Research

Publications

Below you can find a list of our published research.

8684 results

Journal of lipid research, Volume 66, Issue 4, 13 2 2025, Pages 100778 Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R

Plasma 1H-NMR metabolomic measures have yielded significant insight into the pathophysiology of cardiometabolic disease, but their inter-related nature complicates causal inference and clinical interpretation. This study aimed to investigate the associations of unrelated 1H-NMR metabolomic profiles with coronary artery disease (CAD) and ischemic stroke (IS). Principal component (PC) analysis was performed on 168 1H-NMR metabolomic measures in 56,712 unrelated European participants from UK Bioban... Abstract

British journal of clinical pharmacology, 13 2 2025 Pharmacokinetics of betamethasone in pre-eclampsia: An in vivo and ex vivo study. Schoenmakers S, Li L, Kluivers ACM, Broekhuizen M, Harhangi MS, Danser AHJ, Reiss I, Allegaert K, van den Berg SAA, van Zelst BD, van Schaik RHN, DeKoninck PLJ, Ronde E, Sassen SDT, Simons SHP, Koch BCP

Aims: To enhance understanding of betamethasone and its metabolites' pharmacokinetics in pregnancy, specifically early-onset pre-eclampsia, through a population pharmacokinetic model. Additionally, to investigate the placental metabolism and transfer of betamethasone and its main metabolites. Methods: A prospective, single-centre pharmacokinetic study was conducted in pregnant women (n = 28) with imminent preterm birth treated with intramuscular betamethasone. Betamethasone serum concentrat... Abstract

eLife, Volume 14, 12 2 2025, Pages e103728 A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postganglionic neuron differentiation for human disease modeling. Bos TA, Polyakova E, van Gils JM, de Vries AAF, Goumans MJ, Freund C, DeRuiter MC, Jongbloed MRM

Human autonomic neuronal cell models are emerging as tools for modeling diseases such as cardiac arrhythmias. In this systematic review, we compared 33 articles applying 14 different protocols to generate sympathetic neurons and 3 different procedures to produce parasympathetic neurons. All methods involved the differentiation of human pluripotent stem cells, and none employed permanent or reversible cell immortalization. Almost all protocols were reproduced in multiple pluripotent stem cell lin... Abstract

Preventive veterinary medicine, Volume 239, 12 2 2025, Pages 106512 The use of data for health and welfare management of farmed salmons in Norway, Scotland, and Ireland. Zhou X, Boerlage AS, Jensen BB, Gismervik K, Oliveira VHS, Hutchinson I, Burrell A, Graham DA, Doidge C, Kaler J, van Schaik G, Siegrist M, Bearth A

Data-driven solutions can support stakeholders' decision-making when managing health and welfare in Atlantic salmon production. While many different types of data are being collected, knowledge about stakeholders' use and needs regarding this data and data tools in their day-to-day work is limited. The current study explores the status quo of using data and data tools in salmon health management and needs of the stakeholders. Fourteen focus group discussions and three in-depth intervie... Abstract

The Pediatric infectious disease journal, Volume 44, Issue 4, 10 2 2025, Pages 281-286 The Prevalence, Serogroup Distribution and Risk Factors of Meningococcal Carriage in Children, Adolescents and Young Adults in Turkey Meningo-Carr-TR Study PART 3: COVID-19 Pandemic Situation. Kizil MC, Kara Y, Karbuz A, Oz FN, Ciftci E, Kurugol Z, Iseri Nepesov M, Celebi S, Cetin BS, Yilmaz D, Dinleyici M, Kizmaz Isancli D, Kilicaslan O, Ozdemir H, Inceli BH, Penezoglu DN, Dortkardesler B, Sezer Yamanel RG, Aksoy FD, Tekin Can S, Agrali Eröz N, Kaya M, Kilic O, Dinleyici EC

Background: The prevalence of meningococcal carriage and serogroup distribution is crucial for assessing the epidemiology of invasive meningococcal disease, forecasting outbreaks and formulating potential immunization strategies. Following the meningococcal carriage studies conducted in Turkey in 2016 and 2018, we planned to re-evaluate meningococcal carriage in children, adolescents and young adults during the COVID-19 pandemic period. Methods: In the MENINGO-CARR-3 study, we collected nasophar... Abstract

