6301 results
The Journal of thoracic and cardiovascular surgery,
5 1 2025, Pages S0022-5223(25)00648-8
Personalized external aortic root support: The Dutch experience.
Kougioumtzoglou AM, Lam BCY, Bouma BJ, Groenink M, Scholte AJHA, Dolmaci OB, Corsmit OT, Pandey AK, de Blok ACJ, Noter SL, Austin C, Klautz RJM, Hazekamp MG, Koolbergen D
Introduction: Patients with connective tissue disease and aortic root aneurysm are at risk of dissection and progression of the dilatation. Standard treatment of aortic root aneurysm is either a total root replacement or valve-sparing root replacement. Both procedures have drawbacks, such as the need for anticoagulation and long-term exposure to the chance of reoperation or endocarditis. The ExoVasc personalized external aortic root support (PEARS) is a perivascular stent that has been introduce...
Abstract
Virchows Archiv : an international journal of pathology,
5 1 2025
Diagnosing the silent: the molecular landscape of non-functional parathyroid carcinoma.
Jentus MM, Corver WE, Snel M, van Haalen FM, van Wezel T, Ruano D, Kapiteijn E, Crobach S, Appelman-Dijkstra NM, Schepers A, Morreau H
Non-functional parathyroid carcinoma (NFPC) is an exceptionally rare malignancy, with approximately 50 cases reported since the parathyroid glands were first described in the late nineteenth century. Unlike functional parathyroid carcinomas (PC), which typically present with severe hyperparathyroidism (HPT) and are monitored via serum calcium and parathyroid hormone (PTH) levels, NFPC lacks biochemical markers and is monitored solely through imaging. In this study, we present two new cases of pr...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 8, 1 1 2025, Pages ezaf276
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Marsan NA, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 8, 1 1 2025, Pages euaf136
Different underlying aetiologies in patients presenting with ventricular tachycardia fulfilling task force criteria for arrhythmogenic right ventricular cardiomyopathy: initial suspicion based on the 12-lead electrocardiogram.
Hoogendoorn JC, Bosman LP, van der Heijden JF, Wilde AA, van den Berg MP, Yap SC, van Tintelen JP, Dooijes D, Te Riele ASJM, Zeppenfeld K
Aims: The task force criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly sensitive but lack specificity. Atypical RV involvement (aRVi) may indicate different underlying aetiologies and prognosis, requiring specific therapeutic interventions. We aimed to evaluate the role of the baseline 12-lead ECG for initial suspicion of aRVi. Methods: From the Netherlands Heart Institute Arrhythmogenic Cardiomyopathy (NHI-ACM) registry, patients were selected who (i) fulfille...
Abstract
The journal of vascular access,
1 1 2025, Pages 11297298251350745
Cephalic vein dilatation at the elbow by preoperative supervised forearm exercise depends on adherence to therapy: Results from the randomized controlled single-blind PINCH trial.
Wilschut ED, de Winter EP, Bos EJ, de Vries MR, Putter H, van der Steenhoven TJ, Eefting D, Hamming JF, Rotmans JI, van der Bogt KEA
Background: Maturation failure may be as high as 30%-60% of arteriovenous fistulas (AVF). Forearm exercise postoperatively has shown potential in increasing blood vessel size in patients with end-stage renal disease and may promote maturation of AVFs. Little evidence exists on the impact of pre-operative forearm exercises on the increase of vascular diameters. Aim of this study was to evaluate the effect of supervised forearm exercises on vascular diameters and AVF maturation. Methods: The PINCH...
Abstract
European heart journal,
1 1 2025, Pages ehaf480
Heart failure with reduced ejection fraction and ventricular secondary mitral regurgitation: a holistic approach.
Adamo M, Pagnesi M, Ajmone Marsan N, Bauersachs J, Hausleiter J, Zieroth S, Metra M
Optimal management of patients with heart failure with reduced ejection fraction (HFrEF) and secondary mitral regurgitation (SMR) requires the integration of multiple competencies with the interplay of guideline-directed medical therapy (GDMT) for HFrEF, devices, namely cardiac resynchronization therapy (CRT), when indicated, and mitral transcatheter edge-to-edge repair (M-TEER). Both GDMT and CRT can reduce SMR severity. However, GDMT may not be tolerated in patients with HFrEF who develop hypo...
