Research

Publications

Below you can find a list of our published research.

6125 results

Cited 1 times since 1997 (0 per year) source: EuropePMC

Pediatric research, Volume 41, Issue 1, 1 1 1997, Pages 57-64 Perinatal left ventricular performance in fetal sheep: interaction between oxygen ventilation and contractility. Berning RA, Klautz RJ, Teitel DF

Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions are changed by oxygen ventilation. To address this hypothesis, we studied nine fetal sheep acutely placed in a warm water bath (40 degrees C). Conductance and manometric catheters wer... Abstract

Biology of the neonate, Volume 72, Issue 4, 1 1 1997, Pages 227-234 Nitric oxide inhibition after hypoxia-ischemia elevates pulmonary arterial pressure and increases oxygen need. de Beaufort AJ, Lopes Cardozo RH, Dorrepaal CA, Steendijk P, Van Der Velde ET, Van Bel F

Inhibition of nitric oxide (NO) production may reduce post-hypoxic-ischemic (HI) neonatal brain damage, but may also induce pulmonary hypertension by inhibiting endogenous NO production in the pulmonary vascular bed. The aim of this study was to evaluate the effect of nitric oxide inhibition on pulmonary artery pressure and oxygen need after hypoxic ischemia. Severe HI was produced in 18 newborn lambs. After completion of HI the lambs were divided into three groups of 6 animals receiving either... Abstract

Cited 8 times since 1997 (0.3 per year) source: EuropePMC

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, Volume 13, 1 1 1997, Pages 72-76 Restriction coefficients of low molecular weight solutes and macromolecules during peritoneal dialysis. Ho-dac-Pannekeet MM, Koopmans JG, Struijk DG, Krediet RT

The intrinsic permeability of the peritoneal membrane can be functionally represented by the restriction coefficient (RC). The RC can be calculated as the exponent of the power relation between the mass transfer area coefficients (MTACs) of various solutes and their free diffusion coefficients in water. When the RC = 1.0, transport is determined by free diffusion only, as is expected for low molecular weight (LMW) solutes. A RC > 1.0 suggests that transport is restricted by the peritoneal mem... Abstract

Cited 13 times since 1997 (0.5 per year) source: EuropePMC

British journal of cancer, Volume 75, Issue 10, 1 1 1997, Pages 1447-1453 Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan. Borel Rinkes IH, de Vries MR, Jonker AM, Swaak TJ, Hack CE, Nooyen PT, Wiggers T, Eggermont AM

Isolated limb perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan is well tolerated and highly effective in irresectable sarcoma and melanoma. No data are available on isolated hepatic perfusion (IHP) with these drugs for irresectable hepatic malignancies. This study was undertaken to assess the feasibility of such an approach by analysing hepatic and systemic toxicity of IHP with TNF-alpha with and without melphalan in pigs. Ten healthy pigs underwent IHP. After vascular isola... Abstract

Cited 14 times since 1997 (0.5 per year) source: EuropePMC

Biology of the neonate, Volume 72, Issue 4, 1 1 1997, Pages 216-226 Effect of post-hypoxic-ischemic inhibition of nitric oxide synthesis on cerebral blood flow, metabolism and electrocortical brain activity in newborn lambs. Dorrepaal CA, Shadid M, Steendijk P, Van der Velde ET, Van de Bor M, Baan J, Van Bel F

Since an excessive production of nitric oxide upon reperfusion/reoxygenation may play an important role in post-hypoxic-ischemic (HI) brain injury, we investigated whether immediate post-HI blockade of nitric oxide synthesis by N-omega-nitro-L-arginine (NLA) may reduce this injury. In 18 newborn lambs, subjected to severe HI, changes from pre-HI values were measured for carotid blood flow (Qcar [ml/min]) as a measure of changes in brain blood flow, (relative) cerebral metabolic rate of oxygen (C... Abstract

Cited 1 times since 1996 (0 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 140, Issue 52, 1 1 1996, Pages 2632-2635 [Hypertension caused by licorice consumption]. Seelen MA, de Meijer PH, Braun J, Swinkels LM, Waanders H, Meinders AE

In a 38-year-old woman who was hospitalized because of hypertension and hypokalaemic alkalosis, the intake of liquorice (200 g per day) was proven to be the cause. A liquorice provocation test produced all the expected clinical and biochemical abnormalities. Some kinds of liquorice contain glycyrrhetic acid which inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase (e.g. in the kidney) leading to decreased transformation of cortisol into cortisone. The mineralocorticoid action of cortisol ca... Abstract

Cited 4 times since 1996 (0.1 per year) source: EuropePMC

Basic research in cardiology, Volume 91, Issue 6, 1 1 1996, Pages 468-478 Systolic coronary flow reduction in the canine heart in situ: effects of left ventricular pressure and elastance. Baan J, Steendijk P, Mikuniya A, Baan J

