Research

Publications

Below you can find a list of our published research.

6173 results

Cited 30 times since 2000 (1.2 per year) source: EuropePMC

Circulation, Volume 102, Issue 14, 1 1 2000, Pages 1629-1633 Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group. Kastelein JJ, Jukema JW, Zwinderman AH, Clee S, van Boven AJ, Jansen H, Rabelink TJ, Peters RJ, Lie KI, Liu G, Bruschke AV, Hayden MR

Background: Raised triglyceride-rich lipoproteins significantly increase the risk for cardiovascular disease. Variation in the activity of the enzyme lipoprotein lipase (LPL), which is crucial in the removal of these lipoproteins, may therefore modulate this risk. Methods and results: Postheparin levels of LPL activity and mass were measured in a large cohort of male coronary artery disease patients participating in the Regression Growth Evaluation Statin Study (REGRESS), a lipid-lowering regres... Abstract

Cited 39 times since 2000 (1.6 per year) source: EuropePMC

The American journal of cardiology, Volume 86, Issue 7, 1 1 2000, Pages 742-746 Pravastatin reduces restenosis two years after percutaneous transluminal coronary angioplasty (REGRESS trial). Mulder HJ, Bal ET, Jukema JW, Zwinderman AH, Schalij MJ, van Boven AJ, Bruschke AV

The Regression Growth Evaluation Statin Study (REGRESS) is a placebo-controlled multicenter study designed to assess the effect of 2-year treatment with pravastatin on the progression and regression of angiographically documented coronary artery disease. One of the secondary end points was the occurrence of 2-year restenosis in the percutaneous transluminal coronary angioplasty (PTCA) block. We randomly assigned eligible patients to receive pravastatin 40 mg once daily or placebo. The end point... Abstract

Cited 5 times since 2000 (0.2 per year) source: EuropePMC

European journal of pharmacology, Volume 403, Issue 1-2, 1 1 2000, Pages 99-109 In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca(2+) in stunned myocardium. de Zeeuw S, Trines SA, Krams R, Duncker DJ, Verdouw PD

Despite ample in vitro evidence that myofilament Ca(2+)-responsiveness of stunned myocardium is decreased, in vivo data are inconclusive. Conversely, while Ca(2+)-sensitizing agents increase myofilament Ca(2+)-responsiveness in vitro, it has been questioned whether this also occurs in vivo. We therefore tested in open-chest anesthetized pigs whether EMD 57033 (the (+) enantiomer of 5-[1-(3,4-dimethoxybenzoyl)-1,2,3, 4-tetrahydro-6-quinolyl]-6-methyl-3,6-dihydro-2H-1,3, 4-thiadiazin-2-one) increa... Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 279, Issue 3, 1 1 2000, Pages H1264-73 Efficiency of energy transfer, but not external work, is maximized in stunned myocardium. Trines SA, Slager CJ, van der Moer J, Verdouw PD, Krams R

There is no evidence regarding the effect of stunning on maximization of regional myocardial external work (EW) or efficiency of energy transfer (EET) in relation to regional afterload (end-systolic stress, sigma(es)). To that end, we studied these relationships in both the left anterior descending coronary artery (LADCA) and left circumflex coronary artery regions in anesthetized, open-chest pigs before and after LADCA stunning. In normal myocardium, EET vs. sigma(es) was maximal at 75.4 (69.7-... Abstract

Cited 6 times since 2000 (0.2 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 84, Issue 3, 1 1 2000, Pages 460-467 Adenoviral gene transfer of a u-PA receptor-binding plasmin inhibitor and green fluorescent protein: inhibition of migration and visualization of expression. Lamfers ML, Wijnberg MJ, Grimbergen JM, Huisman LG, Aalders MC, Cohen FN, Verheijen JH, van Hinsbergh VW, Quax PH

Smooth muscle cell migration plays a role in the development of intimal hyperplasia. Given the established role of the plasminogen activation system in cell migration, an approach to therapy is to overexpress an inhibitor of plasmin. Therefore, an adenoviral vector was constructed encoding the hybrid protein ATF.BPTI, which contains the active domain of bovine pancreas trypsin inhibitor (BPTI), fused to ATF, the amino terminal fragment or receptor-binding domain of u-PA. Adenoviral vectors expre... Abstract

