7429 results
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 16, 18 3 2015, Pages 1263-1264
Diastolic dysfunction and atrial fibrillation.
Delgado V, Bax JJ
Abstract
Cited 24 times since 2015 (2.4 per year)
source: EuropePMC
European journal of pharmacology,
Volume 763, Issue Pt A, 16 3 2015, Pages 48-63
Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising: A systematic review and meta-analysis of relevant preclinical studies and clinical trials.
Kühnast S, Fiocco M, van der Hoorn JW, Princen HM, Jukema JW
Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) failed to meet their primary goals. This systematic review and meta-analysis investigated the effects of established and novel treatment strategies, specifically targeting HDL, on inhibition of atheroscl...
Abstract
Cited 42 times since 2015 (4.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 194, 15 3 2015, Pages 7-12
Increased aortic tortuosity indicates a more severe aortic phenotype in adults with Marfan syndrome.
Franken R, El Morabit A, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Marquering H, Planken NR, Zwinderman AH, Mulder BJ, Groenink M
Background: Patients with Marfan syndrome (MFS) have a highly variable occurrence of aortic complications. Aortic tortuosity is often present in MFS and may help to identify patients at risk for aortic complications. Methods: 3D-visualization of the total aorta by MR imaging was performed in 211 adult MFS patients (28% with prior aortic root replacement) and 20 controls. A method to assess aortic tortuosity (aortic tortuosity index: ATI) was developed and reproducibility was tested. The relation...
Abstract
Cited 25 times since 2015 (2.5 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 8, Issue 6, 14 2 2015, Pages 697-704
The Functional Effects of Intramural Course of Coronary Arteries and its Relation to Coronary Atherosclerosis.
Uusitalo V, Saraste A, Pietilä M, Kajander S, Bax JJ, Knuuti J
Objectives: This study observed hemodynamic consequences of myocardial bridging and its relation to coronary atherosclerosis. Background: Myocardial bridging is seen as intramural course by computed tomography angiography (CTA) or systolic compression by invasive coronary angiography. Segments with myocardial bridging are in previous studies closely associated with proximal atherosclerotic plaques. Methods: We prospectively studied 100 patients 63 ± 7 years of age with intermediate likelihood of...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Korean journal of radiology,
Volume 16, Issue 3, 13 2 2015, Pages 668-672
Right ventricular cardiomyopathy meeting the arrhythmogenic right ventricular dysplasia revised criteria? Don't forget sarcoidosis!
Vasaturo S, Ploeg DE, Buitrago G, Zeppenfeld K, Veselic-Charvat M, Kroft LJ
A 53-year-old woman was referred for ventricular fibrillation with resuscitation. A CT-angiography showed signs of a right ventricular enlargement without obvious cause. A cardiac MRI demonstrated a dilated and hypokinetic right ventricle with extensive late gadolinium enhancement. Arrhythmogenic right ventricular dysplasia (ARVD) was suspected according to the "revised ARVD task force criteria". An endomyocardial biopsy was inconclusive. The patient developed purulent pericarditis aft...
Abstract
Cited 15 times since 2015 (1.5 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 8, Issue 4, 12 2 2015, Pages 853-862
Reassessing noninducibility as ablation endpoint of post-infarction ventricular tachycardia: the impact of left ventricular function.
de Riva M, Piers SR, Kapel GF, Watanabe M, Venlet J, Trines SA, Schalij MJ, Zeppenfeld K
Background: Noninducibility is frequently used as procedural end point of ventricular tachycardia (VT) ablation after myocardial infarction. We investigated the influence of left ventricular (LV) function on the predictive value of noninducibility for VT recurrence and cardiac mortality. Methods and results: Ninety-one patients (82 men, 67±10 years) with post-myocardial infarction VT underwent ablation between 2009 and 2012. Fifty-nine (65%) had an LV ejection fraction (EF) >30% (mean 41±7) a...
Abstract
Cited 11 times since 2015 (1.1 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 1, Issue 4, 12 2 2015, Pages 232-244
Contemporary registries on P2Y12 inhibitors in patients with acute coronary syndromes in Europe: overview and methodological considerations.