In the externally perfused coronary bed of the isolated heart, LV elastance (Elv) rather than LV pressure (Plv) appears to be the major factor responsible for systolic coronary flow reduction, although effects of both have been demonstrated. However, normal perfusion in the presence of intact autoregulation in the heart in situ may modify these effects. To investigate the systolic coronary flow (Qsyst) responses to changes in end-systolic Elv and in systolic Plv in the intact coronary bed, we st... Abstract

Cited 6 times since 1996 (0.2 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 6, Issue 6, 1 1 1996, Pages 948-949 Development of an MRI-compatible catheter for pacing the heart: initial in vitro and in vivo results. Jerzewski A, Pattynama PM, Steendijk P, Doornbos J, de Roos A, Baan J

An MRI-compatible catheter was developed for pacing the heart during MRI imaging. The device was tested in vitro and in vivo in 10 animal experiments, using spin-echo, gradient-echo, and echo-planar MRI sequences. Images were of good quality in all sequences. Pacing was effective without induced arrhythmias. Therefore, pacing the heart during MRI is feasible and seems to be safe when using dedicated hardware. Abstract

Cited 87 times since 1996 (3.1 per year) source: EuropePMC

Circulation, Volume 94, Issue 7, 1 1 1996, Pages 1503-1505 Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris. REGRESS Study Group. van Boven AJ, Jukema JW, Zwinderman AH, Crijns HJ, Lie KI, Bruschke AV

Background: Lipid-lowering therapy reduces cardiac morbidity and mortality. Less is known about its potential anti-ischemic effect. Methods and results: In a 2-year prospective randomized placebo-controlled study, the effect of pravastatin 40 mg on transient myocardial ischemia was assessed. Forty-eight-hour ambulatory ECGs with continuous ST-segment analysis were performed in 768 male patients with stable angina pectoris, documented coronary artery disease, and serum cholesterol between 4 and 8... Abstract

Cited 59 times since 1996 (2.1 per year) source: EuropePMC

Circulation, Volume 94, Issue 8, 1 1 1996, Pages 1913-1918 The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study. Jukema JW, van Boven AJ, Groenemeijer B, Zwinderman AH, Reiber JH, Bruschke AV, Henneman JA, Molhoek GP, Bruin T, Jansen H, Gagné E, Hayden MR, Kastelein JJ

Background: Many patients suffering from premature coronary artery disease report a family history for such events. A mutation in a particular gene, which confers susceptibility for atherosclerosis, will be found more frequently in individuals suffering from coronary atherosclerosis than in the general population. We have recently reported the identification of an Asp9 Asn substitution in the lipoprotein lipase (LPL) enzyme. We analyzed the impact of this mutation on the progression of coronary... Abstract

Cited 24 times since 1996 (0.8 per year) source: EuropePMC

The veterinary quarterly, Volume 18, Issue 3, 1 1 1996, Pages 95-99 Equine arteritis virus: a review of clinical features and management aspects. Glaser AL, de Vries AA, Rottier PJ, Horzinek MC, Colenbrander B

Sero-epidemiological surveys have revealed that equine arteritis virus (EAV) is prevalent in most European countries. The virus causes sporadic cases of respiratory disease and abortion in horses, the incidence of which has increased in recent years. Mares and geldings eliminate virus after acute infection, but 30% to 60% of stallions become persistently infected. In these animals, EAV is maintained within the reproductive tract and is shed continuously in the semen. Persistent infection with EA... Abstract

Cited 3 times since 1996 (0.1 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 15, Issue 1, 1 1 1996, Pages 131-135 Actinomycosis, a sheep in wolves' clothes. Neijens V, van Heerde P, van der Heijden A, Baas P

We present a patient referred for radiotherapy for a presumed pulmonary malignancy, who was found to suffer from an actinomycotic infection. This case illustrates the importance of early consideration of actinomycosis when diagnostic methods are negative for malignancy or specific chestwall and bony lesions are observed. Abstract

Cited 10 times since 1996 (0.3 per year) source: EuropePMC

European heart journal, Volume 17, Issue 8, 1 1 1996, Pages 1158-1166 Phosphorus magnetic resonance spectroscopy of the human heart: current status and clinical implications. Beyerbacht HP, Vliegen HW, Lamb HJ, Doornbos J, de Roos A, van der Laarse A, van der Wall EE

Abstract

Cited 26 times since 1996 (0.9 per year) source: EuropePMC

European heart journal, Volume 17, Issue 8, 1 1 1996, Pages 1271-1278 Cardiac anatomy, function and metabolism in elite cyclists assessed by magnetic resonance imaging and spectroscopy. Pluim BM, Chin JC, De Roos A, Doornbos J, Siebelink HM, Van der Laarse A, Vliegen HW, Lamerichs RM, Bruschke AV, Van der Wall EE

We investigated whether left ventricular hypertrophy in elite cyclists is associated with functional changes or abnormal energy metabolism. Left ventricular hypertrophy is a powerful risk factor for sudden cardiac death with different prognostic significance among the various geometric forms. Cyclists may have a combination of mixed eccentric and concentric hypertrophy. Magnetic resonance imaging was used to define left ventricular mass, geometry and function. Thirteen highly trained male cyclis... Abstract

