Research

Publications

Below you can find a list of our published research.

6125 results

Cited 12 times since 1990 (0.4 per year) source: EuropePMC

Protein engineering, Volume 4, Issue 2, 1 1 1990, Pages 191-198 Involvement of aspartic and glutamic residues in kringle-2 of tissue-type plasminogen activator in lysine binding, fibrin binding and stimulation of activity as revealed by chemical modification and oligonucleotide-directed mutagenesis. Weening-Verhoeff EJ, Quax PH, van Leeuwen RT, Rehberg EF, Marotti KR, Verheijen JH

Modification of glutamic and aspartic acid residues of tissue-type plasminogen activator (t-PA) with 1-ethyl-3(3-dimethyl-aminopropyl)-carbodiimide leads to a decrease in affinity for lysine and fibrin, to a decrease of plasminogen activation activity in the presence of a fibrin mimic, but leaves amidolytic activity and plasminogen activation without fibrin mimic unaffected. Experiments with kringle-2 ligands and a deletion mutant of t-PA (K2P) suggests that glutamic or aspartic acid residues in... Abstract

Cited 2 times since 1990 (0.1 per year) source: EuropePMC

The American journal of physiology, Volume 259, Issue 5 Pt 2, 1 1 1990, Pages H1419-26 Comparison between force-velocity and end-systolic pressure-volume characterization of intrinsic LV function. van der Linden LP, van der Velde ET, Bruschke AV, Baan J

We reanalyzed experiments in in situ hearts of 16 open-chest anesthetized dogs, in which two different loading interventions were performed, i.e., an occlusion of the descending aorta (InP) and a rapid volume infusion (InV). Previous studies had demonstrated that the end-systolic elastance (Ees) of the InP was substantially larger than the Ees of the InV suggesting either a load dependency of Ees as such, or an increase in contractility during InP. The data were reanalyzed in the light of the mu... Abstract

Helvetica chirurgica acta, Volume 57, Issue 3, 1 1 1990, Pages 415-421 [Long-term results in the treatment of metastasizing kidney carcinoma using recombinant alpha-2 or gamma interferon]. Schneider AW, Otto U, Conrad S, Klosterhalfen H

To evaluate whether response to alpha-2- or gamma-interferon in metastatic renal cell carcinoma is associated with a prolonged survival, we studied a total of 65 patients being treated in two phase-II- or phase-III-trials between 1984 and 1986 with one of these interferons. After a median follow-up of 3 years for the alpha-interferon-treated patients and of more than 4 years for gamma-interferon-therapy, respectively, there is a significantly increased duration of survival for patients showing a... Abstract

Cited 85 times since 1990 (2.5 per year) source: EuropePMC

The American journal of physiology, Volume 259, Issue 4 Pt 2, 1 1 1990, Pages H1254-63 Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias. Lammers WJ, Schalij MJ, Kirchhof CJ, Allessie MA

In isolated superfused left atria of the rabbit, inhomogeneity in conduction was quantified using the activation times measured with a high-density mapping system. At each recording site, the maximal difference with neighboring activation times (i.e., phase difference) was calculated. Local phase differences were plotted in a phase map, revealing the spatial distribution of inhomogeneities in conduction, and from each map a total index of inhomogeneity was calculated. During slow pacing (2 Hz) l... Abstract

Cited 21 times since 1990 (0.6 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 22, Issue 9, 1 1 1990, Pages 987-998 Altered calcium handling at normal contractility in hypertrophied rat heart. Schouten VJ, Vliegen HW, van der Laarse A, Huysmans HA

Left or right ventricular hypertrophy was induced by banding of the aorta or pulmonary artery in different groups of rats. After 5 to 10 weeks the degree of hypertrophy was about 15% in left and 80-160% in right ventricles, as determined by weight of the ventricle or by myocyte size. Action potentials and force-interval relationships were measured in papillary muscles isolated from either ventricle. As compared to muscles from control and SHAM-operated rats, hypertrophied papillary muscles showe... Abstract

Cited 66 times since 1990 (1.9 per year) source: EuropePMC

The Journal of biological chemistry, Volume 265, Issue 26, 1 1 1990, Pages 15560-15563 Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo. Quax PH, van den Hoogen CM, Verheijen JH, Padro T, Zeheb R, Gelehrter TD, van Berkel TJ, Kuiper J, Emeis JJ

The tissue-specific distribution of tissue-type and urokinase-type plasminogen activator (t-PA and u-PA) and their inhibitor type 1 (PAI-1) was analyzed at mRNA level in five major rat organ tissues. t-PA mRNA was detected in lung, kidney, heart, and liver. u-PA mRNA was detected in kidney and lung. Presence of PA mRNA correlated with the detection of PA activity in extracts of these tissues. PAI-1 mRNA was detected predominantly in heart and lung. Although PAI activity could not be measured dir... Abstract

Cited 9 times since 1990 (0.3 per year) source: EuropePMC

The Journal of urology, Volume 144, Issue 3, 1 1 1990, Pages 637-9; discussion 639-40 Quantitative immunocytology in the management of patients with superficial bladder carcinoma. I. A marker to identify patients who do not require prophylaxis. Huland E, Huland H, Schneider AW

