7565 results
Cited 322 times since 2022 (129.3 per year)
source: EuropePMC
Nature,
Volume 610, Issue 7933, 12 2 2022, Pages 704-712
A saturated map of common genetic variants associated with human height.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin X, Chen SH, Ferreira T, Highland HH, Ji Y, Karaderi T, Lin K, Lüll K, Malden DE, Medina-Gomez C, Machado M, Moore A, Rüeger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, Andersen MK, Ani A, Appadurai V, Arbeeva L, Bhaskar S, Bielak LF, Bollepalli S, Bonnycastle LL, Bork-Jensen J, Bradfield JP, Bradford Y, Braund PS, Brody JA, Burgdorf KS, Cade BE, Cai H, Cai Q, Campbell A, Cañadas-Garre M, Catamo E, Chai JF, Chai X, Chang LC, Chang YC, Chen CH, Chesi A, Choi SH, Chung RH, Cocca M, Concas MP, Couture C, Cuellar-Partida G, Danning R, Daw EW, Degenhard F, Delgado GE, Delitala A, Demirkan A, Deng X, Devineni P, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Ekici AB, Engmann JE, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Francescatto M, Freitag-Wolf S, Fuchsberger C, Galesloot TE, Gao Y, Gao Z, Geller F
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered withi...
Abstract
Cited 4 times since 2022 (1.6 per year)
source: EuropePMC
Acta dermato-venereologica,
Volume 102, 11 2 2022, Pages adv00788
Aesthetic Outcome of Propranolol vs Atenolol Treatment of Children with Infantile Haemangioma.
Hermans MM, Breugem CC, Schappin R, Jonge Poerink E, Mendels EJ, Ragamin A, Breur JMPJ, Langeveld HR, Raphael MF, De Laat PCJ, De Wildt SN, Rietman AB, Pasmans SGMA, De Graaf M
Infantile haemangiomas are common benign tumours of infancy, which can be treated effectively with beta-blockers such as propranolol and atenolol. Different types of beta-blockers may result in different long-term aesthetic outcomes. This study evaluated the difference in long-term aesthetic outcomes between infantile haemangiomas treated with either propranolol or atenolol, including the perspective of physicians, parents, and children. Children, aged ≥6 years, treated with propranolol or ateno...
Abstract
Cited 5 times since 2022 (2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 185, 11 2 2022, Pages 53-62
Factors Affecting Rate of Progression of Aortic Stenosis and Its Impact on Outcomes.
Amanullah MR, Pio SM, Sin KYK, Marsan NA, Ding ZP, Stassen J, Leon MB, Genereux P, Delgado V, Ewe SH, Bax JJ
The rate of aortic stenosis (AS) progression in patients with moderate AS is unclear. This study examined the risk factors of progression from moderate to severe AS and its impact on clinical outcomes. A total of 954 patients with moderate AS (valve area >1.0 and ≤1.5 cm²) and follow-up echocardiograms were included. AS progressed to severe (valve area
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Nutrition, metabolism, and cardiovascular diseases : NMCD,
Volume 33, Issue 1, 8 2 2022, Pages 56-64
Development, internal reliability and preliminary construct validity of the Dutch Dietary Intention Evaluation Tool for In-patients (DIETI).
de Frel DL, Wicks H, Bakk Z, van Keulen N, van Adrichem V, van Tussenbroek N, Atsma PDE, Janssen VR
Background and aims: Diet is important in prevention and management of non-communicable disease and in particular, cardiovascular disease. Recently, more hospitals gear towards healthier dietary policies, however, a tool to assess the effect of these interventions in patient populations is currently lacking. The Theory of Planned Behavior (TPB) is generally used to assess health-related behavior and offers a framework for development of questionnaires. In this study, we aim to evaluate the relia...
Abstract
Cited 17 times since 2022 (6.8 per year)
source: EuropePMC
Circulation,
Volume 146, Issue 19, 7 1 2022, Pages 1434-1443
Programmed Ventricular Stimulation as an Additional Primary Prevention Risk Stratification Tool in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Study.
Gasperetti A, Carrick RT, Costa S, Compagnucci P, Bosman LP, Chivulescu M, Tichnell C, Murray B, Tandri H, Tadros R, Rivard L, van den Berg MP, Zeppenfeld K, Wilde AAM, Pompilio G, Carbucicchio C, Dello Russo A, Casella M, Svensson A, Brunckhorst CB, van Tintelen JP, Platonov PG, Haugaa KH, Duru F, Te Riele ASJM, Khairy P, Tondo C, Calkins H, James CA, Saguner AM, Cadrin-Tourigny J
Background: A novel risk calculator based on clinical characteristics and noninvasive tests that predicts the onset of clinical sustained ventricular arrhythmias (VA) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) has been proposed and validated by recent studies. It remains unknown whether programmed ventricular stimulation (PVS) provides additional prognostic value. Methods: All patients with a definite ARVC diagnosis, no history of sustained VAs at diagnosis, and PVS...