Abstract
Cited 2 times since 2025 (15.8 per year)
source: EuropePMC
European heart journal. Quality of care & clinical outcomes,
Volume 11, Issue 5, 1 1 2025, Pages 691-697
Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings.
Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis
European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician...
Abstract
The Journal of asthma : official journal of the Association for the Care of Asthma,
31 5 2025, Pages 1-7
Inhaled muscarinic antagonists during pregnancy in women with asthma: case series from a Dutch prospective observational cohort study.
Kathiravetpillai N, van Buul AR, Ezinga M, Koehorst-Ter Huurne K, Van Nederveen-Bendien SA
Introduction: A large proportion of women with asthma experience worsening of asthma during pregnancy. Well-controlled asthma during pregnancy decreases the risk of maternal and fetal complications. Long-acting muscarinic antagonists (LAMAs) are part of treatment guidelines for poorly controlled asthma. There are no clinical safety data available on LAMA and short-acting muscarinic antagonists (SAMAs) use in pregnancy.Objective: The aim was to evaluate asthma control and pregnancy outcomes in pr...
Abstract
The Journal of dermatological treatment,
Volume 36, Issue 1, 30 5 2025, Pages 2539282
Upadacitinib in daily practice for refractory atopic dermatitis in adolescents: a case series of the BioDay registry.
Vroman F, van der Rijst LP, Bacoş-Cosma OI, Zuithoff NPA, Kamsteeg M, van Lumig PPM, Loman L, Schuttelaar MLA, de Bruin-Weller MS, de Graaf M
Purpose: Upadacitinib is approved for treating moderate-to-severe atopic dermatitis (AD) aged ≥12 years. We evaluated upadacitinib's effectiveness and safety in AD adolescents in daily practice. Materials and methods: Fifteen adolescent AD patients from the BioDay registry, treated with upadacitinib 15 mg once daily were evaluated at baseline and after 4, 8, 16, and 28 weeks. Effectiveness was assessed using Eczema Area and Severity Index (EASI) score and Investigator Global Assessment (IGA...
Abstract
Immuno-oncology technology,
Volume 27, 29 5 2025, Pages 101065
Comprehensive analysis of the systemic immune landscape across breast cancer subtypes and disease stages.
Bakker NAM, Garner H, Geurts VCM, Champanhet E, Klaver C, Duijst M, Nederlof I, Gielen RCAM, de Graaf M, Voorthuis R, Liefaard MC, Lips EH, Oosterkamp HM, Kok M, de Visser KE
Background: Breast cancer is a systemic disease, yet the impact of tumor molecular subtype and disease stage on the systemic immune landscape remains poorly understood. In this study, we comprehensively analyzed the systemic immune landscape in a large cohort of breast cancer patients, encompassing all molecular subtypes and disease stages, alongside a control group of healthy donors. Materials and methods: Using multi-parameter flow cytometry, we assessed the abundance, phenotype, and activatio...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 8, 29 5 2025, Pages 101323
CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis.
de Jong A, Sluiter TJ, Peters HAB, Lamens A, Jukema JW, Arens R, Quax PHA, de Vries MR
Atherosclerotic vein graft failure still presents a major problem. T-cells have been identified as one of the most abundant immune cell subset in atherosclerotic plaques. Their role, however, remains only partly understood. Using a murine vein graft model for advanced, unstable atherosclerotic lesions, we find that T-cells accumulate over time in atherosclerotic vein grafts, and appear to be activated rapidly after engraftment, demonstrated by increased expression of CD137 on plaque T-cells. Tar...
Abstract
European heart journal,
25 4 2025, Pages ehaf456
Arrhythmia ablation in patients with congenital heart disease: challenges and opportunities in using complex spectrum data to guide individual care.
Kimura Y, Zeppenfeld K
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
25 4 2025, Pages S0894-7317(25)00396-7
Left Atrial Strain Index in Patients With Heart Failure With Preserved Ejection Fraction.
