9618 results
Cited 71 times since 2020 (13.7 per year)
source: EuropePMC
Stroke,
Volume 51, Issue 7, 10 2 2020, Pages 2111-2121
Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
Armstrong NJ, Mather KA, Sargurupremraj M, Knol MJ, Malik R, Satizabal CL, Yanek LR, Wen W, Gudnason VG, Dueker ND, Elliott LT, Hofer E, Bis J, Jahanshad N, Li S, Logue MA, Luciano M, Scholz M, Smith AV, Trompet S, Vojinovic D, Xia R, Alfaro-Almagro F, Ames D, Amin N, Amouyel P, Beiser AS, Brodaty H, Deary IJ, Fennema-Notestine C, Gampawar PG, Gottesman R, Griffanti L, Jack CR, Jenkinson M, Jiang J, Kral BG, Kwok JB, Lampe L, C M Liewald D, Maillard P, Marchini J, Bastin ME, Mazoyer B, Pirpamer L, Rafael Romero J, Roshchupkin GV, Schofield PR, Schroeter ML, Stott DJ, Thalamuthu A, Trollor J, Tzourio C, van der Grond J, Vernooij MW, Witte VA, Wright MJ, Yang Q, Morris Z, Siggurdsson S, Psaty B, Villringer A, Schmidt H, Haberg AK, van Duijn CM, Jukema JW, Dichgans M, Sacco RL, Wright CB, Kremen WS, Becker LC, Thompson PM, Mosley TH, Wardlaw JM, Ikram MA, Adams HHH, Seshadri S, Sachdev PS, Smith SM, Launer L, Longstreth W, DeCarli C, Schmidt R, Fornage M, Debette S, Nyquist PA
Background and purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first study, to date, we undertook genome-wide association analyses of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings. Methods: Participants were aged 45 years and older, free of stroke and dementia. We conducted genome-wide association analyses of PVWMH and DWMH in 26,654 pa...
Abstract
Cited 9 times since 2020 (1.7 per year)
source: EuropePMC
Cells,
Volume 9, Issue 6, 10 2 2020, Pages E1439
Arteriogenesis and Therapeutic Angiogenesis in Its Multiple Aspects.
Deindl E, Quax PHA
Arteriogenesis, also frequently called collateral formation or even therapeutic angiogenesis, comprises those processes that lead to the formation and growth of collateral blood vessels that can act as natural bypasses to restore blood flow to distal tissues in occluded arteries [...].
Abstract
Cited 40 times since 2020 (7.7 per year)
source: EuropePMC
JACC. Heart failure,
Volume 8, Issue 8, 10 2 2020, Pages 627-636
Prognostic Implications of Staging Right Heart Failure in Patients With Significant Secondary Tricuspid Regurgitation.
Dietz MF, Prihadi EA, van der Bijl P, Ajmone Marsan N, Delgado V, Bax JJ
Objectives: The purpose of this study was to evaluate the prognostic value of staging right heart failure (RHF) in patients with significant secondary tricuspid regurgitation (TR). Background: Right ventricular dysfunction (RVD), defined as tricuspid annular plane systolic excursion
Abstract
Cited 8 times since 2020 (1.5 per year)
source: EuropePMC
Medical science educator,
Volume 30, Issue 3, 9 2 2020, Pages 1211-1219
Making a Lecture Stick: the Effect of Spaced Instruction on Knowledge Retention in Medical Education.
Timmer MCJ, Steendijk P, Arend SM, Versteeg M
Introduction: Poor knowledge retention is a persistent problem among medical students. This challenging issue may be addressed by optimizing frequently used instructional designs, such as lectures. Guided by neuroscientific literature, we designed a spaced learning lecture in which the educator repeats the to-be-learned information using short temporal intervals. We investigated if this modified instructional design could enhance students' retention. Materials and methods: Second-year medic...
