9618 results
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1296-1297
Diagnostic value of hybrid imaging with computed tomography coronary angiogram and stress positron emission tomography in patients with coronary artery bypass grafting.
Ng ACT, Bax JJ
Abstract
Cited 52 times since 2019 (9 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1307-1314
Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study.
Lee SE, Sung JM, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Kumar A, Lee BK, Leipsic JA, Maffei E, Marques H, Pontone G, Raff G, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ
Aims: Coronary artery calcium score (CACS) is a strong predictor of major adverse cardiac events (MACE). Conversely, statins, which markedly reduce MACE risk, increase CACS. We explored whether CACS progression represents compositional plaque volume (PV) progression differently according to statin use. Methods and results: From a prospective multinational registry of consecutive patients (n = 2252) who underwent serial coronary computed tomography angiography (CCTA) at a ≥ 2-year interval, 654 p...
Abstract
Cited 23 times since 2019 (4 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 8, Issue 21, 1 1 2019, Pages e011194
Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry.
Jurisic S, Gili S, Cammann VL, Kato K, Szawan KA, D'Ascenzo F, Jaguszewski M, Bossone E, Citro R, Sarcon A, Napp LC, Franke J, Noutsias M, Knorr M, Heiner S, Burgdorf C, Koenig W, Pott A, Kherad B, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Meyer P, Arroja JD, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Dworakowski R, Kaiser C, Osswald S, Galiuto L, Dichtl W, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Kozel M, Tousek P, Winchester DE, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Galuszka J, Ukena C, Poglajen G, Paolini C, Bilato C, Carrilho-Ferreira P, Pinto FJ, Opolski G, MacCarthy P, Kobayashi Y, Prasad A, Rihal CS, Widimský P, Horowitz JD, Di Mario C, Crea F, Tschöpe C, Pieske BM, Hasenfuß G, Rottbauer W, Braun-Dullaeus RC, Felix SB, Borggrefe M, Thiele H, Bauersachs J, Katus HA, Schunkert H, Münzel T, Böhm M, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C
Background Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated...
Abstract
Cited 25 times since 2019 (4.3 per year)
source: EuropePMC
Annals of surgery,
Volume 270, Issue 5, 1 1 2019, Pages 852-858
Saccular Abdominal Aortic Aneurysms: Patient Characteristics, Clinical Presentation, Treatment, and Outcomes in the Netherlands.
Karthaus EG, Tong TML, Vahl A, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit and the Dutch Institute for Clinical Auditing
Objective: The aim of this was to analyze differences between saccular-shaped abdominal aortic aneurysms (SaAAAs) and fusiform abdominal aortic aneurysms (FuAAAs) regarding patient characteristics, treatment, and outcome, to advise a threshold for intervention for SaAAAs. Background: Based on the assumption that SaAAAs are more prone to rupture, guidelines suggest early elective treatment. However, little is known about the natural history of SaAAAs and the threshold for intervention is not subs...
Abstract
Cited 5 times since 2019 (0.9 per year)
source: EuropePMC
Annals of surgery,
Volume 270, Issue 5, 1 1 2019, Pages 930-936
Objective Assessment of Fitness to Perform (FTOP) After Surgical Night Shifts in the Netherlands: An Observational Study Using the Validated FTOP Self-test in Daily Surgical Practice.
Tummers FHMP, Huizinga CRH, Stockmann HBAC, Hamming JF, Cohen AF, van der Bogt KEA, FTOP Collaborators*
Background: Surgical skills and decision making are influenced by alertness, reaction time, eye-hand coordination, and concentration. Night shift might impair these functions but it is unclear to what extent. The aim of this study was to investigate whether a night shift routinely impairs the surgeon's fitness to perform and whether this reaches a critical limit as compared to relevant frames of reference. Methods: Consultants (n = 59) and residents (n = 103) conducted fitness to perform me...
Abstract
Cited 11 times since 2019 (1.9 per year)
source: EuropePMC
Annals of surgery,
Volume 270, Issue 5, 1 1 2019, Pages 727-734
Procedural Surgical RCTs in Daily Practice: Do Surgeons Adopt Or Is It Just a Waste of Time?
Oberkofler CE, Hamming JF, Staiger RD, Brosi P, Biondo S, Farges O, Legemate DA, Morino M, Pinna AD, Pinto-Marques H, Reynolds JV, Campos RR, Rogiers X, Soreide K, Puhan MA, Clavien PA, Rinkes IB
Objective: To assess the adoption of recommendation from randomized clinical trials (RCTs) and investigate factors favoring or preventing adoption. Background: RCT are considered to be the cornerstone of evidence-based medicine by representing the highest level of evidence. As such, we expect RCT's recommendations to be followed rigorously in daily surgical practice. Methods: We performed a structured search for RCTs published in the medical and surgical literature from 2009 to 2013, allowi...
