8593 results
Cited 59 times since 2015 (5.7 per year)
source: EuropePMC
G3 (Bethesda, Md.),
Volume 5, Issue 5, 4 1 2015, Pages 719-740
Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.
Leung W, Shaffer CD, Reed LK, Smith ST, Barshop W, Dirkes W, Dothager M, Lee P, Wong J, Xiong D, Yuan H, Bedard JE, Machone JF, Patterson SD, Price AL, Turner BA, Robic S, Luippold EK, McCartha SR, Walji TA, Walker CA, Saville K, Abrams MK, Armstrong AR, Armstrong W, Bailey RJ, Barberi CR, Beck LR, Blaker AL, Blunden CE, Brand JP, Brock EJ, Brooks DW, Brown M, Butzler SC, Clark EM, Clark NB, Collins AA, Cotteleer RJ, Cullimore PR, Dawson SG, Docking CT, Dorsett SL, Dougherty GA, Downey KA, Drake AP, Earl EK, Floyd TG, Forsyth JD, Foust JD, Franchi SL, Geary JF, Hanson CK, Harding TS, Harris CB, Heckman JM, Holderness HL, Howey NA, Jacobs DA, Jewell ES, Kaisler M, Karaska EA, Kehoe JL, Koaches HC, Koehler J, Koenig D, Kujawski AJ, Kus JE, Lammers JA, Leads RR, Leatherman EC, Lippert RN, Messenger GS, Morrow AT, Newcomb V, Plasman HJ, Potocny SJ, Powers MK, Reem RM, Rennhack JP, Reynolds KR, Reynolds LA, Rhee DK, Rivard AB, Ronk AJ, Rooney MB, Rubin LS, Salbert LR, Saluja RK, Schauder T, Schneiter AR, Schulz RW
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25-50%) than euchromatic re...
Abstract
Cited 21 times since 2015 (2 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 22, Issue 2, 3 1 2015, Pages 229-245
Myocardial viability as integral part of the diagnostic and therapeutic approach to ischemic heart failure.
Bax JJ, Delgado V
Chronic heart failure is a major public-health problem with a high prevalence, complex treatment, and high mortality. A careful and comprehensive analysis is needed to provide optimal (and personalized) therapy to heart failure patients. The main 4 non-invasive imaging techniques (echocardiography, magnetic resonance imaging, multi-detector-computed tomography, and nuclear imaging) provide information on cardiovascular anatomy and function, which form the basis of the assessment of the pathophys...
Abstract
Future cardiology,
Volume 11, Issue 2, 1 1 2015, Pages 153-169
Transcatheter mitral valve repair therapies for primary and secondary mitral regurgitation.
Al Amri I, van der Kley F, Schalij MJ, Ajmone Marsan N, Delgado V
Mitral regurgitation is one of the most prevalent valvular heart diseases and its prevalence is related to population aging. Elderly patients with age-associated co-morbidities have an increased risk for conventional mitral valve surgery. Transcatheter mitral valve repair has emerged as a feasible and safe alternative in patients with contraindications for surgery or high operative risk. Several transcatheter mitral repair technologies have been developed during the last decade. While the develo...
Abstract
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
The Journal of biological chemistry,
Volume 290, Issue 12, 1 1 2015, Pages 8013-8014
Does the dorsal mesenchymal protrusion act as a temporary pacemaker during heart development?
Kelder TP, Vicente-Steijn R, DeRuiter MC, Gittenberger-de Groot AC, Jongbloed MR
Abstract
JACC. Clinical electrophysiology,
Volume 1, Issue 1-2, 1 1 2015, Pages 59-61
Catheter Ablation for Ventricular Tachycardia in the Elderly: Safe and Efficacious?
Zeppenfeld K
Abstract
Cited 14 times since 2015 (1.4 per year)
source: EuropePMC
Drug metabolism and personalized therapy,
Volume 30, Issue 1, 1 1 2015, Pages 43-48
No effect of CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) on lipid-lowering response to statins in Greek patients with primary hypercholesterolemia.
