Research

Publications

Below you can find a list of our published research.

6682 results

Cited 9 times since 2022 (3.4 per year) source: EuropePMC

Molecular psychiatry, Volume 27, Issue 11, 16 3 2022, Pages 4419-4431 Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Lahti J, Tuominen S, Yang Q, Pergola G, Ahmad S, Amin N, Armstrong NJ, Beiser A, Bey K, Bis JC, Boerwinkle E, Bressler J, Campbell A, Campbell H, Chen Q, Corley J, Cox SR, Davies G, De Jager PL, Derks EM, Faul JD, Fitzpatrick AL, Fohner AE, Ford I, Fornage M, Gerring Z, Grabe HJ, Grodstein F, Gudnason V, Simonsick E, Holliday EG, Joshi PK, Kajantie E, Kaprio J, Karell P, Kleineidam L, Knol MJ, Kochan NA, Kwok JB, Leber M, Lam M, Lee T, Li S, Loukola A, Luck T, Marioni RE, Mather KA, Medland S, Mirza SS, Nalls MA, Nho K, O'Donnell A, Oldmeadow C, Painter J, Pattie A, Reppermund S, Risacher SL, Rose RJ, Sadashivaiah V, Scholz M, Satizabal CL, Schofield PW, Schraut KE, Scott RJ, Simino J, Smith AV, Smith JA, Stott DJ, Surakka I, Teumer A, Thalamuthu A, Trompet S, Turner ST, van der Lee SJ, Villringer A, Völker U, Wilson RS, Wittfeld K, Vuoksimaa E, Xia R, Yaffe K, Yu L, Zare H, Zhao W, Ames D, Attia J, Bennett DA, Brodaty H, Chasman DI, Goldman AL, Hayward C, Ikram MA, Jukema JW, Kardia SLR, Lencz T, Loeffler M,

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyse... Abstract

Cited 5 times since 2022 (1.9 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 36, Issue 2, 14 2 2022, Pages 163-171 Effects of Atrial Ischemia on Left Atrial Remodeling in Patients with ST-Segment Elevation Myocardial Infarction. Montero-Cabezas JM, Abou R, Chimed S, Fortuni F, Goedemans L, Ajmone Marsan N, Bax JJ, Delgado V

Background: Adverse left atrial (LA) remodeling after ST-segment elevation myocardial infarction (STEMI) has been associated with poor prognosis. Flow impairment in the dominant coronary atrial branch (CAB) may affect large areas of LA myocardium, potentially leading to adverse LA remodeling during follow-up. The aim of this study was to assess echocardiographic LA remodeling in patients with STEMI with impaired coronary flow in the dominant CAB. Methods: Of 897 patients with STEMI, 69 patients... Abstract

Cited 7 times since 2022 (2.6 per year) source: EuropePMC

Animal frontiers : the review magazine of animal agriculture, Volume 12, Issue 4, 12 2 2022, Pages 61-70 Nutritional values and health benefits of dromedary camel meat. Kadim IT, Al-Amri IS, Alkindi AY, Haq QMI

Abstract

Cited 12 times since 2022 (4.5 per year) source: EuropePMC

Prehospital and disaster medicine, Volume 37, Issue 5, 11 2 2022, Pages 600-608 Managing Hospital Capacity: Achievements and Lessons from the COVID-19 Pandemic. de Koning ER, Boogers MJ, Beeres SL, Kramer ID, Dannenberg WJ, Schalij MJ

Introduction: The coronavirus disease 2019 (COVID-19) pandemic challenged health care systems in an unprecedented way. Due to the enormous amount of hospital ward and intensive care unit (ICU) admissions, regular care came to a standstill, thereby overcrowding ICUs and endangering (regular and COVID-19-related) critical care. Acute care coordination centers were set up to safely manage the influx of COVID-19 patients. Furthermore, treatments requiring ICU surveillance were postponed leading to i... Abstract

Cited 6 times since 2022 (2.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 108, Issue 17, 11 2 2022, Pages 1401-1407 Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis. Stassen J, Ewe SH, Butcher SC, Amanullah MR, Mertens BJ, Hirasawa K, Singh GK, Sin KY, Ding ZP, Pio SM, Sia CH, Chew N, Kong W, Poh KK, Cohen D, Généreux P, Leon MB, Ajmone Marsan N, Delgado V, Bax JJ

Objective: To investigate the prognostic impact of left ventricular (LV) diastolic dysfunction in patients with moderate aortic stenosis (AS) and preserved LV systolic function. Methods: Patients with a first diagnosis of moderate AS (aortic valve area >1.0 and ≤1.5 cm2) and preserved LV systolic function (LV ejection fraction ≥50%) were identified. LV diastolic function was evaluated using echocardiographic criteria according to the 2016 American Society of Echocardiography/European Associat... Abstract