Abstract
Cited 20 times since 2020 (3.9 per year)
source: EuropePMC
Expert review of cardiovascular therapy,
Volume 18, Issue 6, 9 2 2020, Pages 363-372
Anticoagulant treatment and bleeding complications in patients with left ventricular assist devices.
den Exter PL, Beeres SLMA, Eikenboom J, Klok FA, Huisman MV
Introduction: The treatment options for advanced heart failure patients drastically changed with the introduction of left ventricular assist devices (LVADs), either as bridge to transplant or as destination therapy for patients ineligible for transplant. Despite major benefits in terms of survival, functional status and quality of life, managing patients with LVADs comes with several challenges. The most significant challenge is balancing between the risks of thrombotic and bleeding complication...
Abstract
Cited 14 times since 2020 (2.7 per year)
source: EuropePMC
eLife,
Volume 9, 8 2 2020, Pages e55921
Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating.
Majumder R, De Coster T, Kudryashova N, Verkerk AO, Kazbanov IV, Ördög B, Harlaar N, Wilders R, de Vries AA, Ypey DL, Panfilov AV, Pijnappels DA
Homeostatic regulation protects organisms against hazardous physiological changes. However, such regulation is limited in certain organs and associated biological processes. For example, the heart fails to self-restore its normal electrical activity once disturbed, as with sustained arrhythmias. Here we present proof-of-concept of a biological self-restoring system that allows automatic detection and correction of such abnormal excitation rhythms. For the heart, its realization involves the inte...
Abstract
Cited 36 times since 2020 (6.9 per year)
source: EuropePMC
Histopathology,
Volume 77, Issue 1, 7 1 2020, Pages 92-99
Performance of the pattern-based interpretation of p53 immunohistochemistry as a surrogate for TP53 mutations in vulvar squamous cell carcinoma.
Kortekaas KE, Solleveld-Westerink N, Tessier-Cloutier B, Rutten TA, Poelgeest MIE, Gilks CB, Hoang LN, Bosse T
Aims: The most commonly mutated gene in vulvar squamous cell carcinoma (VSCC) is TP53 and its prognostic value, particularly in HPV-independent VSCC, is uncertain. In other tumours, p53 immunohistochemistry (IHC) is an excellent surrogate marker for TP53 mutations. In order to study this in VSCC, we assigned six p53 IHC patterns into two final classes: 'wild-type' or 'mutant'. We determined the performance and interobserver variability of this pattern-based p53 IHC approach....
Abstract
Cited 7 times since 2020 (1.3 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 110, Issue 6, 7 1 2020, Pages 2062-2069
Mechanical Mitral Valve Replacement: A Multicenter Study of Outcomes With Use of 15- to 17-mm Prostheses.
IJsselhof RJ, Slieker MG, Gauvreau K, Muter A, Marx GR, Hazekamp MG, Accord R, van Wetten H, van Leeuwen W, Haas F, Schoof PH, Nathan M
Background: The aim of this study was to evaluate early and mid-term outcomes (mortality and prosthetic valve reintervention) after mitral valve replacement with 15- to 17-mm mechanical prostheses. Methods: A multicenter, retrospective cohort study was performed among patients who underwent mitral valve replacement with a 15- to 17-mm mechanical prosthesis at 6 congenital cardiac centers: 5 in The Netherlands and 1 in the United States. Baseline, operative, and follow-up data were evaluated. Res...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
Kidney international reports,
Volume 5, Issue 8, 5 1 2020, Pages 1327-1332
A Randomized Trial of Liposomal Prednisolone (LIPMAT) to Enhance Radiocephalic Fistula Maturation: A Pilot Study.
Voorzaat BM, van der Bogt KEA, Bezhaeva T, van Schaik J, Eefting D, van der Putten K, van Nieuwenhuizen RC, Groeneveld JO, Hoogeveen EK, van der Meer IM, Statius van Eps RG, Vogt L, Huisman L, Gabreëls BATF, Boom H, Verburgh CA, Boon D, Metselaar JM, Weijmer MC, Rotmans JI
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 61, 5 1 2020, Pages 141-146
Lack of diagnostic utility of the ECG-derived ventricular gradient in patients with suspected acute pulmonary embolism.
