Research

Publications

Below you can find a list of our published research.

7401 results

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 26 4 2025 Measurement of Tralokinumab Concentrations in Serum and Tear Fluid of Atopic Dermatitis Patients and the Relationship With Treatment Response and Ocular Surface Disease. Dekkers C, Smeijsters EH, El Amrani M, Jager CDH, van der Elst KCM, van Luin M, van Luijk C, Bakker DS, Huitema ADR, de Graaf M, van Wijk F, de Bruin-Weller MS

Abstract

Cited 3 times since 2025 (12.5 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 380, Issue 1929, 26 4 2025, Pages 20240124 The fish challenge to vertebrate cognitive evolution. Triki Z, van Schaik C, Bshary R

There is tremendous taxonomic variation in the size, shape and structure of vertebrate brains. While many studies use cross-species comparisons to aim at identifying the ecological factors (social and environmental) that explain what cognitive advantages larger brains confer, a more fundamental divide exists between endotherm and ectotherm vertebrates. Relative to body size, ectotherms have ten times smaller brains than endotherms. Existing ecological hypotheses cannot explain this divide, as so... Abstract

Circulation. Arrhythmia and electrophysiology, Volume 18, Issue 7, 25 4 2025, Pages e013670 Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium. Trongtorsak A, De La Rosa Martinez J, Crawford TC, Bogun FM, Gu X, Puroll E, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Soejima K, Bhan AK, Vedantham V, Dickfeld TL, DeLurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Torosoff M, Judson MA, Martin K, Madias C, Hermel M, Nour K, Torbey E, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium

Background: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. Methods: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular assist device implantation, heart transplantation, or implantable cardioverter defibrillator therapy.... Abstract

Cited 1 times since 2025 (4.1 per year) source: EuropePMC

PloS one, Volume 20, Issue 6, 25 4 2025, Pages e0327044 Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury. Yilmaz D, Sahin E, Batar G, Caglayan K, Gulturk E, Aydin Yoldemir S

This retrospective cohort study aimed to assess the predictive value of protein fractions obtained from blood and urine protein electrophoresis, along with various clinical and laboratory parameters, for 1-year all-cause mortality in acute kidney injury (AKI) patients. Data were collected from hospitalized patients who had been diagnosed with AKI. Demographics, smoking status, blood and urine electrophoresis results, serum gamma globulin levels, monoclonal gammopathy status, immunofixation resul... Abstract

Science advances, Volume 11, Issue 26, 25 4 2025, Pages eadt7718 The evolution of infant-directed communication: Comparing vocal input across all great apes. Wegdell F, Fryns C, Schick J, Nellissen L, Laporte M, Surbeck M, van Noordwijk MA, Masi S, Hellwig B, Willems EP, Zuberbühler K, van Schaik CP, Stoll S, Townsend SW

Human language is unique among communication systems since many elements are learned and transmitted across generations. Previous research suggests that this process is best predicted by infant-directed communication, i.e., a mode of communication directed by caregivers to children. Despite its importance for language, whether infant-directed communication is unique to humans or rooted more deeply in the primate lineage remains unclear. To assess this, we investigated directed and surrounding vo... Abstract

JHEP reports : innovation in hepatology, Volume 7, Issue 9, 24 4 2025, Pages 101490 Reply to: "Statins in MASLD: Challenges and future directions". de Jong VD, Trompet S, Jukema JW, Grobbee DE, Cabezas MC

Abstract

Journal of cardiothoracic and vascular anesthesia, 23 4 2025, Pages S1053-0770(25)00499-9 Toward a Consensus for the Definition of Vasoplegia in Cardiac Surgery. Papazisi O, Palmen M, Rao V, Billia F, de Waal EEC

Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 106, Issue 2, 23 4 2025, Pages 1489-1498 Intravascular Lithotripsy for Calcific Coronary Bifurcations: Procedural Success and 1-Year Clinical Outcomes. Oliveri F, D'Acunto G, Oort MJHV, Phagu A, Amri IA, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) has emerged as a promising treatment for heavily calcified coronary lesions. However, evidence regarding its effectiveness in calcific bifurcation lesions remains limited. Objective: We aimed to evaluate the technical success and 1-year clinical outcomes of IVL in calcified coronary bifurcation lesions. Methods: Patients undergoing PCI with the use of IVL from the ongoing prospective BENELUX-IVL registry were included. Participants were stratified into... Abstract