Abstract
Disability and rehabilitation,
Volume 45, Issue 21, 7 1 2022, Pages 3539-3548
Conservative management for lumbar radiculopathy based on the stage of the disorder: a Delphi study.
Thoomes E, Falla D, Cleland JA, Fernández-de-Las-Peñas C, Gallina A, de Graaf M
Purpose: Conservative management of lumbar radiculopathy (LR) is the first treatment option. To date, systematic reviews and clinical practice guidelines have not considered the most appropriate timing of management. This study aimed to establish consensus on effective conservative treatment modalities across different stages (i.e., acute, sub-acute, or chronic) of LR. Materials and methods: Through an iterative multistage Delphi process, experts rated agreement with proposed treatment modalitie...
Abstract
Cited 4 times since 2022 (1.6 per year)
source: EuropePMC
Journal of medical Internet research,
Volume 24, Issue 10, 6 1 2022, Pages e38339
Investigating Rewards and Deposit Contract Financial Incentives for Physical Activity Behavior Change Using a Smartphone App: Randomized Controlled Trial.
de Buisonjé DR, Reijnders T, Cohen Rodrigues TR, Prabhakaran S, Kowatsch T, Lipman SA, Bijmolt THA, Breeman LD, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM
Background: Financial incentive interventions for improving physical activity have proven to be effective but costly. Deposit contracts (in which participants pledge their own money) could be an affordable alternative. In addition, deposit contracts may have superior effects by exploiting the power of loss aversion. Previous research has often operationalized deposit contracts through loss framing a financial reward (without requiring a deposit) to mimic the feelings of loss involved in a deposi...
Abstract
Cited 5 times since 2022 (2 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 9, 6 1 2022, Pages 758265
Acute myocardial infarction induces remodeling of the murine superior cervical ganglia and the carotid body.
Ge Y, van Roon L, van Gils JM, Geestman T, van Munsteren CJ, Smits AM, Goumans MJTH, DeRuiter MC, Jongbloed MRM
A role for cardiac sympathetic hyperinnervation in arrhythmogenesis after myocardial infarction (MI) has increasingly been recognized. In humans and mice, the heart receives cervical as well as thoracic sympathetic contributions. In mice, superior cervical ganglia (SCG) have been shown to contribute significantly to myocardial sympathetic innervation of the left ventricular anterior wall. Of interest, the SCG is situated adjacent to the carotid body (CB), a small organ involved in oxygen and met...
Abstract
Cited 2 times since 2022 (0.8 per year)
source: EuropePMC
British journal of cancer,
Volume 127, Issue 11, 3 1 2022, Pages 2043-2051
Multicentric validation of diagnostic tests based on BC-116 and BC-106 urine peptide biomarkers for bladder cancer in two prospective cohorts of patients.
Mengual L, Frantzi M, Mokou M, Ingelmo-Torres M, Vlaming M, Merseburger AS, Roesch MC, Culig Z, Alcaraz A, Vlahou A, Mischak H, Van der Heijden AG
Background: Non-invasive urine-based biomarkers can potentially improve current diagnostic and monitoring protocols for bladder cancer (BC). Here we assess the performance of earlier published biomarker panels for BC detection (BC-116) and monitoring of recurrence (BC-106) in combination with cytology, in two prospectively collected patient cohorts. Methods: Of the 602 patients screened for BC, 551 were found eligible. For the primary setting, 73 patients diagnosed with primary BC (n = 27) and b...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 30, Issue 10, 1 1 2022, Pages 1196
Correction: Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone).
Matic M, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GAPJM, Weide JV, Wilffert B, Swen JJ, Guchelaar HJ, Deneer VHM, van Schaik RHN
Abstract
Cited 6 times since 2022 (2.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 11, 1 1 2022, Pages 1540-1551
Prognostic implications of mitral valve geometry in patients with secondary mitral regurgitation: the COAPT trial.
Namazi F, Delgado V, Delgado V, Pio SM, Ajmone Marsan N, Asch FM, Medvedofsky D, Weissman NJ, Zhou Z, Redfors B, Lindenfeld J, Abraham WT, Mack MJ, Stone GW, Bax JJ
Aims: The impact of mitral valve geometry on outcomes after MitraClip treatment in secondary mitral regurgitation (MR) has not been examined. We therefore sought to evaluate the association between mitral valve geometry and outcomes of patients with heart failure (HF) and secondary MR treated with guideline-directed medical therapy (GDMT) and MitraClip. Methods and results: Mitral valve geometry was assessed from the baseline echocardiograms in 614 patients from the COAPT trial. The primary endp...
