6272 results
EClinicalMedicine,
Volume 85, 4 1 2025, Pages 103342
Intravascular lithotripsy for the treatment of calcified coronary lesions in individuals of advanced age: a post-hoc analysis of the multicentre, prospective BENELUX-IVL study.
Oliveri F, García PV, van Oort MJH, Phagu A, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Patients of advanced age are frequently underrepresented or excluded from major clinical trials, leading to limited evidence in this population and a reliance on data extrapolated from younger populations. The present study aims to compare and evaluate the safety and efficacy of intravascular lithotripsy (IVL) for the treatment of calcified coronary lesions in individuals of advanced age and in younger populations. Methods: In this post-hoc analysis, from the ongoing prospective, mul...
Abstract
JAMA cardiology,
2 1 2025
Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy.
Bhaskaran A, Ben Yaou R, Helms AS, Fayssoil A, Richard P, Stojkovic T, Anselme F, Labombarda F, Chikhaoui C, De Sandre-Giovannoli A, Jeru I, Leturcq F, Vigouroux C, Dembele M, Elliott P, Savvatis K, Zeppenfeld K, Bouguerra H, Charron P, Kumar S, Bonne G, Wahbi K, Lakdawala NK
Importance: Prior studies have suggested that patients with nonmissense (ie, truncating) variants causing LMNA cardiomyopathy have worse arrhythmic outcomes compared to those with missense variants. However, the effect of the spatial distribution of missense and truncating variants on clinical outcomes remains poorly understood. Objective: To determine the association of the spatial distribution of missense and truncating LMNA variants with cardiac outcomes. Design, setting, and participants: Th...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 8, 1 1 2025, Pages 1466-1474
Left ventricular dilatation in patients with significant aortic regurgitation: association with outcome.
Lopez Santi P, Bernard J, Fortuni F, Butcher SC, Meucci MC, Sarrazyn C, Chua AP, Nabeta T, Zhang J, Popescu BA, Tay ELW, Yiu KH, Clavel MA, Pibarot P, Bax JJ, Ajmone Marsan N
Aims: Left ventricular (LV) dilatation is an important prognostic factor in patients with aortic regurgitation (AR). Although current guidelines recommend the use of LV end-systolic diameter index (LVESDi) to indicate the need for intervention, recent studies suggested that LV end-systolic volume index (LVESVi) may more accurately characterize LV remodelling.The present study aims to evaluate, in a multi-centre setting, whether combining LV linear and volumetric measures could improve risk strat...
Abstract
Heart rhythm,
Volume 22, Issue 7, 1 1 2025, Pages 1877-1879
Top stories on proactive ventricular arrhythmia assessment in repaired tetralogy of Fallot.
Zeppenfeld K, Kimura Y
Abstract
Current heart failure reports,
Volume 22, Issue 1, 1 1 2025, Pages 21
Impact of Multisensor CIED-based Heart Failure Monitoring on Mortality, Heart Failure Hospitalizations and Outpatient Visits: A Systematic Review.
Zwaenepoel BAC, Kluft A, Feijen M, Schoones JW, Heggermont WA, Egorova AD, Beeres SLMA
Purpose of review: Cardiac Implantable Electronic Device (CIED)-based remote monitoring has been proposed to improve heart failure (HF) management by enabling early detection of decompensation. This systematic review evaluates the effectiveness of multisensor CIED-based monitoring in reducing mortality, HF hospitalizations, and unplanned HF outpatient visits. Recent findings: Earlier CIED-based remote monitoring strategies were mainly based on single-sensor impedance-based algorithms, and showed...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf122
Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrhythmia radioablation using a commercial software.
Rademaker R, Cirkel S, Omara S, Dankers FJWM, Sramko M, Solana Munoz J, Kaya YS, Ter Bekke RMA, Schiappacasse L, Teres C, Verhoeven K, Pruvot E, Rasch CRN, Zeppenfeld K
Aims: Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages. Methods and results: In patients considered for STAR, CardTV-E...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf134
Regionalization of the atria for 3D electroanatomical mapping, cardiac imaging, and computational modelling: a clinical consensus statement of the European Heart Rhythm Association and the European Association of Cardiovascular Imaging of the ESC.
Althoff TF, Anderson RH, Goetz C, Petersen SE, Díaz PM, Nijveldt R, Maurovich-Horvat P, Bax J, Hussain S, Schmidt C, Spicer DE, Sanchez-Quintana D, Corsi C, Dössel O, Climent AM, Rodriguez B, Schotten U, Loewe A, Guillem MS, Cabrera JÁ, Merino JL, Wijnmaalen AP, Bertrand PB, de Groot N, Derval N, Didenko M, Donal E, Dweck MR, Ho SY
This clinical consensus document proposes standardized atrial segments for 3D imaging, electroanatomical mapping and computational modelling, based on anatomical, electrophysiological and clinical considerations, with precise definitions of regional borders allowing for reproducible and automated regionalization. 3D imaging and high-resolution electroanatomical mapping have become an integral part of cardiac electrophysiology and the management of patients with arrhythmias. However, to perform r...
