8684 results
Circulation,
Volume 151, Issue 14, 7 1 2025, Pages 1047-1050
Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES.
Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Abstract
Journal of cardiovascular development and disease,
Volume 12, Issue 4, 7 1 2025, Pages 140
Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms.
Bacour N, Theijsse RT, Grewal S, Klautz RJM, Grewal N
(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of early detection and intervention. Despite established clinical risk factors for the early detection of TAAs, the influence of racial disparities on TAAs remains underexplored. This study aims to provide a comprehensive summary of existing...
Abstract
Journal of hazardous materials,
Volume 492, 4 1 2025, Pages 138170
Estimating the emission of microplastics from urban surfaces into the atmosphere using the PI-SWERL.
Leitão IA, van Schaik L, Goossens D, Ferreira AJD, Geissen V
Microplastics (MPs) are a global concern, with the atmosphere being a key pathway for their transport. Understanding their sources is crucial for controlling MP dispersion. This study examines MPs on urban surfaces and their transport through wind erosion using a Portable In Situ Wind Erosion Laboratory (PI-SWERL) under two wind shear conditions. Material was collected in Coimbra, Portugal, from fourteen locations associated with different land uses. MPs number and types were determined with a s...
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
3 1 2025
Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results.
van der Gang LF, Atash K, Zuithoff NPA, Haeck I, Boesjes CM, Bacoş-Cosma OI, Loman L, Kamsteeg M, Stadhouders-Keet S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynksi A, Berntsen-Zandbergen L, Christoffers WA, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, de Graaf M, Schuttelaar MA, de Bruin-Weller MS
Background: Limited data exist on the comparative risk of infections during biologic and Janus kinase inhibitor (JAKi) treatment for atopic dermatitis (AD) in daily practice. Objective: To assess the differential infection risk of biologic and JAKi treatment in patients with moderate-to-severe AD in a real-world setting. Methods: This prospective, multicentre study evaluated treatment-emergent infections in patients (age ≥ 12 years) using biologics or JAKi from the BioDay registry from October 2...
Abstract
Atherosclerosis,
Volume 404, 3 1 2025, Pages 119184
Sex related coronary plaque progression patterns among patients with family history as the sole cardiovascular risk factor: A PARADIGM sub-study.
Conte E, Lee SE, Chang HJ, Hadamitzky M, Kim YJ, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Di Lenarda F, Guarnieri G, Leipsic JA, Shin S, Choi JH, Mouaz AM, Chinnaiyan K, Pedro AG, Sung JM, Virmani R, Samady H, Lin FY, Stone PH, Narula J, Shaw L, Bax JJ, Andreini D
Background and aims: How sex may influence the prevalence and progression of coronary atherosclerosis in patients with positive family history for CAD is still unclear. Aim of the present study was to explore the role of family history of CAD in coronary atherosclerosis expression and progression in male and female subjects. Methods: A total of 2252 patients who underwent clinically indicated serial CCTAs at an interscan interval of more than 2 years were enrolled in the PARADIGM Study. For the...
Abstract
Cited 2 times since 2025 (11.7 per year)
source: EuropePMC
European heart journal,
2 1 2025, Pages ehaf133
Transcatheter vs. surgical aortic valve replacement in women: the RHEIA trial.
Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S, Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ, Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S, Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L, Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J, Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J, Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H
Background and aims: Although women with severe symptomatic aortic stenosis have more complications than men when undergoing surgical valve replacement, they are under-represented in clinical trials. The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial investigates the balance of benefits and risks of transcatheter aortic valve implantation (TAVI) vs. surgery in women. Methods: Women were randomized 1:1 to transfemoral TAVI with a balloon-expandable valve or surgery. Th...
Abstract
Cited 1 times since 2025 (5.7 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 85, Issue 14, 1 1 2025, Pages 1471-1484
Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis.
Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E, CAPRICE Co-Investigators
Background: The extent to which high-sensitivity cardiac troponin can predict cardiovascular disease (CVD) is uncertain. Objectives: We aimed to quantify the potential advantage of adding information on cardiac troponins to conventional risk factors in the prevention of CVD. Methods: We meta-analyzed individual-participant data from 15 cohorts, comprising 62,150 participants without prior CVD. We calculated HRs, measures of risk discrimination, and reclassification after adding cardiac troponin...
Abstract
Diabetes care,
Volume 48, Issue 4, 1 1 2025, Pages 596-604
Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial.
Schwartz GG, Szarek M, Jukema JW, Cobbaert CM, Reijnders E, Bittner VA, Schwertfeger M, Bhatt DL, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Steg PG
Objective: Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. Research design and methods: In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction of NOD by baseline lipoprotein(a), LDL-C, and insulin (or HOMA-insulin resistance [HOMA-IR]) and...