The international journal of cardiovascular imaging, Volume 38, Issue 10, 8 2 2022, Pages 2141-2142 Progression of moderate to severe aortic stenosis: new insights into cardiac remodeling. Stassen J, Singh GK, Butcher SC, Hirasawa K, Marsan NA, Delgado V, Bax JJ

Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

Frontiers in immunology, Volume 13, 5 1 2022, Pages 958952 A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria. Kreft L, Schepers A, Hils M, Swiontek K, Flatley A, Janowski R, Mirzaei MK, Dittmar M, Chakrapani N, Desai MS, Eyerich S, Deng L, Niessing D, Fischer K, Feederle R, Blank S, Schmidt-Weber CB, Hilger C, Biedermann T, Ohnmacht C

The alpha-Gal epitope (α-Gal) with the determining element galactose-α1,3-galactose can lead to clinically relevant allergic reactions and rejections in xenotransplantation. These immune reactions can develop because humans are devoid of this carbohydrate due to evolutionary loss of the enzyme α1,3-galactosyltransferase (GGTA1). In addition, up to 1% of human IgG antibodies are directed against α-Gal, but the stimulus for the induction of anti-α-Gal antibodies is still unclear. Commensal bacteri... Abstract

Cited 4 times since 2022 (1.5 per year) source: EuropePMC

Journal of the American Heart Association, Volume 11, Issue 16, 5 1 2022, Pages e024168 Revealing Unforeseen Diagnostic Image Features With Deep Learning by Detecting Cardiovascular Diseases From Apical 4-Chamber Ultrasounds. Cheng LH, Bosch PBJ, Hofman RFH, Brakenhoff TB, Bruggemans EF, van der Geest RJ, Holman ER

Background With the increase of highly portable, wireless, and low-cost ultrasound devices and automatic ultrasound acquisition techniques, an automated interpretation method requiring only a limited set of views as input could make preliminary cardiovascular disease diagnoses more accessible. In this study, we developed a deep learning method for automated detection of impaired left ventricular (LV) function and aortic valve (AV) regurgitation from apical 4-chamber ultrasound cineloops and inve... Abstract

Cited 7 times since 2022 (2.6 per year) source: EuropePMC

Journal of the American Heart Association, Volume 11, Issue 16, 5 1 2022, Pages e024581 von Willebrand Factor: A Central Regulator of Arteriovenous Fistula Maturation Through Smooth Muscle Cell Proliferation and Outward Remodeling. Laboyrie SL, de Vries MR, de Jong A, de Boer HC, Lalai RA, Martinez L, Vazquez-Padron RI, Rotmans JI

Background Arteriovenous fistula (AVF) maturation failure is a main limitation of vascular access. Maturation is determined by the intricate balance between outward remodeling and intimal hyperplasia, whereby endothelial cell dysfunction, platelet aggregation, and vascular smooth muscle cell (VSMC) proliferation play a crucial role. von Willebrand Factor (vWF) is an endothelial cell-derived protein involved in platelet aggregation and VSMC proliferation. We investigated AVF vascular remodeling i... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Current cardiology reports, Volume 24, Issue 10, 4 1 2022, Pages 1407-1416 Focus on Diagnosis and Prognosis to Guide Timing of Intervention in Valvular Heart Disease. Stassen J, Galloo X, van der Bijl P, Bax JJ

Purpose of review: The present article reviews the role of multimodality imaging to improve risk stratification and timing of intervention in patients with valvular heart disease (VHD), and summarizes the latest developments in transcatheter valve interventions. Recent findings: Growing evidence suggests that intervention at an earlier stage may improve outcomes of patients with significant VHD. Multimodality imaging, including strain imaging and tissue characterization with cardiac magnetic res... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 3, 1 1 2022, Pages ezac401 Obesity and outcomes after left ventricular assist device implantation: insights from the EUROMACS Registry. Angleitner P, Kaider A, De By TMMH, Dimitrov K, Schlöglhofer T, Tops LF, Fiane AE, Rábago G, Laufer G, Zimpfer D

Objectives: The objective was to analyse associations between obesity and outcomes after left ventricular assist device (LVAD) implantation. Methods: A retrospective analysis of the EUROMACS Registry was performed. Adult patients undergoing primary implantation of a continuous-flow LVAD between 2006 and 2019 were included (Medtronic HeartWare® HVAD®, Abbott HeartMate II®, Abbott HeartMate 3™). Patients were classified into 4 different groups according to body mass index at the time of surgery (b... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 3, 1 1 2022, Pages ezac118 Minimally invasive lobectomy versus stereotactic ablative radiotherapy for stage I non-small cell lung cancer. de Ruiter JC, van Diessen JNA, Smit EF, van der Noort V, Damhuis RAM, Hartemink KJ, ESLUNG group