Jukema JW, Lettino M, Widimský P, Danchin N, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Lopez-Sendón J, Tousek P, Weidinger F, Weston CF, Zaman A, Zeymer U, PIRAEUS group
Patient registries that document real-world clinical experience play an important role in cardiology as they complement the data from randomized controlled trials, provide valuable information on drug use and clinical outcomes, and evaluate to what extent guidelines are followed in practice. The Platelet Inhibition Registry in ACS EvalUation Study (PIRAEUS) project is an initiative of registry holders who are managing national or international registries observing patients with acute coronary sy...
Abstract
Cited 48 times since 2015 (4.9 per year)
source: EuropePMC
Nature communications,
Volume 6, 8 2 2015, Pages 7030
Expression of the vault RNA protects cells from undergoing apoptosis.
Amort M, Nachbauer B, Tuzlak S, Kieser A, Schepers A, Villunger A, Polacek N
Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known about the function(s) of the vtRNAs or the vault complex. Here, we individually express latent EBV-encoded proteins in B cells and identify the latent membrane protein 1 (LMP1) as trigger for vtRNA u...
Abstract
Cited 16 times since 2015 (1.6 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 48, Issue 4, 8 2 2015, Pages 463-475
Vectorcardiographic diagnostic & prognostic information derived from the 12-lead electrocardiogram: Historical review and clinical perspective.
Man S, Maan AC, Schalij MJ, Swenne CA
In the course of time, electrocardiography has assumed several modalities with varying electrode numbers, electrode positions and lead systems. 12-lead electrocardiography and 3-lead vectorcardiography have become particularly popular. These modalities developed in parallel through the mid-twentieth century. In the same time interval, the physical concepts underlying electrocardiography were defined and worked out. In particular, the vector concept (heart vector, lead vector, volume conductor) a...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 68, Issue 6, 7 1 2015, Pages 541-543
Proximal Left Anterior Descending Artery Acute Occlusion With an Unusual Electrocardiographic Pattern: Not Everything Is ST Elevation.
Montero-Cabezas JM, van-der-Kley F, Karalis I, Schalij MJ
Abstract
Cited 40 times since 2015 (4.1 per year)
source: EuropePMC
Surgery,
Volume 158, Issue 5, 6 1 2015, Pages 1323-1330
Intraoperative guidance in parathyroid surgery using near-infrared fluorescence imaging and low-dose Methylene Blue.
Tummers QR, Schepers A, Hamming JF, Kievit J, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Background: Identification of diseased and normal parathyroid glands during parathyroid surgery can be challenging. The aim of this study was to assess whether near-infrared (NIR) fluorescence imaging using administration of a low-dose Methylene Blue (MB) at the start of the operation could provide optical guidance during parathyroid surgery and assist in the detection of parathyroid adenomas. Methods: Patients diagnosed with primary hyperparathyroidism planned for parathyroidectomy were include...
Abstract
Cited 30 times since 2015 (3.1 per year)
source: EuropePMC
Clinical and vaccine immunology : CVI,
Volume 22, Issue 7, 6 1 2015, Pages 778-788
Mycobacterium bovis BCG Vaccination Induces Divergent Proinflammatory or Regulatory T Cell Responses in Adults.
Boer MC, Prins C, van Meijgaarden KE, van Dissel JT, Ottenhoff TH, Joosten SA
Mycobacterium bovis bacillus Calmette-Guérin (BCG), the only currently available vaccine against tuberculosis, induces variable protection in adults. Immune correlates of protection are lacking, and analyses on cytokine-producing T cell subsets in protected versus unprotected cohorts have yielded inconsistent results. We studied the primary T cell response, both proinflammatory and regulatory T cell responses, induced by BCG vaccination in adults. Twelve healthy adult volunteers who were tubercu...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
Drug and chemical toxicology,
Volume 39, Issue 2, 5 1 2015, Pages 119-123
Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro.
Yilmaz D, Teksoy O, Bilaloglu R, Çinkilic N
Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 µg/mL) and a single dose of BLM (20 µg/mL). BLM significantly increased the total CAs...
Abstract
Cited 11 times since 2015 (1.1 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 17, Issue 9, 2 1 2015, Pages 1383-1390
Incidence and predictors of dormant conduction after cryoballoon ablation incorporating a 30-min waiting period.
