Research

Publications

Below you can find a list of our published research.

9380 results

Michigan medicine, Volume 113, Issue 4, 1 1 2014, Pages 12-13 Voice of medicine heard in state budget process. Schepers AR

Abstract

Cited 44 times since 2014 (4.1 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 18, Issue 8, 1 1 2014, Pages 1509-1518 Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes. Dambrot C, Braam SR, Tertoolen LG, Birket M, Atsma DE, Mummery CL

It has been known for over 20 years that foetal calf serum can induce hypertrophy in cultured cardiomyocytes but this is rarely considered when examining cardiomyocytes derived from pluripotent stem cells (PSC). Here, we determined how serum affected cardiomyocytes from human embryonic- (hESC) and induced pluripotent stem cells (hiPSC) and hiPSC from patients with hypertrophic cardiomyopathy linked to a mutation in the MYBPC3 gene. We first confirmed previously published hypertrophic effects of... Abstract

Cited 21 times since 2014 (1.9 per year) source: EuropePMC

Asian journal of andrology, Volume 16, Issue 4, 1 1 2014, Pages 607-610 The 5-HT2C receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation. Janssen PK, Schaik Rv, Olivier B, Waldinger MD

It has been postulated that the persistent short intravaginal ejaculation latency time (IELT) of men with lifelong premature ejaculation (LPE) is related to 5-hydroxytryptamine (HT)2C receptor functioning. The aim of this study was to investigate the relationship of Cys23Ser 5-HT2C receptor gene polymorphism and the duration of IELT in men with LPE. Therefore, a prospective study was conducted in 64 Dutch Caucasian men with LPE. Baseline IELT during coitus was assessed by stopwatch over a 1-mont... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

The Turkish journal of pediatrics, Volume 56, Issue 4, 1 1 2014, Pages 458-461 Development of end-stage renal disease at a young age in two cases with Joubert syndrome. Sönmez F, Güzünler-Şen M, Yılmaz D, Cömertpay G, Heise M, Çırak S, Uyanık G

Joubert syndrome (JS) is an autosomal recessive genetic disorder. To date, mutations in 20 genes of the genetically heterogeneous JS and JS-related disorders (JSRD) have been reported. Renal involvement occurs in 2-20% of JS cases. Identified renal abnormalities are cystic dysplasia and nephronophthisis. Here we report the clinical course and management of renal failure in early childhood. We present two cases diagnosed with JS that developed end-stage renal disease at young ages. In the genetic... Abstract

Cited 22 times since 2014 (2 per year) source: EuropePMC

Pharmacogenomics, Volume 15, Issue 10, 1 1 2014, Pages 1287-1295 Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Matic M, Simons SH, van Lingen RA, van Rosmalen J, Elens L, de Wildt SN, Tibboel D, van Schaik RH

Aim: Determine whether SNPs of OPRM1 118A>G (asn(40)asp), COMT 472G>A (val(158)met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. Materials & methods: This is a pharmacogenetic analysis of a randomized controlled trial in (pre)term newborns (n = 64) at a level III Neonatal Intensive Care Unit (NICU) who received placebo infusion and for whom need and dose for rescue morphine was documented. Results: For OPRM1 and COMT separately, the ex... Abstract

Cited 13 times since 2014 (1.2 per year) source: EuropePMC

World journal of surgery, Volume 38, Issue 7, 1 1 2014, Pages 1713-1718 Incidence and epidemiology of casualties treated at the Dutch role 2 enhanced medical treatment facility at multi national base Tarin Kowt, Afghanistan in the period 2006-2010. Hoencamp R, Idenburg FJ, Hamming JF, Tan EC

Background: To improve care for the injured service member, we have analyzed battle casualty patterns and mechanisms. This study is the first documented report of wounding patterns and mechanisms of battle casualties treated at the Dutch role 2 enhanced medical treatment facility at the multi-national base Tarin Kowt, Uruzgan, Afghanistan. Methods: Participants were selected from the trauma registry at the Dutch role 2 enhanced medical treatment facility if they fitted the criteria 'battle... Abstract

Cited 479 times since 2014 (44.1 per year) source: EuropePMC

Nature genetics, Volume 46, Issue 8, 29 5 2014, Pages 818-825 Whole-genome sequence variation, population structure and demographic history of the Dutch population. Genome of the Netherlands Consortium

Whole-genome sequencing enables complete characterization of genetic variation, but geographic clustering of rare alleles demands many diverse populations be studied. Here we describe the Genome of the Netherlands (GoNL) Project, in which we sequenced the whole genomes of 250 Dutch parent-offspring families and constructed a haplotype map of 20.4 million single-nucleotide variants and 1.2 million insertions and deletions. The intermediate coverage (∼13×) and trio design enabled extensive charact... Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