Abstract
Journal of magnetic resonance imaging : JMRI,
30 5 2025
Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.
Bosshardt D, van Andel MM, Schrauben EM, van Kimmenade RRJ, Scholte AJ, Cox MGJP, Robbers-Visser D, Zwinderman AH, Mulder BJM, Nederveen AJ, de Waard V, Groenink M, van Ooij P
Background: New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients. Purpose: To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS. Study type: Prospective single-arm open-label multicenter trial. Population: 46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of ao...
Abstract
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
Volume 210, 27 4 2025, Pages 111004
Transfer of arrhythmia substrate targets from the cardiac electroanatomical and imaging modalities to the planning computed tomography scan for stereotactic arrhythmia radioablation for refractory ventricular tachycardia - a state-of-the-art review on software developments on behalf of the STOPSTORM.eu consortium.
Ter Bekke RMA, Hohmann S, Xie J, Grehn M, Verhoeven K, Volders PGA, Mihl C, Kaya YS, Manninger M, Scherr D, Corradini S, Schweikard A, Rademaker R, Hoeksema WF, Schiappacasse L, Knybel L, Pruvot E, Postema PG, Peichl P, Cvek J, Zeppenfeld K, Blanck O, Boda-Heggemann J
Stereotactic arrhythmia radioablation (STAR) for ventricular tachycardia (VT) is a non-invasive treatment modality to reduce the VT burden by delivering a single high radiation dose to the arrhythmogenic substrate. Identification and delineation of the arrhythmogenic substrate, definition of the radiation target, and transfer of this target across different imaging modalities from the invasive electroanatomic map (EAM) to the planning computed tomography (CT) scan are key to the success of thera...
Abstract
Physics in medicine and biology,
Volume 70, Issue 13, 27 4 2025
Analysis and generation of the fibrosis textures based on histology data of the human hearts with non-ischemic cardiomyopathy.
Okenov A, Nezlobinsky T, Glashan CA, Zeppenfeld K, Vandersickel N, Panfilov AV
Objective.Cardiac arrhythmias, marked by irregular and/or fast heartbeats, can severely compromise heart function and pose serious health risks. Fibrosis alters the propagation of electrical signals in the heart and plays a critical role in arrhythmogenesis. The impact of fibrosis depends not only on its amount, but also on its geometric features and spatial distribution. Therefore, understanding and replicating the structural characteristics of fibrotic tissue is essential for accurate arrhythm...
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
26 4 2025
Measurement of Tralokinumab Concentrations in Serum and Tear Fluid of Atopic Dermatitis Patients and the Relationship With Treatment Response and Ocular Surface Disease.
Dekkers C, Smeijsters EH, El Amrani M, Jager CDH, van der Elst KCM, van Luin M, van Luijk C, Bakker DS, Huitema ADR, de Graaf M, van Wijk F, de Bruin-Weller MS
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 7, 25 4 2025, Pages e013670
Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.
Trongtorsak A, De La Rosa Martinez J, Crawford TC, Bogun FM, Gu X, Puroll E, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Soejima K, Bhan AK, Vedantham V, Dickfeld TL, DeLurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Torosoff M, Judson MA, Martin K, Madias C, Hermel M, Nour K, Torbey E, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium
Background: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. Methods: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular assist device implantation, heart transplantation, or implantable cardioverter defibrillator therapy....
Abstract
Cited 1 times since 2025 (8.3 per year)
source: EuropePMC
PloS one,
Volume 20, Issue 6, 25 4 2025, Pages e0327044
Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury.
Yilmaz D, Sahin E, Batar G, Caglayan K, Gulturk E, Aydin Yoldemir S
This retrospective cohort study aimed to assess the predictive value of protein fractions obtained from blood and urine protein electrophoresis, along with various clinical and laboratory parameters, for 1-year all-cause mortality in acute kidney injury (AKI) patients. Data were collected from hospitalized patients who had been diagnosed with AKI. Demographics, smoking status, blood and urine electrophoresis results, serum gamma globulin levels, monoclonal gammopathy status, immunofixation resul...
Abstract
Journal of cardiothoracic and vascular anesthesia,
23 4 2025, Pages S1053-0770(25)00499-9
Toward a Consensus for the Definition of Vasoplegia in Cardiac Surgery.
Papazisi O, Palmen M, Rao V, Billia F, de Waal EEC
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
23 4 2025
Intravascular Lithotripsy for Calcific Coronary Bifurcations: Procedural Success and 1-Year Clinical Outcomes.
