9618 results
Nederlands tijdschrift voor geneeskunde,
Volume 163, 11 2 2019, Pages D3963
[Suspected traumatic posterior shoulder luxation].
Keulen MHF, de Joode SGCJ, Klemann-Harings SEJM, Samijo SK
BACKGROUND An obstetric brachial plexus lesion arises during childbirth as a consequence of excessive lateral traction of the neonate's head during shoulder dystocia. A small number of patients do not experience spontaneous recovery and secondary glenohumeral deformities can arise due to rotator cuff imbalance. CASE DESCRIPTION A 34-year-old man of Syrian descent with a history of a conservatively treated right-sided obstetric brachial plexus lesion went to the accident and emergency depart...
Abstract
Cited 46 times since 2019 (7.8 per year)
source: EuropePMC
Journal of pineal research,
Volume 68, Issue 1, 10 2 2019, Pages e12614
Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice.
Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, Smits NAM, Guichelaar T, van Baarle D, Koemans L, Berbée JFP, Deboer T, Meijer JH, de Vries MR, Vreeken D, van Gils JM, Willems van Dijk K, van Kerkhof LWM, Lutgens E, Biermasz NR, Rensen PCN, Kooijman S
Disruption of circadian rhythm by means of shift work has been associated with cardiovascular disease in humans. However, causality and underlying mechanisms have not yet been established. In this study, we exposed hyperlipidemic APOE*3-Leiden.CETP mice to either regular light-dark cycles, weekly 6 hours phase advances or delays, or weekly alternating light-dark cycles (12 hours shifts), as a well-established model for shift work. We found that mice exposed to 15 weeks of alternating light-dark...
Abstract
Cited 29 times since 2019 (4.9 per year)
source: EuropePMC
The British journal of surgery,
Volume 107, Issue 2, 9 2 2019, Pages e161-e169
Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery.
EuroSurg Collaborative
Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary ou...
Abstract
Cited 9 times since 2019 (1.5 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 51, Issue 4, 7 1 2019, Pages 1105-1116
Altered Ascending Aorta Hemodynamics in Patients After Arterial Switch Operation for Transposition of the Great Arteries.
van der Palen RLF, Deurvorst QS, Kroft LJM, van den Boogaard PJ, Hazekamp MG, Blom NA, Lamb HJ, Westenberg JJM, Roest AAW
Background: Patients with transposition of the great arteries (TGA) have an altered aortic geometry after an arterial switch operation (ASO), with neo-aortic root dilatation as an important complication. Geometry-related aortic hemodynamics have been assumed to contribute to pathology of the ascending aorta (AAo). Purpose: To evaluate aortic flow displacement (FD) and regional wall shear stress (WSS) in relation to ascending neo-aortic geometry in children after ASO. Study type: Prospective. Pop...
Abstract
Cited 51 times since 2019 (8.7 per year)
source: EuropePMC
Molecular therapy : the journal of the American Society of Gene Therapy,
Volume 28, Issue 1, 7 1 2019, Pages 157-170
MicroRNA-411 and Its 5'-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia.
van der Kwast RVCT, Woudenberg T, Quax PHA, Nossent AY
MicroRNAs are posttranscriptional regulators of gene expression. As microRNAs can target many genes simultaneously, microRNAs can regulate complex multifactorial processes, including post-ischemic neovascularization, a major recovery pathway in cardiovascular disease. MicroRNAs select their target mRNAs via full complementary binding with their seed sequence, i.e., nucleotides 2-8 from the 5' end of a microRNA. The exact sequence of a mature microRNA, and thus of its 5' and 3' end...
Abstract
Cited 17 times since 2019 (2.9 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 109, Issue 6, 5 1 2019, Pages 1858-1863
Total Endovascular Repair of the Aortic Arch: Initial Experience in the Netherlands.
van der Weijde E, Heijmen RH, van Schaik PM, Hazenberg CEVB, van Herwaarden JA
Background: We report procedural and early results in the Netherlands of the Relay Branch device (Terumo Aortic, Sunrise, FL) for total endovascular repair of the aortic arch. Methods: Between 2014 and 2018, all consecutive patients who received the Aortic Relay double-branched stent graft in the Netherlands were included in a multicenter, retrospective registry. Results: The Relay Branch device was used in 11 patients to treat saccular (n = 4), fusiform (n = 5), or false aneurysms (n = 2) in th...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 155, 4 1 2019, Pages 108926
Mean atomic number analysis by the coherent to backscattering intensity ratios at 59.54 and 661.62 photon energies.