Compier MG, De Riva M, Dyrda K, Zeppenfeld K, Schalij MJ, Trines SA
Aims: Electrical reconnection after pulmonary vein (PV) isolation is associated with atrial fibrillation (AF) recurrence. Reconnection may already develop within a 30 min waiting period and may only occur as dormant conduction (DC) revealed by adenosine infusion. This study determines incidence and predictors of DC after cryoballoon ablation incorporating a 30 min waiting period and the effect of treating this 'late' DC on 1 year AF-recurrence. Methods and results: Consecutive patients...
Abstract
Cited 6 times since 2015 (0.6 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 48, Issue 4, 1 1 2015, Pages 498-504
Performance of ST and ventricular gradient difference vectors in electrocardiographic detection of acute myocardial ischemia.
Treskes RW, Ter Haar CC, Man S, De Jongh MC, Maan AC, Wolterbeek R, Schalij MJ, Wagner GS, Swenne CA
Introduction: Serial analysis could improve ECG diagnosis of myocardial ischemia caused by acute coronary occlusion. Methods: We analyzed ECG pairs of 84 cases and 398 controls. In case-patients, who underwent elective percutaneous coronary intervention, ischemic ECGs during balloon occlusion were compared with preceding non-ischemic ECGs. In control-patients, two elective non-ischemic ECGs were compared. In each ECG the ST vector at the J point and the ventricular gradient (VG) vector was compu...
Abstract
Cited 22 times since 2015 (2.2 per year)
source: EuropePMC
Atherosclerosis,
Volume 241, Issue 1, 1 1 2015, Pages 55-61
HDL cholesterol, leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain.
Caselli C, De Graaf MA, Lorenzoni V, Rovai D, Marinelli M, Del Ry S, Giannessi D, Bax JJ, Neglia D, Scholte AJ
Objectives: Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation could predict high risk coronary anatomy at CTA in patients with stable chest pain. Methods: We evaluated a panel of 17 biomarkers in 429 patients (60.3 ± 0.4 years, 268 males) with...
Abstract
Cited 15 times since 2015 (1.5 per year)
source: EuropePMC
The Journal of general virology,
Volume 96, Issue 8, 22 4 2015, Pages 2050-2060
Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data.
Lewis NS, Verhagen JH, Javakhishvili Z, Russell CA, Lexmond P, Westgeest KB, Bestebroer TM, Halpin RA, Lin X, Ransier A, Fedorova NB, Stockwell TB, Latorre-Margalef N, Olsen B, Smith G, Bahl J, Wentworth DE, Waldenström J, Fouchier RAM, de Graaf M
Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassort...
Abstract
Cited 33 times since 2015 (3.3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 65, Issue 18, 22 4 2015, Pages 1954-1959
Predictive value of programmed ventricular stimulation after catheter ablation of post-infarction ventricular tachycardia.
Yokokawa M, Kim HM, Baser K, Stevenson W, Nagashima K, Della Bella P, Vergara P, Hindricks G, Arya A, Zeppenfeld K, de Riva Silva M, Daoud EG, Kumar S, Kuck KH, Tilz R, Mathew S, Ghanbari H, Latchamsetty R, Morady F, Bogun FM
Background: A recent meta-analysis demonstrated a survival benefit in post-infarction patients whose ventricular tachycardia (VT) was rendered noninducible by catheter ablation. Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained inducible after ablation. Objectives: The purpose of this multicenter cohort study was to assess whether noninducibility after VT ablation is independently associated with improved survival. Methods: Data from 1,...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 12, Issue 6, 21 3 2015, Pages 321-322
Genetics: Genetic risk scores--new promises for drug evaluation.
Jukema JW, Trompet S
Abstract
Cited 35 times since 2015 (3.5 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 4, 17 3 2015, Pages e0124347
Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.
Yıldırım C, Vogel DY, Hollander MR, Baggen JM, Fontijn RD, Nieuwenhuis S, Haverkamp A, de Vries MR, Quax PH, Garcia-Vallejo JJ, van der Laan AM, Dijkstra CD, van der Pouw Kraan TC, van Royen N, Horrevoets AJ
Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of galectin-2 on arteriogenesis was confirmed in vivo, but the mechanism is largely unknown. In this study we aimed to explore the effects of galectin-2 on monocyte/macrophage phenotype in vitro and vivo, and to identify the receptor by which galectin-...
Abstract
