Research

Publications

Below you can find a list of our published research.

9618 results

Cited 11 times since 1999 (0.4 per year) source: EuropePMC

International journal of cancer. Supplement = Journal international du cancer. Supplement, Volume 12, 1 1 1999, Pages 32-38 Assessment of health status and health-related quality of life in survivors of Hodgkin's disease in childhood. Van Schaik CS, Barr RD, Depauw S, Furlong W, Feeny D

Although the great majority of children with Hodgkin's disease survive with modern treatment strategies, the list of late sequelae is long, yet there is no published information on the comprehensive health status and health-related quality of life (HRQL) in this population. In the experience of a single institution, survivors of Hodgkin's disease in childhood were invited to self-report on their health status using a 15-item questionnaire connected to the Health Utilities Index, a seri... Abstract

Folia medica, Volume 41, Issue 1, 1 1 1999, Pages 101-103 Statistical report from Uludag Poison Information Center--34-month experience. Ozyurt G, Tokyay N, Kucer N, Mutlu L, Onder I, Yilmaz D, Senay O

Management of poisoned patient requires accurate knowledge of intoxication. Uludaŏ Poison Information Center (UPIC), founded in January 1996, provides acquired information 24 hours a day 7 days a week for physicians and consultants. We received 2270 phone calls since January 1996 till October 1998 and evaluated the cases statistically regarding "distribution of age and gender", "calling time after poison exposure", "source of poisoning", "reason for intoxicatio... Abstract

Cited 2 times since 1999 (0.1 per year) source: EuropePMC

Biology of the neonate, Volume 75, Issue 2, 1 1 1999, Pages 130-136 Effect of exchange transfusion on brain perfusion and electrocortical brain activity in newborn lambs. Benders MJ, Meinesz JH, Dorrepaal CA, Steendijk P, van Bel F, van de Bor M

Changes in brain perfusion (using ultrasonic-determined changes in carotid artery blood flow: Qcar) and electrocortical brain activity (ECBA, obtained by a Lectromed cerebral function monitor) were studied during exchange transfusion using the push-pull method in the newborn lamb. Changes in mean arterial blood pressure (MABP), Qcar, heart rate (HR), and ECBA were observed during all exchange transfusions: MABP, Qcar, and ECBA decreased during the withdrawal period and increased during the infus... Abstract

Cited 6 times since 1999 (0.2 per year) source: EuropePMC

Biology of the neonate, Volume 75, Issue 4, 1 1 1999, Pages 239-249 Effect of deferoxamine on post-hypoxic-ischemic reperfusion injury of the newborn lamb heart. Shadid M, Van Bel F, Steendijk P, Dorrepaal CA, Moison R, Van Der Velde ET, Baan J

Unlabelled: Post-hypoxic-ischemic (HI) reperfusion induces excess production of non-protein-bound iron (NPBI), leading to formation of the highly reactive hydroxyl radical. We investigated whether the iron-chelator deferoxamine (DFO) could reduce reperfusion injury and improve left ventricular (LV) function. We produced severe HI in 14 newborn lambs and measured pre-HI, upon reperfusion, 60 and 120 min after HI the following parameters: mean aortic blood pressure, total peripheral resistance, st... Abstract

Cited 39 times since 1999 (1.5 per year) source: EuropePMC

Psychological research, Volume 62, Issue 1, 1 1 1999, Pages 20-35 Sources of position-perception error for small isolated targets. van der Heijden AH, van der Geest JN, de Leeuw F, Krikke K, Müsseler J

It has often been reported that, in the presence of static reference stimuli, briefly presented visual targets are perceived as being closer to the fixation point than they actually are. The first purpose of the present study was to investigate whether the same phenomenon can be demonstrated in a situation without static reference stimuli. Experiment 1, with position naming as the task, showed that such a central shift is also observed under these conditions. This finding is of importance becaus... Abstract

Cited 2 times since 1999 (0.1 per year) source: EuropePMC

Journal of bioscience and bioengineering, Volume 87, Issue 1, 1 1 1999, Pages 82-86 Use of the yeast Hansenula polymorpha (Pichia angusta) to remove contaminating sugars from ethyl beta-D-fructofuranoside produced during sucrose ethanolysis catalysed by invertase. van der Heijden AM, van Hoek P, Kaliterna J, van Dijken JP, van Rantwijk F, Pronk JT

Alkyl glycosides are interesting intermediates for the production of biodegradable surfactants. Synthesis of ethyl beta-d-fructofuranoside by invertase-catalysed ethanolysis of sucrose has been extensively reported in literature. However, this procedure yields mixtures of glucose, fructose, sucrose and ethyl beta-d-fructofuranoside. Purification of ethyl beta-d-fructofuranoside from such mixtures by chromatographic methods is laborious, difficult to scale up and requires organic solvents. The ye... Abstract

Cited 3 times since 1999 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 143, Issue 4, 1 1 1999, Pages 193-196 [Dehydration due to gastro-enteritis in children]. Kist-van Holthe JE, van der Heijden AJ