Ragia G, Kolovou V, Tavridou A, Elens L, Tselepis AD, Elisaf M, Van Schaik RH, Kolovou G, Manolopoulos VG
Background: Interindividual variability exists in statin lipid-lowering response, partially attributed to genetic factors. CYP3A4 intron 6 C>T polymorphism (CYP3A4*22 allele, rs35599367) has been recently identified and was associated with reduced CYP3A4 expression. We analyzed the association of CYP3A4*22 allele with response to atorvastatin and simvastatin. Methods: A total of 416 statin-treated (207 atorvastatin- and 209 simvastatin-treated) adults with primary hypercholesterolemia were in...
Abstract
Cited 6 times since 2015 (0.6 per year)
source: EuropePMC
Pediatric emergency care,
Volume 31, Issue 3, 1 1 2015, Pages 186-189
Useful but not used: pediatric critical care physician views on bedside ultrasound.
Kornblith AE, van Schaik S, Reynolds T
Objective: The purpose of this study was to assess the learning needs of pediatric critical care (PCC) physicians in bedside ultrasound (BUS) use. Methods: This was a survey-based study conducted at an academic center with a PCC fellowship program. We surveyed PCC fellows and faculty to elicit their views on BUS and asked them about the frequency of use, their perception of the clinical utility, and their level of confidence in performing different BUS applications. Results: There was no statist...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
Volume 26, Issue 2, 1 1 2015, Pages 168-172
A successful desensitization protocol for horse-derived antithymocyte globulin in severe aplastic anemia.
Demir E, Cigerci Günaydın N, Karadaş N, Gülen F, Tanac R, Yılmaz D
Background: Horse antithymocyte globulin (h-ATG) (ATGAM(®) ) is the first choice of treatment in very severe patients with aplastic anemia who do not have any HLA matched sibling donor. h-ATG is a heterologous serum that may cause anaphylaxis. Alternative treatment strategies must be planned in case of hypersensitivity. Desensitization must be considered in patients without an alternative treatment of choice. We aimed to present the h-ATG desensitization protocol and consider its effectiveness i...
Abstract
Cited 52 times since 2015 (5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 16, Issue 9, 1 1 2015, Pages 992-999
Detection of subtle left ventricular systolic dysfunction in patients with significant aortic regurgitation and preserved left ventricular ejection fraction: speckle tracking echocardiographic analysis.
Ewe SH, Haeck ML, Ng AC, Witkowski TG, Auger D, Leong DP, Abate E, Ajmone Marsan N, Holman ER, Schalij MJ, Bax JJ, Delgado V
Aims: The aim of this study was to characterize left ventricular (LV) mechanics in symptomatic and asymptomatic patients with moderate-to-severe or severe aortic regurgitation (AR) and preserved ejection fraction (left ventricular ejection fraction) using two-dimensional speckle tracking echocardiography (2D-STE). The association between baseline LV strain and development of indications for surgery in asymptomatic patients was also evaluated. Methods and results: A total of 129 patients with mod...
Abstract
Cited 202 times since 2015 (19.6 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 8, Issue 3, 1 1 2015, Pages e002179
Detection of significant coronary artery disease by noninvasive anatomical and functional imaging.
Neglia D, Rovai D, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Perrone Filardi P, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Fiechter M, Stehli J, Gaemperli O, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Marinelli M, Puzzuoli S, Mangione M, Marcheschi P, Mariani F, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Kaufmann PA, Underwood SR, Knuuti J, EVINCI Study Investigators
Background: The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy of commonly used imaging techniques for identifying patients with significant CAD. Methods and results: A total of 475 patients with stable chest pain and intermediate likelihood of CAD underwent coronary computed tomographic angiography an...
Abstract
Cited 14 times since 2015 (1.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 184, 25 4 2015, Pages 405-411
High-sensitive troponin-T in adult congenital heart disease.
Eindhoven JA, Roos-Hesselink JW, van den Bosch AE, Kardys I, Cheng JM, Veenis JF, Cuypers JAAE, Witsenburg M, van Schaik RHN, Boersma E
Background: Adult congenital heart disease (ACHD) patients are at risk of late complications including arrhythmias, heart failure and sudden death. High-sensitive troponin-T (hs-TnT) is the standard for diagnosing acute coronary syndrome, but is also associated with cardiac function and prognosis in other cardiac diseases. We aimed to describe hs-TnT level in ACHD patients, and determine its relationship with cardiac function and other biomarkers. Methods: Consecutive ACHD patients, visiting the...
