Research

Publications

Below you can find a list of our published research.

6128 results

Cited 33 times since 2009 (2.1 per year) source: EuropePMC

The American journal of cardiology, Volume 103, Issue 11, 8 2 2009, Pages 1506-1512 Left ventricular rotational mechanics in acute myocardial infarction and in chronic (ischemic and nonischemic) heart failure patients. Bertini M, Nucifora G, Marsan NA, Delgado V, van Bommel RJ, Boriani G, Biffi M, Holman ER, Van der Wall EE, Schalij MJ, Bax JJ

Left ventricular (LV) twist and untwisting rate are emerging as global and thorough parameters for assessment of LV function. This study explored differences of LV twist and untwisting rate in patients with acute myocardial infarction (AMI) and patients with ischemic and nonischemic chronic heart failure (HF). Fifty patients with AMI, 49 with ischemic HF, and 38 with nonischemic HF were studied. As a control group, 28 subjects without evidence of structural heart disease were included. Speckle-t... Abstract

Cited 145 times since 2009 (9.1 per year) source: EuropePMC

Circulation, Volume 119, Issue 15, 6 1 2009, Pages 2069-2077 Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus. van der Meer RW, Rijzewijk LJ, de Jong HW, Lamb HJ, Lubberink M, Romijn JA, Bax JJ, de Roos A, Kamp O, Paulus WJ, Heine RJ, Lammertsma AA, Smit JW, Diamant M

Background: Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Pioglitazone has been associated with improved cardiac outcome but also with an elevated risk of heart failure. We determined the effects of pioglitazone on myocardial function in relation to cardiac high-energy phosphate, glucose, and fatty acid metabolism and triglyceride content in T2DM patients. Methods and results: Seventy-eight T2DM men without structural heart disease or inducible ischemia as... Abstract

Cited 10 times since 2009 (0.6 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 17, Issue 4, 1 1 2009, Pages 155-161 Cardiovascular risk in young apparently healthy descendents from Asian Indian migrants in the Netherlands: the SHIVA study. Liem SS, Oemrawsingh PV, Cannegieter SC, Le Cessie S, Schreur J, Rosendaal FR, Schalij MJ

BACKGROUND.: Asian Indian migrants in the Western world are highly susceptible for ischaemic heart disease (IHD). Until now, most IHD risk studies were performed in first and second generation Asian Indian expatriates. For optimal prevention, knowledge of the cardiovascular risk profile of younger generations is crucial. METHOD.: In a cross-sectional study we assessed the prevalence of conventional IHD risk factors and Framingham risk score in asymptomatic third to seventh generation Asian India... Abstract

Cited 22 times since 2009 (1.4 per year) source: Scopus

JACC. Cardiovascular imaging, Volume 2, Issue 4, 1 1 2009, Pages 522-523 Percutaneous valve-in-valve procedure for severe paravalvular regurgitation in aortic bioprosthesis. Ng AC, van der Kley F, Delgado V, Shanks M, van Bommel RJ, de Weger A, Tavilla G, Holman ER, Schuijf JD, van de Veire NR, Schalij MJ, Bax JJ

Abstract

Cited 35 times since 2009 (2.2 per year) source: EuropePMC

The American journal of cardiology, Volume 103, Issue 10, 1 1 2009, Pages 1451-1456 Relation of resting heart rate to prognosis in patients with idiopathic pulmonary arterial hypertension. Henkens IR, Van Wolferen SA, Gan CT, Boonstra A, Swenne CA, Twisk JW, Kamp O, van der Wall EE, Schalij MJ, Vonk-Noordegraaf A, Vliegen HW

Heart rate (HR) at rest is an important marker of prognosis in heart failure, but has not been addressed in pulmonary arterial hypertension (PAH). To determine the prognostic value of HR at rest in patients with PAH, we retrospectively analyzed 140 consecutive patients with idiopathic PAH. Electrocardiogram (ECG)-derived HR at rest was evaluated as a potential predictor of adverse prognosis (death or lung transplantation), in addition to World Health Organization functional class, 6-minute walk... Abstract

JACC. Cardiovascular imaging, Volume 2, Issue 4, 1 1 2009, Pages 498-510 The year in imaging related to electrophysiology. Tops LF, Bax JJ

Abstract

Cited 14 times since 2009 (0.9 per year) source: EuropePMC

Arthritis and rheumatism, Volume 60, Issue 4, 1 1 2009, Pages 987-993 No increased risk of valvular heart disease in adult poststreptococcal reactive arthritis. van Bemmel JM, Delgado V, Holman ER, Allaart CF, Huizinga TW, Bax JJ, van der Helm-van Mil AH

Objective: Poststreptococcal reactive arthritis (ReA) is a (poly)arthritis presenting after a Streptococcus group A infection. Acute rheumatic fever (ARF), albeit caused by the same pathogen, has different risk characteristics and is considered to be a separate entity. Whereas ARF is known to cause carditis, the risk of carditis in adult poststreptococcal ReA is unknown. Consequently, the prevailing recommendations regarding long-term antibiotic prophylaxis in poststreptococcal ReA are imprecise... Abstract

