Research

Publications

Below you can find a list of our published research.

7235 results

Cited 1 times since 1994 (0 per year) source: EuropePMC

Annales de biologie clinique, Volume 52, Issue 11, 1 1 1994, Pages 775-782 Studies on functional and structural role of urokinase receptor and other components of the plasminogen activation system in malignancy. Weidle UH, Wöllisch E, Rønne E, Ploug M, Behrendt N, de Vries TJ, Quax PH, Verheijen JH, van Muijen GN, Ruiter DJ

Using immunohistochemistry and in-situ hybridization, we studied the expression of the components of the plasminogen activation system during progression to malignant melanoma with fresh melanocytic lesions. Expression of these components is confined to late stages of melanoma. t-PA expression is limited to rare cases of metastatic melanoma. The other components are frequently expressed concomitantly in the same tumour. Urokinase (u-PA) is expressed in stromal cells and only in tumour cells at i... Abstract

Cited 6 times since 1994 (0.2 per year) source: EuropePMC

Magnetic resonance imaging, Volume 12, Issue 3, 1 1 1994, Pages 531-534 Cardiovascular MR imaging: pressure-gating using the arterial pressure signal from a conventional ferromagnetic micromanometer-tip catheter. Pattynama PM, van der Velde ET, Steendijk P, Lamb HJ, Baan J, de Roos A

We used the arterial pressure wave as a reliable trigger to synchronize MR imaging to the cardiac cycle. Pressure readings and MR images remained undistorted using a conventional ferromagnetic micromanometer-tip catheter. As a safe alternative to triggering to ventricular pressure, this approach allows varying the time relation between the trigger and the cardiac cycle while maintaining the advantages of pressure-gating. Abstract

Cited 1 times since 1994 (0 per year) source: EuropePMC

European heart journal, Volume 15, Issue 1, 1 1 1994, Pages 83-88 Acute effects of balloon valvuloplasty and pacing on left ventricular performance in children with moderate pulmonary valve stenosis, analysed by systolic and diastolic pressure-volume relationships. Witsenburg M, van der Velde ET, Klautz RJ, Hess J, Baan J

Right ventricular overload of volume and/or pressure type may affect left ventricular systolic and diastolic function. This has been shown in animal studies and has been suggested in non-invasive studies in man. Altered geometry of the left ventricle, myocardial hypertrophy and changes in contractile state may be responsible for the change in function. Balloon valvuloplasty is an effective treatment for isolated valvular pulmonary stenosis in children, and results in an immediate decrease of rig... Abstract

Cited 21 times since 1994 (0.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 23, Issue 1, 1 1 1994, Pages 82-91 Systemic and cardiac neuroendocrine activation and severity of myocardial ischemia in humans. Remme WJ, Kruyssen DA, Look MP, Bootsma M, de Leeuw PW

Objectives: The purpose of this study was to assess the effect of different degrees of ischemia on circulating and cardiac neurohormones and vasotone. Background: Neuroendocrine activation and subsequent systemic vasoconstriction may complicate ischemia. Whether this relates to severity of ischemia and subsequent cardiac dysfunction, and whether neurohormonal balance in the ischemic area changes, is unknown. Methods: Fifty-six normotensive patients with coronary artery disease were evaluated dur... Abstract

Cited 8 times since 1993 (0.3 per year) source: EuropePMC

Pflugers Archiv : European journal of physiology, Volume 425, Issue 5-6, 1 1 1993, Pages 426-433 Cardiac sympathetic denervation does not change the load dependence of the left ventricular end-systolic pressure/volume relationship in dogs. Schipper IB, Steendijk P, Klautz RJ, van der Velde ET, Baan J

It has been shown that in the intact canine heart the left-ventricular end-systolic pressure/volume relation (ESPVR) depends on loading conditions: an increase in arterial vascular resistance causes a leftwards shift and a steeper slope of the ESPVR, suggesting an increased inotropic state. Our purpose was to investigate the possible contribution of the sympathetic nervous system to this load sensitivity of the ESPVR, using intact, but denervated, hearts with normal coronary perfusion and afterl... Abstract

Cited 58 times since 1993 (1.8 per year) source: EuropePMC

IEEE transactions on bio-medical engineering, Volume 40, Issue 11, 1 1 1993, Pages 1138-1148 The four-electrode resistivity technique in anisotropic media: theoretical analysis and application on myocardial tissue in vivo. Steendijk P, Mur G, Van Der Velde ET, Baan J

Several aspects of the four-electrode resistivity technique were studied with special emphasis on the theoretical determination of penetration depth and sample volume in anisotropic media such as (cardiac) muscle. Moreover, the presence of a thin disturbing layer on top of the medium under study was analyzed. A four-electrode sensor was developed for the measurement of local myocardial resistivity in two orthogonal directions. The sensor was applied to the epicardium of anesthetized open chest d... Abstract