International journal of cardiology, Volume 176, Issue 1, 28 4 2014, Pages 40-47 Beneficial effect of high dose statins on the vascular wall in patients with repaired aortic coarctation? Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Konings TC, Stroes ES, Zwinderman AH, Mulder BJ

Background: Carotid intima-media thickness (CIMT) is a marker for atherosclerosis. Adult post-coarctectomy patients (CoA) demonstrate an increased cardiovascular risk and increased CIMT compared to controls. This study evaluates the effect of high dose statins on the change in CIMT and cardiovascular risk. Methods: We designed a multicenter, prospective, randomized, open label trial with blinded endpoint (PROBE design) to evaluate the effect of three year treatment with atorvastatin 80 mg on CIM... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 8, Issue 4, 27 4 2014, Pages 299-306 Aortic valve and aortic root features in CT angiography in patients considered for aortic valve repair. Regeer MV, Kamperidis V, Versteegh MI, Klautz RJ, Scholte AJ, Bax JJ, Schalij MJ, Marsan NA, Delgado V

Background: The underlying mechanism of aortic regurgitation and aortic valve and root characteristics are associated with the durability of surgical repair. Objective: We investigated whether multidetector CT (MDCT) identifies the characteristics of the aortic valve and root that may be associated with the ability to perform successful surgical repair. Methods: Sixty-one patients with aortic regurgitation and/or aortic root pathology who were evaluated for aortic valve or root repair and underw... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Intensive care medicine, Volume 40, Issue 8, 27 4 2014, Pages 1177-1178 Using tramadol to measure CYP2D6 metabolism in critically ill adults. Lane K, Dixon JJ, McKeown D, Johnston A, van Schaik RH, van Fessem M, MacPhee IA, Philips BJ

Abstract

Cited 27 times since 2014 (2.5 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 15, 26 4 2014, Pages 219 Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures. FAITH Investigators

Background: Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractur... Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 7, Issue 4, 26 4 2014, Pages 671-676 Influence of steroid therapy on the incidence of pericarditis and atrial fibrillation after percutaneous epicardial mapping and ablation for ventricular tachycardia. Dyrda K, Piers SR, van Huls van Taxis CF, Schalij MJ, Zeppenfeld K

Background: This study evaluates the influence of 3 therapeutic approaches on the incidence of pericarditis and atrial fibrillation (AF) after percutaneous epicardial mapping and ablation for ventricular tachycardia. Methods and results: Eighty-five consecutive procedures (2006-2011) were retrospectively reviewed. After the first 17 procedures (20.0%), no steroids were administered. For the subsequent 30 procedures (35.3%), systemic steroids were administered intravenously or orally, whereas the... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 99, Issue 10, 25 4 2014, Pages E2060-6 Investigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures using a micronucleus assay. Unal OK, Cinkilic N, Gul OO, Cander S, Vatan O, Ersoy C, Yilmaz D, Tuncel E

Context: Although patients with acromegaly may have an increased risk of developing several types of cancers, the degree of risk for malignancy in these patients is unresolved. Objective: The present study aimed to investigate the potential genotoxic effects of acromegaly on the cell cycle in peripheral blood lymphocyte cultures. Design: This was a single center, crossover, case-control study conducted on the acromegalic patients in Turkey. Setting: The study was conducted in the outpatient clin... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

BMC health services research, Volume 14, 25 4 2014, Pages 280 Resource use and costs of type 2 diabetes patients receiving managed or protocolized primary care: a controlled clinical trial. van der Heijden AA, de Bruijne MC, Feenstra TL, Dekker JM, Baan CA, Bosmans JE, Bot SD, Donker GA, Nijpels G

Background: The increasing prevalence of diabetes is associated with increased health care use and costs. Innovations to improve the quality of care, manage the increasing demand for health care and control the growth of health care costs are needed. The aim of this study is to evaluate the care process and costs of managed, protocolized and usual care for type 2 diabetes patients from a societal perspective. Methods: In two distinct regions of the Netherlands, both managed and protocolized diab... Abstract

Cited 49 times since 2014 (4.5 per year) source: EuropePMC

Advanced healthcare materials, Volume 4, Issue 1, 24 4 2014, Pages 121-130 Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A

