8684 results
Cardiovascular research,
24 4 2025, Pages cvaf074
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms.
Giammarino L, Matas L, Alerni N, Horváth A, Vashanthakumar V, Nimani S, Barbieri M, Bains S, Lopez R, Louradour J, Ördög B, Hof T, Maguy A, Conte G, Auricchio A, Schotten U, Odening KE
Aims: Pronounced sex-differences are known in the incidence of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence in the younger population, focusing on IK1, a cardiac ion current important for action potential (AP) stability and triggered activity. Methods and results: We assessed sex-differences in P-wave morphology in 12-lead ECG in healthy young New Zealand White rabbits. Males presente...
Abstract
Cardiology and therapy,
Volume 14, Issue 2, 23 4 2025, Pages 219-230
Defibrillation Threshold Testing After ICD Implantation in Patients with Chronic Kidney Disease.
Timal RJ, Osman L, Rotmans JI, Bootsma M, Mertens B, Schalij MJ, Rabelink TJ, Jukema JW
Introduction: Routine defibrillation threshold (DFT) testing at the time of implantable cardioverter-defibrillator (ICD) implantation is no longer recommended because testing did not improve shock efficacy or reduce arrhythmic death. However, patients with severe chronic kidney disease (CKD) were not included in these trials and might benefit from DFT testing. International guidelines shed no light on the subject of the effect of kidney function on DFT testing in patients with CKD. Methods: In t...
Abstract
BMJ open,
Volume 15, Issue 4, 22 4 2025, Pages e093615
C-reactive protein in the first 30 postoperative days and its discriminative value as a marker for postoperative infections, a multicentre cohort study.
van Boekel AM, van der Meijden SL, Geerts BF, van Goor H, van Geloven N, Arbous MS, de Boer MGJ, PERISCOPE Study Group
Objective: To assess the association of C-reactive protein (CRP) with postoperative infections for eight different types of surgery using big data. Design: A multicentre cohort study with longitudinally collected data from electronic health records, collected from 1 January 2011 to 22 September 2023. Setting: Data of two tertiary medical centres in the Netherlands were used. Participants: This study included all procedures (42 125 in total) in adult patients undergoing surgery in two tertiary me...
Abstract
Journal of cardiothoracic and vascular anesthesia,
22 4 2025, Pages S1053-0770(25)00338-6
Effect of Bicuspid or Tricuspid Aortic Valve on Preoperative Coagulation in Patients Scheduled for Thoracic Aortic Surgery.
van Haeren MMT, Bozic C, Eberl S, Hollmann MW, Breel JS, Grewal N, Driessen AHG, Vlaar APJ, Müller MCA, Hermanns H
Objectives: This study aimed to analyze the impact of aortic valve morphology on preoperative coagulation status in patients undergoing elective thoracic aortic surgery. Preoperative ROTEM and conventional coagulation tests of patients with a bicuspid aortic valve (BAV) were compared to those with a tricuspid aortic valve (TAV). Design: An exploratory prospective observational study. Setting: Conducted in a single center. Participants: The study included 169 patients (63 BAV and 106 TAV). Interv...
Abstract
The international journal of cardiovascular imaging,
22 4 2025
Plaque burden improves the detection of ischemic CAD over stenosis from coronary computed tomography angiography.
Kero T, Bär S, Saraste A, Klén R, Bax JJ, Knuuti J, Maaniitty T
In symptomatic patients undergoing coronary CTA for suspected coronary artery disease (CAD), we assessed if quantification of plaque burden, in addition to luminal narrowing and clinical risk factors, offers incremental value for the identification of ischemic CAD on a per patient level. We evaluated 2145 patients who underwent coronary CTA for suspected CAD with sequential selective downstream 15O-water positron emission tomography (PET) myocardial perfusion imaging. Coronary CTA scans were ana...
Abstract
Frontiers in pediatrics,
Volume 13, 22 4 2025, Pages 1511086
Current methods in the diagnosis of invasive meningococcal disease.