Abstract
Cited 15 times since 2019 (2.6 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1231-1238
Referral of patients for fractional flow reserve using quantitative flow ratio.
Smit JM, Koning G, van Rosendael AR, El Mahdiui M, Mertens BJ, Schalij MJ, Jukema JW, Delgado V, Reiber JHC, Bax JJ, Scholte AJ
Aims: Quantitative flow ratio (QFR) is a recently developed technique to calculate fractional flow reserve (FFR) based on 3D quantitative coronary angiography and computational fluid dynamics, obviating the need for a pressure-wire and hyperaemia induction. QFR might be used to guide patient selection for FFR and subsequent percutaneous coronary intervention (PCI) referral in hospitals not capable to perform FFR and PCI. We aimed to investigate the feasibility to use QFR to appropriately select...
Abstract
Cited 19 times since 2019 (3.3 per year)
source: EuropePMC
Physical review letters,
Volume 123, Issue 18, 1 1 2019, Pages 188102
Lateral Subunit Coupling Determines Intermediate Filament Mechanics.
Lorenz C, Forsting J, Schepers AV, Kraxner J, Bauch S, Witt H, Klumpp S, Köster S
The cytoskeleton is a composite network of three types of protein filaments, among which intermediate filaments (IFs) are the most extensible ones. Two very important IFs are keratin and vimentin, which have similar molecular architectures but different mechanical behaviors. Here we compare the mechanical response of single keratin and vimentin filaments using optical tweezers. We show that the mechanics of vimentin strongly depends on the ionic strength of the buffer and that its force-strain c...
Abstract
Cited 87 times since 2019 (15 per year)
source: EuropePMC
Nature communications,
Volume 10, Issue 1, 31 5 2019, Pages 4957
Associations of autozygosity with a broad range of human phenotypes.
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Bo
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p
Abstract
Cited 31 times since 2019 (5.3 per year)
source: EuropePMC
Cardiovascular diabetology,
Volume 18, Issue 1, 31 5 2019, Pages 144
Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina.
Caselli C, Del Turco S, Ragusa R, Lorenzoni V, De Graaf M, Basta G, Scholte A, De Caterina R, Neglia D
Objective: Aim of this study was to evaluate the relationship of plasma PCSK9 with metabolic and inflammatory profile and coronary atherosclerotic burden in patients with suspected CAD enrolled in the EVINCI study. Methods: PCSK9 was measured in 539 patients (60.3 ± 8.6 years, 256 males) with symptoms of CAD characterized by risk factors, bio-humoral profiles, and treatment. N = 412 patients underwent coronary computed tomography angiography (CTA) to assess the presence and characteristics of co...
Abstract
Cited 7 times since 2019 (1.2 per year)
source: EuropePMC
Scientific reports,
Volume 9, Issue 1, 30 5 2019, Pages 15604
Low Power, CMOS-MoS<sub>2</sub> Memtransistor based Neuromorphic Hybrid Architecture for Wake-Up Systems.
Gupta S, Kumar P, Paul T, van Schaik A, Ghosh A, Thakur CS
Neuromorphic architectures have become essential building blocks for next-generation computational systems, where intelligence is embedded directly onto low power, small area, and computationally efficient hardware devices. In such devices, realization of neural algorithms requires storage of weights in digital memories, which is a bottleneck in terms of power and area. We hereby propose a biologically inspired low power, hybrid architectural framework for wake-up systems. This architecture util...
Abstract
Cited 16 times since 2019 (2.8 per year)
source: EuropePMC
Biomaterials,
Volume 229, 29 5 2019, Pages 119577
A novel method for engineering autologous non-thrombogenic in situ tissue-engineered blood vessels for arteriovenous grafting.
Geelhoed WJ, van der Bogt KEA, Rothuizen TC, Damanik FFR, Hamming JF, Mota CD, van Agen MS, de Boer HC, Restrepo MT, Hinz B, Kislaya A, Poelma C, van Zonneveld AJ, Rabelink TJ, Moroni L, Rotmans JI
The durability of prosthetic arteriovenous (AV) grafts for hemodialysis access is low, predominantly due to stenotic lesions in the venous outflow tract and infectious complications. Tissue engineered blood vessels (TEBVs) might offer a tailor-made autologous alternative for prosthetic grafts. We have designed a method in which TEBVs are grown in vivo, by utilizing the foreign body response to subcutaneously implanted polymeric rods in goats, resulting in the formation of an autologous fibrocell...
Abstract
Circulation,
Volume 140, Issue 18, 28 4 2019, Pages e744-e745
Response by Timal and Jukema to Letter Regarding Article, "Random Controlled Trials of Sudden Cardiac Death: Use of Autopsy to Refine Sudden Cardiac Death Outcomes".
Timal RJ, Jukema JW
Abstract
Cited 1926 times since 2019 (330 per year)
source: EuropePMC
Nature,
Volume 575, Issue 7784, 21 3 2019, Pages 693-698
FSP1 is a glutathione-independent ferroptosis suppressor.