Gastroenteritis is the commonest cause of dehydration in children. Infants and young children dehydrate more easily than adults if fluid intake is insufficient or fluid loss too high because of the combination of a large extracellular volume, a large insensible loss and a mediocre concentrating capacity of the kidney. Fluid loss due to gastroenteritis is often accompanied by electrolyte and acid-base disturbances. Oral rehydration with oral rehydration salts (ORS) is nearly always possible. Re-e... Abstract

Cited 12 times since 1998 (0.4 per year) source: EuropePMC

Preventive veterinary medicine, Volume 37, Issue 1-4, 1 1 1998, Pages 101-112 Adaptive conjoint analysis to determine perceived risk factors of farmers, veterinarians and AI technicians for introduction of BHV1 to dairy farms. van Schaik G, Dijkhuizen AA, Huirne RB, Benedictus G

A study was carried out to determine the possibility of a more-closed farming system for (Dutch) dairy farms. The objective of the study was to provide effective and economically profitable management advice for improving the animal-health status of farms. Management measures will only be successfully applied if supported by farmers and their advisors (such as veterinarians). Therefore, the perception of farmers and advisors of the importance of various risk factors for the introduction of disea... Abstract

Cited 18 times since 1998 (0.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 66, Issue 6 Suppl, 1 1 1998, Pages S225-32 Tissue chimerism in human cryopreserved homograft valve explants demonstrated by in situ hybridization. Koolbergen DR, Hazekamp MG, Kurvers M, de Heer E, Cornelisse CJ, Huysmans HA, Bruijn JA

Background: The presence of viable cells may contribute to increased homograft valve durability. These cells may be of infiltrating recipient or persisting donor origin. In this study, in situ hybridization was used to assess the origin of cells in cryopreserved homograft valve explants. Methods: A total of 10 homografts with a donor-recipient gender mismatch were acquired from patients whose graft had been explanted at reoperation or at autopsy. The period of implantation varied from 14 days to... Abstract

Cited 820 times since 1998 (30.7 per year) source: EuropePMC

Clinical and experimental immunology, Volume 114, Issue 3, 1 1 1998, Pages 385-391 Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Dieleman LA, Palmen MJ, Akol H, Bloemena E, Peña AS, Meuwissen SG, Van Rees EP

Oral administration of DSS has been reported to induce an acute and chronic colitis in mice. The aim of our study was to evaluate if the chronic phase of DSS-induced colitis was characterized by a Th1/Th2 response and how this would relate to mucosal regeneration. Swiss Webster mice were fed 5% DSS in their drinking water for 7 days, followed by 2-5 weeks consumption of water. Control mice received only water. The animals were killed at 3 and 6 weeks after induction. Their colons were isolated f... Abstract

Cited 16 times since 1998 (0.6 per year) source: EuropePMC

Development, growth & differentiation, Volume 40, Issue 6, 1 1 1998, Pages 577-582 Hormone-inducible expression of secreted factors in zebrafish embryos. de Graaf M, Zivkovic D, Joore J

The study of gene function at later stages of embryonic development by overexpression experiments is often complicated by genes exerting different functions at multiple stages of development, which renders analysis of stage-specific effects difficult. To address this problem an inducible expression system that supports timed expression of essentially any protein, including secreted proteins was designed. The system is based on a two step mechanism. A glucocorticoid inducible, Gal4-site binding c... Abstract

Cited 45 times since 1998 (1.7 per year) source: EuropePMC

The Journal of biological chemistry, Volume 273, Issue 50, 1 1 1998, Pages 33267-33272 Mitogenic effects of urokinase on melanoma cells are independent of high affinity binding to the urokinase receptor. Koopman JL, Slomp J, de Bart AC, Quax PH, Verheijen JH

The structural and functional properties of the urokinase-type plasminogen activator (u-PA) that are involved in the mitogenic effect of this proteolytic enzyme on human melanoma cells M14 and IF6 and the role of the u-PA receptor (u-PAR) in transducing this signal were analyzed. Native u-PA purified from urine induced a mitogenic response in quiescent IF6 and M14 cells that ranged from 25 to 40% of the mitogenic response obtained by fetal calf serum. The half-maximum response in M14 and IF6 cel... Abstract

Cited 22 times since 1998 (0.8 per year) source: EuropePMC

Proteins, Volume 33, Issue 2, 1 1 1998, Pages 253-264 Identification of functional and unfolding motions of cutinase as obtained from molecular dynamics computer simulations. Creveld LD, Amadei A, van Schaik RC, Pepermans HA, de Vlieg J, Berendsen HJ

The implementation of cutinase from Fusarium solani pisi as a fat-stain removing ingredient in laundry washing is hampered by its unfolding in the presence of anionic surfactants. In this work we present molecular dynamics (MD) computer simulations on cutinase and analysis procedures to distinguish the movements related to its functional behavior (e.g., substrate binding) from those related to the unfolding of the enzyme. Two kinds of MD-simulations were performed: a simulation mimicking the the... Abstract

Cited 3 times since 1998 (0.1 per year) source: EuropePMC

The Journal of endocrinology, Volume 159, Issue 2, 1 1 1998, Pages 331-340 Temporal changes in inhibin subunit mRNAs during atresia of preovulatory follicles in the rat. Uilenbroek JT, Durlinger AL, Tebar M, Kramer P, van Schaik RH, Wierikx CD, de Jong FH