We used monoclonal antibody 486P 3/12 to monitor 55 patients after transurethral resection of stages Ta and T1 transitional cell bladder carcinoma. The method has a high sensitivity (89%) in detecting grades 1 to 3 lesions. We examined voided urinary specimens taken every 4 weeks after transurethral resection for a mean of approximately 2 years. Of the 55 patients 22 remained negative for marker without prophylaxis and only 2 of them had another tumor. Only 6 of 33 patients who were positive for... Abstract

Cited 73 times since 1990 (2.1 per year) source: EuropePMC

Nucleic acids research, Volume 18, Issue 11, 1 1 1990, Pages 3241-3247 All subgenomic mRNAs of equine arteritis virus contain a common leader sequence. de Vries AA, Chirnside ED, Bredenbeek PJ, Gravestein LA, Horzinek MC, Spaan WJ

During the replication of equine arteritis virus (EAV) six subgenomic mRNAs are synthesized. We present evidence that the viral mRNAs form a 3'-coterminal nested set and contain a common leader sequence of 208 nucleotides which is encoded by the 5'-end of the genome. The leader is joined to the bodies of mRNA 5 and 6 at positions defined by the sequence 5' UCAAC 3'. The part of the leader sequence flanking the UCAAC motif is very similar to the 5'-splice site of the Tetr... Abstract

Cited 4 times since 1990 (0.1 per year) source: EuropePMC

European heart journal, Volume 11 Suppl B, 1 1 1990, Pages 162-171 Neurohumoral activation during acute myocardial ischaemia. Effects of ACE inhibition. Remme WJ, Look MP, Bootsma M, Kruyssen HA, Verrostte JM, Krauss XH, van Hoogenhuyze DC, Storm CJ

ACE inhibition may be useful in several manifestations of ischaemic heart disease, such as heart failure due to ischaemic cardiomyopathy. Recent evidence suggests that these effects may also be present in normotensive patients with ischaemic heart disease without heart failure. Theoretically, converting-enzyme inhibition, through coronary and systemic vasodilating effects and negative inotropic properties, should have a favourable effect on the myocardial oxygen supply/demand ratio and, hence, a... Abstract

Cited 45 times since 1990 (1.3 per year) source: EuropePMC

Cancer research, Volume 50, Issue 5, 1 1 1990, Pages 1488-1494 Protein and messenger RNA levels of plasminogen activators and inhibitors analyzed in 22 human tumor cell lines. Quax PH, van Leeuwen RT, Verspaget HW, Verheijen JH

In 22 human tumor cell lines the regulation of production of plasminogen activators urokinase (u-PA) and tissue-type (t-PA) and their inhibitors PAI-1 and PAI-2 was studied. These four components may determine the net plasminogen activator activity, which is often associated with tumor development and metastatic processes. The amount of specific mRNA and protein produced by the cells was measured for all four components. The frequent finding of t-PA (alone or in combination with u-PA) suggests t... Abstract

Der Urologe. Ausg. A, Volume 29, Issue 2, 1 1 1990, Pages 71-76 [Tumor markers and prognostic parameters in urinary bladder cancer]. Schneider AW, Huland H

Ideal tumor markers for use in the primary diagnosis or follow up of superficial or invasive cancers have not yet been found. Nonetheless, the literature contains references to parameters that are relevant to prognosis and to markers for bladder tumors, and many of these are certainly of value when specific questions are addressed. Urinalysis has been considerably refined and yields information on superficial tumors. Quantitative immunocytology is used to check whether prophylactic treatments ar... Abstract

Cited 5 times since 1990 (0.1 per year) source: EuropePMC

Annals of the New York Academy of Sciences, Volume 591, 1 1 1990, Pages 247-256 Electrophysiology of spiral waves in two dimensions: the role of anisotropy. Allessie MA, Schalij MJ, Kirchhof CJ, Boersma L, Huyberts M, Hollen J

Abstract

Cited 10 times since 1990 (0.3 per year) source: EuropePMC

Comparative biochemistry and physiology. A, Comparative physiology, Volume 95, Issue 1, 1 1 1990, Pages 109-114 Different response of cellular DNA content to cardiac hypertrophy in human and rat heart myocytes. Vliegen HW, Bruschke AV, Van der Laarse A

1. Rat and human heart myocytes adapt to overload-induced hypertrophy differently. 2. Human myocyte nuclei respond with polyploidization and multinucleation, thus increasing the DNA content per myocyte from 20 to 40 pg. As a result, nuclear DNA content per 10,000 microns3 of cell volume decreases from 12 to 10 pg. 3. In rat hearts with aortic constriction nuclear DNA content remains constant (13 pg), and the DNA content per 10,000 microns3 of myocyte volume falls from 9 to 6 pg. 4. We hypothesiz... Abstract

Cited 2 times since 1990 (0.1 per year) source: EuropePMC

Progress in clinical and biological research, Volume 350, 1 1 1990, Pages 275-282 Recombinant alpha-2 or gamma interferon in the treatment of metastatic renal cell carcinoma: results of two phase II/III trials. Otto U, Schneider AW, Conrad S, Klosterhalfen H