Cited 57 times since 2000 (2.3 per year) source: EuropePMC

The American journal of cardiology, Volume 86, Issue 4, 1 1 2000, Pages 385-389 Heparin-coated Wiktor stents in human coronary arteries (MENTOR trial). MENTOR Trial Investigators. Vrolix MC, Legrand VM, Reiber JH, Grollier G, Schalij MJ, Brunel P, Martinez-Elbal L, Gomez-Recio M, Bär FW, Bertrand ME, Colombo A, Brachman J

The purpose of this study was to determine the feasibility, safety, and efficacy of elective stenting with heparin-coated Wiktor stents in patients with coronary artery disease. In experimental studies, heparin coating has been shown to prevent subacute thrombosis and restenosis. Recently, a new method of heparin coating was developed, resulting in a more stable and predictable heparin layer on stent devices. This trial constitutes the first in-human use of this coating procedure, applied on the... Abstract

Cited 8 times since 2000 (0.3 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 23, Issue 8, 1 1 2000, Pages 1232-1238 No gender differences in pacemaker selection in patients undergoing their first implantation. Roeters Van Lennep JE, Zwinderman AH, Roeters Van Lennep HW, Van Hemel NM, Schalij MJ, van der Wall EE

Recent studies have indicated that women were less likely to receive sophisticated pacemaker devices than men. These differences could not be fully explained by demographic and clinical variables. The purpose of the present study was to assess whether a gender related difference might exist in pacemaker mode selection in patients undergoing their first implantation in The Netherlands. Records of first implants (n = 39,217) collected from 1988 through 1997 covering 95% of all implantations in The... Abstract

Cited 20 times since 2000 (0.8 per year) source: EuropePMC

American journal of respiratory and critical care medicine, Volume 162, Issue 2 Pt 1, 1 1 2000, Pages 374-379 Right ventricular function in respiratory distress syndrome and subsequent partial liquid ventilation. Homeometric autoregulation in the right ventricle of the newborn animal. Lopes Cardozo RH, Steendijk P, Baan J, Brouwers HA, De Vroomen M, Van Bel F

Infant respiratory distress syndrome (IRDS) and subsequent partial liquid ventilation (PLV) cause increased pulmonary vascular resistance, thus raising afterload. In nine newborn lambs the effects of IRDS and subsequent PLV on right (RV) and left ventricular (LV) contractility and systolic pump function were assessed using indices derived from RV and LV pressure-volume relations, obtained by micromanometric and conductance catheters during transient inferior vena cava occlusion. Pulmonary functi... Abstract

Cited 48 times since 2000 (1.9 per year) source: EuropePMC

Circulation research, Volume 87, Issue 3, 1 1 2000, Pages 248-253 Accelerated atherosclerosis by placement of a perivascular cuff and a cholesterol-rich diet in ApoE*3Leiden transgenic mice. Lardenoye JH, Delsing DJ, de Vries MR, Deckers MM, Princen HM, Havekes LM, van Hinsbergh VW, van Bockel JH, Quax PH

Intimal hyperplasia after vascular injury is usually studied in animal models with healthy, normocholesterolemic animals. Here, we assess the effect of diet-induced hypercholesterolemia on the induction of intimal hyperplasia in ApoE*3Leiden mice. A nonconstrictive polyethylene cuff was placed around the femoral artery of ApoE3*Leiden mice fed a highly cholesterol-rich diet, a mildly cholesterol-rich diet, or a chow diet for 4 weeks. Diets were continued after cuff placement until euthanization.... Abstract

Cited 32 times since 2000 (1.3 per year) source: EuropePMC

Arthritis and rheumatism, Volume 43, Issue 8, 1 1 2000, Pages 1710-1718 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. van der Laan WH, Pap T, Ronday HK, Grimbergen JM, Huisman LG, TeKoppele JM, Breedveld FC, Gay RE, Gay S, Huizinga TW, Verheijen JH, Quax PH