Ciftci E, Ocal D, Somer A, Tezer H, Yilmaz D, Bozkurt S, Dursun OU, Merter Ş, Dinleyici EC
Invasive meningococcal disease (IMD) remains a significant health concern due to its global distribution, potential for epidemic spread, unpredictable nature, rapid progression, and high mortality rates or permanent sequelae. The global elimination of meningococcal illness via immunization is a primary objective of the World Health Organization's strategy to defeat meningitis by 2030. Timely recognition of meningococcal infection and immediate, precise, and specific identification of Neisse...
Abstract
Rheumatology advances in practice,
Volume 9, Issue 2, 18 3 2025, Pages rkae155
Improving efficiency of a rheumatology outpatient clinic through classification of newly referred patients.
Dijkstra S, de Man YA, Braaksma A, de Graaf M, Bernelot Moens HJ, Boucherie RJ
Objectives: Diagnosing a rheumatological disease in patients newly referred by their general practitioner requires assessment by a rheumatologist and often diagnostic tests. Ideally, these tests are performed prior to the patient's first consultation with the rheumatologist, aiming for quick diagnosis and fewer visits. We retrospectively studied whether a pre-first visit digital patient questionnaire can lead to fewer consultations and faster diagnosis. Methods: We applied machine learning-...
Abstract
JACC. Advances,
Volume 4, Issue 5, 18 3 2025, Pages 101728
Investigating the Anrep Effect in Hypertrophic Obstructive Cardiomyopathy With Invasive Pressure-Volume Analysis.
Reil JC, Sequeira V, Reil GH, Scholtz S, Rudolph V, Maack C, Serruys P, Steendijk P
Background: The Anrep effect, an adaptation enhancing left ventricular (LV) contractility in response to raised afterload, is hypothesized to influence hypertrophic cardiomyopathy pathophysiology. Objectives: This study investigated the activation and reversibility of the Anrep effect in obstructive hypertrophic cardiomyopathy (HOCM) patients undergoing percutaneous transluminal septal myocardial ablation (PTSMA) to relieve LV outflow tract obstruction. Methods: Invasive pressure-volume (PV) ana...
Abstract
Heart rhythm,
17 3 2025, Pages S1547-5271(25)02342-2
Visualization of acute atrial injury after ablation by contrast-enhanced T1-weighted short inversion time cardiac magnetic resonance imaging.
van Pouderoijen N, Hopman LHGA, Escartin T, Sheagren C, van Rosendael PJ, Allaart CP, Hofman MBM, Wright GA, Götte MJW
Abstract
European heart journal. Cardiovascular Imaging,
17 3 2025, Pages jeaf121
Derivation and Validation of an Artificial Intelligence-Based Plaque Burden Safety Cut-Off for Long-Term Acute Coronary Syndrome from Coronary Computed Tomography Angiography.
Bär S, Knuuti J, Saraste A, Klén R, Kero T, Nabeta T, Bax JJ, Danad I, Nurmohamed NS, Jukema RA, Knaapen P, Maaniitty T
Aims: Artificial intelligence (AI) has enabled accurate and fast plaque quantification from coronary computed tomography angiography (CCTA). However, AI detects any coronary plaque in up to 97% of patients. To avoid overdiagnosis, a plaque burden safety cut-off for future coronary events is needed. Methods and results: Percent atheroma volume (PAV) was quantified with artificial intelligence-guided quantitative computed tomography (AI-QCT) in a blinded fashion. Safety cut-off derivation was perf...
Abstract
Best practice & research. Clinical endocrinology & metabolism,
17 3 2025, Pages 101998
Growth hormone replacement therapy in childhood-onset craniopharyngioma.
van Iersel L, van Schaik J, van Santen HM
Tumour- or treatment related growth hormone (GH) deficiency is often observed in children diagnosed or treated for childhood onset craniopharyngioma (cCP). Adequate and timely GH replacement therapy (GHRT) is important to improve growth velocity and final height during childhood. GHRT may be continued through adulthood due to its beneficial effects on metabolic health, bone health, mental health and quality of life. The current evidence suggests no increased risk for tumour progression or recurr...