Patient education and counseling, Volume 136, 8 2 2025, Pages 108716 Implementation of a patient decision aid for discharge planning of hospitalized patients with stroke: aprocess evaluation using a mixed-methods approach. Prick JCM, Engelhardt EG, Lansink Rotgerink FK, Deijle IA, van Schaik SM, Garvelink MM, Dahmen R, Brouwers PJAM, van Uden IWM, van der Wees PJ, Van den Berg-Vos RM, van Uden-Kraan CF, Santeon VBHC STROKE group

Objectives: To promote shared decision-making (SDM) during discharge planning of patients with stroke, a patient decision aid (PtDA) was implemented in seven Dutch hospitals. This mixed-methods process evaluation assessed: 1) PtDA use, 2) the SDM process, 3) facilitators and barriers influencing health care professional (HCP) adoption of the PtDA, and 4) HCP experiences with the PtDA. Methods: Rates of PtDA use were derived from hospital registries and PtDA log data. SDM levels in consultations... Abstract

Cited 2 times since 2025 (8 per year) source: EuropePMC

Nature genetics, Volume 57, Issue 3, 6 1 2025, Pages 539-547 Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M,

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development and cell-cell communication at 139 loci. Furthermore, we assayed chromatin accessibility using assay f... Abstract

Cited 1 times since 2025 (4 per year) source: EuropePMC

Gut, Volume 74, Issue 4, 6 1 2025, Pages 547-556 Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy - a multi-arm randomised controlled trial (HELIOS). Te Groen M, Wijnands AM, den Broeder N, de Jong DJ, van Dop WA, Duijvestein M, Fidder HH, van Schaik F, Hirdes MMC, van der Meulen-de Jong AE, Maljaars PWJ, Voorneveld PW, de Boer KHN, Peters CP, Oldenburg B, Hoentjen F, Dutch Initiative on Crohn and Colitis

Background: It remains unclear if the increased colorectal neoplasia detection rate in inflammatory bowel disease (IBD) by high-definition (HD) dye-based chromoendoscopy compared with HD white-light endoscopy is due to enhanced contrast or increased inspection times. Longer withdrawal times may yield similar neoplasia detection rates as found by HD chromoendoscopy. Objective: To compare colorectal neoplasia detection rates for HD white-light endoscopy with segmental re-inspection and HD chromoen... Abstract

JACC. Clinical electrophysiology, 5 1 2025, Pages S2405-500X(25)00086-6 Impact of Anterior Right Ventricular Outflow Tract Conduction Block on QRS Morphology in Repaired Tetralogy of Fallot. Moore JP, Zeppenfeld K

Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 105, Issue 6, 4 1 2025, Pages 1418-1426 Clinical and Technical Predictors of Treatment Success After Coronary Intravascular Lithotripsy in Calcific Coronary Lesions. van Oort MJH, Bingen BO, Oliveri F, Al Amri I, Phagu AAS, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is increasingly used to treat coronary artery calcification (CAC). This study aimed to identify clinical and procedural factors associated with IVL treatment success. Methods: This retrospective analysis included 454 patients (73 ± 9 years, 75% male) treated with IVL from the multicenter BENELUX-IVL registry (May 2019 to February 2024). Treatment success was defined as achieving residual coronary diameter stenosis Abstract

Radiation and environmental biophysics, Volume 64, Issue 2, 4 1 2025, Pages 275-289 Commissioning and performance assessment of diodes and MOSFETs in in-vivo dosimetry for external beam radiation therapy. Al Kharusi O, Al Mamari R, Al Hosni B, Al Amri I, Al Fishawy M, Boulassel MR, Bouchareb Y

The precision of radiation therapy treatment depends on several calibration and quality assurance processes. In-vivo dosimetry (IVD) is used in external beam radiotherapy to evaluate the delivered versus planned dose as a patient-specific quality assurance verification procedure. This study aimed at assessing the performance of diodes (EDP-103G and EDP-203G) and metal oxide semiconductor field-effect transistors (MOSFETs) and corresponding correction factors followed by IVD evaluation in differe... Abstract