Akkuş T, Yılmaz D
In this work, the qualitative analysis has been performed by using ratio of coherent to backscattering intensity ratios. The samples in the mean atomic number range 4.268≤Z‾≤5.786 and 9.743≤Z‾≤83.00 were prepared by using dilution technique. 59.54 and 661.62 keV photon energies are obtained from the radioactive point sources of 241Am and 137Cs an activity of 0.43-0.20 MBq, respectively. The scattered gamma rays were counted by a HPGe detector with a resolution of 182 eV at 5.9 keV. The obtained...
Abstract
Cited 254 times since 2019 (43.1 per year)
source: EuropePMC
Nature,
Volume 574, Issue 7777, 2 1 2019, Pages 268-272
Inducing and exploiting vulnerabilities for the treatment of liver cancer.
Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, Te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R
Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies1,2; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatocellular carcinoma3. The induction of senescence may represent a strategy for the treatment of cancer, especially when combined with a second drug that selectively eliminates senescent cancer cells (senolysis)4,5. Here, using a kinome-focused genetic screen, we show that pharmacological i...
Abstract
Cited 25 times since 2019 (4.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 12, Issue 10, 1 1 2019, Pages 2029-2048
Transcatheter Interventions for Mitral Regurgitation: Multimodality Imaging for Patient Selection and Procedural Guidance.
Bax JJ, Debonnaire P, Lancellotti P, Ajmone Marsan N, Tops LF, Min JK, Piazza N, Leipsic J, Hahn RT, Delgado V
Transcatheter therapies to treat mitral regurgitation are rapidly developing. Currently, there are several devices commercially available to treat mitral regurgitation. The underlying cause of mitral regurgitation and specific anatomical aspects of the mitral valve and surrounding structures are considered when patients with symptomatic severe mitral regurgitation for transcatheter mitral valve therapies are selected. Multimodality imaging plays an important central role in the selection of pati...
Abstract
Cited 78 times since 2019 (13.2 per year)
source: EuropePMC
Human molecular genetics,
Volume 28, Issue 19, 1 1 2019, Pages 3327-3338
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.
Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson
Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13 005 cases (≥95th percentile of body mass index (BMI) achieved 2-18 years old)...
Abstract
Cited 118 times since 2019 (20 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 366, Issue 6464, 1 1 2019, Pages 480-485
Global distribution of earthworm diversity.
Phillips HRP, Guerra CA, Bartz MLC, Briones MJI, Brown G, Crowther TW, Ferlian O, Gongalsky KB, van den Hoogen J, Krebs J, Orgiazzi A, Routh D, Schwarz B, Bach EM, Bennett J, Brose U, Decaëns T, König-Ries B, Loreau M, Mathieu J, Mulder C, van der Putten WH, Ramirez KS, Rillig MC, Russell D, Rutgers M, Thakur MP, de Vries FT, Wall DH, Wardle DA, Arai M, Ayuke FO, Baker GH, Beauséjour R, Bedano JC, Birkhofer K, Blanchart E, Blossey B, Bolger T, Bradley RL, Callaham MA, Capowiez Y, Caulfield ME, Choi A, Crotty FV, Dávalos A, Cosin DJD, Dominguez A, Duhour AE, van Eekeren N, Emmerling C, Falco LB, Fernández R, Fonte SJ, Fragoso C, Franco ALC, Fugère M, Fusilero AT, Gholami S, Gundale MJ, López MG, Hackenberger DK, Hernández LM, Hishi T, Holdsworth AR, Holmstrup M, Hopfensperger KN, Lwanga EH, Huhta V, Hurisso TT, Iannone BV, Iordache M, Joschko M, Kaneko N, Kanianska R, Keith AM, Kelly CA, Kernecker ML, Klaminder J, Koné AW, Kooch Y, Kukkonen ST, Lalthanzara H, Lammel DR, Lebedev IM, Li Y, Lidon JBJ, Lincoln NK,
Soil organisms, including earthworms, are a key component of terrestrial ecosystems. However, little is known about their diversity, their distribution, and the threats affecting them. We compiled a global dataset of sampled earthworm communities from 6928 sites in 57 countries as a basis for predicting patterns in earthworm diversity, abundance, and biomass. We found that local species richness and abundance typically peaked at higher latitudes, displaying patterns opposite to those observed in...