Cited 9 times since 1993 (0.3 per year) source: EuropePMC

Scandinavian journal of gastroenterology, Volume 28, Issue 11, 1 1 1993, Pages 929-933 Detection and management of common bile duct stones in the era of laparoscopic cholecystectomy. van der Hul RL, Plaisier PW, Hamming JF, Bruining HA, van Blankenstein M

Abstract

Cited 16 times since 1993 (0.5 per year) source: EuropePMC

Nuclear medicine and biology, Volume 20, Issue 7, 1 1 1993, Pages 825-833 The labeling of proteins and LDL with 99mTc: a new direct method employing KBH4 and stannous chloride. Pauwels EK, Welling MM, Feitsma RI, Atsma DE, Nieuwenhuizen W

A new direct labeling technique for proteins with technetium-99m (99mTc) has been developed and makes use of borohydride and stannous chloride. The method is simple and reproducible and gives a high labeling efficiency and high retention of biological activity for proteins, including polyclonal immunoglobulin (Ig), antifibrin monoclonal antibody, tissue type plasminogen activator, fibrinogen and low density lipoprotein (LDL). This method can be used in kit-format and takes about 20 min preparati... Abstract

Cited 92 times since 1993 (2.9 per year) source: EuropePMC

The EMBO journal, Volume 12, Issue 10, 1 1 1993, Pages 3921-3929 A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus. Schepers A, Pich D, Hammerschmidt W

oriLyt, the lytic origin of DNA replication of Epstein-Barr virus (EBV), ensures viral DNA amplification during the productive or lytic phase of the virus' life cycle. To understand the contribution of cis- and transacting elements involved in DNA replication of oriLyt, a detailed mutational analysis was undertaken which defined BZLF1, a viral transcriptional activator, as an essential replication factor. The BZLF1 protein belongs to the extended fos/jun family of transcription factors and... Abstract

Cited 3 times since 1993 (0.1 per year) source: EuropePMC

Catheterization and cardiovascular diagnosis, Volume 29, Issue 4, 1 1 1993, Pages 283-284 Nineteen years survival after occlusion of the left main coronary artery by virtue of an anomalous septal branch. Vliegen HW, Cats VM

This case presents a patient who survived 19 years with an occluded left main coronary artery as a result of collateral flow to the anterior wall from an anomalous septal branch arising from the right coronary artery. The case illustrates that minor variations in coronary anatomy may have important effects on the prognosis of a patient. Abstract

Cited 21 times since 1993 (0.7 per year) source: EuropePMC

Pediatric research, Volume 34, Issue 2, 1 1 1993, Pages 178-181 The influence of indomethacin on the autoregulatory ability of the cerebral vascular bed in the newborn lamb. van Bel F, Klautz RJ, Steendijk P, Schipper IB, Teitel DF, Baan J

Prevention of hyperperfusion of the brain in the perinatal period has been thought to be an important mechanism by which indomethacin reduces the risk for severe periventricular-intraventricular hemorrhage. The present study investigated whether an indomethacin-induced enhancement of the upper limit of cerebral vascular autoregulatory ability in the neonate contributed to this reduction in cerebral blood flow. In seven anesthetized newborn lambs, we measured temporal blood flow velocity (TMFV) i... Abstract

Cited 6 times since 1993 (0.2 per year) source: EuropePMC

Biological trace element research, Volume 38, Issue 2, 1 1 1993, Pages 107-115 Dietary fructose vs glucose lowers copper solubility in the digesta in the small intestine of rats. Van den Berg GJ, Yu S, Van der Heijden A, Lemmens AG, Beynen AC

The hypothesis was tested that dietary fructose vs glucose lowers copper solubility in the digesta in the small intestine of rats, which in turn causes a decreased copper absorption. Male rats were fed adequate-copper (5 mg Cu/kg) diets containing either fructose or glucose (709.4 g monosaccharide/kg) for a period of 5 wk. Fructose vs glucose significantly lowered copper concentrations in plasma and the liver, but did not alter hepatic copper mass. Fructose feeding resulted in a significantly le... Abstract

Indian heart journal, Volume 45, Issue 4, 1 1 1993, Pages 259-264 Progression and regression of coronary atherosclerosis. Bruschke AV, Jukema JW, Van der Wall EE

Abstract

Cited 60 times since 1993 (1.9 per year) source: EuropePMC

Journal of virology, Volume 67, Issue 7, 1 1 1993, Pages 4237-4245 cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus. Schepers A, Pich D, Mankertz J, Hammerschmidt W

oriLyt, the cis-acting element of Epstein-Barr virus, mediates viral DNA replication in the lytic phase of the virus's life cycle. Oligonucleotide-directed in vitro mutagenesis of oriLyt plasmids allowed the identification of two noncontiguous components within the complex structure of oriLyt. Both components were indispensable for DNA replication of this origin. The upstream component colocalized with the promoter of the viral BHLF1-encoding gene, and mutants affecting DNA replication affe... Abstract