Abstract
Cited 32 times since 2015 (3.1 per year)
source: EuropePMC
Journal of virological methods,
Volume 217, 21 3 2015, Pages 55-63
Optimization of an enzyme-linked lectin assay suitable for rapid antigenic characterization of the neuraminidase of human influenza A(H3N2) viruses.
Westgeest KB, Bestebroer TM, Spronken MI, Gao J, Couzens L, Osterhaus AD, Eichelberger M, Fouchier RA, de Graaf M
Antibodies to neuraminidase (NA), the second most abundant surface protein of the influenza virus, contribute to protection against influenza virus infection. Although traditional and miniaturized thiobarbituric acid (TBA) neuraminidase inhibition (NI) assays have been successfully used to characterize the antigenic properties of NA, these methods are cumbersome and not easily amendable to rapid screening. An additional difficulty of the NI assay is the interference by hemagglutinin (HA)-specifi...
Abstract
Cited 17 times since 2015 (1.6 per year)
source: EuropePMC
Academic radiology,
Volume 22, Issue 5, 20 3 2015, Pages 632-639
Volumetric and two-dimensional image interpretation show different cognitive processes in learners.
van der Gijp A, Ravesloot CJ, van der Schaaf MF, van der Schaaf IC, Huige JC, Vincken KL, Ten Cate OT, van Schaik JP
Rationale and objectives: In current practice, radiologists interpret digital images, including a substantial amount of volumetric images. We hypothesized that interpretation of a stack of a volumetric data set demands different skills than interpretation of two-dimensional (2D) cross-sectional images. This study aimed to investigate and compare knowledge and skills used for interpretation of volumetric versus 2D images. Materials and methods: Twenty radiology clerks were asked to think out loud...
Abstract
Cited 40 times since 2015 (3.9 per year)
source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance,
Volume 17, 19 3 2015, Pages 18
Characterization and quantification of dynamic eccentric regurgitation of the left atrioventricular valve after atrioventricular septal defect correction with 4D Flow cardiovascular magnetic resonance and retrospective valve tracking.
Calkoen EE, Westenberg JJ, Kroft LJ, Blom NA, Hazekamp MG, Rijlaarsdam ME, Jongbloed MR, de Roos A, Roest AA
Background: To characterize and directly quantify regurgitant jets of left atrioventricular valve (LAVV) in patients with corrected atrioventricular septal defect (AVSD) by four-dimensional (4D)Flow Cardiovascular Magnetic Resonance (CMR), streamline visualization and retrospective valve tracking. Methods: Medical ethical committee approval and informed consent from all patients or their parents were obtained. In 32 corrected AVSD patients (age 26 ± 12 years), echocardiography and whole-heart 4D...
Abstract
Cited 216 times since 2015 (20.9 per year)
source: EuropePMC
Circulation research,
Volume 116, Issue 8, 19 3 2015, Pages 1346-1360
Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data.
Gyöngyösi M, Wojakowski W, Lemarchand P, Lunde K, Tendera M, Bartunek J, Marban E, Assmus B, Henry TD, Traverse JH, Moyé LA, Sürder D, Corti R, Huikuri H, Miettinen J, Wöhrle J, Obradovic S, Roncalli J, Malliaras K, Pokushalov E, Romanov A, Kastrup J, Bergmann MW, Atsma DE, Diederichsen A, Edes I, Benedek I, Benedek T, Pejkov H, Nyolczas N, Pavo N, Bergler-Klein J, Pavo IJ, Sylven C, Berti S, Navarese EP, Maurer G, ACCRUE Investigators
Rationale: The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared collaborative multinational database, including individual data of patients with ischemic heart disease treated with cell therapy. Objective: We analyzed the safety and efficacy of intracoronary cell therapy after acute myocardial infarction (AMI), including individual patient data from 12 randomized trials (ASTAMI, Aalst, BOOST, BONAMI, CADUCEUS, FINCELL, REGENT, REPAIR-AMI, SCAMI, SWISS-AMI, TIME, LATE...