Objective: Joint destruction in rheumatoid arthritis (RA) is a result of degradation and invasion of the articular cartilage by the pannus tissue. The present study was undertaken to examine the role of the plasminogen activation system in cartilage degradation and invasion by synovial fibroblasts and investigate a novel gene therapeutic approach using a cell surface-targeted plasmin inhibitor (ATF.BPTI). Methods: Adenoviral vectors were used for gene transfer. The effects of ATF.BPTI gene trans... Abstract

Cited 22 times since 2000 (0.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 120, Issue 1, 1 1 2000, Pages 55-65 Remodeling of the porcine pulmonary autograft wall in the aortic position. Schoof PH, Gittenberger-De Groot AC, De Heer E, Bruijn JA, Hazekamp MG, Huysmans HA

Objective: Dilatation and valve regurgitation are disturbing sequelae of the pulmonary root functioning at systemic pressures. We tried to characterize the histologic mode of adaptation of the neoaortic wall. Methods: We compared routine histologic studies, immunohistochemical staining, and computer-assisted morphometric analysis of aortic, pulmonary autograft, and native pulmonary wall specimens from pigs in which, as a newborn, a valveless pulmonary autograft had been implanted in the aorta. R... Abstract

Cited 17 times since 2000 (0.7 per year) source: EuropePMC

Journal of clinical microbiology, Volume 38, Issue 6, 1 1 2000, Pages 2065-2075 Monoclonal antibodies directed against conserved epitopes on the nucleocapsid protein and the major envelope glycoprotein of equine arteritis virus. Weiland E, Bolz S, Weiland F, Herbst W, Raamsman MJ, Rottier PJ, De Vries AA

We recently developed a highly effective immunization procedure for the generation of monoclonal antibodies (MAbs) directed against the porcine reproductive and respiratory syndrome virus (E. Weiland, M. Wieczorek-Krohmer, D. Kohl, K. K. Conzelmann, and F. Weiland, Vet. Microbiol. 66:171-186, 1999). The same method was used to produce a panel of 16 MAbs specific for the equine arteritis virus (EAV). Ten MAbs were directed against the EAV nucleocapsid (N) protein, and five MAbs recognized the maj... Abstract

Cited 48 times since 2000 (1.9 per year) source: EuropePMC

Herz, Volume 25, Issue 4, 1 1 2000, Pages 356-364 Arrhythmogenic right ventricular dysplasia: MRI findings. van der Wall EE, Kayser HW, Bootsma MM, de Roos A, Schalij MJ

Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder of unknown cause that is characterized pathologically by fibrofatty replacement of the right ventricular myocardium. Clinical manifestations include structural and functional malformations of the right ventricle, electrocardiographic abnormalities, and presentation with ventricular tachycardias with left bundle branch pattern or sudden death. The disease is often familial with an autosomal inheritance. In addition to ri... Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

International journal of cardiology, Volume 73, Issue 3, 1 1 2000, Pages 209-211 Detecting hibernating myocardium: how and why? Siebelink HJ, Underwood SR, van der Wall EE, Blanksma PK

Abstract

Cited 10 times since 2000 (0.4 per year) source: EuropePMC

Critical care medicine, Volume 28, Issue 5, 1 1 2000, Pages 1599-1606 Evaluation of a new transcardiac conductance method for continuous on-line measurement of left ventricular volume. Steendijk P, Lardenoye JW, van der Velde ET, Schalij MJ, Baan J

Objective: To evaluate a new, less invasive, conductance method to measure continuous on-line left ventricular volume. End-systolic and end-diastolic volumes obtained with this transcardiac conductance method were compared with simultaneous measurements using the conventional intracardiac conductance catheter. Design: Controlled animal study. Setting: Research laboratory in a university hospital. Subjects: Six sheep. Interventions: Anesthetized sheep were instrumented and inotropic condition was... Abstract