Cited 49 times since 1993 (1.5 per year) source: EuropePMC

The American journal of physiology, Volume 264, Issue 6 Pt 2, 1 1 1993, Pages H2198-207 Left ventricular stroke volume by single and dual excitation of conductance catheter in dogs. Steendijk P, Van der Velde ET, Baan J

The conductance method employs a multielectrode catheter to measure intracavitary electric conductance from which left ventricular volume is estimated. A dual-excitation method introduced by us uses a more homogeneous electric field and thereby should enable more accurate volume estimation. In six anesthetized open-chest dogs we compared stroke volume obtained from electromagnetic flow probes with the conventional single-excitation method and with the new dual-excitation conductance method. Cava... Abstract

Cited 15 times since 1993 (0.5 per year) source: EuropePMC

Veterinary immunology and immunopathology, Volume 36, Issue 4, 1 1 1993, Pages 369-378 Effects of inoculum route and dose on the immune response of common carp, Cyprinus carpio to the blood parasite, Trypanoplasma borreli. Jones SR, Palmen M, van Muiswinkel WB

Carp were inoculated intramuscularly (im) or intraperitoneally (ip) with different doses of live Trypanoplasma borreli. Prepatent period was shortened by using the im route and by increasing the dose. Haematocrit was reduced following im inoculation with 9.5 x 10(5) parasites. Most fish recovered between 8 and 13 weeks post-inoculation (wpi). Neither parasitaemia nor anaemia was detected in any recovered fish following homologous challenge. An enzyme-linked immunosorbent assay was developed to q... Abstract

Cited 2 times since 1993 (0.1 per year) source: EuropePMC

Nutricion hospitalaria, Volume 8, Issue 5, 1 1 1993, Pages 279-287 [Effect of increasing protein ingestion on the nitrogen balance of mechanically ventilated critically ill patients receiving total parenteral nutrition]. van der Heijden A, Verbeek MJ, Schreurs VV, Akkermans LM, Vos A

The amount of protein recommended to minimise N loss in critically ill patients receiving total parenteral nutrition (TPN) varies in the literature. Therefore, we studied the effect of increased protein intake on the N balance, administering TPN with either 1.2 g protein/kg/day (low N diet) or 1.8 g protein/kg/day (high N diet). Fifteen mechanically ventilated critically ill patients were studied in a surgical intensive care unit. After at least two days of standard TPN, patients were randomly a... Abstract

Cited 56 times since 1993 (1.8 per year) source: EuropePMC

The American journal of cardiology, Volume 71, Issue 12, 1 1 1993, Pages 1036-1040 Comparison of magnetic resonance imaging studies with enzymatic indexes of myocardial necrosis for quantification of myocardial infarct size. Holman ER, van Jonbergen HP, van Dijkman PR, van der Laarse A, de Roos A, van der Wall EE

To evaluate the potential of gadolinium-diethylene triamine pentaacetic acid (DTPA)-enhanced magnetic resonance imaging (MRI) in the quantification of infarct size in patients with a first acute myocardial infarction, 24 patients with a first acute myocardial infarction were studied by electrocardiographic gated MRI at a mean of 4.3 days after the acute event. Multislice, single-phase, T1-weighted, spin-echo MRI in the true short-axis plane was performed 20 minutes after intravenous injection of... Abstract

Cited 83 times since 1993 (2.6 per year) source: EuropePMC

European heart journal, Volume 14, Issue 4, 1 1 1993, Pages 456-463 Quantitation of global and regional left ventricular function by cine magnetic resonance imaging during dobutamine stress in normal human subjects. van Rugge FP, Holman ER, van der Wall EE, de Roos A, van der Laarse A, Bruschke AV

Magnetic resonance imaging (MRI) provides high-resolution images of the heart. However, physical exercise during MRI is difficult due to space restriction and motion artefacts. To evaluate the feasibility of MRI during stress conditions, dobutamine was used as an alternative to exercise. Haemodynamics, ventricular volumes and wall thickening were measured at rest and during peak dobutamine infusion (15 micrograms.kg-1 x min-1) in 23 normal human subjects. To calculate left ventricular volumes, e... Abstract

Cited 2 times since 1993 (0.1 per year) source: EuropePMC

Journal of cardiovascular pharmacology, Volume 21, Issue 4, 1 1 1993, Pages 552-559 Comparison of diltiazem standard formulation and diltiazem controlled release in patients with stable angina pectoris: a randomized, double-blind, cross-over, multicenter study. Vliegen HW, van der Wall EE, Kragten JA, Holwerda NJ, Schenkel WM, Muijs van de Moer WM, ten Kate JB, Mulder PG, Bruschke AV

In a randomized, double-blind, cross-over, multicenter study with a placebo run-in phase, the efficacy and safety of two oral formulations of diltiazem, standard three or four times daily (t.i.d. or q.i.d.) and controlled release twice daily (b.i.d.), were compared in 49 patients with stable angina pectoris. ST-segment depression at maximum exercise 12 h after tablet intake was less frequently observed with diltiazem controlled release than with standard diltiazem (34 of 49, 69% vs. 43 of 49, 88... Abstract