Abstract
Cited 25 times since 2015 (2.4 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 49, Issue 4, 18 3 2015, Pages 480-486
Elastin is a key regulator of outward remodeling in arteriovenous fistulas.
Wong CY, Rothuizen TC, de Vries MR, Rabelink TJ, Hamming JF, van Zonneveld AJ, Quax PH, Rotmans JI
Objectives: Maturation failure is the major limitation of arteriovenous fistulas (AVFs) as hemodialysis access conduits. Indeed, 30-50% of AVFs fail to mature due to intimal hyperplasia and insufficient outward remodeling. Elastin has emerged as an important determinant of vascular remodeling. Here the role of elastin in AVF remodeling in elastin haplodeficient (eln(+/-)) mice undergoing AVF surgery has been studied. Methods: Unilateral AVFs between the branch of the jugular vein and carotid art...
Abstract
Cited 33 times since 2015 (3.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 17, Issue 5, 16 3 2015, Pages 689-700
How adequate are the current methods of lead extraction? A review of the efficiency and safety of transvenous lead extraction methods.
Buiten MS, van der Heijden AC, Schalij MJ, van Erven L
Currently several extraction tools are available in order to allow safe and successful transvenous lead extraction (TLE) of pacemaker and ICD leads; however, no directives exist to guide physicians in their choice of extraction tools and approaches. To aim of the current review is to provide an overview of the success and complication rates of different extraction methods and tools available. A comprehensive search of all published literature was conducted in the databases of PubMed, Embase, Web...
Abstract
Cited 11 times since 2015 (1.1 per year)
source: EuropePMC
Autonomic neuroscience : basic & clinical,
Volume 189, 14 2 2015, Pages 60-67
New insights in the neuroanatomy of the human adult superior hypogastric plexus and hypogastric nerves.
Kraima AC, van Schaik J, Susan S, van de Velde CJ, Hamming JF, Lakke EA, DeRuiter MC
Background: The superior hypogastric plexus (SHP) is an autonomic plexus, located ventrally to the abdominal aorta and its bifurcation, innervating pelvic viscera. It is classically described as being composed of merely sympathetic fibres. However, post-operative complications after surgery damaging the peri-aortic retroperitoneal compartment suggest the existence of parasympathetic fibres. This immunohistochemical study describes the neuroanatomical composition of the human mature SHP. Material...
Abstract
Cited 14 times since 2015 (1.4 per year)
source: EuropePMC
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation,
Volume 24, Issue 8, 13 2 2015, Pages 2015-2023
Short Musculoskeletal Function Assessment: normative data of the Dutch population.
de Graaf MW, El Moumni M, Heineman E, Wendt KW, Reininga IH
Background: The Short Musculoskeletal Function Assessment (SMFA) is widely used in both research and clinical practice. Despite its frequent use, normative data of the SMFA have remained limited. Aim of this study was to gather normative data for the Dutch SMFA (SMFA-NL). Methods: The SMFA-NL consists of two indices (function index and bother index) and four subscales (upper extremity dysfunction, lower extremity dysfunction, mental and emotional problems, and problems with daily activities). A...
Abstract
Cited 8 times since 2015 (0.8 per year)
source: EuropePMC
Academic radiology,
Volume 22, Issue 5, 13 2 2015, Pages 640-645
Support for external validity of radiological anatomy tests using volumetric images.
Ravesloot CJ, van der Gijp A, van der Schaaf MF, Huige JC, Vincken KL, Mol CP, Bleys RL, ten Cate OT, van Schaik JP
Rationale and objectives: Radiology practice has become increasingly based on volumetric images (VIs), but tests in medical education still mainly involve two-dimensional (2D) images. We created a novel, digital, VI test and hypothesized that scores on this test would better reflect radiological anatomy skills than scores on a traditional 2D image test. To evaluate external validity we correlated VI and 2D image test scores with anatomy cadaver-based test scores. Materials and methods: In 2012,...
Abstract