Oliveri F, D'Acunto G, Oort MJHV, Phagu A, Amri IA, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has emerged as a promising treatment for heavily calcified coronary lesions. However, evidence regarding its effectiveness in calcific bifurcation lesions remains limited. Objective: We aimed to evaluate the technical success and 1-year clinical outcomes of IVL in calcified coronary bifurcation lesions. Methods: Patients undergoing PCI with the use of IVL from the ongoing prospective BENELUX-IVL registry were included. Participants were stratified into...
Abstract
Acta biomaterialia,
Volume 202, 21 3 2025, Pages 262-275
Multilayered trabecular meshwork for dynamic in vitro studies in glaucoma research.
Gładysz MZ, Fernandes M, Li X, Koch M, Marchena F, Hofman A, de Graaf M, Wolters JC, Kamperman M, Nagelkerke A, Włodarczyk-Biegun MK
Glaucoma, an eye disease causing incremental vision loss, currently has no cure. Its primary cause is the malfunction of the trabecular meshwork (TM), a multilayered tissue in the eye responsible for draining aqueous humor (AH) from the anterior chamber. TM clogging increases outflow resistance, elevates intraocular pressure (IOP), and damages optic nerves, leading to irreversible blindness. Existing in vitro TM models are suboptimal, as they lack the hierarchical structure of the TM. This artic...
Abstract
International journal of cardiology. Congenital heart disease,
Volume 21, 21 3 2025, Pages 100603
Echocardiographic effects of sodium-glucose cotransporter 2 inhibitors in single ventricle circulatory failure.
Neijenhuis RML, Regeer MV, Walker NL, Hunter A, Kiès P, Holman ER, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD
Background: Single ventricle patients are at high risk of developing circulatory failure. There is limited evidence for pharmacological treatment. This study assessed the echocardiographic changes in ventricular function during sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy in patients with single ventricle failure (SVF). Methods: SVF patients with a baseline transthoracic echocardiogram within six months before starting SGLT2i and at least one echocardiographic examination within twe...
Abstract
International journal of cardiology,
Volume 438, 19 3 2025, Pages 133526
Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial.
Zamorano JL, Vörös G, Calvi V, Osca J, Quesada A, Vernooy K, Martinez JG, Maass AH, Nof E, Tolosana JM, Pardo M, Barr C, Fernández I, Merino JL, Ellery S, Ricoy-Martínez E, Belotti G, Seidlmayer L, Garcia S, Tönnis T, Campbell NG, Foley P, Brockmeier J, Nürnberg M, Ruiz-Granell R, Prinzen FW, Lorente-Ros Á, Moreno A, Pinart M, Ver Heyen M, Van Erven L
Background: Variable evidence exists about the efficacy of Cardiac resynchronization therapy (CRT) in women vs. men with reduced left ventricular ejection fraction (LVEF) and wide QRS complex. Current guidelines, hindered by underrepresentation of women in clinical trials, lack definitive recommendations. The present study was designed to achieve an equal distribution of women and men to prospectively evaluate sex-specific response to CRT. Methods: The primary endpoint was the absolute increase...
Abstract
Therapeutic advances in chronic disease,
Volume 16, 12 2 2025, Pages 20406223251333570
Systematic review: the use of tacrolimus in steroid-refractory ulcerative colitis.
Jangra V, Yilmaz D, Soares D, Taylor F, Andreani S, Hotouras A
Background: Steroid-refractory ulcerative colitis (SR-UC) is a severe form of ulcerative colitis (UC) that persists despite high-dose corticosteroid therapy. Management is challenging and often requires biologics, immunosuppressants or colectomy. Tacrolimus, a calcineurin inhibitor with immunomodulatory effects, has emerged as a potential alternative, though its efficacy, safety and long-term outcomes remain uncertain. Objectives: This systematic review evaluates the efficacy and safety of tacro...
Abstract
Human vaccines & immunotherapeutics,
Volume 21, Issue 1, 10 2 2025, Pages 2516949
A new quadrivalent meningococcal tetanus toxoid conjugate vaccine: Menquadfi® (MENACWY-TT).
Dinleyici EC, Ciftci E, Somer A, Yilmaz D, Tezer H
Neisseria meningitidis (Nm) remains a major global health concern, causing invasive meningococcal disease (IMD) with significant morbidity and mortality. Despite vaccination efforts, Nm serogroup prevalence and antibiotic resistance continue to evolve, necessitating ongoing surveillance and novel immunization strategies. This review aims to assess the role of MenACWY-TT, a quadrivalent meningococcal conjugate vaccine, in IMD prevention by evaluating its immunogenicity, safety, and real-world eff...
Abstract