Chua APA, Weerts J, Achten A, Nabeta T, Sarrazyn C, Lopez-Santi P, Mourmans SGJ, Su JL, Bax JJ, Knackstedt C, van Empel VPM, Ajmone-Marsan N
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 8, 25 4 2025, Pages e013150
Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging.
Jungen C, Chen HS, Wijnmaalen AP, Dibbets-Schneider P, Meretta A, Piers SR, Kimura Y, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Mertens BJA, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K
Background: In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown. Methods: Consecutive patients from the Leiden Nonischemic Cardiomyopathy Study who underwent progr...
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 24 4 2025, Pages 1649558
Editorial: New trends in vascular biology 2024.
Chelvanambi S, Chen H, De Vries MR, Fang Y, Fredman G, Gomez D, Iwata H, Uchida S, Yanagisawa H, Aikawa M
Abstract
The American journal of cardiology,
Volume 256, 22 4 2025, Pages 72-80
Procedural and Clinical Outcomes of Coronary Intravascular Lithotripsy in Patients With Impaired Renal Function: A Multicenter Retrospective Study.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Chronic kidney disease (CKD) is a prevalent comorbidity in patients undergoing percutaneous coronary intervention (PCI), yet its impact on outcomes following intravascular lithotripsy (IVL) remains insufficiently studied. This study evaluated procedural and long-term outcomes of IVL-assisted PCI in patients with renal insufficiency compared to those with normal renal function. From the BENELUX-IVL registry (May 2019-September 2024), 558 patients were included in a retrospective multicenter analy...
Abstract
Cited 2 times since 2025 (12.7 per year)
source: EuropePMC
Nature medicine,
21 3 2025
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, G
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry...
Abstract
Open heart,
Volume 12, Issue 2, 21 3 2025, Pages e003445
Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure.
Neijenhuis RM, Regeer MV, Walker NL, Mertens BJ, Hunter A, Kiès P, Swan L, Vliegen HW, MacDonald ST, Zemrak F, Zaidi AN, Cedars AM, Jongbloed MR, Jukema JW, Veldtman GR, Egorova AD
Background: Systemic right ventricle (sRV) patients are at an increased risk of developing heart failure. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) could be a valuable treatment option. This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i. Methods: Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram...
Abstract
Water research,
Volume 287, Issue Pt A, 18 3 2025, Pages 124257
Tracking norovirus diversity at a global scale through wastewater metagenomics.
Izquierdo-Lara RW, Worp N, Olthof M, Oude Munnink BB, Schapendonk CME, Prasad DK, Aarestrup FM, Koopmans MPG, de Graaf M
Norovirus is a leading cause of gastroenteritis globally. Understanding the emergence, evolution, and trends in norovirus genotype/strain diversity is essential to develop sustainable strategies to guide the development of interventions. Here, we used urban wastewater samples to assess and compare the diversity of noroviruses worldwide. By using a metagenomics approach, we analyzed 327 sewage samples, collected from 62 cities across 6 continents, collected over the course of two years between 20...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 15, 17 3 2025, Pages e040868
Disproportionate Left Ventricular Enlargement in Mitral Valve Prolapse: Prevalence, Predictors, and Association With Outcomes.
Topilsky Y, Essayagh B, Benfari G, Le Tourneau T, Antoine C, Grigioni F, Roussel JC, Bax JJ, Marsan NA, van Wijngaarden A, Tribouilloy C, Loewenstein I, Hochstadt A, Thapa P, Michelena HI, Enriquez-Sarano M
Background: Left ventricular (LV) end-systolic enlargement in severe degenerative mitral-regurgitation (MR) is a class I surgical trigger. Whether it occurs disproportionately to less-than-severe MR due to mitral valve prolapse and is associated with mortality are unknown. We aimed to analyze prevalence and association with survival of disproportionate LV enlargement in less-than-severe MR. Methods: A multicenter cohort international study enrolled 2848 consecutive patients (52% women, 69±16 yea...
Abstract