Cited 1 times since 2025 (3.9 per year) source: EuropePMC

Nature genetics, Volume 57, Issue 4, 4 1 2025, Pages 815-828 Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Malarstig A, Gratton J, Bond I, Roselli C, Miller D, Chopade S, Schmidt AF, Abner E, Adams L, Andersson C, Aragam KG, Ärnlöv J, Asselin G, Raja AA, Backman JD, Bartz TM, Biddinger KJ, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunak S, Bruun MT, Buckbinder L, Bundgaard H, Carey DJ, Chasman DI, Chen X, Cook JP, Czuba T, de Denus S, Dehghan A, Delgado GE, Doney AS, Dörr M, Dowsett J, Dudley SC, Engström G, Erikstrup C, Esko T, Farber-Eger EH, Felix SB, Finer S, Ford I, Ghanbari M, Ghasemi S, Ghouse J, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Hägg S, Haggerty CM, Hedman ÅK, Helgadottir A, Hemingway H, Hillege H, Hyde CL, Aagaard Jensen B, Jukema JW, Kardys I, Karra R, Kavousi M, Kizer JR, Kleber ME, Køber L, Koekemoer A, Kuchenbaecker K, Lai YP, Lanfear D, Langenberg C, Lin H, Lind L, Lindgren CM, Liu PP, London B, Lowery BD, Luan J, Lubitz SA, Magnusson P, Margulies KB,

Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individuals had HF, of whom 44,012 had a nonischemic etiology (ni-HF). A subset of patients with ni-HF were st... Abstract

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, Volume 34, Issue 5, 4 1 2025, Pages 1801-1809 Analysis of the factors associated with sexual health improvement in patients who underwent surgical management for adult spine deformity. van Schaik D, Baroncini A, Boissiere L, Larrieu D, Goudman L, Pizones J, Pellise F, Alanay A, Kleinstück F, Bourghli A, Obeid I, European Spine Study Group

Background: Spinal deformity can have a severe impact on the patient's sexual health. Eventually, this can lead to depression and relationship distress. Spinal surgical management is suggested to improve sexual function, however, the literature concerning these aspects is still scarce. This study evaluated which factors predicted improvement in sexual health in patients with adult spinal deformity (ASD) who underwent surgical treatment. Methods: Multicentric retrospective study based on a p... Abstract

ERJ open research, Volume 11, Issue 2, 3 1 2025, Pages 619-2024 Enzymatic therapy versus video-assisted thoracoscopic surgery for pleural infections: a systematic review and meta-analysis. de Jonge WR, Smits B, Ket JCF, Altenburg J, Annema J, Daniels JMA, Dickhoff C, van Dorp M, Braun J, Korevaar DA, Heineman DJ

Aims: Parapneumonic pleural infections are frequently encountered, but the optimal treatment regimen remains controversial. The aim of this systematic review was to investigate whether immediate video-assisted thoracoscopic surgery (VATS) has advantages over intrapleural enzymatic therapy (IET). Methods: We searched MEDLINE, Embase and Web of Science Core Collection till November 2023 and included studies comparing IET and VATS in adult patients with parapneumonic pleural infections. Primary out... Abstract

Cited 1 times since 2025 (3.9 per year) source: EuropePMC

Chemphyschem : a European journal of chemical physics and physical chemistry, Volume 26, Issue 8, 3 1 2025, Pages e202400688 Mechanistic Insights into the Photocatalytic Indigo Carmine Dye Decolorization by Co3O4/TiO2. de Graaf ME, Godec N, Kappé BT, Grote RL, Flapper J, Hutter EM, Weckhuysen BM

TiO2 is widely studied as an efficient UV-light photocatalyst for organic compound degradation through reactive oxygen species (ROS) generation. TiO2 can be modified to show photocatalytic activity under visible light illumination by combining with visible-light absorbing metal oxides. Here, we investigated Co3O4/TiO2 composite materials as visible-light absorbing photocatalysts, with various weight loadings of Co3O4, for the decolorization of wastewater pollutant indigo carmine. Under green LED... Abstract