This study aimed to investigate the time course of disappearance of the mRNAs of the various subunits of inhibin in follicles which become atretic. An animal model was used in which atresia of preovulatory follicles could be studied in a chronological order. Injection of gonadotrophin-releasing hormone (GnRH) antagonist (20 microg) at the morning of pro-oestrus (P) blocked ovulation and the 10-12 preovulatory follicles became gradually atretic. A second injection was given the next day to preven... Abstract

Cited 34 times since 1998 (1.3 per year) source: EuropePMC

Circulation, Volume 98, Issue 20, 1 1 1998, Pages 2168-2179 Endocardial activation mapping of ventricular tachycardia in patients : first application of a 32-site bipolar mapping electrode catheter. Schalij MJ, van Rugge FP, Siezenga M, van der Velde ET

Background: Localization of early activated endocardial areas during ventricular tachycardia (VT) is mandatory for performance of surgical or radiofrequency catheter interventions. The use of a multielectrode catheter may shorten the procedure time and increase the accuracy of the procedure compared with single-electrode mapping techniques. This study was performed to evaluate the safety and efficacy of a 32-bipolar-electrode mapping catheter in patients. Methods and results: The basket-shaped m... Abstract

Cited 11 times since 1998 (0.4 per year) source: EuropePMC

Digestive diseases and sciences, Volume 43, Issue 11, 1 1 1998, Pages 2518-2525 Effects of local budesonide treatment on the cell-mediated immune response in acute and relapsing colitis in rats. Palmen MJ, Dieleman LA, Soesatyo M, Peña AS, Meuwissen SG, van Rees EP

Glucocorticosteroids (GCS) are effective in treatment of inflammatory bowel disease (IBD), but also have unwanted systemic side effects. Here, we describe the effects of budesonide and dexamethasone on acute experimental colitis and on T cells in thymus and spleen, as well as the effect of budesonide treatment on relapsing colitis. Acute colitis was induced by intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in ethanol, and a relapse was induced by an intraperitoneal boo... Abstract

Cited 1 times since 1998 (0 per year) source: EuropePMC

The Journal of heart valve disease, Volume 7, Issue 6, 1 1 1998, Pages 615-619 Short-term follow up of the Ross operation in children. Braun J, Hazekamp MG, Schoof PH, Ottenkamp J, Huysmans HA

Background and aims of the study: Aortic valve disease in the pediatric population poses special problems to surgeons and cardiologists. The pulmonary autograft has proven to be a good alternative for aortic valve replacement and left ventricular outflow tract (LVOT) reconstruction in this special group. Methods: Forty-one children (mean age 10.0 +/- 4.8 (SD) years; range: 35 days to 18.8 years) underwent aortic root replacement with a pulmonary autograft between February 1994 and April 1998. Tw... Abstract

Cited 37 times since 1998 (1.4 per year) source: EuropePMC

The Journal of biological chemistry, Volume 273, Issue 45, 1 1 1998, Pages 29905-29914 Structural requirements for O-glycosylation of the mouse hepatitis virus membrane protein. de Haan CA, Roestenberg P, de Wit M, de Vries AA, Nilsson T, Vennema H, Rottier PJ

The mouse hepatitis virus (MHV) membrane (M) protein contains only O-linked oligosaccharides. We have used this protein as a model to study the structural requirements for O-glycosylation. We show that MHV M is modified by the addition of a single oligosaccharide side chain at the cluster of 4 hydroxylamino acids present at its extreme amino terminus and identified Thr at position 5 as the functional acceptor site. The hydroxylamino acid cluster, which is quite conserved among O-glycosylated cor... Abstract

Cited 76 times since 1998 (2.8 per year) source: EuropePMC

Canadian journal of physiology and pharmacology, Volume 76, Issue 10-11, 1 1 1998, Pages 945-951 Whole-body plethysmography, does it measure tidal volume of small animals? Enhorning G, van Schaik S, Lundgren C, Vargas I

A whole-body plethysmograph was used for mice. The increase in pressure caused by each inhalation was equivalent to the increase that could be calculated to result from heating and humidification of the inhaled air. However, comprehending that a drop in temperature and humidity would cause an abrupt pressure decline during exhalation was difficult. Pressure changes in the plethysmograph were also studied with an artificial chest, modeling the respiratory mechanics, but without the "inhaled&... Abstract

Cited 636 times since 1998 (23.6 per year) source: EuropePMC

Nature, Volume 395, Issue 6701, 1 1 1998, Pages 462-469 The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C

In addition to triggering the activation of B- or T-cell antigen receptors, the binding of a ligand to its receptor at the cell surface can sometimes determine the physiological outcome of interactions between antigen-presenting cells, T and B lymphocytes. The protein SLAM (also known as CDw150), which is present on the surface of B and T cells, forms such a receptor-ligand pair as it is a self-ligand. We now show that a T-cell-specific, SLAM-associated protein (SAP), which contains an SH2 domai... Abstract