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme glutathione peroxidase 4 (GPX4)3,4 and radical-trapping antioxidants5,6. However, elucidation of the factors that underlie the sensitivity of a given cell type to ferroptosis7 is crucial to understand the pathophysiological role of ferroptosis and how it may be exploited for the t...
Abstract
Cited 58 times since 2019 (9.9 per year)
source: EuropePMC
Nature communications,
Volume 10, Issue 1, 18 3 2019, Pages 4755
Identification of atrial fibrillation associated genes and functional non-coding variants.
van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Hill MC, Montefiori LE, Scholman KT, Liu J, de Vries AAF, Boukens BJ, Ellinor PT, Goumans MJTH, Efimov IR, Nobrega MA, Barnett P, Martin JF, Christoffels VM
Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized....
Abstract
Cited 25 times since 2019 (4.3 per year)
source: EuropePMC
Frontiers in microbiology,
Volume 10, 17 3 2019, Pages 2394
Metavirome Sequencing to Evaluate Norovirus Diversity in Sewage and Related Bioaccumulated Oysters.
Strubbia S, Schaeffer J, Oude Munnink BB, Besnard A, Phan MVT, Nieuwenhuijse DF, de Graaf M, Schapendonk CME, Wacrenier C, Cotten M, Koopmans MPG, Le Guyader FS
Metagenomic sequencing is a promising method to determine the virus diversity in environmental samples such as sewage or shellfish. However, to identify the short RNA genomes of human enteric viruses among the large diversity of nucleic acids present in such complex matrices, method optimization is still needed. This work presents methodological developments focused on norovirus, a small ssRNA non-enveloped virus known as the major cause of human gastroenteritis worldwide and frequently present...
Abstract
Cited 5 times since 2019 (0.9 per year)
source: EuropePMC
Cardiology and therapy,
Volume 8, Issue 2, 16 3 2019, Pages 345-356
Electrocardiographic Detection of Left Ventricular Hypertrophy; Adding Body Mass Index and Spatial QRS-T Angle: A Cross-Sectional Study.
Elffers TW, Trompet S, de Mutsert R, Maan AC, Lamb HJ, Macfarlane PW, Rosendaal FR, Jukema JW
Introduction: We investigated improvement of electrocardiographic LVH detection by adding measures of adiposity and/or novel electrocardiographic measures. Left ventricular hypertrophy (LVH) is an important risk factor for adverse cardiovascular outcomes. Improvement of electrocardiographic criteria for LVH is desirable, since electrocardiography is widely used. Methods: We included 1091 participants of the Netherlands Epidemiology of Obesity Study (NEO) who underwent cardiac magnetic resonance...
Abstract
Cited 14 times since 2019 (2.4 per year)
source: EuropePMC
Brain research,
Volume 1726, 16 3 2019, Pages 146510
Artificial Intelligence and the detection of pediatric concussion using epigenomic analysis.
Bahado-Singh RO, Vishweswaraiah S, Er A, Aydas B, Turkoglu O, Taskin BD, Duman M, Yilmaz D, Radhakrishna U
Concussion, also referred to as mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury. Currently concussion is an area ofintensescientific interest to better understand the biological mechanisms and for biomarker development. We evaluated whole genome-wide blood DNA cytosine ('CpG') methylation in 17 pediatric concussion isolated cases and 18 unaffected controls using Illumina Infinium MethylationEPIC assay. Pathway analysis was performed using Ingenuity...
Abstract
Cited 5 times since 2019 (0.9 per year)
source: EuropePMC
Nanomedicine (London, England),
Volume 14, Issue 21, 16 3 2019, Pages 2783-2798
Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.
Khan A, Al-Harrasi A, Rehman NU, Sarwar R, Ahmad T, Ghaffar R, Khan H, Al-Amri I, Csuk R, Al-Rawahi A
Aim: Acetyl-11-keto-β-boswellic acid (AKBA) is a potent anti-inflammatory compound limited by its low water solubility and bioavailability. To load AKBA on silver nanoparticles (AgNPs) to improve bioavailability and water solubility of the compound. Materials & methods: AKBA-AgNPs were chemically synthesized and characterized by UV-Vis spectrophotometry, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. AKBA and AKBA-Ag were studied f...
Abstract
Cited 13 times since 2019 (2.2 per year)
source: EuropePMC
BMC cardiovascular disorders,
Volume 19, Issue 1, 15 3 2019, Pages 217
Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs.
Abawi D, Faragli A, Schwarzl M, Manninger M, Zweiker D, Kresoja KP, Verderber J, Zirngast B, Maechler H, Steendijk P, Pieske B, Post H, Alogna A
Background: Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min- 1 is obtained sharing the same unit as CPO (W). We aimed to validate CPO as a marker of LV SW min- 1 und...
Abstract