Abstract

Cited 26 times since 1990 (0.7 per year) source: EuropePMC

International journal of cancer, Volume 45, Issue 1, 1 1 1990, Pages 16-20 Frequency and degree of aneuploidy in benign and malignant thyroid neoplasms. Schelfhout LJ, Cornelisse CJ, Goslings BM, Hamming JF, Kuipers-Dijkshoorn NJ, van de Velde CJ, Fleuren GJ

The frequency and degree of aneuploidy in 44 benign and 124 malignant thyroid neoplasms were analyzed by DNA flow cytometry. Single aneuploid cell populations were found in 72% of the undifferentiated carcinomas, 64% of the follicular carcinomas, 24% of the papillary carcinomas and in 24% of the follicular adenomas. Multiple aneuploid cell populations were detected in 4% of the papillary and in 36% of the follicular carcinomas but not in undifferentiated carcinomas. A low degree of aneuploidy wa... Abstract

Cited 82 times since 1990 (2.3 per year) source: EuropePMC

Archives of internal medicine, Volume 150, Issue 1, 1 1 1990, Pages 113-116 The value of fine-needle aspiration biopsy in patients with nodular thyroid disease divided into groups of suspicion of malignant neoplasms on clinical grounds. Hamming JF, Goslings BM, van Steenis GJ, van Ravenswaay Claasen H, Hermans J, van de Velde CJ

The accuracy of clinical diagnosis and fine-needle aspiration biopsy (FNAB) was evaluated in 169 patients surgically treated for nodular thyroid disease. Patients were divided into three groups with high, moderate, or low suspicion of malignant neoplasms on clinical grounds without previous knowledge of cytologic or histologic results. Histologic examination revealed an overall malignant neoplasm rate of 23%; the rate was 71%, 14%, and 11% for the groups with high, moderate, and low suspicion, r... Abstract

Cited 8 times since 1990 (0.2 per year) source: EuropePMC

Lasers in surgery and medicine, Volume 10, Issue 4, 1 1 1990, Pages 363-374 Early and late arterial healing response to catheter-induced laser, thermal, and mechanical wall damage in the rabbit. Oomen A, van Erven L, Vandenbroucke WV, Verdaasdonk RM, Slager CJ, Thomsen SL, Borst C

Pulsed lasers are being promoted for laser angioplasty because of their capacity to ablate obstructions without producing adjacent thermal tissue injury. The implicit assumption that thermal injury to the artery is to be avoided was tested. Thermal lesions were produced in the iliac arteries and aorta of normal rabbits by a) electrical spark erosion, b) the metal laser probe, and c) continuous wave neodymium-yttrium aluminum garnet (Nd-YAG) laser energy through the sapphire contact probe. High-e... Abstract

Der Urologe. Ausg. A, Volume 29, Issue 1, 1 1 1990, Pages 19-22 [Use of electronic data processing at a urologic polyclinic--a program packet for recording and evaluating data of specialized consultations]. Schneider AW, Otto U, Conrad S, Klosterhalfen H

A software package was developed for computerized recording and processing of clinical data in a urological out-patient clinic. In a pilot study this program proved to be useful for the rapid evaluation of all important clinical and laboratory results of patients with renal cell carcinoma, and its use also accelerated the preparation of medical reports. The experience gained in this initial project shows that the application of this newly developed concept of data processing can easily be extend... Abstract

Cited 49 times since 1989 (1.4 per year) source: EuropePMC

European heart journal, Volume 10 Suppl E, 1 1 1989, Pages 2-8 Experimental electrophysiology and arrhythmogenicity. Anisotropy and ventricular tachycardia. Allessie MA, Schalij MJ, Kirchhof CJ, Boersma L, Huybers M, Hollen J

In a 2-D model of anisotropy, created by freezing the intramural and endocardial layers of a Langendorf perfused rabbit heart, sustained ventricular tachycardia (VT) with a cycle length of 130 ms and an excitable gap of 30 ms could be initiated by rapid pacing. High resolution mapping (256 points) of the thin surviving epicardial layer revealed that the VT was based on epicardial re-entry without the involvement of a gross anatomic obstacle and a central line of functional conduction block orien... Abstract

Cited 18 times since 1989 (0.5 per year) source: EuropePMC

European journal of cancer & clinical oncology, Volume 25, Issue 9, 1 1 1989, Pages 1317-1323 Prognosis and morbidity after total thyroidectomy for papillary, follicular and medullary thyroid cancer. Hamming JF, Van de Velde CJ, Goslings BM, Schelfhout LJ, Fleuren GJ, Hermans J, Zwaveling A

The prognosis and the morbidity results after total thyroidectomy are reported for 148 patients with differentiated thyroid cancer. Ninety-two patients (62%) had papillary cancer, 27 (18%) had follicular cancer and 29 (20%) had medullary cancer. In the latter group, 16 patients had no clinical signs of a tumour and underwent total thyroidectomy after elevated calcitonin levels were found in a family screening programme. The mean follow-up period was 9.7 years in the present series. The 5- and 10... Abstract