Meijer FMM, Hendriks SV, Huisman MV, van der Hulle T, Swenne CA, Kies P, Jongbloed MRM, Egorova AD, Vliegen HW, Klok FA
Introduction: The YEARS algorithm was successfully developed to reduce the number of computed tomography pulmonary angiography (CTPA) investigations in the diagnostic management of patients with suspected pulmonary embolism (PE), although half of patients still needed to be referred for CTPA. We hypothesized that ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO), an easy to use tool for detecting PE-induced pulmonary hypertension (PH), may further impro...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Circulation reports,
Volume 2, Issue 7, 5 1 2020, Pages 364-371
Effect of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Physicians' Clinical Behavior - Differences Between Sites With and Without Appropriate Use Criteria as Designated by the Japanese Reimbursement System.
Matsuo H, Kawasaki T, Amano T, Kawase Y, Sobue Y, Kondo T, Morino Y, Yoda S, Sakamoto T, Ito H, Shite J, Otake H, Tanaka N, Terashima M, Kadota K, Patel MR, Nieman K, Rogers C, Norgaard BL, Bax JJ, Chinnaiyan KM, Berman DS, Fairbairn TA, Hurwitz Koweek LM, Leipsic J, Akasaka T
Background: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT) is an established tool for identifying lesion-specific ischemia that is now approved for use by the Japanese insurance system. However, current clinical reimbursement is strictly limited to institutions with designated appropriate use criteria (AUC). This study assessed differences in physicians' behavior (e.g., use and interpretation of FFRCT, final management) according to Japanese AUC and...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
PloS one,
Volume 15, Issue 6, 4 1 2020, Pages e0233769
Phenotypic and lifestyle determinants of HbA1c in the general population-The Hoorn Study.
Wisgerhof W, Ruijgrok C, den Braver NR, Borgonjen-van den Berg KJ, van der Heijden AAWA, Elders PJM, Beulens JWJ, Alssema M
Aim: To investigate the relative contribution of phenotypic and lifestyle factors to HbA1c, independent of fasting plasma glucose (FPG) and 2h post-load glucose (2hPG), in the general population. Methods: The study populations included 2309 participants without known diabetes from the first wave of the Hoorn Study (1989) and 2619 from the second wave (2006). Multivariate linear regression models were used to analyze the relationship between potential determinants and HbA1c in addition to FPG and...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 164, 4 1 2020, Pages D4191
[Pharmacogenetics in daily practice].
van Gelder T, van Schaik RHN
With the exception of a few medical specialties, the implementation of pharmacogenetic tests in daily practice has thus far been limited. The Royal Dutch Pharmacists Association (KNMP) has developed pharmacogenetics-based therapeutic doserecommendations for 80 medicinal product combinations on the basis of a systematic literature review. Genotyping of patients can take place on a reactive or pre-emptive basis; the advantage of pre-emptive genotyping is that it provides genetic information the mo...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
International journal of STD & AIDS,
Volume 31, Issue 8, 2 1 2020, Pages 800-807
Designing an electronic blood-borne virus risk alert to improve uptake of testing.
van Schaik P, Lorrimer S, Chadwick D
The primary aim of the current study was to test the effect of the presentation design of a test alert system on healthcare workers' (HCWs') decision-making regarding blood-borne virus (BBV) testing. The secondary aim was to determine HCWs' acceptance of the system. An online survey used a within-subjects research design with four design factors as independent variables. The dependent variable was clinical decision. Ten realistic descriptions of hypothetical patients were presente...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 68, 2 1 2020, Pages 159-165
Identifying Factors Influencing Decision Making in Patients Diagnosed with Carotid Body Tumors: An Exploratory Study.
Alimohamad H, Yilmaz D, Hamming JF, Schepers A
Background: Carotid body tumors (CBTs) are rare highly vascularized and slow enlarging tumors arising from the paraganglionic tissue at the carotid bifurcation. Main treatment options for CBTs are surgical resection or "wait and scan" strategy. The choice for either strategy may be equally good medically in many patients. A structured "shared decision making" (SDM) might be helpful for guiding patients. Objectives: To develop an SDM strategy for the surgical treatment, we aim...
