites (defined as site...
Abstract