Abstract
Cancers,
Volume 17, Issue 8, 17 3 2025, Pages 1352
Molecular-Targeted Fluorescence Lymph Node Imaging Could Play a Clinical Role in the Surgical Setting: A Systematic Review.
Zweedijk BE, Dalmeijer SWR, van Manen L, Galema HA, Lauwerends LJ, Abbasi H, Kremer B, Verhoef C, Robinson DJ, Koppes SA, Vahrmeijer AL, van der Vorst JR, Hilling DE, Keereweer S
The lymphatic system plays a crucial role in the spread of solid tumors and is often the first site of metastasis, as cancer cells typically invade nearby lymph nodes (LN) before potentially spreading to other LNs through the lymphatic system and distant organs through the bloodstream [...].
Abstract
European urology focus,
16 3 2025, Pages S2405-4569(25)00074-4
External Urinary Devices for Stress Urinary Incontinence: Does One Size Fit All?
Cobussen-Boekhorst H, van Benthum-van Ooijen N, Janssen V, Schuurmans C
Both males and females can be effected by stress urinary incontinence (SUI), with symptoms ranging from mild to severe. External urinary devices (EUDs) can help in managing incontinence in daily life and thus improve quality of life. EUDs include absorbent products, female external catheters, male external catheters/sheaths, and penile compression devices/clamps. To address the needs of individual patient, a shared decision-making process is essential, with the involvement of health care profess...
Abstract
Clinical cancer research : an official journal of the American Association for Cancer Research,
16 3 2025
Anti-tumor immunity mediated by engineered allogeneic stem cells exploiting TRAIL-induced cell death and FLT3L immunomodulation.
van Schaik TA, Chen KS, Kanaya N, Moreno-Lama L, Freeman NW, Wang M, Li W, Zhang YS, Vrbanac V, Huang R, Wakimoto H, Reardon D, Shah K
Purpose: Death receptor (DR)-targeted therapies offer a promising tumor cell-specific therapeutic strategy for highly malignant brain tumors, such as glioblastoma (GBM). However, whether DR-mediated cell death leads to activation of the adaptive immune system and impacts the tumor immune microenvironment (TIME) remains unknown. In this study we explored the 1) immunomodulatory role of secretable human DR4/5 ligand, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (S-TRAIL); and 2) t...
Abstract
Digestive diseases and sciences,
16 3 2025
Obesity Is Associated with Inferior Clinical Treatment Outcomes in Inflammatory Bowel Disease: A Nationwide Dutch Registry Study.
Oomkens D, Mujagic Z, de Vries A, van der Meulen-de Jong A, Straatmijer T, Löwenberg M, van der Marel S, West R, Bodelier A, van Schaik F, Visschedijk M, Duijvestein M, Initiative on Crohn and Colitis (ICC)
Purpose: To examine the impact of obesity on treatment outcomes in inflammatory bowel disease (IBD). Methods: Patients aged ≥ 16 years, with IBD, a documented baseline body mass index (BMI), and starting thiopurines and allopurinol, intravenous (iv) vedolizumab, subcutaneous (sc) vedolizumab, ustekinumab, ozanimod, filgotinib, or tofacitinib were selected from the Dutch Initiative on Crohn and Colitis (ICC) registry. Underweight patients (BMI
Abstract
Cardiovascular drugs and therapy,
14 2 2025
Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY).