Frontiers in medicine, Volume 12, 3 1 2025, Pages 1492596 Quality assessment of a training program for undergraduate sonography peer tutors: paving the future way for peer-assisted learning in medical ultrasound education. Weimer J, Yilmaz D, Ille C, Weinmann-Menke J, Müller L, Büchner H, Buggenhagen H, Stäuber M, Neubauer R, Winter L, Weimer A, Dirks K, Künzel J, Rink M, Dionysopoulou A, Lorenz L, Kloeckner R, Recker F, Schiestl L

Introduction: Peer tutoring has been increasingly used to support university sonography teaching, necessitating well-qualified tutors. This study aims to evaluate the quality of a training program for sonography peer tutors developed and implemented at a university hospital. Materials and methods: A training program consisting of 11 modules was developed and subsequently evaluated for success with two subjective and two objective assessments of peer-tutoring quality. The two subjective assessmen... Abstract

Interdisciplinary cardiovascular and thoracic surgery, Volume 40, Issue 3, 1 1 2025, Pages ivaf071 The arterial switch operation for transposition of the great arteries with left ventricular outflow tract obstruction and ventricular septal defect: clinical outcomes and specimen study. van der Palen RLF, den Ouden A, Knobbe I, Bouma BJ, Koolbergen DR, Jongbloed MRM, Hazekamp MG

Objectives: In selected patients with transposition of the great arteries (TGA), ventricular septal defect (VSD) and left ventricular outflow tract obstruction (LVOTO), the arterial switch operation (ASO) may be the procedure of choice. This study reviews the clinical outcomes of TGA-VSD-LVOTO patients after ASO and compares mechanisms of LVOTO in this patient group to a historical series of cardiac specimens. Methods: This retrospective analysis included all cases with TGA-VSD-LVOTO who underwe... Abstract

European heart journal. Cardiovascular Imaging, Volume 26, Issue 3, 1 1 2025, Pages 385-413 The role of multi-modality imaging for the assessment of left atrium and left atrial appendage: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC). Sade LE, Faletra FF, Pontone G, Gerber BLM, Muraru D, Edvardsen T, Cosyns B, Popescu BA, Klein A, Marwick TH, Cameli M, Saric M, Thomas L, Ajmone Marsan N, Fontes-Carvalho R, Podlesnikar T, Fontana M, La Gerche A, Petersen SE, Moharem-Elgamal S, Bittencourt MS, Vannan MA, Glikson M, Peichl P, Cochet H, Stankovic I, Donal E, Thomas D, Marta RS

Structural, architectural, contractile, or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodelling has become a cornerstone diagnostic and prognostic marker. The structure and the function of the LA and left atrial appendage (LAA), which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillat... Abstract

Cureus, Volume 17, Issue 3, 1 1 2025, Pages e79898 Synovial Sarcoma of the Hand: A Case Report and Literature Review on a Significant Challenge in Treatment. Tajammul SS, Mohammed K, Al Farii H, Shalaby A, Munir J, Al-Amri I, Alfishawy M, Al Mandhari Z

Soft tissue sarcomas (STS) of the hand are extremely uncommon, with synovial sarcomas being even rarer. Despite their small size at presentation, hand sarcomas can indeed be aggressive and may result in significant morbidity and mortality if not effectively managed. A considerable proportion of these tumors are treated by unplanned excision before referral to a specialist oncological center. Additionally, hand sarcomas can mimic benign lesions, leading to misinterpretation and delayed diagnosis.... Abstract

World journal of biological chemistry, Volume 16, Issue 1, 1 1 2025, Pages 104535 Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction. Farhadi S, Mohammadi S, AlKindi AY, Al-Amri IS

Alcohol-associated liver disease (ALD) is a major global health concern, contributing to liver injury, morbidity, and mortality. Elafibranor (EFN), a dual peroxisome proliferator-activated receptor α/δ agonist, has shown promise as a therapeutic candidate in preclinical studies. EFN reduces liver fibrosis by inhibiting lipid accumulation, apoptosis, and inflammatory pathways (LPS/TLR4/NF-κB), while enhancing autophagy and antioxidant responses. It also improves intestinal barrier function and mo... Abstract