Abstract
Cited 31 times since 2019 (5.3 per year)
source: EuropePMC
BJU international,
Volume 124, Issue 4, 1 1 2019, Pages 693-700
Androgen receptor (AR) splice variant 7 and full-length AR expression is associated with clinical outcome: a translational study in patients with castrate-resistant prostate cancer.
Del Re M, Crucitta S, Sbrana A, Rofi E, Paolieri F, Gianfilippo G, Galli L, Falcone A, Morganti R, Porta C, Efstathiou E, van Schaik R, Jenster G, Danesi R
Objectives: To investigate if full-length androgen receptor (AR-FL) is associated with resistance to androgen receptor (AR)-directed therapy independently and/or combined with AR splice variant 7 (AR-V7). Patients and methods: Plasma samples were prospectively collected from 73 patients with castrate-resistant prostate cancer before first- or second-line AR-directed therapy. mRNA was isolated from exosomes and AR-FL and AR-V7 were analysed by droplet digital PCR. Results: AR-FL was detected in a...
Abstract
Cited 1 times since 2019 (0.2 per year)
source: EuropePMC
Pharmacogenomics,
Volume 20, Issue 15, 1 1 2019, Pages 1063-1069
4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation.
Sipeky C, Llerena A, Manolopoulos VG, Pearson E, Mlakar V, Gozzo L, Simmaco M, Marchetti P, Re MD, Stankovic S, Meyer U, Cascorbi I, Ingelman-Sundberg M, Suarez-Kurtz G, Marc J, Katsila T, Paulmichl M, Nofziger C, Ansari M, Drago F, van Schaik RH
The Fourth European Society of Pharmacogenomics and Personalized Therapy biennial conference was organized in collaboration with the Italian Society of Personalized Medicine (SIMeP) and was held at Benedictine Monastery of San Nicolò l'Arena in Catania, Sicily (Italy) on 4-7 October 2017. The congress addressed the research progress and clinical implementation in pharmacogenomics and personalized medicine. The Fourth European Society of Pharmacogenomics and Personalized Therapy congress bro...
Abstract
Cited 13 times since 2019 (2.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 21, Issue 10, 1 1 2019, Pages 1519-1526
Incidence and predictors of implantable cardioverter-defibrillator therapy and its complications in idiopathic ventricular fibrillation patients.
Blom LJ, Visser M, Christiaans I, Scholten MF, Bootsma M, van den Berg MP, Yap SC, van der Heijden JF, Doevendans PA, Loh P, Postema PG, Barge-Schaapsveld DQ, Hofman N, Volders PGA, Wilde AA, Hassink RJ
Aims: Idiopathic ventricular fibrillation (IVF) is a rare cause of sudden cardiac arrest. Implantable cardioverter-defibrillator (ICD) implantation is currently the only treatment option. Limited data are available on the prevalence and complications of ICD therapy in these patients. We sought to investigate ICD therapy and its complications in patients with IVF. Methods and results: Patients were selected from a national registry of IVF patients. Patients in whom no underlying diagnosis was fou...
Abstract
Cited 12 times since 2019 (2 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 10, 1 1 2019, Pages 1112-1119
Left ventricular remodelling and change in left ventricular global longitudinal strain after cardiac resynchronization therapy: prognostic implications.
van der Bijl P, Kostyukevich MV, Khidir M, Ajmone Marsan N, Delgado V, Bax JJ
Aims: Cardiac resynchronization therapy (CRT) can reduce left ventricular end-systolic volume (LVESV), and a decrease of ≥15% is defined as a response. CRT can also improve LV global longitudinal strain (GLS). Changes in LVESV and LV GLS are individually associated with outcome post-CRT. We investigated LVESV and LV GLS changes and prognostic implications of improvement in LVESV and/or LV GLS, compared with no improvement in either parameter. Methods and results: Baseline and 6-month echocardiog...