S Ramos K, Nassiri S, Wijdeveld LFJ, van der Palen RL, Kuipers MF, Hills MT, Slijkerman P, van Raalte DH, Handoko ML, de Groot NMS, Grewal N, Klautz RJM, Eringa EC, Brundel BJJM
Purpose: Interestingly, 30-50% of patients undergoing elective cardiothoracic surgery develop postoperative AF (PoAF). Unfortunately, preventive PoAF therapy is still suboptimal. In our previous studies, we showed that oral Geranylgeranylacetone (GGA) administration increased cardioprotective heat shock protein (HSP) protecting against AF onset and progression in clinically relevant animal model studies. Methods: The GENIALITY study is a phase II single-center, double-blind, placebo-controlled r...
Abstract
International journal of cardiology,
Volume 432, 11 2 2025, Pages 133269
Early aortic valve replacement versus conservative management in asymptomatic severe aortic stenosis: Meta-analysis of time-to-event data of randomized controlled trials.
Jacquemyn X, Sá MP, Marín-Cuartas M, Bax JJ, Borger MA, Clavel MA, Pibarot P, Généreux P, Sultan I
Background: Current guidelines recommend aortic valve replacement (AVR) for symptomatic patients with severe aortic stenosis (AS), but the optimal timing for intervention in asymptomatic patients is still debated. Recent randomized controlled trials (RCTs) have offered new insights, prompting a reevaluation of the potential benefits of early AVR. Methods: A systematic review and pooled meta-analysis of Kaplan-Meier-derived reconstructed time-to-event data of RCTs published by November 2024 was c...
Abstract
JACC. Cardiovascular imaging,
10 2 2025, Pages S1936-878X(25)00130-5
Prognostic Time Frame of Plaque and Hemodynamic Characteristics and Integrative Risk Prediction for Acute Coronary Syndrome.
Yang S, Jung JW, Park SH, Zhang J, Lee K, Hwang D, Lee KS, Na SH, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Taylor CA, Bax JJ, Shaw LJ, Stone PH, Narula J, Koo BK
Background: The relevant time frame for predicting future acute coronary syndrome (ACS) based on coronary lesion characteristics remains uncertain. Objectives: The aim of this study was to investigate the association of lesion characteristics with test-to-event time and their prognostic impact on ACS. Methods: The EMERALD II (Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II) study analyzed 351 patients who unde...
Abstract
Journal of experimental botany,
9 2 2025, Pages eraf143
Gpa2 detects potato cyst nematode effector RBP-1 in the cytoplasm yet requires a nucleocytoplasmic balance for cell death.
Zheng Q, Putker V, Slootweg EJ, Overmars H, van Leeuwen F, van Schaik CC, Sterken MG, Sukarta OCA, Smant G, Goverse A
The potato immune receptor Gpa2 confers host-specific resistance to the cyst nematode Globodera pallida. When transiently expressed in Nicotiana benthamiana it triggers cell death upon recognition of the matching effector GpRBP-1. Effector-triggered immunity by Gpa2 depends on the host factor RanGAP2, which is known to regulate the nucleocytoplasmic distribution and functioning of the highly homologous potato immune receptor Rx1. However, the subcellular localisation of Gpa2 and the role of RanG...
Abstract
European journal of preventive cardiology,
9 2 2025, Pages zwaf193
Lifestyle behaviour change of patients following cardiac rehabilitation: the BENEFIT intervention study with one-year follow-up.
Breeman LD, Janssen VR, Kraaijenhagen RA, Al-Dhahir I, IJzerman RVH, Wolstencroft K, Kraaij W, Bonten TN, Atsma DE, Chavannes NH, van Gemert-Pijnen L, Kemps HMC, Scholte Op Reimer W, Evers AWM
Background: The majority of people with cardiovascular disease (CVD) do not maintain a healthy lifestyle. To help patients implement behaviour change at home, the BENEFIT programme was developed as an addition to cardiac rehabilitation (CR) care. Methods: Using a cluster non-randomised controlled trial design involving 7 CR centres, we examined whether intervention group patients (n=587) showed increased improvements in health behaviour change compared to control group patients (n=298) who (only...
Abstract