Objectives: A minimally invasive lobectomy (MIL) is the standard treatment for stage I non-small cell lung cancer (NSCLC) in medically operable patients. Stereotactic ablative radiotherapy (SABR) is recommended for inoperable patients and has been proposed as a potential alternative for operable patients as well. Here, we present the results of a feasibility study in preparation for a nationwide retrospective cohort study, comparing outcomes between both treatment modalities. Methods: In this re... Abstract

Mathematical biosciences and engineering : MBE, Volume 19, Issue 11, 1 1 2022, Pages 10941-10962 Assessing the therapeutic response of tumors to hypoxia-targeted prodrugs with an in silico approach. Yilmaz D, Tuzer M, Unlu MB

Tumor hypoxia is commonly recognized as a condition stimulating the progress of the aggressive phenotype of tumor cells. Hypoxic tumor cells inhibit the delivery of cytotoxic drugs, causing hypoxic areas to receive insufficient amounts of anticancer agents, which results in adverse treatment responses. Being such an obstruction to conventional therapies for cancer, hypoxia might be considered a target to facilitate the efficacy of treatments in the resistive environment of tumor sites. In this r... Abstract

Cited 12 times since 2022 (4.5 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 3, 1 1 2022, Pages ezac374 Surgical aortic valve replacement with a stented pericardial bioprosthesis: 5-year outcomes. Klautz RJM, Dagenais F, Reardon MJ, Lange R, Moront MG, Labrousse L, Weissman NJ, Rao V, Patel HJ, Liu F, Sabik JF

Objectives: This analysis evaluated the safety, durability and haemodynamic performance of a stented bovine pericardial valve through 5 years of follow-up in patients with an indication for surgical aortic valve replacement. Methods: Kaplan-Meier analysis was used to estimate the incidence of survival and valve-related thromboembolism, major paravalvular leak, endocarditis, structural valve deterioration (SVD) and reintervention. The mean aortic gradient and New York Heart Association (NYHA) fun... Abstract

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, Volume 32, Issue 8, 1 1 2022, Pages 1094-1095 Langerhans Cell Histiocytosis with an Undetected Ileal Polyp. Kiyak M, Tanoglu A, Yilmaz D

Null. Abstract

Cited 26 times since 2022 (9.7 per year) source: EuropePMC

American journal of human genetics, Volume 109, Issue 8, 1 1 2022, Pages 1366-1387 A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL, Chesi A, Wells A, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Lee WJ, Hsiung CA, Warren HR, Ramirez J, Bork-Jensen J, Kårhu

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow... Abstract

Cited 7 times since 2022 (2.6 per year) source: EuropePMC

Research and practice in thrombosis and haemostasis, Volume 6, Issue 6, 1 1 2022, Pages e12809 Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units: A retrospective cohort study. Noordermeer T, Schutgens REG, Visser C, Rademaker E, de Maat MPM, Jansen AJG, Limper M, Cremer OL, Kruip MJHA, Endeman H, Maas C, de Laat B, Urbanus RT, Dutch COVID & Thrombosis Coalition (DCTC)

Background: Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) is a strong acquired risk factor for thrombosis in various diseases and is frequently observed in patients with COVID-19. Whether LA is associated with thrombosis in patients with severe COVID-19 is currently unclear. Objective: To investigate if LA is associated with thrombosis in critically ill patients with COVID-... Abstract

Cited 31 times since 2022 (11.5 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 15, Issue 16, 1 1 2022, Pages 1664-1674 Impact of Moderate Aortic Stenosis on Long-Term Clinical Outcomes: A Systematic Review and Meta-Analysis. Coisne A, Scotti A, Latib A, Montaigne D, Ho EC, Ludwig S, Modine T, Généreux P, Bax JJ, Leon MB, Bauters C, Granada JF

Background: The clinical course of patients with moderate aortic stenosis (AS) remains incompletely defined. Objectives: This study sought to analyze the clinical course of moderate AS and compare it with other stages of the disease. Methods: Multiple electronic databases were searched to identify studies on adult moderate AS. Random-effects models were used to derive pooled estimates. The primary endpoint was all-cause death. The secondary endpoints were cardiac death, heart failure, sudden dea... Abstract

Cited 48 times since 2022 (17.9 per year) source: EuropePMC

European heart journal, Volume 43, Issue 32, 1 1 2022, Pages e1-e9 A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy. Cadrin-Tourigny J, Bosman LP, Nozza A, Wang W, Tadros R, Bhonsale A, Bourfiss M, Fortier A, Lie ØH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE, Judge DP, Yap SC, van der Heijden JF, Tandri H, Jongbloed JDH, Guertin MC, van Tintelen JP, Platonov PG, Duru F, Haugaa KH, Khairy P, Hauer RNW, Calkins H, Te Riele ASJM, James CA

Aims: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods and results: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interq... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 3, 1 1 2022, Pages ezac240 Mechanical circulatory support in the failing systemic right ventricle: a step towards better outcome. Koolbergen DR

Abstract