Cited 31 times since 2000 (1.2 per year) source: EuropePMC

Annals of surgical oncology, Volume 7, Issue 4, 1 1 2000, Pages 268-275 Systemic toxicity and cytokine/acute phase protein levels in patients after isolated limb perfusion with tumor necrosis factor-alpha complicated by high leakage. Stam TC, Swaak AJ, de Vries MR, ten Hagen TL, Eggermont AM

Background: Since the introduction of high-dose tumor necrosis factor-alpha (TNFalpha) in the setting of isolated limb perfusion (ILP) in the clinic, prevention of leakage to the body of the patient is monitored with great precision for fear of TNF-mediated toxicity. That we observed remarkably little toxicity in patients with and without leakage prompted us to determine patterns of cytokines and acute phase proteins in patients with high leakage and in patients without any leakage. Methods: TNF... Abstract

Cited 3 times since 2000 (0.1 per year) source: EuropePMC

Annals of the New York Academy of Sciences, Volume 902, 1 1 2000, Pages 17-24; discussion 24-6 Tailored therapy to fit individual profiles. Genetics and coronary artery disease. Jukema JW, Kastelein JJ

In the twentieth century, coronary artery disease (CAD) was the major cause of morbidity and mortality in western societies. Genetics and environmental influences clearly contribute to CAD. Our genetic makeup contributes to not only coronary risk factors, but also determines an individual's response to environmental challenges such as diet, drugs, and tobacco. Genetic testing is likely to be more predictive of our predisposition to CAD than current conventional testing of known risk factors... Abstract

Cited 13 times since 2000 (0.5 per year) source: EuropePMC

British journal of pharmacology, Volume 129, Issue 7, 1 1 2000, Pages 1413-1422 Cardiovascular profile of the calcium sensitizer EMD 57033 in open-chest anaesthetized pigs with regionally stunned myocardium. de Zeeuw S, Trines SA, Krams R, Verdouw PD, Duncker DJ

1. Ca(2+) sensitizers enhance systolic function, but may impair relaxation in vitro; these effects may differ in stunned and normal myocardium. We therefore studied the effect of EMD 57033 on systolic and diastolic function of normal and stunned porcine myocardium in vivo. 2. Myocardial stunning by 15 min coronary occlusion and 30 min reperfusion abolished systolic shortening (SS) (baseline 13+/-1%) and decreased end-systolic elastance (E(es)) from 67+/-7 to 47+/-5 mmHg mm(-1) (both P Abstract

Cited 4 times since 2000 (0.2 per year) source: EuropePMC

The Journal of invasive cardiology, Volume 12, Issue 4, 1 1 2000, Pages 187-193 Clinical and angiographic outcome of stent implantation without predilatation using the Jostent Flex stent. Oemrawsingh PV, Schalij MJ, Srimahachota S, Jukema JW, Bruschke AV

Conventional stenting requires predilatation which potentially increases vessel wall injury and cost of the procedure. In this study, the safety and efficacy of direct Jostent Flex (Jomed AB, Helsingborg, Sweden) stent placement was evaluated in 50 patients. Quantitative coronary angiography was performed at baseline, post-stent and 6 months follow-up. Clinical follow-up was done up to 9 months. In 50 patients (38 male/12 female; age 61+/-12 years) with stable (n = 42; 84%) or unstable (n = 8; 1... Abstract

Cited 14 times since 2000 (0.6 per year) source: EuropePMC

Magnetic resonance imaging, Volume 18, Issue 3, 1 1 2000, Pages 245-253 Spin echo MRI in the evaluation of hearts with a double outlet right ventricle: usefulness and limitations. Beekmana RP, Roest AA, Helbing WA, Hazekamp MG, Schoof PH, Bartelings MM, Sobotka MA, de Roos A, Ottenkamp J

The surgical approach to a double outlet right ventricle (DORV) is dependent on the spatial relationship of the semilunar valves, outflow tracts and ventricular septal defect (VSD). The purpose of the study was to assess the value of MRI for the evaluation of cardiovascular anatomy in patients before and after surgery for DORV. Spin echo MRI was performed in 12 patients with DORV (eight preoperative and four postoperative patients). Thin-section MRI was performed in three orthogonal planes and s... Abstract