Abstract
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 63, Issue 10, 1 1 2022, Pages 1455-1458
Integrating Nuclear Imaging and Cardiology in Clinical Practice: A Conversation Between Jeroen J. Bax and Frank M. Bengel.
Bax JJ, Bengel FM
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Journal of global health,
Volume 12, 1 1 2022, Pages 05042
Community-based SARS-CoV-2 testing in low-income neighbourhoods in Rotterdam: Results from a pilot study.
Vink M, Iglói Z, Fanoy EB, van Beek J, Boelsums T, de Graaf M, Voeten HACM, Molenkamp R, Koopmans MP, Mevissen FE
Background: High incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and low testing uptake were reported in low-income neighbourhoods in Rotterdam. We aimed to improve willingness and access to testing by introducing community-based test facilities, and to evaluate the effectiveness of a rapid antigen detection test (RDT). Methods: Two to eleven test facilities operated consecutively in three low-income neighbourhoods in Rotterdam, offering the options of walk-in or appoin...
Abstract
Cited 5 times since 2022 (2 per year)
source: EuropePMC
Current protocols,
Volume 2, Issue 10, 1 1 2022, Pages e564
Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells.
Bulut M, Vila Cuenca M, de Graaf M, van den Hil FE, Mummery CL, Orlova VV
Blood vessels are composed of endothelial cells (ECs) that form the inner vessel wall and mural cells that cover the ECs to mediate their stabilization. Crosstalk between ECs and VSMCs while the ECs undergo microfluidic flow is vital for the function and integrity of blood vessels. Here, we describe a protocol to generate three-dimensional (3D) engineered vessels-on-chip (VoCs) composed of vascular cells derived from human induced pluripotent stem cells (hiPSCs). We first describe protocols for...
Abstract
Cited 4 times since 2022 (1.6 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 29, Issue 14, 1 1 2022, Pages 1842-1851
Achievement of ESC/EAS LDL-C treatment goals after an acute coronary syndrome with statin and alirocumab.
Landmesser U, McGinniss J, Steg PG, Bhatt DL, Bittner VA, Diaz R, Dilic M, Goodman SG, Jukema JW, Loy M, Pećin I, Pordy R, Poulsen SH, Szarek M, White HD, Schwartz GG, ODYSSEY OUTCOMES Investigators
Aims: European guidelines set low-density lipoprotein cholesterol (LDL-C) treatment goals <1.4 mmol/L after acute coronary syndrome (ACS), and <1.0 mmol/L for patients with recurrent cardiovascular events ≤2 years. Many ACS patients do not achieve these goals on statin alone. We examined actual goal achievement with alirocumab and projected achievement with ezetimibe, either added to optimized statin therapy. Methods and results: The ODYSSEY OUTCOMES trial (NCT01663402) compared al...
Abstract
Cited 911 times since 2022 (361.4 per year)
source: EuropePMC
European heart journal,
Volume 43, Issue 40, 1 1 2022, Pages 3997-4126
2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.
Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, Charron P, Corrado D, Dagres N, de Chillou C, Eckardt L, Friede T, Haugaa KH, Hocini M, Lambiase PD, Marijon E, Merino JL, Peichl P, Priori SG, Reichlin T, Schulz-Menger J, Sticherling C, Tzeis S, Verstrael A, Volterrani M, ESC Scientific Document Group
Abstract
Cited 2 times since 2022 (0.8 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 11, 1 1 2022, Pages 1457-1458
Using deep learning to diagnose pulmonary hypertension.
van der Bijl P, Bax JJ
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European heart journal,
Volume 43, Issue 38, 1 1 2022, Pages 3599-3600
The mentorship programme: a new initiative at the European Heart Journal.
Ajmone Marsan N, Cavalcante J, Bucciarelli-Ducci C
Abstract
Cited 3 times since 2022 (1.2 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 9, 30 5 2022, Pages e0274478
Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas.
Bayley JP, Rebel HG, Scheurwater K, Duesman D, Zhang J, Schiavi F, Korpershoek E, Jansen JC, Schepers A, Devilee P
The neuroendocrine tumours paraganglioma and pheochromocytoma (PPGLs) are commonly associated with succinate dehydrogenase (SDH) gene variants, but no human SDH-related PPGL-derived cell line has been developed to date. The aim of this study was to systematically explore practical issues related to the classical 2D-culture of SDH-related human paragangliomas and pheochromocytomas, with the ultimate goal of identifying a viable tumour-derived cell line. PPGL tumour tissue/cells (chromaffin cells)...
Abstract
Cited 204 times since 2022 (80.8 per year)
source: EuropePMC
Nature,
Volume 611, Issue 7934, 30 5 2022, Pages 115-123
Stroke genetics informs drug discovery and risk prediction across ancestries.
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-M
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-r...
Abstract