Cited 16 times since 2009 (1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 2, Issue 4, 1 1 2009, Pages 486-497 Imaging cardiac resynchronization therapy. Abraham T, Kass D, Tonti G, Tomassoni GF, Abraham WT, Bax JJ, Marwick TH

Although a prognostic benefit has been shown from cardiac resynchronization therapy, questions are often directed toward the prediction of symptomatic or functional benefit. Recent multicenter trials have shown the pitfalls of current mechanical markers of left ventricular synchrony, but these negative trial results have not marked the conclusion of efforts to predict outcome. Potential new contributors to the assessment of mechanical synchrony include echocardiographic and magnetic resonance te... Abstract

Cited 3 times since 2009 (0.2 per year) source: EuropePMC

American heart journal, Volume 157, Issue 5, 25 4 2009, Pages 882.e1-8 Real-time 3-dimensional echocardiography early after acute myocardial infarction: incremental value of echo-contrast for assessment of left ventricular function. Nucifora G, Marsan NA, Holman ER, Siebelink HM, van Werkhoven JM, Scholte AJ, van der Wall EE, Schalij MJ, Bax JJ

Background: Accurate and reproducible assessment of left ventricular (LV) systolic function is important in patients with acute myocardial infarction (AMI). Real-time 3-dimensional echocardiography (RT3DE) is an accurate technique, but it relies heavily on good image quality. The aim of the present study was to evaluate the incremental value of contrast-enhanced RT3DE. Methods: A total of 140 consecutive patients (58 +/- 11 years, 78% men) with ST-elevation AMI clinically underwent nonenhanced a... Abstract

Cited 254 times since 2009 (15.9 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 2, Issue 3, 23 4 2009, Pages 183-190 Infarct tissue heterogeneity assessed with contrast-enhanced MRI predicts spontaneous ventricular arrhythmia in patients with ischemic cardiomyopathy and implantable cardioverter-defibrillator. Roes SD, Borleffs CJ, van der Geest RJ, Westenberg JJ, Marsan NA, Kaandorp TA, Reiber JH, Zeppenfeld K, Lamb HJ, de Roos A, Schalij MJ, Bax JJ

Background: The relation between infarct tissue heterogeneity on contrast-enhanced MRI and the occurrence of spontaneous ventricular arrhythmia (or sudden cardiac death) is unknown. Therefore, the study purpose was to evaluate the predictive value of infarct tissue heterogeneity assessed with contrast-enhanced MRI on the occurrence of spontaneous ventricular arrhythmia with subsequent implantable cardioverter-defibrillator (ICD) therapy (as surrogate of sudden cardiac death) in patients with pre... Abstract

Cited 25 times since 2009 (1.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 35, Issue 6, 20 3 2009, Pages 953-7; discussion 957 Therapeutic decisions for patients with symptomatic severe aortic stenosis: room for improvement? van Geldorp MW, van Gameren M, Kappetein AP, Arabkhani B, de Groot-de Laat LE, Takkenberg JJ, Bogers AJ

Objective: Symptomatic severe aortic stenosis is an indication for aortic valve replacement. Some patients are denied intervention. This study provides insight into the proportion of conservatively treated patients and into the reasons why conservative treatment is chosen. Methods: Of a patient cohort presenting with severe aortic stenosis between 2004 and 2007, medical records were retrospectively analyzed. Only symptomatic patients (n=179) were included. We studied their characteristics, treat... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Acta physiologica (Oxford, England), Volume 196, Issue 4, 19 3 2009, Pages 375-383 Left ventricular mechanical dyssynchrony is load independent at rest and during endotoxaemia in a porcine model. A'roch R, Steendijk P, Oldner A, Weitzberg E, Konrad D, Johansson G, Haney M

Aim: In diseased or injured states, the left ventricle displays higher degrees of mechanical dyssynchrony. We aimed at assessing mechanical dyssynchrony ranges in health related to variation in load as well as during acute endotoxin-induced ventricular injury. Methods: In 16 juvenile anaesthetized pigs, a five-segment conductance catheter was placed in the left ventricle as well as a balloon-tipped catheter in the inferior vena cava. Mechanical dyssynchrony during systole, including dyssynchrony... Abstract

Cited 9 times since 2009 (0.6 per year) source: EuropePMC

Atherosclerosis, Volume 206, Issue 2, 19 3 2009, Pages 444-450 Mannose binding lectin deficiency and triglyceride-rich lipoprotein metabolism in normolipidemic subjects. Alipour A, van Oostrom AJ, Van Wijk JP, Verseyden C, Plokker HW, Jukema JW, Rabelink AJ, Castro Cabezas M

Mannose binding lectin (MBL) is one of the three initiators of complement activation and is therefore closely linked to inflammation. MBL deficiency has been associated with the generation of atherosclerosis. Since atherosclerosis, the complement system and postprandial lipemia are linked to inflammation, we studied postprandial lipoprotein metabolism in MBL deficiency. An observational study was carried out in 107 volunteers (21% MBL deficient). Classical cardiovascular risk factors were not di... Abstract