Abstract
Multiple sclerosis journal - experimental, translational and clinical,
Volume 11, Issue 2, 1 1 2025, Pages 20552173251335625
Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis.
Yilmaz D, Adams C, Horton MK, Graves JS, Francisco C, Edwards A, Quach H, Quach D, Aaen G, Lotze T, Mar S, Ness J, Wheeler Y, Gorman MP, Benson L, Weinstock-Guttman B, Waldman A, Schreiner T, Tillema JM, Chitnis T, Rose J, Casper TC, Rensel M, Waubant E, Barcellos LF, Network of Pediatric Multiple Sclerosis Centers
Background and objectives: The genetic basis of adult-onset multiple sclerosis (MS) is well-studied, but less is known about pediatric-onset MS (pedMS), comprising approximately 5% of all MS onsets. Mendelian randomization (MR) studies have demonstrated evidence for a causal association between MS and both 25-hydroxyvitamin D [25(OH)D] serum levels and genetic variation related to vitamin D receptor (VDR) binding. The objective was to identify whether VDR binding variants (VDR-BVs) previously im...
Abstract
Cancer discovery,
1 1 2025, Pages OF1-OF19
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes.
Sharifi MN, Sperger JM, Taylor AK, Tippins KE, Reese SR, Carreno V, Kaufmann KR, Chang AH, Nunamaker LA, Linebarger C, Mora-Rodriguez L, Schehr JL, Krause HM, Helzer KT, Bootsma ML, Blitzer GC, Floberg JM, Kyriakopoulos CE, Emamekhoo H, Heath EI, Wells M, Tagawa ST, Sjöström M, Choudhury AD, Yu M, Armstrong AJ, Rathkopf DE, Beltran H, Nelson PS, Feng FY, Dehm SM, Kosoff D, Wei XX, McKay RR, Zhao SG, Lang JM
Significance: Treatment resistance remains a universal driver of lethal metastatic prostate cancer, associated with acquired genomic alterations and lineage transitions. Using a novel high-purity CTC isolation approach for CTC transcriptional profiling, we identified four lineage phenotypes differentially associated with prognosis in metastatic prostate cancer.
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 5, 1 1 2025, Pages 918-927
The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting.
Myagmardorj R, Fortuni F, Généreux P, Nabeta T, Stassen J, Galloo X, Meucci MC, Butcher S, van der Kley F, Cohen DJ, Clavel MA, Pibarot P, Leon MB, Regeer MV, Delgado V, Ajmone Marsan N, Bax JJ
Aims: This study aims to assess the changes in cardiac damage stage in a real-world cohort of patients undergoing transcatheter aortic valve implantation (TAVI), and to investigate the prognostic value of cardiac damage stage evolution. Methods and results: Patients with severe aortic stenosis (AS) undergoing TAVI were retrospectively analysed. A five-stage system based on the presence and extent of cardiac damage assessed by echocardiography was applied before and 6 months after TAVI. Multivari...
Abstract
The Review of scientific instruments,
Volume 96, Issue 4, 1 1 2025, Pages 044504
Controlled partial gravity platform for milligravity in drop tower experiments.
Joeris K, Keulen M, Kollmer JE
We detail a platform for partial gravity environment and an experiment for simulated impacts on asteroid surfaces based on it. The partial gravity environment is created by a two stage approach: First, we place the experiment in the microgravity of a free-falling drop tower capsule in the ZARM (German acronym for Center of Applied Space Technology and Microgravity) Bremen drop tower. Second, we convert microgravity to partial gravity by steady acceleration of the experiment volume on a linear dr...
Abstract
Journal of Crohn's & colitis,
Volume 19, Issue 4, 1 1 2025, Pages jjae166
Effectiveness of Transitional Care in Inflammatory Bowel Disease; Development, Validation, and Initial Outcomes of a Transition Success Score.
van Gaalen MAC, van Pieterson M, Waaijenberg P, Kindermann A, Wolters VM, Dijkstra A, van Wering H, Wessels M, de Ridder L, Rizopoulos D, Derikx CLAAP, Escher JC, Kids with Crohn’s, Colitis (KiCC) Working Group for Collaborative Paediatric IBD Research in the Netherlands, the Dutch Initiative on Crohn and Colitis (ICC) and Dutch Nurses Network Inflammatory Bowel Disease (NIBD)
Background and aims: The effectiveness of transition programs from pediatric to adult healthcare in adolescents with inflammatory bowel disease (IBD) is not clear, as prospective studies using validated outcome measures for transition are lacking. This study aimed to develop and validate a quantitative Transition Success Score (TSS), and to apply it in a multicenter setting to assess the effectiveness of transitional care. Methods: The Top 10 outcome items related to a successful transition, ide...