Cited 29 times since 1996 (1 per year) source: EuropePMC

Surgical endoscopy, Volume 10, Issue 7, 1 1 1996, Pages 721-723 Advantages of limited thoracoscopic sympathectomy. Bonjer HJ, Hamming JF, du Bois NAJJ, van Urk H

Background: Thoracoscopic resection of the first through the fourth thoracic sympathetic ganglion for palmary and axillary hyperhidrosis and Raynaud's syndrome is associated with a high initial success rate. However, the reported incidence of compensatory hyperhidrosis of the trunk and legs and Horner's syndrome are high. This study assesses the results of thoracoscopic sympathectomy limited to transection of the interganglionic trunk or resection of one or two thoracic ganglia. Method... Abstract

Cited 2 times since 1996 (0.1 per year) source: EuropePMC

Angiology, Volume 47, Issue 7, 1 1 1996, Pages 633-642 The influence of angiographic endpoints on the outcome of lipid intervention studies. A proposal for standardization. REGRESS study group. Jukema JW, van Boven AJ, Zinderman AH, Bal ET, Reiber JH, Bruschke AV

The aims of this study were to evaluate the influence of different coronary angiographic endpoints on the outcome of lipid intervention studies and to formulate a proposal for angiographic endpoint standardization. In recent angiographic intervention studies a confusing diversity in angiographic endpoints has been used to determine the outcome. In addition, differences in study populations (eg, bypass patients included or not) could influence results. This makes comparisons between studies cumbe... Abstract

Cited 5 times since 1996 (0.2 per year) source: EuropePMC

Catheterization and cardiovascular diagnosis, Volume 38, Issue 2, 1 1 1996, Pages 135-143 Micro stent, quantitative coronary angiography, and procedural results. Tresukosol D, Schalij MJ, Savalle LH, Jukema JW, Buis B, Reiber JH, Bruschke AV

The Micro stent (MS) is a radiopaque stainless steel balloon expandable intracoronary stent. The stent is mounted on a rapid-exchange delivery system. From August 1994-March 1995, 127 MS were implanted in 85 patients (pts, 1.5 stents/pt, 85 in native vessels and 42 in bypass vein grafts, 61 males and 24 female, age 33-77 yr, mean age 61 +/- 10 yr). Pts studied were scheduled for either elective PTCA (n = 62, 73%) or PTCA for acute myocardial infarction (n = 23, 27%). Elective stent implantation... Abstract

Cited 11 times since 1996 (0.4 per year) source: EuropePMC

International journal of cardiac imaging, Volume 12, Issue 2, 1 1 1996, Pages 69-78 Left ventricular regression equations from single plane cine and digital X-ray ventriculograms revisited. Reiber JH, Viddeleer AR, Koning G, Schalij MJ, Lange PE

For the assessment of left ventricular volume from X-ray ventriculograms, widely known regression equations are used to correct for the irregular shape of the left ventricular lumen and the presence of the papillary muscles and trabeculations. These regression equations were derived in the late nineteen sixties and seventies. With all the changes in X-ray technology that have taken place over the past 20-30 years, the question was raised whether these regression equations were still valid. There... Abstract

Cited 2 times since 1996 (0.1 per year) source: EuropePMC

International journal of cardiac imaging, Volume 12, Issue 2, 1 1 1996, Pages 79-83 Imaging of recurrent ventricular septal defect and supravalvular pulmonary stenosis eight years after assumed total surgical repair of tetralogy of Fallot. van Dijkman PR, Voskuil K, Hazekamp MG, van der Wall EE

A 42-year-old man underwent assumed total surgical repair of an acyanotic tetralogy of Fallot: a perimembranous ventricular septal defect (VSD) was closed with a dacron patch and myectomy of the infundibulum of the right ventricular outflow tract was performed. Reexamination eight years later revealed a large recurrent VSD and by surprise a narrow supravalvular ridge above rudimentary pulmonary cusps in the pulmonary trunk, leading to a pressure drop of 70 mmHg across the supravalvular stenosis.... Abstract

Cited 4 times since 1996 (0.1 per year) source: EuropePMC

The American journal of physiology, Volume 270, Issue 6 Pt 2, 1 1 1996, Pages H2149-56 Low external pH limits cell death of energy-depleted cardiomyocytes by attenuation of Ca2+ overload. Atsma DE, Bastiaanse EM, Van der Valk L, Van der Laarse A

We studied the effect of external pH (pHe) on cell injury, ATP content, and intracellular concentration of Ca2+ ([Ca2+]i), Na+ ([Na+]i), and H+ (pHi) during metabolic inhibition (NaCN + 2-deoxyglucose) in neonatal rat cardiomyocytes. Cell death during metabolic inhibition decreased at pHe < 7.4, with almost no cell death at pHe 6.0. Lowering pHe resulted in only temporary ATP conservation. During metabolic inhibition at pHe 7.4, [Ca2+]i rose from 86 +/- 44 nM to 2.5 +/- 0.4 microM, but at pHe... Abstract