Three dimensional (3D) hydrogel platforms are powerful tools, providing controllable, physiologically relevant microenvironments that could aid in understanding how various environmental factors direct valvular interstitial cell (VIC) phenotype. Continuous activation of VICs and their transformation from quiescent fibroblast to activated myofibroblast phenotype is considered to be an initiating event in the onset of valve disease. However, the relative contribution VIC phenotypes is poorly under... Abstract

Cited 51 times since 2014 (4.7 per year) source: EuropePMC

Nature methods, Volume 11, Issue 8, 22 4 2014, Pages 868-874 Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Lundby A, Rossin EJ, Steffensen AB, Acha MR, Newton-Cheh C, Pfeufer A, Lynch SN, QT Interval International GWAS Consortium (QT-IGC), Olesen SP, Brunak S, Ellinor PT, Jukema JW, Trompet S, Ford I, Macfarlane PW, Krijthe BP, Hofman A, Uitterlinden AG, Stricker BH, Nathoe HM, Spiering W, Daly MJ, Asselbergs FW, van der Harst P, Milan DJ, de Bakker PI, Lage K, Olsen JV

Genome-wide association studies (GWAS) have identified thousands of loci associated with complex traits, but it is challenging to pinpoint causal genes in these loci and to exploit subtle association signals. We used tissue-specific quantitative interaction proteomics to map a network of five genes involved in the Mendelian disorder long QT syndrome (LQTS). We integrated the LQTS network with GWAS loci from the corresponding common complex trait, QT-interval variation, to identify candidate gene... Abstract

Cited 25 times since 2014 (2.3 per year) source: EuropePMC

The Journal of allergy and clinical immunology, Volume 134, Issue 5, 20 3 2014, Pages 1051-6.e2 Predictors for the development of progressive severity in new-onset adult asthma. Westerhof GA, Vollema EM, Weersink EJ, Reinartz SM, de Nijs SB, Bel EH

Background: A proportion of patients with adult-onset asthma have severe disease. Risk factors for an increase in asthma severity are poorly known. Objective: We sought to identify predictors for the development of severe asthma in adults. Methods: A cohort of 200 adults with new-onset asthma was prospectively followed for 2 years. At baseline, patients underwent a comprehensive assessment of clinical, functional, and inflammatory parameters. After 2 years, change in asthma severity was assessed... Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

The American journal of cardiology, Volume 114, Issue 5, 19 3 2014, Pages 763-768 New insights on Carpentier I mitral regurgitation from multidetector row computed tomography. van Rosendael PJ, Katsanos S, Kamperidis V, Roos CJ, Scholte AJ, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V

The underlying mechanism of mitral regurgitation (MR) because of isolated annulus dilation (Carpentier type I) remains controversial in patients with atrial fibrillation (AF). The present study evaluated changes in mitral valve geometry of patients with AF and structurally and functionally normal left ventricles and mitral leaflets. Grade of MR and left ventricular (LV) function was evaluated with echocardiography. Changes in mitral valve geometry were evaluated with multidetector row computed t... Abstract

Cited 21 times since 2014 (1.9 per year) source: EuropePMC

PloS one, Volume 9, Issue 6, 19 3 2014, Pages e99882 TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. Bastiaansen AJ, Karper JC, Wezel A, de Boer HC, Welten SM, de Jong RC, Peters EA, de Vries MR, van Oeveren-Rietdijk AM, van Zonneveld AJ, Hamming JF, Nossent AY, Quax PH

Aims: We investigated the role of the TLR4-accessory molecule RP105 (CD180) in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated activation of pro-inflammatory Ly6Chi monocytes is crucial for effective neovascularization. Immunohistochemical analyses revealed that RP105+ monocytes are present in the perivascular space of remodeling collateral arterioles. As RP105 inhibits TLR4 signaling, we hypothesized that RP105 deficiency would lead to an unrestrained TLR4-... Abstract

Cited 6 times since 2014 (0.6 per year) source: EuropePMC

Surgery, Volume 156, Issue 2, 19 3 2014, Pages 492-502 Treatment planning for peripheral arterial disease based on duplex ultrasonography and computed tomography angiography: consistency, confidence and the value of additional imaging. de Vos MS, Bol BJ, Gravereaux EC, Hamming JF, Nguyen LL

Background: Duplex ultrasonography (DUS) can be used for treatment planning for lower extremity peripheral arterial disease (PAD), but has not replaced contrast-enhanced imaging such as computed tomography angiography (CTA). We assessed DUS-based treatment planning for consistency, confidence, and the value of additional CTA among multinational surgeons. Methods: Data from 12 patients with PAD were reviewed by 2 American vascular surgeons individually and 1 Dutch vascular department by consensus... Abstract