Cited 1 times since 2025 (4 per year) source: EuropePMC

Gut microbes, Volume 17, Issue 1, 22 4 2025, Pages 2519700 <i>Staphylococcus haemolyticus</i> is a reservoir of antibiotic resistance genes in the preterm infant gut. Lamberte LE, Darby EM, Kiu R, Moran RA, Acuna-Gonzalez A, Sim K, Shaw AG, Kroll JS, Belteki G, Clarke P, Felgate H, Webber MA, Rowe W, Hall LJ, Van Schaik W

Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemolyticus among preterm infants, we generated genome sequences of S. haemolyticus strains (n = 140) from 44 stool samples of 22 preterm infants from four hospitals in England. Core genome phylogenetic analyses, incorporating 126 publicly available S. haemolyticus genome sequences, showed that 85/140 (60.... Abstract

Acta biomaterialia, Volume 202, 21 3 2025, Pages 262-275 Multilayered trabecular meshwork for dynamic in vitro studies in glaucoma research. Gładysz MZ, Fernandes M, Li X, Koch M, Marchena F, Hofman A, de Graaf M, Wolters JC, Kamperman M, Nagelkerke A, Włodarczyk-Biegun MK

Glaucoma, an eye disease causing incremental vision loss, currently has no cure. Its primary cause is the malfunction of the trabecular meshwork (TM), a multilayered tissue in the eye responsible for draining aqueous humor (AH) from the anterior chamber. TM clogging increases outflow resistance, elevates intraocular pressure (IOP), and damages optic nerves, leading to irreversible blindness. Existing in vitro TM models are suboptimal, as they lack the hierarchical structure of the TM. This artic... Abstract

Cited 1 times since 2025 (3.9 per year) source: EuropePMC

International journal of cardiology. Congenital heart disease, Volume 21, 21 3 2025, Pages 100603 Echocardiographic effects of sodium-glucose cotransporter 2 inhibitors in single ventricle circulatory failure. Neijenhuis RML, Regeer MV, Walker NL, Hunter A, Kiès P, Holman ER, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD

Background: Single ventricle patients are at high risk of developing circulatory failure. There is limited evidence for pharmacological treatment. This study assessed the echocardiographic changes in ventricular function during sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy in patients with single ventricle failure (SVF). Methods: SVF patients with a baseline transthoracic echocardiogram within six months before starting SGLT2i and at least one echocardiographic examination within twe... Abstract

Critical reviews in oncology/hematology, Volume 214, 20 3 2025, Pages 104815 Trimodal treatment vs radical cystectomy for muscle-invasive bladder cancer: The neglected impact of informative censoring. A systematic review and meta-analysis. Robesti D, Micheli F, Rai SN, Fallara G, Gallina A, Montorsi F, Briganti A, Fossati N, van der Heijden AG, Ploussard G, Malavaud B, Martini A

Introduction: Informative censoring (IC) is a statistical bias that occurs when there is an imbalance in the dropout rate among study arms and this imbalance is not random, but can be ascribed to information that is not accounted for. Studies on trimodal therapy (TMT) versus radical cystectomy (RC) yielded conflicting results. We conducted a meta-analysis to assess the potential impact of informative censoring in influencing study outcomes. Materials and methods: A systematic literature search i... Abstract

Frontiers in big data, Volume 8, 19 3 2025, Pages 1596615 Conceptualization and scale development for big data-based learning organization capability. Alkan N, Yilmaz DE, Alkan BB

Introduction: In today's competitive business landscape, organizations must enhance learning and adaptability to gain a strategic edge. While big data significantly influences organizational learning, a comprehensive tool to measure this capability has been lacking in the literature. This study aims to develop a valid and reliable scale to assess big data-based learning organization capability. Methods: A two-phase research design was employed. In the first phase, Exploratory Factor Analysi... Abstract

Cited 1 times since 2025 (3.8 per year) source: EuropePMC

International journal of cardiology, Volume 438, 19 3 2025, Pages 133526 Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial. Zamorano JL, Vörös G, Calvi V, Osca J, Quesada A, Vernooy K, Martinez JG, Maass AH, Nof E, Tolosana JM, Pardo M, Barr C, Fernández I, Merino JL, Ellery S, Ricoy-Martínez E, Belotti G, Seidlmayer L, Garcia S, Tönnis T, Campbell NG, Foley P, Brockmeier J, Nürnberg M, Ruiz-Granell R, Prinzen FW, Lorente-Ros Á, Moreno A, Pinart M, Ver Heyen M, Van Erven L

Background: Variable evidence exists about the efficacy of Cardiac resynchronization therapy (CRT) in women vs. men with reduced left ventricular ejection fraction (LVEF) and wide QRS complex. Current guidelines, hindered by underrepresentation of women in clinical trials, lack definitive recommendations. The present study was designed to achieve an equal distribution of women and men to prospectively evaluate sex-specific response to CRT. Methods: The primary endpoint was the absolute increase... Abstract