Abstract
Cited 75 times since 2020 (14.4 per year)
source: EuropePMC
JAMA cardiology,
Volume 5, Issue 6, 1 1 2020, Pages 709-713
An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial.
Bergmark BA, O'Donoghue ML, Murphy SA, Kuder JF, Ezhov MV, Ceška R, Gouni-Berthold I, Jensen HK, Tokgozoglu SL, Mach F, Huber K, Gaciong Z, Lewis BS, Schiele F, Jukema JW, Pedersen TR, Giugliano RP, Sabatine MS
Importance: Despite recent advances in treatment of severe aortic valve stenosis (AS), AS remains a life-threatening condition with no proven disease-modifying therapy. Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) have been implicated in the pathobiology of AS. The proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab reduces circulating LDL-C concentrations by 50% to 60% and Lp(a) by 20% to 30%. Objective: To determine whether evolocumab reduces the risk o...
Abstract
Cited 24 times since 2020 (4.6 per year)
source: EuropePMC
Bioinformatics (Oxford, England),
Volume 36, Issue 12, 1 1 2020, Pages 3874-3876
gplas: a comprehensive tool for plasmid analysis using short-read graphs.
Arredondo-Alonso S, Bootsma M, Hein Y, Rogers MRC, Corander J, Willems RJL, Schürch AC
Summary: Plasmids can horizontally transmit genetic traits, enabling rapid bacterial adaptation to new environments and hosts. Short-read whole-genome sequencing data are often applied to large-scale bacterial comparative genomics projects but the reconstruction of plasmids from these data is facing severe limitations, such as the inability to distinguish plasmids from each other in a bacterial genome. We developed gplas, a new approach to reliably separate plasmid contigs into discrete componen...
Abstract
Cited 7 times since 2020 (1.3 per year)
source: EuropePMC
Human nature (Hawthorne, N.Y.),
Volume 31, Issue 2, 1 1 2020, Pages 155-173
Why Class Formation Occurs in Humans but Not among Other Primates : A Primate Coalitions Model.
Pandit SA, Pradhan GR, van Schaik CP
Most human societies exhibit a distinct class structure, with an elite, middle classes, and a bottom class, whereas animals form simple dominance hierarchies in which individuals with higher fighting ability do not appear to form coalitions to "oppress" weaker individuals. Here, we extend our model of primate coalitions and find that a division into a bottom class and an upper class is inevitable whenever fitness-enhancing resources, such as food or real estate, are exploitable or trad...
Abstract
Cited 44 times since 2020 (8.4 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 24, 1 1 2020, Pages 2248-2258
Effect of alirocumab on cardiovascular outcomes after acute coronary syndromes according to age: an ODYSSEY OUTCOMES trial analysis.
Sinnaeve PR, Schwartz GG, Wojdyla DM, Alings M, Bhatt DL, Bittner VA, Chiang CE, Correa Flores RM, Diaz R, Dorobantu M, Goodman SG, Jukema JW, Kim YU, Pordy R, Roe MT, Sy RG, Szarek M, White HD, Zeiher AM, Steg PG, ODYSSEY OUTCOMES Investigators
Aims: Lowering low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular risk irrespective of age, but the evidence is less strong for older patients. Methods and results: This prespecified analysis from ODYSSEY OUTCOMES compared the effect of alirocumab vs. placebo in 18 924 patients with recent acute coronary syndrome (ACS) according to age. We examined the effect of assigned treatment on occurrence of the primary study outcome, a composite of coronary heart disease death, myocardial...
Abstract
Journal of religion and health,
Volume 59, Issue 3, 1 1 2020, Pages 1189-1200
Determination of the Personal Values of the University Students in Different Departments.
Tunç GÇ, Yılmaz D, Özyazıcıoğlu N
This research aims to examine the personal values of the first-year university students studying in different departments. This is a descriptive cross-sectional survey study. Research population is composed of first-grade students approving to participate and studying in the Nursing Department in the School of Health, Biology Department in the Faculty of Science and Letters and the Department of Early Childhood Education in the Faculty of Education of Uludağ University. "Student Information...
Abstract