Cited 88 times since 2009 (5.5 per year) source: EuropePMC

American journal of human genetics, Volume 84, Issue 4, 12 2 2009, Pages 468-476 Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. Alders M, Koopmann TT, Christiaans I, Postema PG, Beekman L, Tanck MW, Zeppenfeld K, Loh P, Koch KT, Demolombe S, Mannens MM, Bezzina CR, Wilde AA

Idiopathic Ventricular Fibrillation (IVF) is defined as spontaneous VF without any known structural or electrical heart disease. A family history is present in up to 20% of probands with the disorder, suggesting that at least a subset of IVF is hereditary. A genome-wide haplotype-sharing analysis was performed for identification of the responsible gene in three distantly related families in which multiple individuals died suddenly or were successfully resuscitated at young age. We identified a h... Abstract

Cited 24 times since 2009 (1.5 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 35, Issue 5, 9 2 2009, Pages 847-52; discussion 852-3 Wall motion score index predicts mortality and functional result after surgical ventricular restoration for advanced ischemic heart failure. Klein P, Holman ER, Versteegh MI, Boersma E, Verwey HF, Bax JJ, Dion RA, Klautz RJ

Objective: Advanced ischemic heart failure can be treated with surgical ventricular restoration (SVR). While numerous risk factors for mortality and recurrent heart failure have been identified, no plain predictor for identifying SVR patients with left ventricular damage beyond recovery is yet available. We tested echocardiographic wall motion score index (WMSI) as a predictor for mortality or poor functional result. Methods: One hundred and one patients electively operated between April 2002 an... Abstract

Cited 48 times since 2009 (3 per year) source: EuropePMC

Circulation, Volume 119, Issue 11, 9 2 2009, Pages 1467-1472 Tricuspid valve surgery in adults with a dysfunctional systemic right ventricle: repair or replace? Scherptong RW, Vliegen HW, Winter MM, Holman ER, Mulder BJ, van der Wall EE, Hazekamp MG

Background: In patients with a right ventricle (RV) in the systemic position, tricuspid valve surgery for regurgitation beyond adolescence is a subject of debate. The aim of the present study was to evaluate the complications, survival, and benefit of tricuspid surgery in adult patients with an atrium-level correction for transposition of the great arteries or congenitally corrected transposition of the great arteries. Methods and results: All adult patients (n=16; 7 men, 9 women; age 35+/-11 ye... Abstract

Cited 6 times since 2009 (0.4 per year) source: EuropePMC

European journal of pediatrics, Volume 168, Issue 12, 5 1 2009, Pages 1479-1481 Double aortic arch with double aneuploidy--rare anomaly in combined Down and Klinefelter syndrome. Gerretsen MF, Peelen W, Rammeloo LA, Koolbergen DR, Hruda J

A 14-month-old boy with double aneuploidy and a double aortic arch suffered from frequently recurrent severe feeding and respiratory problems. Chromosomal analysis showed a 48,XXY + 21 karyotype: a double aneuploidy of Down syndrome (DS) and Klinefelter syndrome (KS). Only four cases of double aneuploidy (DS + KS) associated with congenital heart defects have been published of which none had a double aortic arch. Our case report should draw attention to the possibility of a double aortic arch in... Abstract

Cited 16 times since 2009 (1 per year) source: EuropePMC

The Journal of general virology, Volume 90, Issue Pt 6, 4 1 2009, Pages 1408-1416 Fusion protein is the main determinant of metapneumovirus host tropism. de Graaf M, Schrauwen EJA, Herfst S, van Amerongen G, Osterhaus ADME, Fouchier RAM

Human metapneumovirus (HMPV) and avian metapneumovirus subgroup C (AMPV-C) infect humans and birds, respectively. This study confirmed the difference in host range in turkey poults, and analysed the contribution of the individual metapneumovirus genes to host range in an in vitro cell-culture model. Mammalian Vero-118 cells supported replication of both HMPV and AMPV-C in contrast to avian quail fibroblast (QT6) cells in which only AMPV-C replicated to high titres. Inoculation of Vero-118 and QT... Abstract

Cited 12 times since 2009 (0.7 per year) source: EuropePMC

Echocardiography (Mount Kisco, N.Y.), Volume 26, Issue 3, 1 1 2009, Pages 315-323 The role of speckle tracking strain imaging in cardiac pacing. Tops LF, Delgado V, Bax JJ

In recent years, concerns have been raised about possible harmful effects of long-term right ventricular (RV) apical pacing. These detrimental effects may be related to changes in left ventricular (LV) mechanics during RV apical pacing. As a consequence, alternative RV pacing sites have been proposed, and in selected patients an upgrade from RV to biventricular pacing may be considered. Novel two-dimensional (2D) speckle tracking strain imaging allows detailed evaluation of LV mechanics, includi... Abstract

Critical care medicine, Volume 37, Issue 3, 1 1 2009, Pages 1130-1131 The fate and role of mesenchymal stem cells engrafted in the heart after a myocardial infarction during a second ischemic event. Steendijk P

Abstract