Abstract
Cited 1 times since 2025 (5.7 per year)
source: EuropePMC
Acta anaesthesiologica Scandinavica,
Volume 69, Issue 4, 1 1 2025, Pages e70021
Characteristics and outcomes of older patients undergoing out- versus inpatient surgery in Europe. A secondary analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Grüßer L, Coburn M, Schmid M, Rossaint R, Ziemann S, Kowark A, POSE Study group
Background: The number of older patients undergoing surgical procedures with anaesthesia care is projected to rise. In order to cope with the increased demand, the expansion of outpatient surgery may play a decisive role. We aim to investigate the characteristics and outcomes of the older outpatient population. Patients and methods: The Peri-interventional Outcome Study in the Elderly in Europe (POSE) was a prospective multicenter study investigating characteristics and outcomes in 9497 patients...
Abstract
Neural computation,
Volume 37, Issue 5, 1 1 2025, Pages 926-956
The Leaky Integrate-and-Fire Neuron Is a Change-Point Detector for Compound Poisson Processes.
Mani S, Hurley P, van Schaik A, Monk T
Animal nervous systems can detect changes in their environments within hundredths of a second. They do so by discerning abrupt shifts in sensory neural activity. Many neuroscience studies have employed change-point detection (CPD) algorithms to estimate such abrupt shifts in neural activity. But very few studies have suggested that spiking neurons themselves are online change-point detectors. We show that a leaky integrate-and-fire (LIF) neuron implements an online CPD algorithm for a compound P...
Abstract
The clinical teacher,
Volume 22, Issue 2, 1 1 2025, Pages e70063
Navigating Crossroads: Collaborative Strategies to Assess and Enhance the Quality of Clinical Learning Environments.
Daya S, Bernal J, van Schaik S
Abstract
Cited 2 times since 2025 (11.5 per year)
source: EuropePMC
Cardiovascular research,
Volume 121, Issue 1, 1 1 2025, Pages 143-156
miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues.
Senesi G, Lodrini AM, Mohammed S, Mosole S, Hjortnaes J, Veltrop RJA, Kubat B, Ceresa D, Bolis S, Raimondi A, Torre T, Malatesta P, Goumans MJ, Paneni F, Camici GG, Barile L, Balbi C, Vassalli G
Aims: Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular matrix-producing myofibroblasts. miR-24-3p regulates this process in animal models. Here, we investigated whether miR-24-3p plays similar roles in human models. Methods and results: Gain- and loss-of-function experiments were performed using human induced pluripotent stem cell-derived cardiomyoc...
Abstract
Circulation. Cardiovascular imaging,
31 5 2025
AI-Quantitative CT Coronary Plaque Features Associate with a Higher Relative Risk in Women: CONFIRM2-Registry.
Feuchtner GM, Lacaita PG, Bax JJ, Rodriguez F, Nakanishi R, Pontone G, Mushtaq S, Buechel RR, Gräni C, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho GW, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves Pereira PM, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, van Assen M, De Cecco CN, Foldyna B, Brendel JM, Cheng VY, Branch K, Bittencourt M, Bhatti S, Polsani Md V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Bloom S, Kamperidis V, Barbieri F, Aquino M, Danad I, van Rosendael A
Background: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative coronary computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACE). Methods: Global multicenter registry (CONFIRM2) including symptomatic patients with suspicion...
Abstract
JACC. Cardiovascular imaging,
29 5 2025, Pages S1936-878X(25)00138-X
The Last Decade in Tricuspid Regurgitation: How Imaging Shaped a Field.
Hahn RT, Badano L, Praz F, Muraru D, Agricola E, Ajmone Marsan N, Bartkowiak J, Delgado V, Dreyfus J, Hausleiter J, Lurz P, Maisano F, Margonato D, Messika-Zeitoun D, Enriquez-Sarano M, Cavalcante JL
The tricuspid valve has become a major focus of novel structural heart interventions, with the Conformité Européenne approval of 5 devices in Europe and the U.S. Food and Drug Administration approval of 2 devices in the United States. Multiple meta-analyses and large population-based registries have shown that although significant tricuspid regurgitation (TR) often accompanies left heart or pulmonary vascular diseases, it is associated with an increased risk of mortality and a reduced quality of...
Abstract
Journal of cardiothoracic and vascular anesthesia,
29 5 2025, Pages S1053-0770(25)00272-1
Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience.
Pandey AK, Kougioumtzoglou AM, Lam BCY, Kho E, Eberl S, Dilai J, Koolbergen DR, Hermanns H
Objective: To delineate anesthesia management during the personalized external aortic root support (PEARS) procedure, with a focus on the use of multimodal monitoring and deliberate profound hypotension. Design: A single-center retrospective cohort study. Setting: Tertiary academic hospital. Participants: Patients undergoing the PEARS procedure due to aortic aneurysm. Interventions: None. Methods: Patient characteristics and anesthesia management are described, with particular emphasis on multim...
Abstract