Inflammatory bowel diseases, 16 3 2025, Pages izaf126 Food Compounds Associated With Disease Activity in Inflammatory Bowel Disease. Meima M, Westerhout J, Meijerink M, Bijlsma S, van Schaik F, Oldenburg B, Houben G

Background: Diet plays a modulatory role in inflammatory bowel disease (IBD), but specific relevant dietary factors have yet to be identified. To advance our understanding, we performed multivariate analyses of food compound intakes using dietary data from an IBD cohort. Methods: We used dietary and disease status data from IBD patients at the University Medical Center Utrecht, The Netherlands. Intake levels for 768 compounds from 135 patients were calculated. Using random forest analyses, we ex... Abstract

Archives of microbiology, Volume 207, Issue 8, 13 2 2025, Pages 174 Biochemical characterization of lipase from Cryptococcus albidus (D24) and its application in sugar fatty acid ester synthesis. Yilmaz DE, Kula C, Demirci H

Microbial lipases are widely used in industrial applications. The lipase enzyme from Cryptococcus albidus (D24) strain was biochemically characterized and evaluated for its potential in catalyzing esterification reactions, particularly in the synthesis of sugar fatty acid esters. The enzyme demonstrated enhanced activity in solvents like acetone, isopropanol, and dimethylformamide. The effects of different metal ions on the stability of the enzyme were also evaluated, and the results revealed an... Abstract

Open medicine (Warsaw, Poland), Volume 20, Issue 1, 12 2 2025, Pages 20251219 Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults. Uysal O, Yılmaz D

Objectives: The aim of the study was to examine peripheral oxygen saturation values in the index and middle fingers of the dominant hand in healthy young adults measured while lying in a supine position or sitting straight up. Methods: This study was a non-randomized and non-controlled, quasi-experimental repeated measures study. It was conducted with 200 healthy young adults in Turkey. A pulse oximeter was located at the same time on the index and middle fingers of the active hand of each parti... Abstract

Therapeutic advances in chronic disease, Volume 16, 12 2 2025, Pages 20406223251333570 Systematic review: the use of tacrolimus in steroid-refractory ulcerative colitis. Jangra V, Yilmaz D, Soares D, Taylor F, Andreani S, Hotouras A

Background: Steroid-refractory ulcerative colitis (SR-UC) is a severe form of ulcerative colitis (UC) that persists despite high-dose corticosteroid therapy. Management is challenging and often requires biologics, immunosuppressants or colectomy. Tacrolimus, a calcineurin inhibitor with immunomodulatory effects, has emerged as a potential alternative, though its efficacy, safety and long-term outcomes remain uncertain. Objectives: This systematic review evaluates the efficacy and safety of tacro... Abstract

Microbiology spectrum, Volume 13, Issue 7, 10 2 2025, Pages e0062825 Transposon-directed insertion-site sequencing (TraDIS) analysis of <i>Enterococcus faecium</i> using nanopore sequencing and a WebAssembly analysis platform. Krause AL, Wirth W, Turner AM, Judd L, Li L, van Schaik W, Howden BP, Carter GP, Seemann T, Wick R, Stinear TP, Buultjens AH, Monk IR

Vancomycin-resistant Enterococcus faecium (VREfm) are healthcare-associated opportunistic pathogens of global significance. Genetic tools are needed to understand the molecular basis for VREfm clinically relevant phenotypes, such as persistence within the human gut or antimicrobial resistance. Here, we present a transposon-directed insertion-site sequencing (TraDIS) platform optimized for E. faecium. We engineered a transposon delivery plasmid, pIMTA(tetM), that can generate high-density transpo... Abstract

Human vaccines & immunotherapeutics, Volume 21, Issue 1, 10 2 2025, Pages 2516949 A new quadrivalent meningococcal tetanus toxoid conjugate vaccine: Menquadfi® (MENACWY-TT). Dinleyici EC, Ciftci E, Somer A, Yilmaz D, Tezer H

Neisseria meningitidis (Nm) remains a major global health concern, causing invasive meningococcal disease (IMD) with significant morbidity and mortality. Despite vaccination efforts, Nm serogroup prevalence and antibiotic resistance continue to evolve, necessitating ongoing surveillance and novel immunization strategies. This review aims to assess the role of MenACWY-TT, a quadrivalent meningococcal conjugate vaccine, in IMD prevention by evaluating its immunogenicity, safety, and real-world eff... Abstract