Abstract
Cited 12 times since 2019 (2 per year)
source: EuropePMC
Molecular ecology resources,
Volume 20, Issue 1, 1 1 2019, Pages 66-78
Attack of the PCR clones: Rates of clonality have little effect on RAD-seq genotype calls.
Euclide PT, McKinney GJ, Bootsma M, Tarsa C, Meek MH, Larson WA
Interpretation of high-throughput sequence data requires an understanding of how decisions made during bioinformatic data processing can influence results. One source of bias that is often cited is PCR clones (or PCR duplicates). PCR clones are common in restriction site-associated sequencing (RAD-seq) data sets, which are increasingly being used for molecular ecology. To determine the influence PCR clones and the bioinformatic handling of clones have on genotyping, we evaluate four RAD-seq data...
Abstract
Cited 29 times since 2019 (4.9 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 27, Issue 10, 1 1 2019, Pages 480-486
The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update.
Bosman LP, Verstraelen TE, van Lint FHM, Cox MGPJ, Groeneweg JA, Mast TP, van der Zwaag PA, Volders PGA, Evertz R, Wong L, de Groot NMS, Zeppenfeld K, van der Heijden JF, van den Berg MP, Wilde AAM, Asselbergs FW, Hauer RNW, Te Riele ASJM, van Tintelen JP, Netherlands ACM Registry
Background: Clinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and inconsistent definitions. Aim: To create a large national ACM patient cohort with a vast amount of uniformly collected high-quality data that is readily available for future research. Methods: This is a multicentre, longitudinal, observational cohort study that includes (1) patients with a definite ACM diagnosis, (2) at-risk relatives of ACM patient...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 56, Issue 4, 1 1 2019, Pages 631-642
The optimal treatment strategy for secondary mitral regurgitation: a subject of ongoing debate.
Petrus AHJ, Klautz RJM, De Bonis M, Langer F, Schäfers HJ, Wakasa S, Vahanian A, Obadia JF, Assi R, Acker M, Siepe M, Braun J
Abstract
Cited 20 times since 2019 (3.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 10, 1 1 2019, Pages 1105-1111
Time course of left ventricular remodelling and mechanics after aortic valve surgery: aortic stenosis vs. aortic regurgitation.
Vollema EM, Singh GK, Prihadi EA, Regeer MV, Ewe SH, Ng ACT, Mertens BJA, Klautz RJM, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Pressure overload in aortic stenosis (AS) and both pressure and volume overload in aortic regurgitation (AR) induce concentric and eccentric hypertrophy, respectively. These structural changes influence left ventricular (LV) mechanics, but little is known about the time course of LV remodelling and mechanics after aortic valve surgery (AVR) and its differences in AS vs. AR. The present study aimed to characterize the time course of LV mass index (LVMI) and LV mechanics [by LV global longit...
Abstract
Cited 10 times since 2019 (1.7 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 5, Issue 4, 1 1 2019, Pages 216-225
High burden of drug therapy in adult congenital heart disease: polypharmacy as marker of morbidity and mortality.
Woudstra OI, Kuijpers JM, Meijboom FJ, Post MC, Jongbloed MRM, Duijnhouwer AL, van Dijk APJ, van Melle JP, Konings TC, Zwinderman AH, Mulder BJM, Bouma BJ
Aims: To assess medication use in adult congenital heart disease (ACHD) patients compared to the age- and sex-matched general population, identify patterns of pharmacotherapy, and analyse associations between pharmacotherapy and adverse outcomes in ACHD. Methods and results: Data of 14 138 ACHD patients from the CONCOR registry [35 (24-48) years, 49% male] and age- and sex-matched referents (1:10 ratio) were extracted from the Dutch Dispensed Drug Register for the years 2006-14. Adult congenital...
Abstract
